Navigation Links
Montreal researchers prove that insulin-producing cells can give rise to stem-like cells in-vitro
Date:7/21/2008

Montreal, 17 July 2008 The question of whether insulin-producing cells of the pancreas can regenerate is key to our understanding of diabetes, and to the further development of regenerative therapies against the disease. Dr Rosenberg from the McGill University Health Centre (MUHC) and McGill University together with Dr Bernard Massie from the Centre hospitalier de l'Universit de Montral (CHUM) have just concluded that they can. The results of their study have been published in the July issue of the journal Laboratory Investigation.

The researchers have shown in vitro that insulin-producing β-cells (beta cells) can return to a more primitive developmental state called stem-like cells. This process is known as "dedifferentiation" and highlights the plasticity of this cell type. This same result has also been validated for the three additional types of cells that along with β-cells make up the islets of Langerhans. Together, these islet cells produce insulin and other hormones in the pancreas.

"The potential for dedifferentiation of all the different cells that make up the islets of Langerhans is a totally new finding," Dr. Rosenberg said.

"At this stage, we can't confirm whether the cells' ability to turn into stem-like cells occur naturally in a healthy pancreas, but the results are very encouraging for the development of regenerative therapies to fight diabetes," he continued. The cell's in-vitro plasticity opens up totally new avenues of investigation into the underlying causes of diabetes, and will validate the development of innovative treatments.

This study is the latest step in an extensive regenerative therapies research program based on a peptide called Islet Neogenesis Associated Protein, or INGAP. Dr. Rosenberg and his colleagues have demonstrated INGAP's potential to induce new islet formation in the pancreas. Clinical trials with INGAP have already demonstrated that it is possible to regrow
'/>"/>

Contact: Rebecca Burns
rebecca.burns@muhc.mcgill.ca
514-843-2189
McGill University Health Centre
Source:Eurekalert

Page: 1 2

Related medicine news :

1. The Montreal Heart Institute presents findings on congestive heart failure and atrial fibrillation
2. Haemacure to Present at Busines$ Meets Finance on May 20, 2008 at the Montreal Sheraton Centre
3. The Montreal Childrens Hospital of the MUHC begins search for causes of autism
4. Worrell Inc. Acquires Gad Shaanan Design Operations in Montreal and San Diego
5. World fertility experts to meet in Montreal - IVF and IVM patients to provide first-person accounts at 14th World Congress
6. Researchers Find Link Between Organ Transplants, Cancer
7. Tufts researchers discover link between DNA palindromes and disease
8. Researchers hone technique to KO pediatric brain tumors
9. Researchers link Huntingtons disease to overactive immune response in the brain
10. Researchers: Program discourages HIV transmission in Russia
11. Stanford Bio-X researchers use needle-thin probe to get first look at working muscle fiber
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... Epidemiologists forecast an increase in the diagnosed incident ... incident cases in 2013 to 11,568 diagnosed incident cases ... 4.35%, during the forecast period. In 2023, the US ... of aGVHD in the 6MM, with 4,989 diagnosed incident ... diagnosed incident cases of aGVHD, with 704 diagnosed incident ...
(Date:7/13/2014)... OH (PRWEB) July 13, 2014 Wright ... bellwether trial has been scheduled in July of 2015, ... Lipitor lawsuits are in the discovery process ... Richard M. Gergel is presiding over the multidistrict litigation ... filed on behalf of individuals who allege that they ...
(Date:7/13/2014)... 13, 2014 Hope Palliative & Hospice Care ... support group at the Tamarack Senior Living Community in Palatine, ... 10:30 A.M. on the 3rd Wednesdays of every month. ... the Tamarack Community located at 55 S. Greeley St. Palatine, ... and there is no cost for the group. , ...
(Date:7/13/2014)... Recently, iFitDress.com, one of the most popular suppliers ... added a new selection of beautiful evening dresses ... a promotion for these evening gowns. Now, everybody can ... providing thousands of graceful gowns in its online store. ... France, Italy and many other countries. They are highly ...
(Date:7/12/2014)... July 12, 2014 The Chicken ... the past five years, buoyed by stable demand for ... management system. “Eggs are a relatively affordable staple for ... egg consumption generally grows in line with the size ... McKitterick. Furthermore, demand for new specialty egg products with ...
Breaking Medicine News(10 mins):Health News:Graft-Versus-Host Disease Market (GVHD) Growing at 4.35% AGR to 2023 Says a New Report Available at ReportsnReports.com 2Health News:Graft-Versus-Host Disease Market (GVHD) Growing at 4.35% AGR to 2023 Says a New Report Available at ReportsnReports.com 3Health News:Graft-Versus-Host Disease Market (GVHD) Growing at 4.35% AGR to 2023 Says a New Report Available at ReportsnReports.com 4Health News:Lipitor Lawsuits Move Forward With Scheduling Of First Bellwether Trial 2Health News:Lipitor Lawsuits Move Forward With Scheduling Of First Bellwether Trial 3Health News:Lipitor Lawsuits Move Forward With Scheduling Of First Bellwether Trial 4Health News:Hope Hospice Announces Grief Support Group at the Tamarack Senior Living Community 2Health News:New and Beautiful Evening Dresses Unveiled by iFitDress.com 2Health News:Chicken Egg Production in Canada Industry Market Research Report Now Available from IBISWorld 2Health News:Chicken Egg Production in Canada Industry Market Research Report Now Available from IBISWorld 3
... ... announcing the launch of its new website, Herbal Fen Phen Lawyers ( http://www.herbalfenphenlawyers.com/ ). ... to Fen Phen, despite warnings from the FDA that herbal Fen Phen may be ... attacks, strokes or death. , ...
... efficient to use the drug cetuximab only in colorectal cancer ... a study published online August 7 in the Journal ... tumors harbored wild-type KRAS were found to have a higher ... by the National Cancer Institute of Canada Clinical Trials Group. ...
... BEIJING, Aug. 7 /PRNewswire-Asia-FirstCall/ -- ... CMED ), a leading China-based medical device,company that ... announced the appointment of PricewaterhouseCoopers ("PwC") as,the Company,s ... previous independent auditors, KPMG. , ...
... , Senate Finance Committee Urged Not to ... , WASHINGTON, Aug. 7 America,s local and regional ... a provision imposing a 20% co-pay on laboratory services under Medicare. ... system, this provision would shift billions of dollars in costs to ...
... , MORRISTOWN, N.J., Aug. 7 Watson Pharmaceuticals, ... announced today that one lot of 100 mcg/hr Fentanyl Transdermal System ... wholesalers and pharmacies. The recalled patches are from Lot Number ... Watson Laboratories, Inc. and distributed by Watson Pharma, Inc. The ...
... , NEW YORK, Aug. 7 ... the final results of the previously announced offers by its ... "Issuers"), to purchase for cash (i) any and all of ... Secured Floating Rate Notes due 2010 (the "Floating Rate Notes") ...
Cached Medicine News:Health News:Hissey Kientz Announces the Launch of Herbal Fen Phen Lawyers Website 2Health News:Hissey Kientz Announces the Launch of Herbal Fen Phen Lawyers Website 3Health News:Cost-effectiveness of cetuximab in metastatic colorectal cancer 2Health News:China Medical Technologies Announces Change of Independent Auditors 2Health News:Seniors: Get Your Checkbooks Ready 2Health News:Watson Announces Limited Recall Of Fentanyl Transdermal System 2Health News:Watson Announces Limited Recall Of Fentanyl Transdermal System 3Health News:Duane Reade Holdings, Inc. Announces Expiration and Results of Tender Offers for Senior Secured Floating Rate Notes and Senior Subordinated Notes and Solicitation of Consents to Related Indentures 2Health News:Duane Reade Holdings, Inc. Announces Expiration and Results of Tender Offers for Senior Secured Floating Rate Notes and Senior Subordinated Notes and Solicitation of Consents to Related Indentures 3
(Date:7/10/2014)... , July 10, 2014 CVS Caremark Corporation (NYSE: ... directors has approved a quarterly dividend of $0.275 (27.5 cents) ... payable on August 1, 2014, to holders of record on ... CVS Caremark is dedicated to helping people on their ... in the United States . Through the ...
(Date:1/15/2014)... 15, 2014 Most osteoporosis patients want a choice ... online survey* sponsored by Mission Pharmacal Company. The survey, ... Foundation online support community, revealed that 74 percent of ... in a form other than a pill or a ...
(Date:1/15/2014)... Texas , Jan. 15, 2014  Novation, the leading ... awarded several new IT value-added reseller (VAR) national contracts ... IT goods and services at lower costs. These include ... services such as initiative assistance and ongoing IT consulting ...
Breaking Medicine Technology:Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 2Mission Pharmacal Conducts Online Survey of Osteoporosis Patients 3New Novation Information Technology VAR Contracts Offer Significant Savings to Hospitals 2
... , RYE, N.Y. , July 28 Curemark, ... on the treatment of neurological diseases, announced that Saint Peter,s University Hospital ... Phase III clinical trials for CM-AT , Curemark,s autism treatment.   ... Saint Peter,s is affiliated ...
... SEATTLE , July 28 HemaQuest Pharmaceuticals, ... for sickle cell disease, beta thalassemia and EBV-related cancers, ... to its Series B financing by new investor, ... B financing to $16M . The financing is ...
Cached Medicine Technology:Curemark Opens Autism Trials at New Jersey Site 2Curemark Opens Autism Trials at New Jersey Site 3HemaQuest Pharmaceuticals Raises Additional $4M to Bring Total to $16M in Series B Financing 2
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: