Navigation Links
Molecule prompts damaged heart cells to repair themselves after a heart attack
Date:4/10/2009

DALLAS April 10, 2009 A protein that the heart produces during its early development reactivates the embryonic coronary developmental program and initiates migration of heart cells and blood vessel growth after a heart attack, researchers at UT Southwestern Medical Center have found.

The molecule, Thymosin beta-4 (TB4), is expressed by embryos during the heart's development and encourages migration of heart cells. The new findings in mice suggest that introducing TB4 systemically after a heart attack encourages new growth and repair of heart cells. The research findings indicate that the molecule affects developmental gene expression as early as 24 hours after systemic injection. The UT Southwestern study is online and will appear in an upcoming issue of the Journal of Molecular and Cellular Cardiology.

"This molecule has the potential to reprogram cells in the body to get them to do what you want them to do," said Dr. J. Michael DiMaio, associate professor of cardiothoracic surgery at UT Southwestern and senior author of the study. Obviously, the clinical implications of this are enormous because of the potential to reverse damage inflicted on heart cells after a heart attack."

Tremendous medical progress has been made to counter the damaging effects of heart attacks, but ordinarily, mammalian hearts are incapable of repairing themselves following damage. They are also limited in their ability to form new blood vessels. Earlier studies demonstrated that TB4 is expressed in the embryonic heart and stimulates cardiac vessels to form. It was therefore thought that introduction of TB4 might activate new vessel growth in the adult heart.

In this mouse study researchers found that TB4 initiates capillary tube formation of adult coronary endothelial cells in tissue culture. The molecule also encourages cardiac regeneration by inhibiting death in heart cells after an injury such as a heart attack and by stimulating new vessel growth.

"We observed that by injecting this protein systemically, there was increased cardiac function after a heart attack," said Dr. Ildiko Bock-Marquette, assistant professor of cardiothoracic surgery at UT Southwestern and the study's lead author. "We hope this protein can inhibit cell death that occurs during a heart attack in the short term, and that it may initiate new growth of coronary vessels by activating progenitor cells in the long term."

Researchers assessed the effect of TB4 on new vessel growth in adult mice after inducing heart attacks and then following up by introducing TB4 into the animals. An examination of the capillary smooth muscle cells following treatment with TB4 showed a significant increase in capillary density in the heart three days afterward near the site of the heart attack, the scientists reported.

Further studies will examine whether the same events occur in larger mammals and which receptors are responsible for the action of this molecule.


'/>"/>

Contact: Katherine Morales
katherine.morales@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
Source:Eurekalert  

Related medicine news :

1. Avineuro Pharmaceuticals, Inc. Announces Beginning of Phase I Clinical Studies of AVN-101, Potent Small Molecule for Treatment of Alzheimers Disease.
2. Naturally fluorescent molecules may serve as cancer biomarker
3. BioNanomatrix Awarded Phase II NIH Grant to Support Development of Its Single-Molecule Nanoscale Whole Genome Analyzer
4. Researchers Report Combined Molecules in Red Wine by Far Exceed the Biological Activity of Plain Resveratrol, Consistent With the Composition of Longevinex(R)
5. Molecule tracking reveals mechanism of chromosome separation in dividing cells
6. Nostrum Pharmaceuticals Obtains Worldwide Licensing Rights From IMTECH for Clinical Development of the Small Molecule Caerulomycin and Its Proprietary Derivatives for Their Novel Indication of Immunosuppression
7. From molecules to populations: Fighting the epidemics of obesity and diabetes
8. OHSU School of Dentistry team discovers new molecule in blood-pressure control system
9. Researcher refining synthetic molecules to prevent HIV resistance
10. Tumors grow faster without blood-supply promoting molecule
11. Avineuro Announced Advancing Potent Small Molecule for Treatment of Alzheimers Disease to Clinical Development
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecule prompts damaged heart cells to repair themselves after a heart attack
(Date:5/23/2017)... ... 2017 , ... New England Journal Of Medicine Confirms Viability of Rory’s Regulations ... Rory Staunton Foundation Calls on Health & Human Services, Tom Price to Adopt Rory’s ... ) today reported on a new study released on May 21, 2017 in the ...
(Date:5/23/2017)... ... May 23, 2017 , ... London, May 23, 2017: Walter Schindler, the ... month as a Guest Speaker and Contributor to a weeklong series of classes, meetings, ... , Walter Schindler and SAIL Capital have received an ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... patients on peri-implantitis in Las Vegas, NV, and the importance of ... gum disease consultation and leading care for peri-implantitis, with or without a referral. ...
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... New patients ... Kevin Hogan, an experienced dentist practicing in Mt. Pleasant, SC, with or without a ... often recommended for patients with missing teeth in Charleston, SC. Those who ...
(Date:5/23/2017)... (PRWEB) , ... May 23, 2017 , ... ... now receive treatment using the SPEED System™ Orthodontics, with or without a referral, ... orthodontist in El Segundo, CA, who is skilled in providing patients with ...
Breaking Medicine News(10 mins):
(Date:5/4/2017)...  A new tight-tolerance microextrusion medical tubing product ... is being launched by Natvar, a Tekni-Plex company. ... recent years to service a wide variety of ... expensive materials such as glass and fluoropolymers have ... their ability to consistently hold tolerances. This is ...
(Date:5/3/2017)... May 3, 2017 A Catheterization Laboratory ... or healthcare facility. Commonly referred to as cath ... with diagnostic imaging technology to give physicians visual ... In these spaces, a team of physicians perform ... percutaneous coronary intervention, congenital heart defect closure, stenotic ...
(Date:5/3/2017)... , May 3, 2017  Getinge, a leading ... to quality enhancement and cost efficiency within healthcare ... study of contemporary practice demonstrating that intra-aortic balloon ... for critically ill patients. The single-center, retrospective, observational ... large volume MEGA ® 50cc intra-aortic balloon ...
Breaking Medicine Technology: