Navigation Links
Monell scientists identify elusive taste stem cells
Date:2/3/2013

PHILADELPHIA (February 4, 2013) Scientists at the Monell Center have identified the location and certain genetic characteristics of taste stem cells on the tongue. The findings will facilitate techniques to grow and manipulate new functional taste cells for both clinical and research purposes.

"Cancer patients who have taste loss following radiation to the head and neck and elderly individuals with diminished taste function are just two populations who could benefit from the ability to activate adult taste stem cells," said Robert Margolskee, M.D., Ph.D., a molecular neurobiologist at Monell who is one of the study's authors.

Taste cells are located in clusters called taste buds, which in turn are found in papillae, the raised bumps visible on the tongue's surface.

Two types of taste cells contain chemical receptors that initiate perception of sweet, bitter, umami, salty, and sour taste qualities. A third type appears to serve as a supporting cell.

A remarkable characteristic of these sensory cells is that they regularly regenerate. All three taste cell types undergo frequent turnover, with an average lifespan of 10-16 days. As such, new taste cells must constantly be regenerated to replace cells that have died.

For decades, taste scientists have attempted to identify the stem or progenitor cells that spawn the different taste receptor cells. The elusive challenge also sought to establish whether one or several progenitors are involved and where they are located, whether in or near the taste bud.

Drawing on the strong physiological relationship between oral taste cells and endocrine (hormone producing) cells in the intestine, the Monell team used a marker for intestinal stem cells to probe for stem cells in taste tissue on the tongue.

Stains for the stem cell marker, known as Lgr5 (leucine-rich repeat-containing G-protein-coupled receptor 5), showed two patterns of expression in taste tissue
'/>"/>

Contact: Leslie Stein
stein@monell.org
267-519-4707
Monell Chemical Senses Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Pet Hedgehogs Linked to Salmonella Outbreak in 8 States
2. Salmonella Cause of Most Foodborne-Illness Outbreaks: CDC
3. Vaccination responsible for dramatic fall in Salmonella infections
4. Salmonella spreads by targeting cells in our gut, study shows
5. Health Officials Tracking Salmonella Outbreak Linked to Pet Turtles
6. FDA Cites Possible Source of Cantaloupe-Salmonella Outbreak
7. 33 Sickened by Salmonella Linked to Ground Beef: CDC
8. Ohio Mail-Order Hatchery Now Linked to Salmonella in 23 States
9. American Association of Radon Scientists and Technologists (AARST) Releases Nation's First Standard for Mitigating Radon (Radioactivity) in Multifamily Buildings
10. Scientists Find Clue to Aging Reversal in Mice
11. Leading researchers warn of brain drain as scientists struggle to find funding
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/5/2015)... May 05, 2015 NCPDP announced today ... Program. The program establishes a three-year commitment of strategic ... of 10 Elite Partners. “AmerisourceBergen has supported our multi-stakeholder ... of NCPDP, “and this is a wonderful continuation and ... We can trace AmerisourceBergen back to our very first ...
(Date:5/5/2015)... DC (PRWEB) May 05, 2015 ... Optimity) will present at the 24th ... at 1:15 p.m. MT in Scottsdale, AZ. WEDI, ... nation’s leading nonprofit authority on the use of ... exchange. Donald Graf, National Director of Telemedicine for ...
(Date:5/5/2015)... May 05, 2015 Viverae®, a ... Bard Inc., a leading multinational developer, manufacturer and ... fields of vascular, urology, oncology and surgical specialty ... Award. The Vanguard Award recognizes outstanding achievement ... programs among Viverae’s significant client base. , Viverae ...
(Date:5/5/2015)... Los Angeles, CA (PRWEB) May 05, 2015 ... to treat and actually prevent a variety of health ... Doc utilized this modern research to adopt clean eating ... preservatives and artificial dyes associated with over-consumption of fast ... eating diet plans easy to follow and report ...
(Date:5/5/2015)... TX (PRWEB) May 05, 2015 MAP ... programs and revenue cycle management for addiction treatment facilities, ... as Vice President of Business Development. Mr. Mooney, who ... addiction treatment field, will be responsible for developing new ... distribution of MAP’s core products and new initiatives. , ...
Breaking Medicine News(10 mins):Health News:AmerisourceBergen Joins NCPDP Elite Partner Program 2Health News:AmerisourceBergen Joins NCPDP Elite Partner Program 3Health News:Optimity Advisors’ Hiliary Critchley, Telemedicine Expert, to Speak at WEDI Conference May 20th in Scottsdale, AZ 2Health News:Viverae® Honors C. R. Bard, Inc. with 2015 Vanguard Award 2Health News:Diet Doc Introduces Diet Plans that Teach Patients how to Eat Clean by Getting Back to Basics and Exchanging Processed Foods for Clean, Nutritious Foods 2Health News:Diet Doc Introduces Diet Plans that Teach Patients how to Eat Clean by Getting Back to Basics and Exchanging Processed Foods for Clean, Nutritious Foods 3Health News:Jimmy Mooney, an Addiction Treatment Veteran, Named Vice President of Business Development at MAP Health Management, LLC 2
... from oocytes (eggs) cryopreserved by the vitrification method are ... those involving fresh oocytes, the 26th annual meeting of ... today. Dr. Ana Cobo, Cryobiology Unit director at Institut ... the results of her team,s research would make egg ...
... ... Presence Catering to Members in all 50 States. , ... (PRWEB) June 30, 2010 -- MedTouch , a leading provider ... revitalized online presence for Sterling Life Insurance Company . The new website includes a ...
... ... Ondine Biopharma Corporation, a medical technology company developing photodisinfection ... owned subsidiary, “Sinuwave Technologies Corporation”, dedicated to the development and ... market. The subsidiary will license technology developed by Ondine Biopharma ...
... ... shortest skirts at Wimbledon. , ... London (PRWEB) June 30, 2010 -- With the tennis season now firmly underway, leading voucher ... tennis players to reveal the top five shortest tennis skirts at Wimbledon this tournament., , ...
... Lexington Health Care ... facilities in the Chicago area. OnShift enabled the company to reduce overtime by 71% in ... ... and employee communication software, recently announced it had been selected by Lexington Health Care ( ...
... ... ... their independence from tobacco cigarettes with a new e-cigarette system offered exclusively from PrimeVapor.com., , ... for smokers who want an alternative to inhaling a lit tobacco cigarette that is ...
Cached Medicine News:Health News:Ongoing pregnancy rates from vitrified eggs as good as those from fresh 2Health News:MedTouch Launches Revitalized Website for Sterling Life Insurance Company 2Health News:MedTouch Launches Revitalized Website for Sterling Life Insurance Company 3Health News:Ondine Biopharma Announces Sinuwave Technologies Spinout 2Health News:Ondine Biopharma Announces Sinuwave Technologies Spinout 3Health News:All Eyes on Hemlines, Not Henman, at Wimbledon This Year 2Health News:Lexington Health Care Chooses OnShift for Nurse Scheduling and Employee Communications in all Facilities 2Health News:Lexington Health Care Chooses OnShift for Nurse Scheduling and Employee Communications in all Facilities 3Health News:Electronic Cigarettes and the Declaration of Independence 2
(Date:5/5/2015)... Ardelyx, Inc. (NASDAQ: ARDX ), ... and metabolic diseases, today announced that a 154-patient ... 3 chronic kidney disease patients with type 2 ... primary endpoint of decreasing the urinary albumin-creatinine ratio ... Ardelyx formed a partnership with ...
(Date:5/5/2015)... May 5, 2015 /CNW Telbec/ - Ergoresearch Ltd ... and known under the « Équilibre, ... of the transaction previously announced on April 23, 2015 ... outstanding  shares of Orthoconcept (2008) inc.   ... common shares (TSXV: ERG) to the vending shareholder, namely ...
(Date:5/5/2015)... , May 5, 2015  The preclinical contract research ... pharmacokinetic testing of drugs and safety testing of medical ... Director of Preclinical Studies, presented at this week,s annual ... Ophthalmology (ARVO) in Denver, CO. ... Assessment of a Novel, Cross-Linked, Bio-Absorbable Carboxymethyl Hyaluronic Acid ...
Breaking Medicine Technology:Ardelyx Reports Results from Phase 2a Clinical Trial Evaluating Tenapanor in Chronic Kidney Disease Patients with Type 2 Diabetes Mellitus and Albuminuria 2Ardelyx Reports Results from Phase 2a Clinical Trial Evaluating Tenapanor in Chronic Kidney Disease Patients with Type 2 Diabetes Mellitus and Albuminuria 3Ardelyx Reports Results from Phase 2a Clinical Trial Evaluating Tenapanor in Chronic Kidney Disease Patients with Type 2 Diabetes Mellitus and Albuminuria 4Ardelyx Reports Results from Phase 2a Clinical Trial Evaluating Tenapanor in Chronic Kidney Disease Patients with Type 2 Diabetes Mellitus and Albuminuria 5Ardelyx Reports Results from Phase 2a Clinical Trial Evaluating Tenapanor in Chronic Kidney Disease Patients with Type 2 Diabetes Mellitus and Albuminuria 6Ergoresearch announces closing of the acquisition of 49% of the shares of Orthoconcept (2008) inc. 2Ergoresearch announces closing of the acquisition of 49% of the shares of Orthoconcept (2008) inc. 3Dr. Glen Gum of Absorption Systems Presents at The Association for Research in Vision and Ophthalmology (ARVO) Meeting 2Dr. Glen Gum of Absorption Systems Presents at The Association for Research in Vision and Ophthalmology (ARVO) Meeting 3
Fisherbrand* Micro Slide Storage Cabinets and Bases (New), available in dark beige, tan, green, or white. Optional bases available with or without legs....
Fisherbrand* Micro Slide Cabinet is made of heavy gauge, reinforced steel....
... special drawers for just about everything imaginable that ... laboratory. Each box is designed for long term ... advantages of wood over metal systems is overlooked, ... a subtle kind of desiccator and insulator, providing ...
Allows for the organized storage of blocks that have been embedded using: Tissue Cassettes, Biopsy Cassettes, Mesh Cassettes, Mega Cassettes, Processing/Embedding Cassettes and Embedding Rings....
Medicine Products: