Navigation Links
Molecule movements that make us think
Date:4/24/2012

Every thought, every movement, every heartbeat is controlled by lightning-quick electrical impulses in the brain, the muscles, and the heart. But too much electrical excitability in the membranes of the cells can cause things like epilepsy and cardiac arrhythmia. A research group at Linkping University has now published new discoveries that can lead to new medicines for these diseases.

The key molecules behind the electrical impulses are voltage-activated ion channels pores in cell membranes, the opening and closing of which are controlled by the electrical potential between the inside and outside of the cell.

Research over the past few years has revealed the ion channels' molecular structure, and how the pores change form when they open and close. On the other hand, the mechanism explaining how the electric potential is detected on the molecular level remains unclear.

LiU researchers have now shown how an ion channel's voltage sensor can change its form. This change of form leads to the pore in the channel opening up.

Ulrike Henrion, Jakob Renhorn, Sara Brjesson, and Erin Nelson, all in Professor Fredrik Elinder's research group, have succeeded through comprehensive experimental work in identifying 20 different molecular interactions that occur in the voltage sensor's different states.

In collaboration with Professor Erik Lindahl's group at the KTH Royal Institute of Technology, and associate professor Bjrn Wallner at the Department of Physics, Chemistry and Biology at LiU, the group has built five different molecular models of the voltage sensor, which together can explain all the experimental data. The five models were then linked together to a film that shows how a central part of the voltage detector moves between the outer walls of the voltage sensor.

The published work is an important piece of the puzzle in the research group's quest to develop substances with raised electrical excitability, which hopefully can lead to new medicines for epilepsy and cardiac arrhythmia.


'/>"/>
Contact: Fredrik Elinder
fredrik.elinder@liu.se
46-737-538-370
Linkping University
Source:Eurekalert

Related medicine news :

1. IU research team discovers TB disease mechanism and molecule to block it
2. Tiny molecules may tell big story about cardiovascular disease risk
3. New Cancer-Fighting Strategy Focuses On Signaling Molecules
4. Small molecule with high impact
5. Sigma-Aldrich Reaches Agreement to Sell Pfizers Bioactive Small Molecule Compounds
6. Inflammation Molecule May Determine Fat Levels
7. Exploring the Davids and Goliaths of therapeutic molecules
8. ACS Webinar focuses on drug discovery process for small molecule therapeutics
9. Fit People Release More Fat-Burning Molecules During Exercise
10. NIH-supported finding on cocaine addiction: Tiny molecule, big promise
11. MicroRNA molecule increases number of blood stem cells, may help improve cancer treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... , ... "FCPX editors can now reveal their media with growing colorful split ... Austin - CEO of Pixel Film Studios. , ProSlice Color brings the split ... now reveal the media of their split screens with growing colorful panels. , ProSlice ...
(Date:6/27/2016)... ... June 27, 2016 , ... TopConsumerReviews.com recently awarded their highest five-star rating to ... of individuals in the United States and Canada wear eyeglasses. Once considered to be ... vision and make a fashion statement. Even celebrities use glasses as a way of ...
(Date:6/26/2016)... ... 26, 2016 , ... PawPaws brand pet supplements owned by Whole ... enhance the health of felines. The formula is all-natural and is made from Chinese ... PawPaws Cat Kidney Support Supplement Soft Chews are Astragalus Root Extract and ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Austin residents ... the American College of Mohs Surgery and to Dr. Russell Peckham for medical and ... highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed ...
(Date:6/25/2016)... ... June 25, 2016 , ... As a lifelong Southern Californian, Dr. Omkar ... M.D from the David Geffen School of Medicine at UCLA. He trained in Internal ... complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...   Bay Area Lyme Foundation , collaborating ... for Tick Borne Illness , Harvard Medical School ... Medicine, University of California, Berkeley, and the Veterans ... finalists of Lyme Innovation , the first ... scientists, clinicians, researchers, entrepreneurs, and investors from several ...
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June 24, 2016 ... mobile pulmonary function testing company, is now able to perform sophisticated ... by ndd Medical Technologies , Inc. Patients ... hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ARL patients ... get any needed testing done in the comfort of her own ...
(Date:6/24/2016)... June 24, 2016  Arkis BioSciences, a leading ... and more durable cerebrospinal fluid treatments, today announced ... Series-A funding is led by Innova Memphis, followed ... other private investors.  Arkis, new financing will accelerate ... the market release of its in-licensed Endexo® technology. ...
Breaking Medicine Technology: