Navigation Links
Molecules can block breast cancer's ability to spread
Date:1/9/2008

Researchers have identified a specific group of microRNA molecules that are responsible for controlling genes that cause breast cancer metastasis. The study, led by scientists at Memorial Sloan-Kettering Cancer Center (MSKCC), appears in the January 10, 2008, issue of Nature.

MicroRNAs are known to inhibit the activity of entire sets of genes associated with cancer metastasis a process that leads to the majority of cancer-related deaths. The new work explains how the loss of certain microRNAs allows cancer cells to migrate through organ tissue and to grow more rapidly.

The researchers examined human breast cancer cells with strong metastatic ability and found that the cells had lost large numbers of three different microRNA molecules. Conversely, when researchers put those molecules back into human breast cancer tumors in mice, the tumors lost their ability to spread.

In addition, the researchers looked at breast cancer patients and discovered that those with tumors that had lost these molecules were much more likely to suffer from cancer metastasis to the lung and bone.

The identification of molecules that inhibit a cells metastatic potential may help guide clinical decision-making in the future by enabling oncologists to more accurately identify patients at highest risk for metastatic relapse, said the studys lead author Sohail Tavazoie, MD, PhD, a postdoctoral fellow in the Oncology-Hematology Fellowship program at MSKCC.

In further analyzing one of these microRNAs, called miR-335, investigators found that miR-335 works by suppressing certain genes that are associated with human metastasis, particularly SOX4, which acts as a transcription factor (meaning that it regulates a group of genes responsible for cell development and migration), and tenascin-C, which functions outside the cell in what is called the extracellular matrix and is implicated in cell migration.

We now have a better understanding of the role this molecular pathw
'/>"/>

Contact: Esther Napolitano
napolite@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Major Advance in the Observation of DNA Molecules
2. Researchers identify molecules with interesting anti-clotting properties
3. Study Describes Molecules That Control Blood Pressure
4. New class of RNA molecules may be important in human cancer
5. Forever young: Differentiation blocked in tumor stem cells
6. FDA approves Bystolic, a novel beta blocker
7. Blood-vessel blocker aids cancer-killing virus
8. Study Finds a Lack of Health Insurance May Roadblock Some Diabetes Patients From Seeking Critical Treatment
9. Grape powder blocks genes linked to colon cancer
10. Blocking Potent Oxidant Could Prevent Morphine Tolerance
11. Conseco Completes Divestiture of Old Block of Fixed and Equity-Indexed Annuities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... 2014 B. E. Smith, the only ... has been retained to lead a national chief ... Franklin, Ind. The top executive search firm in the ... than 900 healthcare executives into organizations. , Johnson ... providing care to the residents of Johnson County and ...
(Date:12/19/2014)... 2014 If you have ever been ... you probably wished you had an arsenal of treatments ... fibrosis, and other breathing disorders. Currently, the only proven ... triggers, but other common treatments do exist. At ... San Antonio, TX, 34 asthma educators responded to a ...
(Date:12/19/2014)... December 19, 2014 Consilium Staffing, ... the AMSUS Society for Federal Health Professionals annual ... tenens industry to military and federal healthcare providers. ... National Veterans Small Business Engagement (NVSBE) conference last ... to be a vital solution in addressing our ...
(Date:12/19/2014)... Amy Norton HealthDay Reporter ... born to moms who were exposed to high levels of ... of developing autism, a U.S. study suggests. Researchers found ... 1990 and 2002, those exposed to the most air pollution ... who later developed autism. And exposure during the third trimester, ...
(Date:12/17/2014)... 17, 2014 While countless companies tempt patients ... realize the potential dangers of their purchase. Not only is ... a qualified doctor, but patients who buy hCG online are ... there is actually no real hCG present. Illegal internet hCG ... are no safety standards and may contain unknown fillers that ...
Breaking Medicine News(10 mins):Health News:Johnson Memorial Hospital Retains B. E. Smith to Recruit New Chief Financial Officer 2Health News:Johnson Memorial Hospital Retains B. E. Smith to Recruit New Chief Financial Officer 3Health News:Harmonica Techs, Inventors of the Pulmonica®, Unveil New Findings on Complementary Treatments for Asthma 2Health News:Harmonica Techs, Inventors of the Pulmonica®, Unveil New Findings on Complementary Treatments for Asthma 3Health News:Consilium Staffing Increasing Awareness of Locum Tenens through Conference Appearances 2Health News:Smog Exposure During Pregnancy Linked to Autism Risk 2Health News:Smog Exposure During Pregnancy Linked to Autism Risk 3Health News:Diet Doc Reveals the Real Dangers for Those who Buy hCG Online 2Health News:Diet Doc Reveals the Real Dangers for Those who Buy hCG Online 3
... News) -- About 9.3 million American adults lost health insurance ... nine times more than in the 2001 recession, according to ... children under age 18 gained health insurance coverage during the ... as intended as part of the social safety net, said ...
... Men who have lost their partner to cancer and who ... run a far greater risk of developing mental illness than ... a unique study of 691 Swedish widowers carried out at ... cancer in Sweden each year. It has been scientifically proven ...
... News) -- Working mothers have better health and fewer symptoms ... The researchers also found that mothers with part-time jobs can ... full-time jobs. For the study, published in ... , researchers analyzed data collected from over 1,300 mothers in ...
... at Mayo Clinic in Arizona ( http://www.mayoclinic.org/arizona/ ) and ... that dramatically reduces tumors in a mouse model that ... cases including those that are resistant to common ... the early edition of the journal Proceedings of the ...
... Hitching a ride into the retina on nanoparticles called ... degeneration and retinitis pigmentosa. A study by investigators at ... shows that steroids attached to the dendrimers target the ... the eye unaffected and preserving vision. The findings appear ...
... HealthDay Reporter , TUESDAY, Dec. 13 (HealthDay News) ... be at higher risk for Sudden Infant Death Syndrome ... underdeveloped nervous systems can,t control drops in blood pressure ... unexpected death of an apparently healthy baby. The national ...
Cached Medicine News:Health News:Loss of Health Insurance Much Likelier for Adults This Recession 2Health News:New relationship important for the mental health of widowers 2Health News:Working Moms Happier, Healthier Than Stay-at-Home Peers: Study 2Health News:Scientists develop vaccine that successfully attacks breast cancer in mice 2Health News:Scientists develop vaccine that successfully attacks breast cancer in mice 3Health News:Nanoparticles help Mayo Clinic researcher deliver steroids to retina 2Health News:Study Sheds Light on Preemies' Higher SIDS Risk 2
(Date:12/17/2014)... Dec. 17, 2014 PCCA received the ... ( http://bit.ly/1382OkS ) program seal for best practices ... program highlights medical practices, materials and goods that ... Children affected by autism often have ... exacerbated by ingredients found in food and medicine ...
(Date:12/15/2014)... Dec. 12, 2014 Research and Markets ... "Electrocardiogram (ECG) Devices - Global Trends, Estimates and ... http://photos.prnewswire.com/prnh/20130307/600769 Global Electrocardiogram ... by 2016. The North America ... share while Europe claims approximately ...
(Date:12/15/2014)... , December 15, 2014 BerGenBio ... for aggressive drug resistant cancers, today announces that it ... private placing from new and existing investors. ... support the development of its pipeline of innovative cancer ... its lead drug candidate, BGB324, a first-in-class selective Axl ...
Breaking Medicine Technology:Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 2Parents Of Children With Autism Spectrum Disorder Have New Options When Administering Medications 3Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 2Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 3Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 4BerGenBio Completes NOK90 Million Fundraising 2
... Perfect Single Vac Manifold is ... plate in 30 minutes; the ... "open/closed" switch and a vacuum ... operation. contains vacuum chamber, on/off ...
... The TurboVap Concentration Workstations from Caliper provide an automated alternative to Kuderna-Danish, Rotary, Vacuum-Style and Nitrogen ... in use around the world today. ... ... ...
Plastic Tray Type Vacuum Manifold...
... Vacuum Manifold system for sample processing consists ... a vacuum is applied, a chemical-resistant polypropylene ... convenience in sample handling. The manifold is ... up to 12 samples simultaneously. Loading, washing, ...
Medicine Products: