Navigation Links
Molecule in Skin May Link Eczema and Asthma
Date:5/19/2009

Finding in mice might explain progression from skin to breathing condition

TUESDAY, May 19 (HealthDay News) -- A substance secreted by eczema-damaged skin might trigger asthma in children, U.S. researchers suggest.

The theory comes from a study of mice with an eczema-like condition, which suggested that early treatment of eczema and inhibition of the trigger substance might help prevent asthma.

An estimated 50 percent to 70 percent of children with severe eczema, known as atopic dermatitis, develop asthma, compared with about 9 percent of children in the general population. In the United States, about 17 percent of children have eczema, although not all cases are severe.

The progression from eczema to asthma is called the atopic march.

"Over the years, the clinical community has struggled to explain atopic march," Raphael Kopan, a professor of developmental biology and dermatology at Washington University School of Medicine in St. Louis and an author of the study, said in a news release from the school.

"So, when we found that the skin of mice with an eczema-like condition produced a substance previously implicated in asthma, we decided to investigate further," Kopan said. "We found that the mice also suffered from asthma-like responses to inhaled allergens, implicating the substance, called TSLP, as the link between eczema and asthma."

The researchers found that TSLP (thylmic stromal lymphopoietin) is secreted by damaged skin to alert the body that the skin's protective barrier has failed. TSLP activates an immune response that fights invaders.

"We are excited, because we've narrowed down the problem of atopic march to one molecule," Kopan said. "We've shown that skin can act as a signaling organ and drive allergic inflammation in the lung by releasing TSLP. Now, it will be important to address how to prevent defective skin from producing TSLP."

"If that can be done," she said, "the link between eczema and asthma could be broken."

The study appears May 19 in the journal PLoS Biology.

More information

The American Academy of Dermatology has more about eczema.



-- Robert Preidt



SOURCE: Washington University School of Medicine in St. Louis, news release, May 18, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New class of RNA molecules may be important in human cancer
2. Molecule Promising Against Huntingtons Disease
3. Free Access to Literature Data on Chagas Disease Offered Online: Collaborative Drug Discovery, Inc. provides Neglected Disease researchers with archive mine and collaborate access to small molecule bioactivity SAR data on parasitic disease
4. Vulnerability to Stress Linked to Brain Molecule
5. Amira Pharmaceuticals Announces Favorable Phase 1 Clinical Trial Results for Lead Product Candidate AM103 and Initiates Clinical Studies for the 2nd Entry Molecule for the Treatment of Respiratory and Cardiovascular Disease
6. Study Describes Molecules That Control Blood Pressure
7. Researchers identify molecules with interesting anti-clotting properties
8. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
9. St. Jude finds molecule that could improve cancer vaccines and therapy for other diseases
10. Major Advance in the Observation of DNA Molecules
11. Molecules can block breast cancers ability to spread
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecule in Skin May Link Eczema and Asthma
(Date:12/6/2016)... ... ... Why does the prevalence of obesity continue to increase worldwide? Some would say lifestyle, ... cause of obesity in his new book “Body Weight Regulation.” , “Body Weight ... healthy life. Proietto said understanding the regulation of body weight and the causes of ...
(Date:12/6/2016)... Alpharetta, GA (PRWEB) , ... December 06, 2016 ... ... list of largest patient satisfaction measurement firms. The ranking is based on ... healthcare organizations such as hospitals, health systems, ambulatory surgical centers, clinically integrated networks, ...
(Date:12/6/2016)... ... December 06, 2016 , ... Public middle ... 15, 2017 to apply for a 2016/2017 California Casualty Thomas R. Brown Athletics ... Qualifying schools can receive up to $3,000. , The grant is named ...
(Date:12/6/2016)... ... December 06, 2016 , ... United ... to announce it has added CXC Solutions (CXC) as a new Strategic Partner. ... solutions are tailored to help benefits advisors reduce operating costs and generate additional ...
(Date:12/6/2016)... ... December 06, 2016 , ... Gateway Analytical, one of the ... counting and sizing services for USP 788 and 789 particulate standards compliance. The ... a response to the needs of pharmaceutical and medical device manufacturers, who are ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... , Dec. 6, 2016 Two new disaster ... in a simulated mass casualty event Tuesday at John ... The technology debuted before an audience including ... representatives from Homeland Security, Federal Law Enforcement Agencies, and ... known as HiRO (Health Integrated Rescue Operations), was developed ...
(Date:12/6/2016)... 6, 2016  Regulus Therapeutics Inc. (NASDAQ: ... discovery and development of innovative medicines targeting microRNAs, ... its R&D day, held in New ... an anti-miR targeting microRNA-27 (miR-27) for the treatment ... an anti-miR targeting microRNA-17 (miR-17) for the treatment ...
(Date:12/6/2016)... DIEGO , Dec. 6, 2016 /PRNewswire/ ... on the development of Conditionally Active Biologic ... and Beijing Sinobioway Group Company, Limited (Sinobioway) ... for development.  The specific program candidates and ... March 2015, BioAtla and Sinobioway entered into ...
Breaking Medicine Technology: