Navigation Links
Molecule movements that make us think
Date:4/24/2012

Every thought, every movement, every heartbeat is controlled by lightning-quick electrical impulses in the brain, the muscles, and the heart. But too much electrical excitability in the membranes of the cells can cause things like epilepsy and cardiac arrhythmia. A research group at Linkping University has now published new discoveries that can lead to new medicines for these diseases.

The key molecules behind the electrical impulses are voltage-activated ion channels pores in cell membranes, the opening and closing of which are controlled by the electrical potential between the inside and outside of the cell.

Research over the past few years has revealed the ion channels' molecular structure, and how the pores change form when they open and close. On the other hand, the mechanism explaining how the electric potential is detected on the molecular level remains unclear.

LiU researchers have now shown how an ion channel's voltage sensor can change its form. This change of form leads to the pore in the channel opening up.

Ulrike Henrion, Jakob Renhorn, Sara Brjesson, and Erin Nelson, all in Professor Fredrik Elinder's research group, have succeeded through comprehensive experimental work in identifying 20 different molecular interactions that occur in the voltage sensor's different states.

In collaboration with Professor Erik Lindahl's group at the KTH Royal Institute of Technology, and associate professor Bjrn Wallner at the Department of Physics, Chemistry and Biology at LiU, the group has built five different molecular models of the voltage sensor, which together can explain all the experimental data. The five models were then linked together to a film that shows how a central part of the voltage detector moves between the outer walls of the voltage sensor.

The published work is an important piece of the puzzle in the research group's quest to develop substances with raised electrical excitability, which hopefully can lead to new medicines for epilepsy and cardiac arrhythmia.


'/>"/>
Contact: Fredrik Elinder
fredrik.elinder@liu.se
46-737-538-370
Linkping University
Source:Eurekalert

Related medicine news :

1. IU research team discovers TB disease mechanism and molecule to block it
2. Tiny molecules may tell big story about cardiovascular disease risk
3. New Cancer-Fighting Strategy Focuses On Signaling Molecules
4. Small molecule with high impact
5. Sigma-Aldrich Reaches Agreement to Sell Pfizers Bioactive Small Molecule Compounds
6. Inflammation Molecule May Determine Fat Levels
7. Exploring the Davids and Goliaths of therapeutic molecules
8. ACS Webinar focuses on drug discovery process for small molecule therapeutics
9. Fit People Release More Fat-Burning Molecules During Exercise
10. NIH-supported finding on cocaine addiction: Tiny molecule, big promise
11. MicroRNA molecule increases number of blood stem cells, may help improve cancer treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2016)... Indianapolis, Indiana (PRWEB) , ... April 30, 2016 , ... ... USA Wrestling as they go for gold in Rio. Under the care of ... including two golds! , In an unprecedented showing, Maximized Living is sending the largest ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... the Accreditation Council for Graduate Medical Education (ACGME) that it has received accreditation ... the first accreditation of three residency programs that Memorial is currently pursuing, including ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... and author of best seller "LOVE, MEDICINE and MIRACLES") addresses touchy topics related ... 2016 and podcasted thereafter . Dr. Bernie Siegel, author of a plethora ...
(Date:4/29/2016)... ... April 29, 2016 , ... Spine Team Texas, a ... proud to announce one of their physicians has been invited to be a featured ... ACOFP) Family Practice Review conference on April 30, 2016. , Dr. R. Scott ...
(Date:4/29/2016)... ... ... the deadliest type of skin cancer. Although only about 1 percent of skin cancer cases ... 10,000 people are expected to die of melanoma this year. The risk increases with age, ... most commonly diagnosed cancers in young women. A recent breakthrough in genetic studies may give ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... 2016 , Net Sales of $1.90 billion ... the prior year period, and an increase of 1.2% on ... EPS for the first quarter were $0.52 reported, a decrease ... an increase of 29.9% over the prior year period ... guidance for 2016 Zimmer Biomet Holdings, Inc. (NYSE ...
(Date:4/28/2016)... N.J. , April 28, 2016   Acsis ... today announced that leading IT market research and advisory ... " in the IDC MarketScape: Worldwide Pharmaceutical Track and ... 2016).  The report provides an assessment of the capabilities ... track and trace software market. Logo - ...
(Date:4/28/2016)... 28, 2016 New market ... is a report that provides an overview of ... pipelines by identifying new targets and MOAs to ... Profiles discussed in this H1 2016 Osteoarthritis Pipeline ... AbbVie Inc., Abiogen Pharma S.p.A., Ablynx NV, Achelios ...
Breaking Medicine Technology: