Navigation Links
Monoclonal antibody Hb3: A marker for colon cancer progression or as a therapeutic target?
Date:4/30/2008

There are a number of researchers who are searching for useful tumor markers to indicate cure. Antigens are being applied as an effective target in clinical therapy. Hb3 is an anti-colorectal cancer monoclonal antibody produced in the researchers laboratory, and whose sensitivity and specificity are superior to that of anti-CEA. Previous results have showed that CA-Hb3 may be useful in the clinical diagnosis of colorectal cancer.

This study, carried out by a team led by Professor G. C. Li, is described in a research article that will be published on March 14, 2008, in the World Journal of Gastroenterology.

To comprehensively identify the proteins of the tumor-associated antigen Ca-Hb3 which is recognized by colorectal carcinoma monoclonal antibody Hb3, Ca-Hb3 was isolated by SDS-PAGE followed by digestion with trypsin. The trypsin peptides were analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS). Applying bioinformatics to analyze the proteins which were identified by mass spectrometry, Ca-Hb3 was identified as CKAP4-similar protein by nano-HPLC tandem mass spectrometry analysis. The molecular weight of CKAP4-similar protein is 62.02 kDa, including one hydrophobic region, one transmembrane domain, five coiled coils, four glycosylation sites and forty-nine phosphorylation sites. CKAP4-similar protein has high homogeneity with Np63, and the characteristic expression of agrNp63 alpha that is considered a potential oncogene in the isoforms of p63 is similar to Ca-Hb3.

Np63 is an isoform of the p63 family. A number of studies have highlighted the oncogenic potential of agrNp63 alpha.agrNp63 alpha is overexpressed in several epithelial cancers, often as a result of gene amplification. The overexpression of an Np63 isoform in Rat 1A cells increases colony growth in soft agar and xenograft tumor formation in nude mice. It is hypothesized that agrNp63 alpha promotes survival and the maintenance of proliferative capacity in both epithelial stem cells and cancer cells.


'/>"/>

Contact: Jing Zhu
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. Panacea Pharmaceuticals Announces Selection of PAN-622 - A Fully Human Sequence Monoclonal Antibody Against HAAH - As Its Lead Cancer Therapeutic Product
2. Autisms origins: Mothers antibody production may affect fetal brain
3. Vaccine/antibody therapy effective, milder side effects in melanoma and ovarian cancer
4. EUSA Pharma Out-Licenses Preclinical-Stage Human Antibody to GlaxoSmithKline for up to $44 Million Plus Royalties
5. Antibody Engineering Company f-star Appoints Three Pioneers in Antibody Engineering and Development to its Newly Established Scientific Advisory Board
6. Micromet and MedImmune to Present New Clinical Data for Anti-CD19 BiTE(R) Antibody at American Society of Hematology Annual Meeting Showing Objective Clinical Responses in Relapsed Non-Hodgkins Lymphoma Patients
7. Antibody responses in patients with Lyme arthritis
8. ThromboGenics Begins Preclinical Development of Anti-VPAC Antibody for Thrombocytopenia
9. Ono and Medarex Announce Allowance of Investigational New Drug Application for Fully Human Anti-PD1 Antibody
10. Antibody Helps Repair MS Nerve Damage
11. Antibody leads to repair of myelin sheath in lab study of multiple sclerosis and related disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/13/2017)... ... January 13, 2017 , ... ... world’s first and most comprehensive franchise ranking. Recognized by entrepreneurs and franchisors as ... for its exceptional performance in areas including financial strength and stability, growth rate, ...
(Date:1/13/2017)... ... January 13, 2017 , ... "Devotions from the Heart" ... crafts, and antique hunting. She and her husband, Gene, reside in Missoula, Montana, with ... wait and learn to lean upon His strength., So keep trusting in the Master ...
(Date:1/13/2017)... Viejo, California (PRWEB) , ... January 13, 2017 , ... ... back into any video project," said Christina Austin - CEO of Pixel Film Studios. ... drop transition presets. Each preset contains a unique shadow fade that masks the first ...
(Date:1/13/2017)... ... January 13, 2017 , ... Dr. Les Latner, ... of a fundraising campaign for the American Academy of Cosmetic Dentistry Charitable Foundation ... assist in rebuilding the smiles and lives of adults who have suffered dental ...
(Date:1/13/2017)... ... January 13, 2017 , ... Sharon Kleyne, America’s leading water researcher, advocate ... Water, Global Climate Change and Your Health on Voice America, celebrated on January 9th ... yesterday,” said Sharon Kleyne to her listening audience, “yet here it is the beginning ...
Breaking Medicine News(10 mins):
(Date:1/13/2017)... 12, 2017   JDRF , the leading ... is pleased to announce that after more than ... Medicare & Medicaid Services (CMS) has recognized continuous ... for use in making diabetes treatment decisions as ... them eligible for coverage under Medicare. JDRF has ...
(Date:1/13/2017)... , Jan. 13, 2017 Over the last 10 years ... developing rapidly (6% – 10% yoy) and are expected to deliver remarkable ... the region, followed by Thailand , the ... , and Singapore .  A member of the G20 ... represents almost 40% of the SEA,s economic output and the largest pharma ...
(Date:1/12/2017)... Ind. , Jan. 12, 2017 Zimmer ... leader in musculoskeletal healthcare, announced today that it has ... and the U.S. Securities and Exchange Commission (SEC) to ... (FCPA) matters involving Biomet, Inc., as well as in ... to final judgment that Biomet entered into with DOJ ...
Breaking Medicine Technology: