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Momentum builds in quest to find cure for childhood brain disease
Date:2/19/2013

How do you find a cure for a devastating pediatric brain disease so rare that it can take decades to build a meaningful research base?

In 2010, the parents of a patient created the Rasmussen Encephalitis (RE) Children's Project to help solve this problem. In a short amount of time, the foundation has raised funds to establish a consortium of top researchers, build a collection of samples of the disease from around the world and support projects to study the disease tissue and search for genetic links. The goal is to find a cure.

Researchers at the David Geffen School of Medicine at UCLA have played a vital role in the ongoing research, and the foundation recently provided a second round of funding to continue their work. The gift of $125,000 builds on the organization's donation of $111,000 made in 2011.

"We are still in the early stages of research, but our momentum is building," said Seth H. Wohlberg, founder of the RE Children's Project, and father of Grace, 15, who was stricken by the disease when she was 10 years old. "One of our key accomplishments has been to create an international system so that we can coordinate and transfer RE brain tissue and DNA material from the patients and parents. Collecting these samples is vital to advancing the research."

With the additional funding, UCLA researchers will apply cutting-edge DNA sequencing technology to determine whether a virus, or some other infectious agent, causes RE. They also plan to develop an animal model of the disease using cells obtained from the RE samples.

The researchers include Dr. Gary Mathern, professor of pediatric neurosurgery and director of the UCLA Pediatric Epilepsy Program at Mattel Children's Hospital; Carol Kruse, professor of neurosurgery; and Geoffrey Owens, visiting assistant researcher in neurosurgery.

"I am grateful to collaborate with a devoted father who has taken on the enormous task of advancing research fo
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Contact: Amy Albin
aalbin@mednet.ucla.edu
310-794-8672
University of California - Los Angeles Health Sciences
Source:Eurekalert  

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