Navigation Links
Molecule tracking reveals mechanism of chromosome separation in dividing cells
Date:3/6/2009

University of Washington (UW) researchers are helping to write the operating manual for the nano-scale machine that separates chromosomes before cell division. The apparatus is called a spindle because it looks like a tiny wool-spinner with thin strands of microtubules or spindle fibers sticking out. The lengthening and shortening of microtubules is thought to help push and pull apart chromosome pairs.

Understanding how this machine accurately and evenly divides genetic material is essential to learning why its parts sometimes fail. Certain cancers or birth defects, like Down syndrome or Trisomy 18, result from an uneven distribution of chromosomes.

In a study published March 6 in the journal Cell, a team led by UW scientists reports on the workings of a key component of this machine. Named a kinetochore, it is a site on each chromosome that mechanically couples to spindle fibers.

"Kineochores are also regulatory hubs," the researchers noted. "They control chromosome movements through the lengthening and shortening of the attached microtubules. They sense and correct errors in attachment. They emit a "wait" signal until the microtubules properly attach." Careful control over microtubules, they added, is vital for accurate splitting of the chromosomes.

The lead researchers on the study were Andrew F. Powers and Andrew D. Frank from the UW Department of Physiology and Biophysics and Daniel R. Gestaut, from the UW Department of Biochemistry. The senior authors of the study were Charles "Chip" Asbury, assistant professor, and Linda Wordeman, associate professor, both of physiology and biophysics and both members of the UW Center for Cell Dynamics; and Trisha Davis, professor of biochemistry, and director of the Yeast Resource Center.

Asbury is known for research on molecular machines and motors, Wordeman for work on chromosome movement, and Davis for studies of spindle poles. All are part of the Seattle Mito
'/>"/>

Contact: Leila Grau
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Nostrum Pharmaceuticals Obtains Worldwide Licensing Rights From IMTECH for Clinical Development of the Small Molecule Caerulomycin and Its Proprietary Derivatives for Their Novel Indication of Immunosuppression
2. From molecules to populations: Fighting the epidemics of obesity and diabetes
3. OHSU School of Dentistry team discovers new molecule in blood-pressure control system
4. Researcher refining synthetic molecules to prevent HIV resistance
5. Tumors grow faster without blood-supply promoting molecule
6. Avineuro Announced Advancing Potent Small Molecule for Treatment of Alzheimers Disease to Clinical Development
7. MS patients have higher spinal fluid levels of suspicious immune molecule
8. Key protein molecule linked to diverse human chronic inflammatory diseases
9. Molecule Keeps Bacteria Like Salmonella in Check
10. Tiny molecule helps control blood-vessel development, UT Southwestern researchers find
11. Mouse Study Finds Molecule That Tells Hair to Grow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... July 10, 2014 For the first time, researchers ... Aboriginal population in Canada uses health care. A new ... to clearly demonstrate the unique challenges faced by urban ... St. Michael,s Hospital. , The findings, published today ... urban First Nations individuals and the general population. , ...
(Date:7/9/2014)... that captures heretofore hidden ways that cells are regulated, ... makes breast cancer cells more likely to metastasize. , ... in part by blocking two other proteins that are ... two disease processes could have unexpected ties. , ... of Nature , points to the possibility of ...
(Date:7/9/2014)... users in Russia might contribute to HIV transmission ... by researchers from Boston University Schools of Medicine ... Pavlov State University, sought to discover the effect ... a cohort of HIV-positive people with lifetime of ... by police were more likely to share needlesincreasing ...
(Date:7/9/2014)... 8, 2014) Researchers from Montefiore Medical Center ... of Yeshiva University will present new findings at ... 12 July 17 in Copenhagen, Denmark. Data from ... prompt transition from cognitive normality to mild cognitive impairment ... Einstein Aging Study , established in 1980 to examine ...
(Date:7/9/2014)... one of the most important organs in the human ... our food properly this is its synthesis function ... organism this is its detoxification function. Lack of ... all damage the liver. The resulting diseased cells can ... life-threatening liver failure. According to the German Liver Foundation, ...
Breaking Medicine News(10 mins):Health News:Urban Aboriginal people face unique health challenges 2Health News:Protein pushes breast cancer cells to metastasize 2Health News:Protein pushes breast cancer cells to metastasize 3Health News:BU researchers relate arrests with HIV risk environment 2Health News:Investigators from Montefiore and Einstein to present data at 2014 Alzheimer's Association International Conference 2Health News:Investigators from Montefiore and Einstein to present data at 2014 Alzheimer's Association International Conference 3Health News:Telemedicine for patients with chronic liver diseases 2Health News:Telemedicine for patients with chronic liver diseases 3
... SAN DIEGO, Nov. 5 Volcano Corporation (Nasdaq: VOLC ... products for the diagnosis and treatment of coronary and peripheral ... third quarter of fiscal 2009. , The results for the ... percent over revenues of $44.1 million in the third quarter ...
... mix of bacteria for each person , THURSDAY, Nov. ... on and within the human body has uncovered the fact ... Nations of germs. , The scientists, using sophisticated gene-sequencing technologies, ... on and within the body. They found a wide variability ...
... countries , THURSDAY, Nov. 5 (HealthDay News) -- The United ... health-care practices, according to a new international survey of primary ... the other countries in the survey, yet a majority of ... care, and a wide majority of primary care physicians don,t ...
... ... , ... -- Now there are some five-star reasons for Houston-area Medicare beneficiaries to choose ... of its annual Consumer Assessment of Healthcare Providers and Systems (CAHPS) survey, and KelseyCare ...
... SHENZHEN, China, Nov. 5 /PRNewswire-Asia/ ... ), China,s leading stem cell research,and regenerative ... an,agreement with Yokohama-based Biomaster Inc. ( http://www.biomaster.jp ... Biomaster specializes in research,and commercialization of adipose-based stem ...
... COLUMBIA, S.C., Nov. 5 Companion Life Insurance Co. ... to offer its dental policyholders preferred pricing on travel ... , Traveling abroad for credentialed dental care, also known ... Prices at the international clinics average 60 to 80 ...
Cached Medicine News:Health News:Volcano Reports 22 Percent Increase in Third Quarter Revenues 2Health News:Volcano Reports 22 Percent Increase in Third Quarter Revenues 3Health News:Volcano Reports 22 Percent Increase in Third Quarter Revenues 4Health News:Volcano Reports 22 Percent Increase in Third Quarter Revenues 5Health News:Volcano Reports 22 Percent Increase in Third Quarter Revenues 6Health News:Volcano Reports 22 Percent Increase in Third Quarter Revenues 7Health News:Volcano Reports 22 Percent Increase in Third Quarter Revenues 8Health News:Volcano Reports 22 Percent Increase in Third Quarter Revenues 9Health News:Volcano Reports 22 Percent Increase in Third Quarter Revenues 10Health News:Volcano Reports 22 Percent Increase in Third Quarter Revenues 11Health News:Volcano Reports 22 Percent Increase in Third Quarter Revenues 12Health News:Volcano Reports 22 Percent Increase in Third Quarter Revenues 13Health News:Volcano Reports 22 Percent Increase in Third Quarter Revenues 14Health News:Germs Mingle Most on Palms, Feet, Forearms 2Health News:Germs Mingle Most on Palms, Feet, Forearms 3Health News:Doctors Point Out Gaps in U.S. Health Care 2Health News:Local Medicare Advantage Plan Gets Five-Star Ratings from Medicare 2Health News:Local Medicare Advantage Plan Gets Five-Star Ratings from Medicare 3Health News:Beike Biotechnology Invests in Leading Japanese Regenerative Medicine Co., Biomaster Inc. 2Health News:Beike Biotechnology Invests in Leading Japanese Regenerative Medicine Co., Biomaster Inc. 3Health News:Beike Biotechnology Invests in Leading Japanese Regenerative Medicine Co., Biomaster Inc. 4Health News:Companion Life Adds Dental Tourism Option to Help Policyholders Save 2Health News:Companion Life Adds Dental Tourism Option to Help Policyholders Save 3
(Date:1/15/2014)... Jan. 15, 2014 Reportlinker.com announces ... is available in its catalogue: ... Technologies for Advanced Drug Delivery Systems ... http://www.reportlinker.com/p01941928/Global-Markets-and-Technologies-for-Advanced-Drug-Delivery-Systems----Focus-on-Routes-of-Administration.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Drug_Delivery_Technology ...
(Date:1/15/2014)... , Jan. 15, 2014  A novel wearable injector slightly ... and painless for patients to self-inject prescription drugs in the ... including cancer, blood diseases, autoimmune deficiencies, and genetic disorders.  ... grow to $220B by 2018, according to analysts.   Many of ...
(Date:1/14/2014)... , Jan. 14, 2014  Luminex Corporation (Nasdaq: LMNX ... the fourth quarter of 2013 on Monday, February 3, 2014. ... after the close of trading. (Logo: ... to discuss the operating highlights and financial results for the ...
Breaking Medicine Technology:Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on Routes of Administration 16Enable Injections Presents A New Class of Injectors for Drug Delivery at PEPTalk, Drug Delivery Partnership Meetings 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 3
... Inc. (NYSE: RMD ) today announced changes ... his position as Chief Executive Officer and President, and ... has appointed Dr. Peter C. Farrell, ResMed,s founder and ... and President, effective January 28, 2011.  Dr. Farrell will ...
... CardioGenics Holdings Inc. (OTC Bulletin Board: ... Merck Chimie SAS continue the commercialization process of ... while it is refining its encapsulation of the ... of magnetic beads coated with CardioGenics, proprietary silver-coating ...
Cached Medicine Technology:ResMed Inc. Announces Management Changes 2ResMed Inc. Announces Management Changes 3CardioGenics to Continue Commercialization of its Magnetic Beads with Merck Chimie SAS 2CardioGenics to Continue Commercialization of its Magnetic Beads with Merck Chimie SAS 3
The Mini Vidas is a compact version of the Vidas system with a built-in computer, keyboard and printer. Two independent sections each accept six tests and can process up to 12 samples simultaneously....
The ACE Alera clinical chemistry system serves a wide variety of chemistry diagnostic needs with the power of a large floor model analyzer in an easily integrated and economizing compact footprint of...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: