"The monocytes are coming out of the bone marrow and they are not responsive to steroid regulation, so they overproduce proinflammatory signals when they're stimulated. We think this is the key to the prolonged anxiety-like disorders that we see in these animals," Sheridan said.
These findings do not apply to all forms of anxiety, the scientists noted, but they are a game-changer in research on stress-related mood disorders.
"Our data alter the idea of the neurobiology of mood disorders," said Eric Wohleb, first author of the study and a predoctoral fellow in Ohio State's Neuroscience Graduate Studies Program. "These findings indicate that a bidirectional system rather than traditional neurotransmitter pathways may regulate some forms of anxiety responses. We're saying something outside the central nervous system something from the immune system is having a profound effect on behavior."
|Contact: John Sheridan|
Ohio State University