Navigation Links
Molecule tracking reveals mechanism of chromosome separation in dividing cells
Date:3/6/2009

University of Washington (UW) researchers are helping to write the operating manual for the nano-scale machine that separates chromosomes before cell division. The apparatus is called a spindle because it looks like a tiny wool-spinner with thin strands of microtubules or spindle fibers sticking out. The lengthening and shortening of microtubules is thought to help push and pull apart chromosome pairs.

Understanding how this machine accurately and evenly divides genetic material is essential to learning why its parts sometimes fail. Certain cancers or birth defects, like Down syndrome or Trisomy 18, result from an uneven distribution of chromosomes.

In a study published March 6 in the journal Cell, a team led by UW scientists reports on the workings of a key component of this machine. Named a kinetochore, it is a site on each chromosome that mechanically couples to spindle fibers.

"Kineochores are also regulatory hubs," the researchers noted. "They control chromosome movements through the lengthening and shortening of the attached microtubules. They sense and correct errors in attachment. They emit a "wait" signal until the microtubules properly attach." Careful control over microtubules, they added, is vital for accurate splitting of the chromosomes.

The lead researchers on the study were Andrew F. Powers and Andrew D. Frank from the UW Department of Physiology and Biophysics and Daniel R. Gestaut, from the UW Department of Biochemistry. The senior authors of the study were Charles "Chip" Asbury, assistant professor, and Linda Wordeman, associate professor, both of physiology and biophysics and both members of the UW Center for Cell Dynamics; and Trisha Davis, professor of biochemistry, and director of the Yeast Resource Center.

Asbury is known for research on molecular machines and motors, Wordeman for work on chromosome movement, and Davis for studies of spindle poles. All are part of the Seattle Mito
'/>"/>

Contact: Leila Grau
leilag@u.washington.edu
206-685-0381
University of Washington
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Nostrum Pharmaceuticals Obtains Worldwide Licensing Rights From IMTECH for Clinical Development of the Small Molecule Caerulomycin and Its Proprietary Derivatives for Their Novel Indication of Immunosuppression
2. From molecules to populations: Fighting the epidemics of obesity and diabetes
3. OHSU School of Dentistry team discovers new molecule in blood-pressure control system
4. Researcher refining synthetic molecules to prevent HIV resistance
5. Tumors grow faster without blood-supply promoting molecule
6. Avineuro Announced Advancing Potent Small Molecule for Treatment of Alzheimers Disease to Clinical Development
7. MS patients have higher spinal fluid levels of suspicious immune molecule
8. Key protein molecule linked to diverse human chronic inflammatory diseases
9. Molecule Keeps Bacteria Like Salmonella in Check
10. Tiny molecule helps control blood-vessel development, UT Southwestern researchers find
11. Mouse Study Finds Molecule That Tells Hair to Grow
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... ... July 31, 2015 , ... “Engage: Don’t ... the industry’s premier thought leadership symposiums, hosted by Massachusetts-based Harmony Healthcare International ... event attracts over 250 “C”-level executives, administrators, directors of nursing, rehabilitation managers and ...
(Date:7/31/2015)... ... July 31, 2015 , ... The Mount Sinai Health ... projects that evaluate the potential of related, experimental treatments. The collaboration moves into the ... to award Columbia Care one of five state licenses to produce and dispense medical ...
(Date:7/31/2015)... ... ... Like nearly every other form of surgery, it shouldn't come as a surprise ... intrusive and painful. Leading these advances in the United States has been Dr. ... the only doctor in the United States who is qualified to practice, and is ...
(Date:7/31/2015)... , ... July 31, 2015 , ... The Heart Fit ... don't experience angina until a heart rate of 150 beats versus 100 beats, this ... Calgary. "We are able to give life back to patients with heart disease," he ...
(Date:7/31/2015)... ... July 31, 2015 , ... Burnaby sports physiotherapy ... encourages the understanding and treatment of ankle sprains. A common sports injury, ankle ... can be dangerous if the condition augments and causes more disruption. Absolute PhysioCare’s ...
Breaking Medicine News(10 mins):Health News:Harmony Healthcare International Announces Speaker Line-up for “HARMONY 2015” 2Health News:Harmony Healthcare International Announces Speaker Line-up for “HARMONY 2015” 3Health News:Mount Sinai to Collaborate with Columbia Care on Medical Marijuana Research 2Health News:Mount Sinai to Collaborate with Columbia Care on Medical Marijuana Research 3Health News:Loria Medical Penile Enlargement Center to Expand, Offering Practice Partnership to Doctors 2Health News:Heart Fit Clinic Helps Patient Increase Fitness Level with External Counterpulsation 2Health News:Absolute PhysioCare & Sports Rehab Promotes Understanding & Treatment of Ankle Sprains 2
... PRUSSIA, Pa., July 17 Universal,Health Services, Inc. (NYSE: ... voted to pay a cash dividend of $0.08 per ... of September 2, 2008., Universal Health Services, Inc. ... its subsidiaries, acute care and behavioral,health hospitals, and ambulatory ...
... MX Grand Prix, CAPE TOWN, South Africa, July ... Corporation headquartered in,Cape Town, South Africa, and the distributor ... prevent potentially devastating motor sport,injuries to the cervical spine ... Sponsor to the South African Leg of the 2008 ...
... July 16, 2008 Galderma Pharma S.A., a ... that Japan,s Ministry of Health, Labor and Welfare has ... for acne vulgaris in Japan. The drug will be ... arm of Galderma, and strategic alliance partner Shionogi. , ...
... help those at risk of obesity or with high ... babies ready to graduate from breast milk or formula ... they receive whole milk, instead of reduced-fat or fat-free ... of Pediatrics (AAP) now advise parents of toddlers who ...
... and Equipment to Young Patients and Helps ... Raise Money for Make-A-Wish Foundation, PITTSBURGH, ... train-themed "JR" autonomous mobile robot to children,s,hospitals across the country ... Foundation for each JR TUG that is deployed. The JR ...
... July 17 /Xinhua-PRNewswire-FirstCall/ -- Mindray,Medical International Limited (NYSE: ... of medical devices worldwide has announced today that ... products as well as,unveil three new units and ... Chemistry (AACC) conference. The conference will be attended,by ...
Cached Medicine News:Health News:Leatt Corporation To Sponsor 2008 South African Motocross Grand Prix 2Health News:Leatt Corporation To Sponsor 2008 South African Motocross Grand Prix 3Health News:Galderma announces approval for Differin gel 0.1 percent in Japan 2Health News:Low-Fat Milk OK for Some Toddlers 2Health News:Aethon's Train-Themed Delivery Robot Available To Children's Hospitals Nationwide 2Health News:Mindray to Unveil Three New Products and Reagents at AACC Annual Meeting 2Health News:Mindray to Unveil Three New Products and Reagents at AACC Annual Meeting 3
(Date:7/31/2015)... According to a new market research report " ... Oxide, Filtration, E-beam, Gamma), Services (Onsite & Offsite), Consumables (Indicators, ... to 2020", published by MarketsandMarkets, The Sterilization Equipment Market is ... a CAGR of 7.6%.from 2015 to 2020. ... ables and 37 F igures ...
(Date:7/31/2015)... Inc. (Nasdaq: SMLR ), a company that provides ... groups, today reported financial results for the second quarter ... second quarter of 2015, Semler reported continued progress with ... quarter revenue growth of 8%, and quarter over quarter ... 18%," said Doug Murphy-Chutorian, M.D., chief executive officer of ...
(Date:7/31/2015)... Magnaquest, a leading Subscription ... cloud computing operators has signed a Proof of ... Internet of Things (IoT) related initiative. The PoC ... model.      (Logo: http://photos.prnewswire.com/prnh/20140807/700645 ) ... business innovations to make healthcare services more accessible ...
Breaking Medicine Technology:Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 2Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 3Sterilization Equipment Market is Expected to Reach USD 6.1 Billion by 2020 4Semler Reports Second Quarter 2015 Financial Results 2Semler Reports Second Quarter 2015 Financial Results 3Semler Reports Second Quarter 2015 Financial Results 4Semler Reports Second Quarter 2015 Financial Results 5Semler Reports Second Quarter 2015 Financial Results 6Magnaquest Signs a POC With a Leading Pharma Giant in Europe to Manage Subscription Management and Billing for Internet of Things (IoT) 2
... DANBURY, Conn., Sept. 22, 2011 Biodel Inc. (Nasdaq: ... President and Chief Executive Officer, will be presenting at the ... Hotel in New York.  The presentation is scheduled for Tuesday, ...  To listen to the live webcast or a replay of ...
... 22, 2011 Reportlinker.com announces that ... available in its catalogue: ... Packaging: Global Markets ... REPORT HIGHLIGHTS * ...
Cached Medicine Technology:Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets 2Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets 3Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets 4Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets 5Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets 6Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets 7Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets 8Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets 9Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets 10Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets 11Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets 12Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets 13Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets 14Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets 15Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets 16Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets 17Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets 18Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets 19Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets 20Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets 21Contract Pharmaceutical Manufacturing, Research and Packaging: Global Markets 22
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: