Navigation Links
Molecules generated that can halt metastasis of colon cancer
Date:2/19/2013

A Basque research consortium has managed to halt the progress of colon cancer and its metastasis in the liver in an experimental model with mice. This advance, that may open a new path for the future treatment of such pathologies, has been achieved by creating molecules which interfere with the adhesion of tumour cells to other cells of the organism. In this way, the molecules halt both the growth of the tumour and the dissemination of the tumour to and its proliferation in other organs.

The research, published in the prestigious North American Journal of Medicinal Chemistry, is based on a previous work by researchers at the University of the Basque Country (UPV-EHU) which had described a series of molecules which reduced the metastasis of melanoma (a serious variety of skin cancer) in mice. That research opened up the possibility of generating new molecules with this activity in other types of cancer and following a similar strategy, something which has been achieved in this, later research, applied to colon cancer and its metastasis of the liver.

The Basque research consortium is made up of the CIC bioGUNE biociences research centre, the UPV/EHU, the Institute of Genetics and a Molecular and Cell Biology (IGBMC) in Strasbourg (France), and the Ikerchem spin-off Enterprise. Moreover, researchers from the Rocasolano Chemical-Physical Institute, from the CSIC (the Spanish Council for Scientific Research) and from the Novartis Institute for Biomedical Research took part.

"In this project we first designed inhibitors to cell adhesion involved in the metastasis of murine melanomas, and then undertook the chemical synthesis of these molecules, testing their biological potential and activity. What was surprising was that our calculations predicted that, by introducing relatively small changes, we would be able to generate new molecules with the capacity to inhibit cell adhesion involved in another type of cancer. This prediction was
'/>"/>

Contact: Oihane Lakar Iraizoz
o.lakar@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Measuring molecules with the naked eye
2. Prions in the brain eliminated by homing molecules
3. Ecommerce Software Provider, Shopping Cart Elite Launches Visitor Generated SEO Plugin
4. ABC Rx Cards Announced it Generated Over $237,000 of Savings for Clients
5. Immune responses can be generated locally within human melanoma skin metastases
6. Abnormal gene product associated with prostate cancer generated by unusual mechanism
7. RNA promotes metastasis in lung cancer
8. Preclinical study identifies master proto-oncogene that regulates ovarian cancer metastasis
9. Research breakthrough could halt melanoma metastasis
10. Lactation protein suppresses tumors and metastasis in breast cancer
11. Lack of oxygen in cancer cells leads to growth and metastasis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... The U.S. Pharmacopeial Convention is pleased ... Clinical Pharmacy Services at North Carolina State’s College of ... 2015 Beal Award for Distinguished Volunteer Service—the organization’s highest ... the contributions of volunteer experts to direct its work ...
(Date:1/22/2015)... January 22, 2015 Gabe’s Chemo Duck Program is ... the first app ever created for kids with cancer. The Chemo ... and devices, is filled with enjoyable games to help children of ... The free app helps to keep kids entertained, educated and at ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Blue Cross and ... Minnesotans who exemplify what it means to “Live Fearless.” ... for people to share their stories about how they or ... simply inspired others by living in the moment. By telling ...
(Date:1/22/2015)... York, New York (PRWEB) January 22, 2015 ... filed after Fresenius Medical Care recalled its GranuFlo and ... federal multidistrict litigation underway in U.S. District Court, District ... Order dated January 20th, the Court has remanded a ...
(Date:1/22/2015)... January 22, 2015 A study ... Medicine flagship journal Medicine & Science in Sports ... exercise may help reduce gastrointestinal (GI) problems associated ... , Participants in the double-blind, placebo-controlled study took ...
Breaking Medicine News(10 mins):Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 2Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 3Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 4Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 2Health News:Chemo Duck Launches First App Ever Created for Kids with Cancer 3Health News:Blue Cross and Blue Shield of Minnesota to Showcase “Faces of Fearless” 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 2Health News:Study Shows Kyowa Hakko’s L-Citrulline May Help Reduce Gastrointestinal Injury During Strenuous Exercise 3
... , FRIDAY, April 20 (HealthDay News) -- Patients are much ... surgery if they have open surgery rather than minimally invasive ... a blockage in the small intestines -- can develop within ... and is a common reason for emergency admission to a ...
... improved public health infrastructure that works collaboratively with physicians ... was made today by the American College of Physicians ... of a new policy paper, Strengthening the Public Health ... in New Orleans. "This paper points ...
... American Association for Dental Research (AADR) acknowledged the ... the American Heart Association (AHA) on the relationship ... titled "Periodontal disease and atherosclerotic vascular disease: Does ... statement from the American Heart Association" was published ...
... to ensure that Medicare beneficiaries have access to high-quality, ... of Physicians (ACP). The new policy paper, Reforming ... at Internal Medicine 2012, ACP,s annual scientific meeting. ... and disadvantages of proposals to reform Medicare in an ...
... Gordon HealthDay Reporter , FRIDAY, April 20 (HealthDay News) ... eye experts now say it generally doesn,t have to be that ... have vision for a lifetime," said Dr. Mark Fromer, an ophthalmologist ... Centers, both in New York City, and the eye surgeon director ...
... HealthDay Reporter , FRIDAY, April 20 (HealthDay News) -- ... with long-lasting damage in 2011 -- the highest number in ... problem," a new report claims. The finding is based ... Catastrophic Sports Injury Research at the University of North Carolina ...
Cached Medicine News:Health News:Lower Risk for Bowel Obstruction With Less Invasive Surgery: Study 2Health News:Physicians call for improvements to country's public health system to protect US residents 2Health News:Physicians call for improvements to country's public health system to protect US residents 3Health News:Physicians call for improvements to country's public health system to protect US residents 4Health News:AADR comments on review that validates association between oral health and heart health 2Health News:Internal medicine physician specialists release policy paper on reforming Medicaid 2Health News:Internal medicine physician specialists release policy paper on reforming Medicaid 3Health News:Internal medicine physician specialists release policy paper on reforming Medicaid 4Health News:Glaucoma Need Not Steal Sight, Experts Say 2Health News:Glaucoma Need Not Steal Sight, Experts Say 3Health News:'Catastrophic' Head Injuries to High School Football Players Rising 2Health News:'Catastrophic' Head Injuries to High School Football Players Rising 3
(Date:1/22/2015)... Jan. 22, 2015  BiOptix is pleased to announce the ... President of Chemistry and Biochemistry. Scott joins the company after ... and Amgen throughout the course of his nearly 20 ... "Scott is a nationally recognized thought leader in the ...
(Date:1/22/2015)... (NYSE: RMD ) today announced results for its ... $423.0 million, a 10 percent increase compared to the quarter ... constant currency basis). Net income was $91.2 million, an increase ... 2013. Diluted earnings per share for the quarter were $0.64, ...
(Date:1/22/2015)... OAKS, Calif. , Jan. 22, 2015  Amgen (NASDAQ: ... and full year 2014 financial results on Tuesday, Jan. 27, 2015, ... be followed by a conference call with the investment community at ... Robert A. Bradway , chairman and chief executive officer, and ...
Breaking Medicine Technology:BiOptix Expands Leadership Team with the Appointment of Dr. Scott Klakamp as Vice President of Chemistry and Biochemistry 2ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 2ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 3ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 4ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 5ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 6ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 7ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 8ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 9ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 10ResMed Inc. Announces Results for the Second Quarter of Fiscal Year 2015 11Amgen Announces Webcast of 2014 Fourth Quarter and Full Year Financial Results 2
Colloidal Gold Conjugated, Streptavidin - 50 OD...
Colloidal Gold Conjugated, Goat anti-rabbit IgG (H&L) - 12 OD...
Colloidal Gold Conjugated, Goat anti-mouse IgG (H&L) - 50 OD...
Colloidal Gold Conjugated, Goat anti-human IgG (H&L) - 12 OD...
Medicine Products: