Navigation Links
Molecule movements that make us think

Every thought, every movement, every heartbeat is controlled by lightning-quick electrical impulses in the brain, the muscles, and the heart. But too much electrical excitability in the membranes of the cells can cause things like epilepsy and cardiac arrhythmia. A research group at Linkping University has now published new discoveries that can lead to new medicines for these diseases.

The key molecules behind the electrical impulses are voltage-activated ion channels pores in cell membranes, the opening and closing of which are controlled by the electrical potential between the inside and outside of the cell.

Research over the past few years has revealed the ion channels' molecular structure, and how the pores change form when they open and close. On the other hand, the mechanism explaining how the electric potential is detected on the molecular level remains unclear.

LiU researchers have now shown how an ion channel's voltage sensor can change its form. This change of form leads to the pore in the channel opening up.

Ulrike Henrion, Jakob Renhorn, Sara Brjesson, and Erin Nelson, all in Professor Fredrik Elinder's research group, have succeeded through comprehensive experimental work in identifying 20 different molecular interactions that occur in the voltage sensor's different states.

In collaboration with Professor Erik Lindahl's group at the KTH Royal Institute of Technology, and associate professor Bjrn Wallner at the Department of Physics, Chemistry and Biology at LiU, the group has built five different molecular models of the voltage sensor, which together can explain all the experimental data. The five models were then linked together to a film that shows how a central part of the voltage detector moves between the outer walls of the voltage sensor.

The published work is an important piece of the puzzle in the research group's quest to develop substances with raised electrical excitability, which hopefully can lead to new medicines for epilepsy and cardiac arrhythmia.

Contact: Fredrik Elinder
Linkping University

Related medicine news :

1. IU research team discovers TB disease mechanism and molecule to block it
2. Tiny molecules may tell big story about cardiovascular disease risk
3. New Cancer-Fighting Strategy Focuses On Signaling Molecules
4. Small molecule with high impact
5. Sigma-Aldrich Reaches Agreement to Sell Pfizers Bioactive Small Molecule Compounds
6. Inflammation Molecule May Determine Fat Levels
7. Exploring the Davids and Goliaths of therapeutic molecules
8. ACS Webinar focuses on drug discovery process for small molecule therapeutics
9. Fit People Release More Fat-Burning Molecules During Exercise
10. NIH-supported finding on cocaine addiction: Tiny molecule, big promise
11. MicroRNA molecule increases number of blood stem cells, may help improve cancer treatment
Post Your Comments:
(Date:11/29/2015)... (PRWEB) , ... November 29, 2015 , ... While conventional ... kneeling or provide ready access to exercise weights. Fortunately, an inventor from Uniontown, Pa., ... THE TOMMY WALKER to enhance the benefits of a standard walker to improve the ...
(Date:11/29/2015)... ... November 29, 2015 , ... Key Housing, a top-rated corporate ... their December, 2015, featured apartment community: Epic. In showcasing this featured apartment community in ... tight Bay Area rental market to efficiently find housing suitable to their needs by ...
(Date:11/28/2015)... ... 28, 2015 , ... Beginning November 30th at 6:00 a.m. EST until 11:59 p.m. EST, ... possible savings of up to 20% off orders $80 or more to free gifts with ... few hours. , As a competitive e-commerce website for skin care and cosmetic needs, customers ...
(Date:11/27/2015)... CA (PRWEB) , ... November 27, 2015 , ... According ... carried out by the University of Toronto and the University of British Columbia suggested ... hospitalizations for head injuries. The article explains that part of the reason for the ...
(Date:11/27/2015)... (PRWEB) , ... November 27, 2015 , ... ... a safe and convenient way to dispense prescription medications at home, so he ... effective way to monitor and dispense prescription medications. In doing so, it could ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... Sectra (STO: SECT B) ... into a multi-year agreement to provide Breast Imaging PACS ... Breast Care to increase collaboration with sub-specialists around the ... --> Sectra (STO: SECT B) ... into a multi-year agreement to provide Breast Imaging PACS ...
(Date:11/29/2015)... AMSTERDAM , Nov. 29, 2015  Strengthening its ... (NYSE: PHG, AEX: PHIA) today announced IntelliSpace Portal ... sharing, analytics and visualization platform that helps radiologists detect, ... the 2015 Radiological Society of North America Annual ... , IntelliSpace Portal 8.0 helps address the changing demands ...
(Date:11/29/2015)... Nov. 29, 2015   Royal Philips  (NYSE: PHG, ... solutions at the 2015 Radiological Society of North America ... McCormick Place in Chicago . Visitors ... the company,s broad portfolio of integrated Diagnostic Imaging, Clinical ... increase clinical performance, improve workflow and create a superior ...
Breaking Medicine Technology: