Navigation Links
Montreal researchers shed light on common juvenile cancer

This release is available in French.

Montreal, June 16, 2010 A team of researchers from the Institute for Research in Immunology and Cancer (IRIC) of the Universit de Montral have defined for the first time the mechanism behind three cancer-causing genes in acute lymphoblastic leukemia. Published in the journal Genes and Development, the findings offer insight on the complex interaction between the genes and their contributions to leukemia, thereby providing the foundation for the design of targeted therapies.

The study was conducted by primary authors Mathieu Tremblay, Ph.D. student and Cdric Tremblay, post-doctoral fellow in the Hematopoiesis and Leukemia Laboratory at the Universit de Montral and led by corresponding author and IRIC Principal Investigator, Trang Hoang.

Acute lymphoblastic leukemia (ALL) is the most frequent childhood cancers and affects lymphocytes, the cells in the body that normally fight infections. ALL starts when a single, immature white blood cell called a "blast" develops a series of mistakes or mutations that allow it to multiply uncontrollably. Eventually, these leukemic blasts take over the lymphoid organs, the bone marrow and crowd out normal blood cells.

While extensive research has been conducted over the years to understand this type of cancer, deciphering the complex process responsible for transforming normal cells into cancerous cells remains a challenge. In this study, researchers started from the well-known basis that the interaction between two genes, SCL and LMO, is involved at the onset of a specific type of ALL, called T-cell leukemia.

"We wanted to uncover the precise mechanism behind the process that causes a normal cell to become cancerous. Our study reveals that SCL and LMO expand the pool of immature lymphocytes, which proliferate intensively under the influence of a specific signal. These SCL-LMO-primed cells then acquire mutations in a third gene, Notch1, which is known to play a role in the majority of T-ALL patients," explains Trang Hoang. "In short, the synergy between these three genes in a permissive cell is sufficient to induce leukemia."

Although chemotherapy can cure up to 80 percent of ALL in children, researchers hope to minimize the side effects by designing new therapies that specifically target cancer causing genes. "The knowledge from our study could be instrumental in the development of less invasive cancer therapies," adds Dr. Hoang.


Contact: Carolyne Lord
University of Montreal

Related medicine news :

1. UCSF Researchers Identify Regulator of Human Sperm Cells
2. Researchers find broad spectrum antiviral that fights multitude of viruses
3. University of Alberta researchers develop drug interface to save lives
4. Caregivers of ICU patients are collateral damage of critical illness, say Pitt researchers
5. Researchers fight world hunger by mapping the soybean genome
6. HIV researchers solve key puzzle after 20 years of trying
7. UC Davis researchers identify brain protein for synapse development
8. UCLA cancer researchers perform complete genomic sequencing of brain cancer cell line
9. Researchers find new way to study how enzymes repair DNA damage
10. UCLA researchers image earliest signs of Alzheimers, before symptoms appear
11. Researchers find leukemia cells metabolize fat to avoid cell death
Post Your Comments:
(Date:6/24/2016)... ... ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief Products, join The ‘Business for ... $12 an hour by 2020 and then adjusting it yearly to increase at the same ... wage, assure the wage floor does not erode again, and make future increases more predictable. ...
(Date:6/24/2016)... ... June 24, 2016 , ... ... Clinical Decision Making in Emergency Medicine conference in Ponte Vedra Beach, FL. The ... published in Emergency Medicine Practice and Pediatric Emergency Medicine Practice. , ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... client, The Grove Investment Group (TGIG), has initiated cultivation and processing operations at ... Las Vegas and Pahrump, Nevada. , Puradigm is the manufacturer of a complete ...
(Date:6/24/2016)... ... June 24, 2016 , ... National recruitment firm Slone Partners ... extensive sequencing and genomics experience, as Vice President of North American Capital Sales at ... responsible for leading the sales team in the commercialization of the HTG EdgeSeq system ...
(Date:6/24/2016)... ... 24, 2016 , ... Today, MTI-GlobalStem, a provider of optimized ... difficult to transfect cells, announces its launch of the PluriQ™ G9™ Gene Editing ... is a complete system for culturing and transfecting human pluripotent stem cells ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... ITASCA, Ill. , June 23, 2016  In a startling ... states are failing their residents by lacking a comprehensive, proven plan ... , a definitive ranking of how states are tackling the ... rating to only four states – Kentucky , ... and Vermont . Of the 28 failing states, ...
(Date:6/23/2016)... , June 23, 2016 Bracket , a ... its next generation clinical outcomes platform, Bracket eCOA (SM) ... on June 26 – 30, 2016 in Philadelphia ... electronic Clinical Outcome Assessment product of its kind to fully ... Bracket eCOA 6.0 is a flexible platform for ...
(Date:6/23/2016)... 23, 2016  Guerbet announced today that it has ... Horizon Award . One of 12 suppliers ... for its support of Premier members through exceptional local ... and commitment to lower costs. ... of our outstanding customer service from Premier," says ...
Breaking Medicine Technology: