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Monitoring whether patients take medicines can help anticipate HIV treatment failure in Africa
Date:5/19/2008

ilto:bisson@mail.med.upenn.edu">bisson@mail.med.upenn.edu

Related PLoS Medicine Perspective article:

Citation: Bangsberg DR (2008) A paradigm shift to prevent HIV drug resistance. PLoS Med 5(5): e11.doi:10.1371/journal.pmed.005011

IN YOUR COVERAGE PLEASE LINK TO THIS URL, WHICH WILL PROVIDE ACCESS TO THE PUBLISHED PAPER: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050111

PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-05-05-bangsberg.pdf

CONTACT:
David Bangsberg
University of California San Francisco
San Francisco General Hospital
Division of Infectious Diseases and the Positive Health Program
San Francisco, CA 92037
United States of America
+1 415-206-3462
db@epi-center.ucsf.edu


Role for vegf messenger RNA in promoting malignancy of human colon cancer cells

Vascular endothelial growth factor-A (VEGF) is a key regulator of tumor development, and a therapeutic target for cancer treatment. However, clinical trials have suggested that anti-VEGF monotherapy is less effective than standard chemotherapy. Shigetada Teshima-Kondo and colleagues from the Institute of Health Bioscience, Tokushima, Japan investigated the role of vegf messenger (m)RNA in a line of cells from a colonic cancer. They showed that these cancer cells have a survival system that is regulated by vegf mRNA and hence that vegf mRNA and its protein may work together to promote the malignancy of tumor cells. Further work will need to be done to investigate how generalizable these findings are. The findings are discussed further in a Perspective article by Thomas Hughes and Pamela Jones, indep
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Contact: Andrew Hyde
press@plos.org
01-223-463-330
Public Library of Science
Source:Eurekalert

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