Navigation Links
Monoclonal antibody Hb3: A marker for colon cancer progression or as a therapeutic target?
Date:4/30/2008

There are a number of researchers who are searching for useful tumor markers to indicate cure. Antigens are being applied as an effective target in clinical therapy. Hb3 is an anti-colorectal cancer monoclonal antibody produced in the researchers laboratory, and whose sensitivity and specificity are superior to that of anti-CEA. Previous results have showed that CA-Hb3 may be useful in the clinical diagnosis of colorectal cancer.

This study, carried out by a team led by Professor G. C. Li, is described in a research article that will be published on March 14, 2008, in the World Journal of Gastroenterology.

To comprehensively identify the proteins of the tumor-associated antigen Ca-Hb3 which is recognized by colorectal carcinoma monoclonal antibody Hb3, Ca-Hb3 was isolated by SDS-PAGE followed by digestion with trypsin. The trypsin peptides were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Applying bioinformatics to analyze the proteins which were identified by mass spectrometry, Ca-Hb3 was identified as CKAP4-similar protein by nano-HPLC tandem mass spectrometry analysis. The molecular weight of CKAP4-similar protein is 62.02 kDa, including one hydrophobic region, one transmembrane domain, five coiled coils, four glycosylation sites and forty-nine phosphorylation sites. CKAP4-similar protein has high homogeneity with Np63, and the characteristic expression of agrNp63 alpha that is considered a potential oncogene in the isoforms of p63 is similar to Ca-Hb3.

Np63 is an isoform of the p63 family. A number of studies have highlighted the oncogenic potential of agrNp63 alpha.agrNp63 alpha is overexpressed in several epithelial cancers, often as a result of gene amplification. The overexpression of an Np63 isoform in Rat 1A cells increases colony growth in soft agar and xenograft tumor formation in nude mice. It is hypothesized that agrNp63 alpha promotes survival and the maintenance of proliferative capacity in b
'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Panacea Pharmaceuticals Announces Selection of PAN-622 - A Fully Human Sequence Monoclonal Antibody Against HAAH - As Its Lead Cancer Therapeutic Product
2. Autisms origins: Mothers antibody production may affect fetal brain
3. Vaccine/antibody therapy effective, milder side effects in melanoma and ovarian cancer
4. EUSA Pharma Out-Licenses Preclinical-Stage Human Antibody to GlaxoSmithKline for up to $44 Million Plus Royalties
5. Antibody Engineering Company f-star Appoints Three Pioneers in Antibody Engineering and Development to its Newly Established Scientific Advisory Board
6. Micromet and MedImmune to Present New Clinical Data for Anti-CD19 BiTE(R) Antibody at American Society of Hematology Annual Meeting Showing Objective Clinical Responses in Relapsed Non-Hodgkins Lymphoma Patients
7. Antibody responses in patients with Lyme arthritis
8. ThromboGenics Begins Preclinical Development of Anti-VPAC Antibody for Thrombocytopenia
9. Ono and Medarex Announce Allowance of Investigational New Drug Application for Fully Human Anti-PD1 Antibody
10. Antibody Helps Repair MS Nerve Damage
11. Antibody leads to repair of myelin sheath in lab study of multiple sclerosis and related disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... July 31, 2014 In today’s world, a ... to get. Snoring and sleep apnea (a medical problem where ... and their bed partners of the rest they need to ... the population snores and 20 million people in the United ... been diagnosed and treated; and of those treated, many cannot ...
(Date:7/31/2014)... NV (PRWEB) July 31, 2014 Niche Profit ... Adam Short that is designed to provide a blueprint for ... the attention of Shane Michaels, prompting an investigative review. ... , “What really speaks volumes about the success of the ... and strategies included in it have stayed effective even through ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 Hook Your Ex, a ... get ex’s to feel emotionally hungry for their partner, to the ... chance. This little trick has been taught to hundreds of ... a quick Hook Your Ex review , Shane Michaels agrees ... suffering pain from a breakup a second chance at getting back ...
(Date:7/31/2014)... CA (PRWEB) July 31, 2014 Cosmetic ... benefit both patients and doctors. Doctors will be able ... to leave reviews , which guarantees their authenticity. ... options on the site to receive information that has ... This unprecedented validation system allows Cosmetic Town to filter ...
(Date:7/31/2014)... Farmington, NY (PRWEB) July 31, 2014 ... restaurants incorporating Pioneer Millworks’ reclaimed wood to create ... the environment. Their newest location features reclaimed ... the restaurant, with custom selected mixed softwoods flowing ... trusses crafted by Pioneer Millworks’ sister company ...
Breaking Medicine News(10 mins):Health News:Snoring: Bad for Relationships, Bad for Health 2Health News:Snoring: Bad for Relationships, Bad for Health 3Health News:Niche Profit Classroom: Review Exposes Adam Short’s Guide to Building Niche Websites 2Health News:Hook Your Ex Review by Shane Michaels Exposes Steve Pratt And His New Method For Getting Back With The Ex 2Health News:Cosmetic Town Improves Patient Experience Through Secure Verification of Patients and Doctors 2Health News:Popular Tavern Restaurant Features Pioneer Millworks’ Reclaimed Wood in New Locations 2
... have raised questions regarding differences in quality of care ... In fact, a growing body of health services research ... the weekend and increased mortality. This "weekend effect" has ... specific intensive treatments and procedures. , Two recent studies ...
... the March 1 issue of the journal SLEEP ... promising model for addressing adolescent sleep problems, given ... healthy sleep knowledge and practice. , The program, ... period, had a high retention rate of 83 percent ...
... green vegetables such as broccoli and cabbage could ... cancer researchers. Tests on mice suggest that these ... safely and effectively than conventional therapy. , "There ... that trigger melanoma," said Gavin Robertson, associate professor ...
... Bethesda, MD (March 1, 2009) Although the ... is well established, studies investigating the association between ... (BE) and esophageal adenocarcinoma (EAC) have reported inconsistent ... of alcohol on BE, especially related to alcohol ...
... Brian Schweitzer, Chair of the Democratic Governors Association, today ... Gov. Kathleen Sebelius as Secretary of Health and Human ... Kathleen Sebelius is an excellent choice to lead the ... our health care system, Governor Sebelius will bring a ...
... precautions should be abandoned, experts note , , SATURDAY, ... trip is as important as packing the right clothes. ... doesn,t mean it,s safe," Laura Gonzalez, a nurse with The ... said in a news release issued by the school. "You ...
Cached Medicine News:Health News:Patients with GI bleeding admitted on the weekend have higher death rate 2Health News:Patients with GI bleeding admitted on the weekend have higher death rate 3Health News:School-based intervention is a promising model for improving adolescent sleep habits 2Health News:School-based intervention is a promising model for improving adolescent sleep habits 3Health News:Vegetable-based drug could inhibit melanoma 2Health News:Alcohol types and socioeconomic status are associated with Barrett's esophagus risk 2Health News:Alcohol types and socioeconomic status are associated with Barrett's esophagus risk 3Health News:Travel Safety Can Be a Passport to Good Health 2
(Date:7/31/2014)... -- Xencor Inc. (NASDAQ: XNCR ), ... for the treatment of autoimmune diseases, asthma and ... for the second quarter ended June 30, 2014 and ... "In the second quarter, we presented preclinical ... Conference (ATS) demonstrating three novel mechanisms of action ...
(Date:7/31/2014)... , July 31, 2014   Auxilium Pharmaceuticals , ... specialty biopharmaceutical company, today announced that the Company will ... Thursday, August 7, 2014 before the opening of the ... conference call that day at 8:30 a.m. ET to ... 2014. The presentation slides to be used during the ...
(Date:7/31/2014)...  A substantial share of pharmacy and therapeutics ... are included in formularies—say patient support resources from ... Manhattan Research study, Taking the Pulse® Formulary ... P&T committee members in hospitals, managed care organizations ... a high bar for these programs, requiring that ...
Breaking Medicine Technology:Xencor Reports Second Quarter 2014 Financial Results 2Xencor Reports Second Quarter 2014 Financial Results 3Xencor Reports Second Quarter 2014 Financial Results 4Xencor Reports Second Quarter 2014 Financial Results 5Xencor Reports Second Quarter 2014 Financial Results 6Xencor Reports Second Quarter 2014 Financial Results 7Xencor Reports Second Quarter 2014 Financial Results 8Auxilium Pharmaceuticals, Inc. To Announce Second Quarter 2014 Results On August 7, 2014 2Auxilium Pharmaceuticals, Inc. To Announce Second Quarter 2014 Results On August 7, 2014 3Formulary Decision Makers Say Pharma-Provided Patient Support Solutions Influence Formulary Placement 2Formulary Decision Makers Say Pharma-Provided Patient Support Solutions Influence Formulary Placement 3
... CHICAGO , June 5 Scientists from ... presented preliminary data that shows nitrogen-containing bisphosphonates, therapeutic agents used ... slightly poorer survival rate in post-menopausal women with early stage ... findings were announced today at the 2010 American Society of ...
... BARBARA, Calif. , June 4 Abviva, Inc. (Pink ... of breast cancer related applications of Mammastatin, today provided further details ...   , , , ... appoints W.T. Uniack & Co. as its independent auditor. ...
Cached Medicine Technology:Karmanos Cancer Institute Researchers Study Bisphosphonates and Their Affect on Early Stage Breast Cancer 2Karmanos Cancer Institute Researchers Study Bisphosphonates and Their Affect on Early Stage Breast Cancer 3Karmanos Cancer Institute Researchers Study Bisphosphonates and Their Affect on Early Stage Breast Cancer 4Abviva Engages W.T. Uniack & Co. As Independent Auditor 2
Lyphochek Therapeutic Drug Monitoring Control (TDM) contains over 40 analytes with assayed values at three clinically significant levels....
Lyphochek Endocrine Control is a human based product designed to monitor plasma catecholamine testing procedures by HPLC. The analytes are spiked at critical concentrations to cover the dynamic range...
Lyphochek Urine Metals Control incorporates two levels of critical trace elements, heavy metals and organic metabolites, and is ideal for environmental and industrial testing....
Lyphochek Whole Blood Control is a unique product designed to monitor immunosuppressants, red cell folate and lead in whole blood assays. This control has three critical levels for each analyte and i...
Medicine Products: