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Molecule regulates production of antibacterial agent used by immune cells
Date:6/20/2014

ung tissue of septic mice that could produce NFATc3.

"Our study demonstrates that NFATc3 is required for macrophages to effectively fight infection, because without it, they can't make their primary bactericidal agent -- nitric oxide," Ranjan said. The immune system must strike a balance between fighting infection and going overboard as it does in sepsis and actually causing harm, Ranjan said.

"An overproduction of nitric oxide can actually contribute to lung injury even as it helps clear bacterial infections," he said.

"An NFATc3 inhibitor, given as a drug to people in septic shock, may be a way to attenuate the harmful effects that come with an overproduction of nitric oxide." Other authors on the paper are Dr. Gye Young Park, assistant professor of clinical medicine, and Dr. Lei Xiao, assistant professor of medicine, both in the division of pulmonary, critical care, sleep and allergy at UIC; Manjula Karpurapu, Jing Deng, Sangwoon Chung, Yong Gyu Lee and Dr. John William Christman of the Ohio State University Wexner Medical Center; and Myungsoo Joo of Pusan University, Korea.


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Contact: Sharon Parmet
sparmet@uic.edu
312-413-2695
University of Illinois at Chicago
Source:Eurekalert

Page: 1 2

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