Tel Aviv -- Ferrography, a practice used by the American and Israeli air forces to monitor the condition of machinery, extracts tiny iron particles from lubricants such as oil and grease to analyze wear in machines. Determining whether a system requires preventative maintenance can be the key to preventing catastrophic failure.
Now Tel Aviv University scientists are exploring a modification of this technique for human analysis -- called "bio-ferrography" -- to diagnose diseases in their early stages, determine the efficacy of drugs, and ascertain the condition of orthopedic implants.
Prof. Noam Eliaz, head of Tel Aviv University's Materials and Nanotechnologies Program, says bio-ferrography has the potential to help develop better medications and better implants, and to diagnose the development of diseases, including cancer, at a very early stage. The research was recently published in a three-part series in the journal Acta Biomaterialia.
Wear of cartilage and bone
Osteoarthritis is characterized by damage to the cartilage in the joints. In severe cases, the cartilage is degraded to the point where bones rub together, which leads to pain and limited movement, says Prof. Eliaz. X-rays, the common diagnostic tool for osteoarthritis, are often insufficient to determine the precise level of the disease. But bio-ferrography can be used for early detection of the disease in a more objective and quantitative way, he explains.
To test the extent of damage to the joints, the researchers use a bio-ferrograph, an apparatus that allows magnetic isolation of target cells or tissues. They capture magnetically-labelled bone and cartilage particles from the synovial fluids extracted from patients' joints, count them, then analyze their chemical composition, shapes and dimensions. The number and dimensions of the wear particles can be correlated to the level of disease, while their chemical composition and
|Contact: George Hunka|
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