Navigation Links
Molecule plays early role in nonsmoking lung cancer
Date:7/27/2009

le was equally high in early stage tumors and late stage tumors, suggesting that this change happens early in lung cancer development, says Croce, who also directs Ohio State's Human Cancer Genetics program.

Using lung cancer cell lines, the investigators learned that EGFR regulates miR-21. For example, altering EGFR levels caused corresponding changes in miR-21.

Last, the investigators took cells that had a mutated EGFR gene and treated them with an anti-EGFR agent (the agent was related to gefitinib and erlotinib, targeted drugs used to treat lung cancers with EGFR mutations). As expected, many of the cells died. But when they blocked both EGFR and miR-21, the proportion of cells killed rose still more.

Overall, Croce says, "Our study suggests that the combined use of an EGFR inhibitor and a miR-21 inhibitor might improve therapy for many cases of lung cancer, and rescue lung cancer cases that have acquired resistance to several targeted drugs."


'/>"/>

Contact: Darrell E. Ward
Darrell.Ward@osumc.edu
614-293-3737
Ohio State University Medical Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Molecule Helps Leukemia Cells Hide From Immune System
2. Small Molecule Might Play Big Part in Lung Cancer
3. New role discovered for molecule important in development of the pancreas
4. Fate Therapeutics to Present Data on Stimulation of Osteogenic Activity Using Small Molecule Modulators of Wnt Pathway
5. Ready for relapse: Molecule helps breast cancer cells to survive in the bone marrow
6. LSUHSC research identifies enzyme that makes survival molecule for key vision cells
7. Ludwig Institute of Cancer Research Ltd., Brussels Branch, Issues Statement Concerning Prospect Therapeutics Incs. GCS-100 Molecule
8. Small molecule inhibitor shows promise in trastuzumab-resistant metastatic breast cancer
9. Molecule in Skin May Link Eczema and Asthma
10. Molecule prompts damaged heart cells to repair themselves after a heart attack
11. Avineuro Pharmaceuticals, Inc. Announces Beginning of Phase I Clinical Studies of AVN-101, Potent Small Molecule for Treatment of Alzheimers Disease.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... ... September 01, 2015 , ... ... retailer of professional hair salons. This highly anticipated partnership between Curly Hair Solutions™ ... Keeper™ Styling Collection. Founder Jonathan Torch and the Curly Hair Solutions™ team could ...
(Date:8/31/2015)... ... September 01, 2015 , ... The PT Outcomes Registry is an ... for physical therapy patients. The Registry is being developed by the American Physical Therapy ... are happy to be selected to contribute FOTO Outcomes measures as one of the ...
(Date:8/31/2015)... GA (PRWEB) , ... August 31, 2015 , ... ... to the healthcare industry, released their latest predictive use case focused on helping ... Purchasing Program (HVBP). Under this program, hospital payments are adjusted based on performance ...
(Date:8/31/2015)... , ... August 31, 2015 , ... ... giving potential patients the resources they need to have a successful cosmetic procedure; ... certified plastic surgeons; Cosmetic Town Journal is always ready to help. , It ...
(Date:8/31/2015)... ... August 31, 2015 , ... ... (WDI) at Western University of Health Sciences to learn more about its integrated ... School of Dental Sciences and Institute of Cellular Medicine at Newcastle University, and ...
Breaking Medicine News(10 mins):Health News:Curly Hair Solutions™ Partners With Trade Secrets 2Health News:FOTO Selected as Official Registry Partner with Physical Therapy Outcomes Registry 2Health News:Jvion Releases Value-Based Purchasing Predictive Use Case 2Health News:Cosmetic Town: A One Stop Plastic Surgery Community 2Health News:Western Diabetes Institute Collaborates with UK team 2Health News:Western Diabetes Institute Collaborates with UK team 3Health News:Western Diabetes Institute Collaborates with UK team 4
... Health Recognize the Nation,s Best Health Systems for Patient ... WASHINGTON, Dec. 2 As medical errors continue to ... leaders at the Henry Ford Health System (Detroit, MI) ... created cultures of safety that start with the executive-suite ...
... social activities are part of the fun of the holiday season. Not ... reports the December 2008 issue of Harvard Women,s Health Watch . ... ... gatherings, parties, and other social activities are part of the fun of ...
... Ingenious Med (IM) welcomes new CEO, S.,Hart Williford. ... with an extensive background as a leader in healthcare,software, ... Founder and nine-year ... company,s success and development in all sectors, as he ...
... of a new health website providing in-depth news on breast cancer. ... medicine, more and more patients are finding out that information is ... , Responding to the growing demand ... and drugs to treat it, EIN News is introducing Breast Cancer ...
... sodium, study says , , TUESDAY, Dec. 2 (HealthDay News) ... as salt -- in foods that seem to be health-friendly, ... more sodium than full-fat products. , That,s the finding of ... magazine. , Researchers analyzed 37 common supermarket items and found ...
... The University of Nottingham has identified a gene that protects ... the journal Proceedings of the National Academy of Sciences ... British Lung Foundation, has found that the tumour suppressor gene, ... cancer paving the way for possible new treatments and ...
Cached Medicine News:Health News:Leaders at Henry Ford Health System and Memorial Hermann Healthcare System Awarded for Commitment to Creating Safer, More Transparent Environments for Patients 2Health News:Leaders at Henry Ford Health System and Memorial Hermann Healthcare System Awarded for Commitment to Creating Safer, More Transparent Environments for Patients 3Health News:Leaders at Henry Ford Health System and Memorial Hermann Healthcare System Awarded for Commitment to Creating Safer, More Transparent Environments for Patients 4Health News:Leaders at Henry Ford Health System and Memorial Hermann Healthcare System Awarded for Commitment to Creating Safer, More Transparent Environments for Patients 5Health News:Easing Social Anxiety During the Holidays: Tips from Harvard Women's Health Watch 2Health News:Ingenious Med Hires New CEO to Maintain and Further Expand Company Development 2Health News:EIN News Introduces 'Breast Cancer News Today'; Website Offers Information on Risk Factors, Treatment, Drugs 2Health News:High Salt Levels Common in Many Foods 2Health News:Gene which protects against lung cancer identified 2
(Date:8/31/2015)... Pa. , Aug. 31, 2015  The departments ... an event today at Gaudenzia Concept 90 to raise ... drug overdose crisis in Pennsylvania ... treatment and focus on recovery through the Building ... many Pennsylvanians are dying every day to a disease ...
(Date:8/31/2015)... MOUNTAIN VIEW, Calif. , Aug. 31, 2015 ... SAN) and the life sciences team at Google announced ... outcomes for people with type 1 and type 2 ... devices with Google,s expertise in analytics, miniaturized electronics and ... to improve diabetes care by developing new tools that ...
(Date:8/31/2015)... Calif. , Aug. 31, 2015  Asterias ... focused on the emerging field of regenerative medicine, ... dosed at Chicago -based Rush ... trial evaluating activity of escalating doses of AST-OPC1 ... sensory and motor complete cervical spinal cord injury ...
Breaking Medicine Technology:Pennsylvania Departments of Drug & Alcohol Programs and Health Kick-off Second Annual Building Bridges to Recovery Initiative 2Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 2Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 3Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 4Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 5Sanofi to Collaborate with Google Life Sciences to Improve Diabetes Health Outcomes 6Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 4Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 5Asterias Biotherapeutics Concludes Recruitment of Initial Safety Cohort of the SCiStar Phase 1/2a Dose-Escalation Clinical Trial of AST-OPC1 for Complete Cervical Spinal Cord Injury 6
... Masimo (Nasdaq: MASI ) announced ... Welfare (MHLW) regulatory clearance of its noninvasive and ... the Masimo rainbow SET® platform.  Representing a breakthrough ... hemoglobin level in real-time, SpHb tracks and trends ...
... As US doctors consider the switch from paper charts to ... have teamed up to provide an absolutely free EMR ... only ad-supported EMR platform for medical providers in a sector ... for a five provider practice in the first year. Since ...
Cached Medicine Technology:Masimo Noninvasive and Continuous Hemoglobin Receives Market Clearance in Japan 2Masimo Noninvasive and Continuous Hemoglobin Receives Market Clearance in Japan 3Masimo Noninvasive and Continuous Hemoglobin Receives Market Clearance in Japan 4Can an Ad-Supported EMR Fuel Healthcare's Technology Revolution? 2Can an Ad-Supported EMR Fuel Healthcare's Technology Revolution? 3Can an Ad-Supported EMR Fuel Healthcare's Technology Revolution? 4
Hemagglutination slide test for the qualitative and quantitative detection of Rheumatoid Factor in serum or synovial fluid....
Hemagglutination slide test for the differential qualitative detection and quantitative determination of infectious mononucleosis and other heterophile antibodies in serum or plasma....
Color-enhanced hemagglutination slide test for the rapid qualitative and semi-quantitative detection of infectious mononucleosis heterophile antibodies in serum or plasma....
... Inverness Medical Professional Diagnostics is a leading ... IFA and DFA test menu that includes ... STDs as well as miscellaneous conjugates and ... you a wide assortment of substrates and ...
Medicine Products: