Navigation Links
Monoclonal antibody appears effective and safe in asthma Phase IIa trial
Date:5/21/2013

ATS 2013, PHILADELPHIA ─ A novel approach to obstructing the runaway inflammatory response implicated in some types of asthma has shown promise in a Phase IIa clinical trial, according to U. S. researchers.

Their research will be presented at the American Thoracic Society 2013 International Conference and published simultaneously online in the New England Journal of Medicine.

The randomized, double-blind, placebo-controlled trial tested the efficacy and safety of the monoclonal antibody, dupilumab, in patients with "persistent, moderate-to-severe asthma" and elevated eosinophils, which are immune cells that mobilize in response to allergens and infections and are commonly seen in asthma.

According to lead author Sally Wenzel, MD, director of the University of Pittsburgh Asthma Institute, the combination of inhaled glucocorticosteroids (ICS) and long-acting beta agonists (LABA), which is a cornerstone of asthma controller therapy, does not work sufficiently in 10 to 20 percent of asthma patients in the United States.

"Asthma that is difficult to treat is increasingly recognized as comprising different phenotypes," she said. "With this study, we wanted to see whether dupilumab would reduce a surrogate index for asthma exacerbations when given with ICS and LABA and when those two therapies were withdrawn."

Dupilumab, a fully human monoclonal antibody discovered by Regeneron Pharmaceuticals and being developed by Regeneron and Sanofi, thwarts activation of the Th2 immune response implicated in asthma by blocking two cytokines, interleukin-4 and interleukin-13.

Over the course of a 12-week blinded treatment period and an 8-week follow-up, those patients who had received weekly injections of dupilumab experienced an 87 percent reduction in protocol defined asthma exacerbations, the primary endpoint of the study, vs. weekly placebo injections (odds ratio [95% CI]=0.08 [0.021 to 0.28]; p<0.01). Signi
'/>"/>

Contact: Nathaniel Dunford
ndunford@thoracic.org
American Thoracic Society
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. New monoclonal antibody inhibits tumor growth in advanced solid tumors in phase I clinical trial
2. Antibody therapy prevents gastrointestinal damage following radiation exposure in mice
3. Scientists Pinpoint Antibody That May Be Specific to MS Patients
4. NIH scientists map first steps in flu antibody development
5. Elevated Antibody Levels May Predict Rheumatoid Arthritis Risk
6. Antibody-coated stents: Indication of disadvantages
7. Evolution in the antibody factory
8. Scientists ID Antibody That Might Boost Cancer Therapy
9. Your Autoantibody Profile Might Someday Help Spot Illness
10. Off-Label Drug Use Appears Common
11. Exercise Appears to Ease Nerve-Damage Pain in Rat Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 22, 2015 EBSCO Information Services ... expanding their relationship in an effort to further promote visibility ... While EBSCO has long made AMA journals available via its ... for The JAMA Network. , Long known as ...
(Date:1/22/2015)... JJsHouse.com is a famous dress online store ... announces its latest collection of wedding dresses , and ... issue is the wedding dress on your big day; the ... life. Every bride wants to find the most suitable wedding ...
(Date:1/22/2015)... Lower-Auto-Insurance.com has released a new blog post explaining the importance ... reducing the costs of an auto insurance policy . , ... lower prices for their vehicle insurance policies. The safety a vehicle ... costs. Because of this, drivers should always carry a first ...
(Date:1/22/2015)... 2015 State Forestry Institute of Mecklenburg-Vorpommern ... with support from GEOSYSTEMS, a dedicated Hexagon Geospatial and ... leverage Hexagon Geospatial’s ERDAS APOLLO for cataloging, ... as point clouds and documents. This effort will enable ...
(Date:12/26/2014)... It is said that nothing makes a lady feel more ... dress supplier, shows its new selection of navy cocktail ... , UWDress.com’s navy cocktail gowns are the cornerstones of the ... styles. Simple dresses in bright neon colors can be dressed ...
Breaking Medicine News(10 mins):Health News:EBSCO Expands Partnership with the American Medical Association 2Health News:EBSCO Expands Partnership with the American Medical Association 3Health News:EBSCO Expands Partnership with the American Medical Association 4Health News:Find The Most Suitable Wedding Dress At JJsHouse.com 2Health News:Driving Safe And Other Factors That Make Auto Insurance Affordable! 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 2Health News:State Forestry Institute Mecklenburg-Vorpommern, Germany Embraces Hexagon Geospatial Technology 3Health News:UWDress.com Shows Its New Navy Cocktail Dresses For 2015 2
... University of Minnesota researchers are using salmonella the ... residents each year to do what was once unthinkable: ... believe salmonella may be a valuable tool in the fight ... the liver, spleen, and colon since that,s where salmonella ...
... are shaped by our ability to recognise people. Faces and ... that enable us to identify individual people, and they are ... that lead to a unique identity for a person. A ... the various brain regions responsible for face recognition and voice ...
... we become aware of. Often images enter our brain without ... reach consciousness, that is, we do not have an impression ... unconscious perception, and can both forms of perception be changed ... research, but also for the treatment of patients with perceptual ...
... Predictive Biomarker Sciences (PBS-Bio) has uncovered how the experimental ... Previous studies have shown that over-activity of a gene ... out of control. PBS-Bio, which is owned in part ... co-discovered that UNBS1450 effectively shuts off the gene and ...
... enjoy listening to music on portable music players or cell ... in noisy surroundings. In a study published March 2, 2011 ... the potential effects of this behavior on hearing. ... Ryusuke Kakigi from the National Institute for Physiological Sciences, Japan, ...
... Ellin Holohan HealthDay Reporter , TUESDAY, March 8 (HealthDay ... heart stops beating could help save lives, according to a new ... likely to take action than those who did not. "Cardiac ... United States," said Dr. Bentley Bobrow, lead author of the study, ...
Cached Medicine News:Health News:U of M researchers using salmonella to fight cancer 2Health News:How do we combine faces and voices? 2Health News:Learning to see consciously 2Health News:Learning to see consciously 3Health News:PBS-Bio uncovers how Unibioscreen drug kills cancer 2Health News:High-volume portable music players may impair ability to clearly discriminate sounds 2Health News:Simply Watching a CPR Video Might Save Lives 2Health News:Simply Watching a CPR Video Might Save Lives 3
(Date:1/22/2015)... , Jan. 22, 2015  ViewRay™, a privately held medical ... an exclusive distributor agreement with ITOCHU Corporation (Tokyo Stock ... system for the treatment of cancer in ... is the world,s first and only MRI-guided radiation therapy ...
(Date:1/22/2015)... Calif. , Jan. 22, 2015  Amgen (NASDAQ: AMGN ... full year 2014 financial results on Tuesday, Jan. 27, 2015, after ... followed by a conference call with the investment community at 2 ... Robert A. Bradway , chairman and chief executive officer, and other ...
(Date:1/22/2015)... Jan. 22, 2015 Research and Markets ... the "Microbiology Testing/Clinical Microbiology Market by Product, ... to 2019" report to their offering. ... of techniques for the detection of infectious diseases. ...
Breaking Medicine Technology:ITOCHU Named the Exclusive Distributor for ViewRay's MRI-Guided Radiation Therapy System in Japan 2Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2Global Microbiology Testing/Clinical Microbiology (Instrument, Analyzer, Incubator, Kit, Microscope, Molecular Diagnostics) Market - Forecast to 2019 2Global Microbiology Testing/Clinical Microbiology (Instrument, Analyzer, Incubator, Kit, Microscope, Molecular Diagnostics) Market - Forecast to 2019 3
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: