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Monogram Announces Commercial Availability of the HERmark(TM) Breast Cancer Assay
Date:7/8/2008

Accurate and Quantitative Measurement of Breast Cancer Patient's HER2

Status Now Available to Physicians

SOUTH SAN FRANCISCO, Calif., July 8 /PRNewswire-FirstCall/ -- Monogram Biosciences, Inc. (Nasdaq: MGRM) today announced that, effective July 15, the HERmark(TM) Breast Cancer Assay will be available to physicians throughout the U.S. for assessment of HER2 status in patients with breast cancer. HERmark provides a precise and quantitative measurement of HER2 total protein and HER2 homodimer levels and will be offered as a CLIA-validated assay through Monogram's CAP-certified clinical laboratory.

Physicians currently use semi-quantitative measures to determine HER2 status as an indicator of HER2 protein over-expression or HER2 gene amplification to determine whether or not to prescribe Herceptin(R). Inaccurate measurements of HER2 status may lead to inappropriate therapy selection. Guidance recently issued jointly by ASCO and CAP (the College of American Pathologists) indicated that approximately 20% of HER2 determinations by current testing technologies may be inaccurate.

"HER2 targeted therapies have been proven to be critical in the treatment of women with HER2-positive breast cancer," said Peter A. Kaufman, MD, Associate Professor of Medicine at the Norris Cotton Cancer Center, Dartmouth- Hitchcock Medical Center. "Breast cancer researchers and oncologists have come to agree that current testing methods for HER2 are not adequate. HERmark's direct quantitative measurements of HER2 total protein and HER2 homodimer levels provide much needed insight as to the real HER2 status of a patient's breast cancer. This technology may allow us to more accurately determine which patients will, and which wo
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SOURCE Monogram Biosciences, Inc.
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