Navigation Links
Molecule in Skin May Link Eczema and Asthma
Date:5/19/2009

Finding in mice might explain progression from skin to breathing condition

TUESDAY, May 19 (HealthDay News) -- A substance secreted by eczema-damaged skin might trigger asthma in children, U.S. researchers suggest.

The theory comes from a study of mice with an eczema-like condition, which suggested that early treatment of eczema and inhibition of the trigger substance might help prevent asthma.

An estimated 50 percent to 70 percent of children with severe eczema, known as atopic dermatitis, develop asthma, compared with about 9 percent of children in the general population. In the United States, about 17 percent of children have eczema, although not all cases are severe.

The progression from eczema to asthma is called the atopic march.

"Over the years, the clinical community has struggled to explain atopic march," Raphael Kopan, a professor of developmental biology and dermatology at Washington University School of Medicine in St. Louis and an author of the study, said in a news release from the school.

"So, when we found that the skin of mice with an eczema-like condition produced a substance previously implicated in asthma, we decided to investigate further," Kopan said. "We found that the mice also suffered from asthma-like responses to inhaled allergens, implicating the substance, called TSLP, as the link between eczema and asthma."

The researchers found that TSLP (thylmic stromal lymphopoietin) is secreted by damaged skin to alert the body that the skin's protective barrier has failed. TSLP activates an immune response that fights invaders.

"We are excited, because we've narrowed down the problem of atopic march to one molecule," Kopan said. "We've shown that skin can act as a signaling organ and drive allergic inflammation in the lung by releasing TSLP. Now, it will be important to address how to prevent defective skin from producing TSLP."

"If that can be
'/>"/>

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. New class of RNA molecules may be important in human cancer
2. Molecule Promising Against Huntingtons Disease
3. Free Access to Literature Data on Chagas Disease Offered Online: Collaborative Drug Discovery, Inc. provides Neglected Disease researchers with archive mine and collaborate access to small molecule bioactivity SAR data on parasitic disease
4. Vulnerability to Stress Linked to Brain Molecule
5. Amira Pharmaceuticals Announces Favorable Phase 1 Clinical Trial Results for Lead Product Candidate AM103 and Initiates Clinical Studies for the 2nd Entry Molecule for the Treatment of Respiratory and Cardiovascular Disease
6. Study Describes Molecules That Control Blood Pressure
7. Researchers identify molecules with interesting anti-clotting properties
8. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
9. St. Jude finds molecule that could improve cancer vaccines and therapy for other diseases
10. Major Advance in the Observation of DNA Molecules
11. Molecules can block breast cancers ability to spread
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecule in Skin May Link Eczema and Asthma
(Date:7/11/2014)... WWTrek Human Outreach Project Team ... in Tanzania. Opened in 2012, the KKC is now home ... HOP Founder, Dean Cardinale, started the KKC to create a ... children he encountered while running treks on Tanzania's Mount Kilimanjaro. ... have all made astounding progress in school over the three ...
(Date:7/11/2014)... prescribed exercise as medicine, according to a QUT ... is essential to reducing the risk of death ... QUT,s Institute of Health and Biomedical Innovation, said ... and mental health, health professionals should be prescribing ... Anderson and QUT,s Dr Charlotte Seib co-authored a ...
(Date:7/11/2014)... Emily Johnson, owner of the Portland Fit Body Boot ... camp has held two charity workout events and is about ... from 7:15 - 8:30 at Col Summers City Park, SE 20th ... session raised $510 for Medical Teams International. Their second workout event ... Dream. On July 26th, Johnson and Portland Fit Body Boot ...
(Date:7/11/2014)... CO (PRWEB) July 11, 2014 H.E.A.R ... A new organization launches this week to provide comprehensive ... Reaching almost half a million Coloradoans with hearing ... to provide all encompassing information of the local and ... the deaf and hearing impaired. , H.E.A.R. Me Out ...
(Date:7/11/2014)... Leeds, England (PRWEB) July 11, 2014 Having ... later as a member of mental hospital staff, Roger Grainger ... among medical professionals in his new book, “You Never Get ... 4 people in the United Kingdom will experience some kind ... , “Society still needs to take a look at ...
Breaking Medicine News(10 mins):Health News:Human Outreach Project Sees Incredible Progress in the Kilimanjaro Kids Community 2Health News:Exercise is the best medicine: QUT study 2Health News:Portland Fit Body Boot Camp Invites Public to Fitness Boot Camp Session Benefiting Children’s Cancer Association 2Health News:Portland Fit Body Boot Camp Invites Public to Fitness Boot Camp Session Benefiting Children’s Cancer Association 3Health News:H.E.A.R Me Out Listens to Needs of Hearing Impaired 2Health News:H.E.A.R Me Out Listens to Needs of Hearing Impaired 3Health News:Psychiatric Hospital Patient and Registered Psychologist Explores Mental Health and Therapy in New Book "You Never Get Out" 2
... This release is available in French . ... researchers from the Institute for Research in Immunology and Cancer ... in the understanding of blood-producing (hematopoietic) stem cells. The study ... Guy Sauvageau, identifies factors that control the production of hematopoietic ...
... Singer/songwriter ... as the latest famous faces to lend their support to Hear the World, the ... of hearing and the consequences of hearing loss. , , ... (PRWEB) July 6, 2010 -- Singer/songwriter Corinne ...
... is often seen as the result of overpopulation, bad ... book, "The Atlas of World Hunger," reveals that the ... and in some ways more easily addressed than ... of Illinois geography professor Thomas Bassett and Illinois agricultural ...
... ... a larger office and more convenient location within the Boise medical community. Still ... close proximity to one of the major medical centers in Boise. This new ... collaboratively to help patients get and stay healthy. , ...
... cancer patients will together take part in the Hope on Wheels ... and apply colorful handprints to a white Hyundai Santa Fe. ... the country, is the symbol of Hyundai Hope on Wheels (TM). ... in the general population of young adults, 1 in 500 will ...
... A pilot study conducted in a small private high school ... of a delayed school start time. Judy Owens, MD, a ... delay in school start time of only 30 minutes was ... Her findings are published in the July issue of the ...
Cached Medicine News:Health News:Researchers identify factors behind blood-making stem cells 2Health News:More Big Names Line Up To Support Global Hearing Loss Awareness Initiative 2Health News:More Big Names Line Up To Support Global Hearing Loss Awareness Initiative 3Health News:Hunger atlas takes a new look at an old problem 2Health News:Hunger atlas takes a new look at an old problem 3Health News:Boise Acupuncture Clinic Grows into Larger Office 2Health News:New study confirms positive effects of delayed school start times 2Health News:New study confirms positive effects of delayed school start times 3
(Date:7/10/2014)... July 11, 2014  Major advances in radiation ... are being highlighted in a three-day Oncology Summit ... from 10-12 July, 2014.  Renowned national and international cancer experts ... practices and exchange knowledge on modern technologies making ... efficient. The Summit will address ...
(Date:7/10/2014)... CARLSBAD, Calif. , July 10, 2014 /PRNewswire/ ... products and services, has launched the FreeRunner™ knee ... runners, who suffer from patella mal-tracking return to ... anatomy differently than other braces, providing support when ... move normally when they don,t. Patellofemoral ...
(Date:7/10/2014)... July 10, 2014 Yesterday, former Congressman ... medical device manufacturing facility. Rep. Kennedy and ... monitors facilitate cutting-edge research in neurological disease and ... mental health advocate, Garen Staglin , created ... fostering fundamental changes that will radically accelerate the ...
Breaking Medicine Technology:Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5Breg Introduces Knee Brace to Help Runners with Patellofemoral Pain Syndrome 2Representative Patrick Kennedy visits Moberg's medical device facility to discuss improvement in brain injury care 2
... Advanced BioHealing, Inc. (ABH), a leader in commercializing ... regenerative medicine, today announced results from a health economics ... that showed the addition of Dermagraft® to conventional care ... resulted in a significant therapeutic and cost benefit compared ...
... DIEGO, June 24, 2011 /PRNewswire/ -- ... Lilly and Company (NYSE: LLY ) today announced ... that showed the addition of BYETTA® (exenatide) injection to pre-existing ... heart failure, especially among patients receiving insulin. These findings will ...
Cached Medicine Technology:Health Economics Model Shows That Dermagraft® Combined With Conventional Care is a Cost-Effective Treatment for Diabetic Foot Ulcers in Medicare and Commercially Insured Populations 2Health Economics Model Shows That Dermagraft® Combined With Conventional Care is a Cost-Effective Treatment for Diabetic Foot Ulcers in Medicare and Commercially Insured Populations 3Health Economics Model Shows That Dermagraft® Combined With Conventional Care is a Cost-Effective Treatment for Diabetic Foot Ulcers in Medicare and Commercially Insured Populations 4Health Economics Model Shows That Dermagraft® Combined With Conventional Care is a Cost-Effective Treatment for Diabetic Foot Ulcers in Medicare and Commercially Insured Populations 5Analysis Finds BYETTA® Associated with Lower Likelihood of Heart Failure Compared with Other Diabetes Therapies: Results Presented at ADA 2011 2Analysis Finds BYETTA® Associated with Lower Likelihood of Heart Failure Compared with Other Diabetes Therapies: Results Presented at ADA 2011 3Analysis Finds BYETTA® Associated with Lower Likelihood of Heart Failure Compared with Other Diabetes Therapies: Results Presented at ADA 2011 4Analysis Finds BYETTA® Associated with Lower Likelihood of Heart Failure Compared with Other Diabetes Therapies: Results Presented at ADA 2011 5Analysis Finds BYETTA® Associated with Lower Likelihood of Heart Failure Compared with Other Diabetes Therapies: Results Presented at ADA 2011 6Analysis Finds BYETTA® Associated with Lower Likelihood of Heart Failure Compared with Other Diabetes Therapies: Results Presented at ADA 2011 7
...
... within reach of virtually any facility...from a ... advanced cardiology hospital. This PC-based system includes ... for a Philips ergonomic stress cart and ... is designed to interface with the TrackMaster ...
... Cardioscan Viewer Phonocardiogram (PCG). The ZAC-Viewer ... you to record, condition, display and print ... The product acquires and displays the ... four sites, and allows user-selectable filtering of ...
... The biograph 6 offers ... improved disease diagnosis and treatment ... It delivers high-quality PET/CT whole ... 15 minutes. Our comprehensive suite ...
Medicine Products: