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Monitoring whether patients take medicines can help anticipate HIV treatment failure in Africa
Date:5/19/2008

t adherence assessments could be used for early identification of patients at high risk of treatment failure, averting its health impact and helping to prioritize limited viral load testing. Studies in other settings (such as public clinics where medication is provided without charge) are needed to confirm the general reliability of these findings.

These results do not change that fact that monitoring CD4 counts plays an important role in deciding when to begin HIV medications, or when to provide treatment to prevent conditions that occur at low CD4 counts. Nonetheless, according to the researchers, approaches to HIV treatment in resource-limited settings should include an adherence-based monitoring approach.

In an accompanying perspective article, David Bangsberg (University of California San Francisco, USA), who did not participate in the research, discusses the importance of proactive prevention rather than reactive response to HIV treatment failure.

Citation:Bisson GP, Gross R, Bellamy S, Chittams J, Hislop M, et al. (2008) Pharmacy refill adherence compared with CD4 count changes for monitoring HIV-infected adults on

antiretroviral therapy. PLoS Med 5(5): e109. doi:10.1371/journal.pmed.0050109

IN YOUR COVERAGE PLEASE LINK TO THIS URL, WHICH WILL PROVIDE ACCESS TO THE PUBLISHED PAPER: http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0050109

PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-05-05-bisson.pdf

CONTACTS:
Gregory P. Bisson
University of Pennsylvania School of Medicine
Center for Clinical Epidemiology and Biostatistics
Philadelphia, PA 19104-6021
United States of America
+1 215 573-5811
+1 215 573-5315

Contact: Andrew Hyde
press@plos.org
01-223-463-330
Public Library of Science
Source:Eurekalert

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