Navigation Links
Molecules may help predict survival in liver cancer

COLUMBUS, Ohio Tiny molecules that help cells regulate which proteins they make might one day help doctors predict which liver-cancer patients are likely to live longer than others, new research suggests.

Researchers compared levels of molecules called microRNA in tumor cells and adjacent nontumor cells from liver-cancer patients, most of whom also had hepatitis and cirrhosis.

The study found that patients with poor disease-free survival had low overall levels of 19 particular microRNAs compared with those showing better survival after 16 years of follow-up.

The work was led by researchers at the Ohio State University Comprehensive Cancer Center in collaboration with investigators at the Mayo Clinic and the University of Oklahoma Health Sciences Center.

The study is published in the Jan. 15 issue of the journal Clinical Cancer Research.

The findings must be verified in larger groups of patients, but they suggest that we might improve survival in some liver-cancer cases by adding back those microRNAs as a drug, says principal investigator Thomas D. Schmittgen, associate professor of pharmacy and a researcher with Ohio States Comprehensive Cancer Center.

But that possibility will require years of additional laboratory and preclinical research, Schmittgen says.

Liver cancer, or hepatocellular carcinoma, is the third most common cause of cancer death worldwide, killing some 662,000 people in 2005, according to the World Health Organization. The disease is more common in men and is usually caused by hepatitis infection or cirrhosis of the liver.

For this study, Schmittgen and his collaborators examined specimens from 43 liver tumors, 28 of which were paired with nearby nontumor tissue, and specimens from six normal livers. Two-thirds of the cancerous livers also had hepatitis and cirrhosis.

The researchers examined the levels of 196 different microRNAs in liver-cancer cells vs. nearby noncancer cells, and in liver cells with hepatitis and cirrhosis vs. healthy cells.

Both comparisons showed interesting differences in microRNA levels, but the most important finding came when the researchers looked for a correlation between cancer-cell microRNA levels and disease-free survival times in 25 patients for whom disease-free survival data was available.

The analysis showed that patients with poor survival had generally lower levels of 19 particular microRNAs than did patients with significantly better survival.

This may also be a good clue as to which microRNAs are most important in liver cancer, Schmittgen says.


Contact: Darrell E. Ward
Ohio State University Medical Center

Related medicine news :

1. Molecules might identify high-risk acute-leukemia patients
2. Tiny RNA Molecules Control Breast Cancers Spread
3. Molecules can block breast cancers ability to spread
4. Major Advance in the Observation of DNA Molecules
5. Researchers identify molecules with interesting anti-clotting properties
6. Study Describes Molecules That Control Blood Pressure
7. New class of RNA molecules may be important in human cancer
8. Accelerated head growth can predict autism before behavioral symptoms start
9. Gene predicts heart attack response and cardiac damage
10. MicroRNAs May Predict Colon Cancer Prognosis
11. In silico modeling helps predict severity of mitochondrial disease
Post Your Comments:
(Date:11/30/2015)... ... November 30, 2015 , ... Olympic Gold Medalists ... collaborating with brands across various categories through traditional and social media marketing campaigns ... elite group of Gold Medal Moms who can connect with today’s most important ...
(Date:11/30/2015)... ... December 01, 2015 , ... ... as a 2015-2016 inductee into its VIP Woman of the Year Circle. ... the nation’s leading networking organization exclusively for professional women, boasting 850,000 members and ...
(Date:11/30/2015)... (PRWEB) , ... November 30, 2015 , ... ... programs of the19th Bi-National Convention of the Federation of Philippine American Chambers of ... in Las Vegas, Nevada. , 1Heart Caregiver Services, as an active delegate ...
(Date:11/30/2015)... ... 2015 , ... Until now, the St. Louis Fetal Care Institute ... Myelomeningocele Study) trial. One of these exclusion criteria was a BMI above 34.9. According ... 24.9 is considered normal, 25 - 29.9 is overweight and above 30 is obese. ...
(Date:11/30/2015)... ... November 30, 2015 , ... According to research by the ... dental technicians to be certified or obtain continuing education. To increase awareness of ... Your Mouth?” campaign to inform dentists that the technicians they trust could lack ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... RATON, Fla. , Nov. 30, 2015   ... (the Institute) announced today that it has finalized ... device start-up company with technology developed at Florida State ... publicly-funded research, and bridges early funding gaps for companies ... and research institutions. --> ...
(Date:11/30/2015)... Ended 30 September 2015 2014RestatedChange%Turnover 545,575 , 518,852 , 5.2 ... 384,242 , 9.8 Hospital Management Service Income ... (18.3) Medical Insurance Administration Service Income , 2,780 ... Accessories Sales , 89,645 , 94,580 ... , 2,917 , (3.3) Gross Profit ...
(Date:11/30/2015)... -- PTS Diagnostics, the U.S.-based manufacturer of point-of-care biometric testing ... systems, and PTS Detect™ cotinine systems, has announced ... propel the company into the mHealth market. ... . The technology is a system that interfaces with ... tablets, and uses test strip technology already developed by ...
Breaking Medicine Technology: