Navigation Links
Montreal researchers prove that insulin-producing cells can give rise to stem-like cells in-vitro
Date:7/21/2008

Montreal, 17 July 2008 The question of whether insulin-producing cells of the pancreas can regenerate is key to our understanding of diabetes, and to the further development of regenerative therapies against the disease. Dr Rosenberg from the McGill University Health Centre (MUHC) and McGill University together with Dr Bernard Massie from the Centre hospitalier de l'Universit de Montral (CHUM) have just concluded that they can. The results of their study have been published in the July issue of the journal Laboratory Investigation.

The researchers have shown in vitro that insulin-producing β-cells (beta cells) can return to a more primitive developmental state called stem-like cells. This process is known as "dedifferentiation" and highlights the plasticity of this cell type. This same result has also been validated for the three additional types of cells that along with β-cells make up the islets of Langerhans. Together, these islet cells produce insulin and other hormones in the pancreas.

"The potential for dedifferentiation of all the different cells that make up the islets of Langerhans is a totally new finding," Dr. Rosenberg said.

"At this stage, we can't confirm whether the cells' ability to turn into stem-like cells occur naturally in a healthy pancreas, but the results are very encouraging for the development of regenerative therapies to fight diabetes," he continued. The cell's in-vitro plasticity opens up totally new avenues of investigation into the underlying causes of diabetes, and will validate the development of innovative treatments.

This study is the latest step in an extensive regenerative therapies research program based on a peptide called Islet Neogenesis Associated Protein, or INGAP. Dr. Rosenberg and his colleagues have demonstrated INGAP's potential to induce new islet formation in the pancreas. Clinical trials with INGAP have already demonstrated that it is possible to regrow
'/>"/>

Contact: Rebecca Burns
rebecca.burns@muhc.mcgill.ca
514-843-2189
McGill University Health Centre
Source:Eurekalert

Page: 1 2

Related medicine news :

1. The Montreal Heart Institute presents findings on congestive heart failure and atrial fibrillation
2. Haemacure to Present at Busines$ Meets Finance on May 20, 2008 at the Montreal Sheraton Centre
3. The Montreal Childrens Hospital of the MUHC begins search for causes of autism
4. Worrell Inc. Acquires Gad Shaanan Design Operations in Montreal and San Diego
5. World fertility experts to meet in Montreal - IVF and IVM patients to provide first-person accounts at 14th World Congress
6. Researchers Find Link Between Organ Transplants, Cancer
7. Tufts researchers discover link between DNA palindromes and disease
8. Researchers hone technique to KO pediatric brain tumors
9. Researchers link Huntingtons disease to overactive immune response in the brain
10. Researchers: Program discourages HIV transmission in Russia
11. Stanford Bio-X researchers use needle-thin probe to get first look at working muscle fiber
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2015)... (PRWEB) April 25, 2015 The impact ... still eliciting the excitement of the public and is ... the months of May and June. From March ... their biannual tradition of "Special Prayers." More than 600 ... attended previous Special Prayers and have reported intense experiences ...
(Date:4/25/2015)... 25, 2015 Parker and Sons projects growth ... has spiked in Arizona alongside the growing economy. As a ... employees for April to help account for the rising need ... in April is something we are enthusiastic about. It means ... Kelly, president at Parker and Sons. , Indeed, Parker and ...
(Date:4/25/2015)... 2015 On Friday, April 17, Interstate ... annual Best Implementation Award. This award is given ... use of RFID technology to improve its manufacturing, supply ... that best demonstrates how RFID is delivering real value ... Journal Live! 2015 in San Diego, the RFID industries ...
(Date:4/24/2015)... April 24, 2015 Constellations Recovery celebrates ... in Westchester County. Just 35 miles from New York ... back into everyday life while recovering from addiction. The ... 2015, will allow therapists, doctors and treatment centers to ... more about the opportunities offered by Constellations Recovery.,  , ...
(Date:4/24/2015)... (PRWEB) April 24, 2015 Ryadon is ... wide range of capabilities and services to complement any ... Ryadon's Quantity Discount Program will be offered on all ... , Order 4-19: Receive 10% discount - Order 20+: ... Using the Drawer Slides Products, ...
Breaking Medicine News(10 mins):Health News:Trivedi Master Wellness™ Announces the Resounding Success of their Special Prayers Human Wellness Program 2Health News:Trivedi Master Wellness™ Announces the Resounding Success of their Special Prayers Human Wellness Program 3Health News:Parker and Sons Plans to Expand in 2015 2Health News:Seeonic’s Industry Leading Technology Powers Interstate Batteries to Winning Award 2Health News:Constellations Recovery Opens The First Luxury Sober Living Residence in Westchester New York 2Health News:Constellations Recovery Opens The First Luxury Sober Living Residence in Westchester New York 3Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 2Health News:Ryadon Inc. Offers Quantity Drawer Slide Discount Program Nationwide in May 2015 3
... HealthDay Reporter , WEDNESDAY, June 15 (HealthDay News) -- ... leading nations in terms of life expectancy, and the gap ... Life expectancy in some areas of the United States is ... nations, the report found. "The gap between the U.S. ...
... Reporter , WEDNESDAY, June 15 (HealthDay News) -- Severely ... fade or become less frequent after having weight-reducing gastric ... the three years following surgery, 70 percent of the ... saw their migraines reduced from five to two a ...
... as nave and irrational, can actually help consumers cope ... to a new study in the Journal of ... an individual invokes mystical, supernatural forces to understand, predict, ... write authors Yannik St. James (HEC Montreal), Jay M. ...
... 2011, the New York Academy of Sciences will ... molecular biologists and patient advocates to discuss current ... and management of the cognitive symptoms of MS. ... Dysfunction in Multiple Sclerosis: New Approaches to Diagnosis ...
... -- A person scanning baggage or X-rays stands a ... they aren,t feeling anxious, according to a new laboratory ... a test in which they searched for particular shapes ... searching performed by airport security teams and radiologists. ...
... of asbestos-contaminated dust, have a higher level of genetic somatic ... lower. This has been shown in a new study carried ... the University of Haifa,s Department of Biology in Oranim. "This ... higher levels of asbestos in the environment and the frequency ...
Cached Medicine News:Health News:U.S. Found to Be Losing Ground in Life Expectancy 2Health News:U.S. Found to Be Losing Ground in Life Expectancy 3Health News:For Many, Weight-Loss Surgery Also Eases Migraines 2Health News:For Many, Weight-Loss Surgery Also Eases Migraines 3Health News:Magical thinking helps dieters cope with unrealistic expectations 2Health News:The New York Academy of Sciences to host a symposium on cognitive dysfunction in multiple sclerosis 2Health News:Anxious searchers miss multiple objects 2Health News:Genetic mutation linked to asbestos exposure 2
(Date:4/23/2015)... HILL, S.C. , April 23, 2015 ... on and strengthening our commitment to patient safety. ... in the fight against infectious disease. The ... Medical gas sensors are now mounted in ... reducing the need to open ceiling tiles potentially releasing ...
(Date:4/23/2015)... April 23, 2015 Nektar Therapeutics (Nasdaq: NKTR ... ended March 31, 2015 on Thursday, April 30, 2015, after ... president and chief executive officer, will host a conference call ... (ET)/2:00 p.m. Pacific Time (PT). The press ... can be accessed through a link that is posted on ...
(Date:4/23/2015)... 23, 2015  DanDrit Biotech A/S ("DanDrit Denmark"), ... , Inc. ("DanDrit"), (symbol : OTCQB:DDRT) a ... for the treatment of colorectal cancer, announced that ... signed a partnership agreement in Saudi ... advances DanDrit,s goal to deliver an innovative portfolio ...
Breaking Medicine Technology:BeaconMedaes launches new Zone Valve Box Assembly 2Nektar to Announce Financial Results for the First Quarter 2015 on Thursday, April 30, 2015, After Close of U.S.-Based Financial Markets 2DanDrit Biotech and Riyadh Pharma Sign Partnership Agreement 2
... 2011 Henry Schein, Inc. (NASDAQ: ... services to office-based practitioners, announced today that Ferdinand ... the CL King 9th Annual Best Ideas Conference 2011. The ... New York City. Henry Schein,s presentation is ...
... VILLAGE, Nev., Sept. 13, 2011 PDL BioPharma, Inc. (PDL) ... McLaughlin, the company,s president and chief executive officer, will present ... ) UBS Global Life Sciences Conference ... The JMP Securities Healthcare Conference Tuesday, ...
Cached Medicine Technology:Henry Schein to Present at the CL King 9th Annual Best Ideas Conference 2011 2
Carl Zeiss has created a special configuration of the OPMI pico surgical microscope for neurosurgical applications, combining the benefits of optical excellence and superb illumination with outstandi...
... M501 TTS offers the comfort of a ... training application. The microscope offers brilliant resolution, ... and natural color reproduction. A separate prism ... be optimized with a special jalousie diaphragm. ...
... The Leica MS2 is designed to perfectly ... as multidisciplinary use. The Leica MS2 combines ... M500 N with a innovative stand concept ... brakes, patented ABC balancing system for the ...
... system has been designed to ... The maneuverability of this system ... fatigue-free viewing even at the ... in posterior fossa, cerebral tumor, ...
Medicine Products: