Navigation Links
Mom's Cells Prime Fetal Immune System
Date:12/4/2008

Process prevents growing baby from rejecting the mother, researchers find

THURSDAY, Dec. 4 (HealthDay News) -- During pregnancy, many of the mother's cells enter the fetus and produce immune cells that prevent the growing baby from rejecting its mother, new research shows.

This finding shows that the two coexist by making the fetus' immune system able to tolerate foreign antigens and could lead to new techniques in stem cell treatments and ways to deal with chronic infections, researchers say.

"The fetal immune system may be considerably more active than previously thought, and a better understanding of fetal immunity may help us to better understand a range of health concerns including fetal infections and autoimmunity," said lead researcher Jeff Mold, a graduate student in the Division of Experimental Medicine at the University of California, San Francisco.

"The findings also suggest that the fetal immune system may be a good target for vaccination strategies aimed at promoting immunological tolerance in human beings," he said.

Modifying the immune system could be important in treating autoimmune diseases, in which the body attacks its own cells, and in preventing organ transplant rejection, where the body rejects the transplanted tissue, the researchers noted.

In addition, the finding may also be important in developing treatments for infectious diseases such as HIV.

"Only 5 to 10 percent of babies born to untreated HIV-infected mothers in the absence of antiretroviral interventions are born infected with HIV. Perhaps some aspect of the immunological tolerance of the fetal immune system explains how the baby could avoid HIV infection in utero," study co-author Dr. Joseph M. McCune, head of the Division of Experimental Medicine, said in a statement.

This study opens up new avenues of research that could be important in developing effective HIV vaccines, McCune noted.

The report was published in the Dec. 5 issue of Science.

In experiments with human tissue, the researchers found that maternal cells were present in the developing fetal lymphoid tissues early in pregnancy when the fetal immune system is first developing, Mold said.

"In addition, we found that the fetal immune system contains a large population of regulatory T-cells (Treg), which blocked fetal T-cell responses to maternal cells," Mold said.

Mold's team also showed that when fetal T-cells were stimulated with cells from an unrelated donor, they became regulatory T-cells. These newly developed Treg were able to suppress fetal T-cell responses against this donor.

"Finally, we showed some evidence that Tregs in the blood of children 7 to 17 [years old] were more effective in blocking T-cell responses to maternal cells than they were to paternal cells," Mold said.

The human fetal immune system may play a specific role in mediating immune tolerance to both self and foreign antigens encountered during fetal development, Mold said.

"Little is currently known about the fetal adaptive immune system and the functional properties of fetal T-cells," Mold said. "These are current areas of investigation in the lab. This paper represents a first step in trying to understand the role of the fetal adaptive immune system but much more is needed to be done," he added.

Dr. Rachel L. Miller, an associate professor of medicine and environmental health sciences at New York Presbyterian Hospital/Columbia University Medical Center in New York City, thinks the finding dispels that myth that the fetal immune system is not well-developed.

"The paper demonstrates beautifully that the fetal adaptive immune system is competent and functional enough to establish tolerance when needed," Miller said. "This work provides another example about how sophisticated the fetal immune system can be."

Sandra L. Nehlsen-Cannarella, director of Immunogenetics at Detroit Medical Center and an expert in fetal immunity, agreed that the infant immune system is actually well-developed.

"Their immune system is quite capable of doing things," Nehlsen-Cannarella said.

Nehlsen-Cannarella noted the study confirms what is seen in clinical practice. "This is a great verification of what many of us have already believed," she said. "This forms a basis to do what we have all been looking for; to induce tolerance for transplantation as well as protecting the infant against infections in its future."

More information

For more about the immune system, visit the U.S. National Institute of Allergy and Infectious Diseases.



SOURCES: Jeff Mold, graduate student, Division of Experimental Medicine, University of California, San Francisco; Rachel L. Miller, M.D., associate professor, medicine and environmental health sciences, New York Presbyterian Hospital/Columbia University Medical Center, New York City; Sandra L. Nehlsen-Cannarella, Ph.D., director, Immunogenetics, Detroit Medical Center; Dec. 5, 2008, Science


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Parents of Murdered Dating Violence Victim, Legislators, and Teachers Unite to Launch MADE - Moms and Dads for Education to Stop Teen Dating Abuse
2. Moms Find Fun, Healthy Snacks That Help Fight Childhood Obesity
3. Alternative Therapy for Adhesion and Endometriosis Pain Examined in New Book 'Miracle Moms, Better Sex, Less Pain'
4. Bariatric Surgery Before Pregnancy Benefits Moms, Babies
5. Chef Art Smith, Moms and Schools Partner to Teach Kids to Love Their Veggies
6. Moms Smoking Linked to Increased Risk of Birth Defects
7. Moms smoking linked to increased risk of birth defects
8. Norwegian American Hospital Launches Awareness Campaign Targeting Hispanic, African-American and General-Market Moms
9. Enjoy Life Foods Teams with AllergyMoms.com to Ensure Halloween Isn't 'Tricky' for Food-Allergic Kids and Families : Provides tips for being allergy-aware this Halloween
10. Generation Huggies Celebrates 30 Years With 30 Moms
11. Natural Childbirth Moms More Attuned to Babies Cry
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Mom's Cells Prime Fetal Immune System
(Date:5/27/2016)... ... May 27, 2016 , ... An influential resource amongst ... third time to shed lights on the variety of topics detailing why we appreciate ... Appreciation” tackles why this career has gone from being in a major recession to ...
(Date:5/27/2016)... ... May 27, 2016 , ... An educational campaign ... inspiring human-interest stories, courtesy of awareness-driven celebrities and thought leaders. It also provides ... associations and industry leaders such as Bioness. , As patients feel increasingly ...
(Date:5/27/2016)... (PRWEB) , ... May 27, 2016 , ... ... this installment is bolstered by inspiring human interest stories, courtesy of leaders in ... trends and tech within the industry, from leading advocates and associations—namely Jones & ...
(Date:5/27/2016)... ... May 27, 2016 , ... With a team of ... food industries. Aside from its GMP accreditation, Validation Center is also a registered ... products, services and staff. , Validation Center is ISO17025 accredited and only offers ...
(Date:5/26/2016)... Gilsum, New Hampshire (PRWEB) , ... May 26, 2016 , ... ... natural skin care products, has been honored with a 2016 When Work Works Award ... This prestigious award, part of the national When Work Works project administered by the ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... CAESAREA, Israel , May 27, 2016 ... developer of the Dario™ Diabetes Management Tool, today announced that ... present at the Marcum MicroCap Conference being held June 1-2 ... LD Micro Invitational, being held June 7-9 in ... Mr. Ben-David will discuss recent corporate and operational milestones, including ...
(Date:5/27/2016)... 2016 Kitov Pharmaceuticals ... on late-stage drug development, today announced the completion ... pivotal batches required for registration of KIT-302 with ... follows Kitov,s announcement in December 2015, ... its primary efficacy endpoint. "We are ...
(Date:5/26/2016)... -- According to a new market report published ... Industry Analysis, Size, Share, Growth, Trends, and Forecast 2015 - ... valued at US$ 5.89 Bn in 2014 and is anticipated ... 2023 to reach US$ 7.99 Bn in 2023. ... free drug delivery devices and the market is estimated based ...
Breaking Medicine Technology: