Navigation Links
Molecule found that inhibits recovery from stroke
Date:7/27/2012

FINDINGS:

Researchers at UCLA have identified a novel molecule in the brain that, after stroke, blocks the formation of new connections between neurons. As a result, it limits the brain's recovery. In a mouse model, the researchers showed that blocking this moleculecalled ephrin-A5--induces axonal sprouting, that is, the growth of new connections between the brain's neurons, or cells, and as a result promotes functional recovery.

IMPACT:

If duplicated in humans, the identification of this molecule could pave the way for a more rapid recovery from stroke and may allow a synergy with existing treatments, such as physical therapy.

UCLA AUTHOR:

Dr. S. Thomas Carmichael, professor of neurology, and colleagues

JOURNAL:

The research appears online this week in the journal PNAS.

MORE:

Stroke is the leading cause of adult disability because of the brain's limited capacity for repair. An important process in recovery after stroke may be in the formation of new connections, termed axonal sprouting. The adult brain inhibits axonal sprouting and the formation of these connections. In previous work the researchers found, paradoxically, that the brain sends mixed signals after a strokeactivating molecules that both stimulate and inhibit axonal sprouting. In this present work, the researchers have identified the effect of one molecule that inhibits axonal sprouting and determined the new connections in the brain that are necessary to form for recovery.

The researchers also developed a new tissue bioengineering approach for delivering drugs to the brain after stroke. This approach uses a biopolymer hydrogel, or a gel of naturally occurring brain proteins, to release neural repair molecules directly to the target region for recovery in strokethe tissue adjacent to the center of the stroke.

Last, the paper also shows that the more behavior
'/>"/>

Contact: Mark Wheeler
mwheeler@mednet.ucla.edu
310-794-2265
University of California - Los Angeles Health Sciences
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Molecule movements that make us think
2. Prions in the brain eliminated by homing molecules
3. Researchers identify a life-and-death molecule on chronic leukemia cells
4. Inhibitors of shuttle molecule show promise in acute leukemia
5. Mayo Clinic: Molecule thought cancer foe actually helps thyroid tumors grow
6. Cleveland Clinic researchers discover molecule that may prevent atherosclerosis
7. More Fake Avastin Found in U.S., FDA Says
8. Kessler Foundation names Dr. John Whyte recipient of Foundations 2nd Annual DeLisa Award
9. History of abandoned urban sites found stored in soil
10. Wilderness Medicine founder offers health tips for summer season
11. Concerns about MRSA for expectant mothers may be unfounded
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2015)... “ LiveSchool ” was featured on NewsWatch as ... at the latest and coolest applications on the market ... of AppWatch and technology expert, conducted the app review ... to reward students with good behavior. , Positive re-enforcement ... classroom. And the good people at LiveSchool have ...
(Date:5/4/2015)... 2015 Baptist Medical Center Jacksonville ... Get With The Guidelines®-Stroke Gold Plus Quality Achievement ... The award recognizes the hospital’s commitment and success ... appropriate treatment according to nationally recognized, research-based guidelines ... receive the Gold Plus Quality Achievement Award, hospitals ...
(Date:5/4/2015)... Ticket Down is a reputable source for authentic tickets ... While the World Cup is the most known soccer tournament ... International Champions Cup is one of the biggest tournaments held ... for soccer in the United States set when Manchester United ... of Michigan. This year, the defending champion Manchester United club ...
(Date:5/4/2015)... Ticket Down is a reputable source for authentic ... Columbia, South Carolina. Fans of Paul McCartney have to ... which originally kicked off in 2013. The most visited continent ... legendary performer recently announced that he would be adding additional ... 21st, in Charlottesville, VA at John Paul Jones Arena ...
(Date:5/4/2015)... (PRWEB) May 04, 2015 Sheltering Arms ... Center from Hale House. The Mother Hale Learning Center ... affordable Early Childhood Education. Sheltering Arms will begin operating ... to be served by the center. , Opened in ... ages six weeks to five years, many of whom ...
Breaking Medicine News(10 mins):Health News:An Application for Teachers to Reward Students with Good Behavior Was Featured on NewsWatch Television 2Health News:Baptist Medical Center Jacksonville Receives Top Honor for Stroke Care 2Health News:Baptist Medical Center Jacksonville Receives Top Honor for Stroke Care 3Health News:Baptist Medical Center Jacksonville Receives Top Honor for Stroke Care 4Health News:Cheap 2015 International Champions Cup (ICC) Tickets: Ticket Down Slashes Ticket Prices on International Champions Cup (ICC) Presale Tickets 2Health News:Cheap 2015 International Champions Cup (ICC) Tickets: Ticket Down Slashes Ticket Prices on International Champions Cup (ICC) Presale Tickets 3Health News:Cheap 2015 International Champions Cup (ICC) Tickets: Ticket Down Slashes Ticket Prices on International Champions Cup (ICC) Presale Tickets 4Health News:Paul McCartney Tickets at Colonial Life Arena in Columbia, SC: Ticket Down Slashes Paul McCartney Ticket Prices in Columbia, South Carolina at Colonial Life Arena 2Health News:Sheltering Arms Acquires the Mother Hale Learning Center 2
... adults who consume one to seven alcoholic beverages a week may ... do not drink, according to a latest study. // ... University of Florida, showed that when compared with never or occasional ... cent lower risk of death over all and an almost 30 ...
... that Gardasil, which is a vaccine by Merck, for the ... ,The drug Gardasil, which is reported to offer ... onset of cervical cancer, making it a very practical option ... have indicated that there is a slow uptake for the ...
... (CFIA) has issued a warning for those who are allergic ... Flavor// 3 in 1 Coffee mix brand. This product is ... have not disclosed on the label. ,Though there ... of consumption of this product, yet it could cause a ...
... Health and Safety Executive (HSE) says that recycling boxes are ... In a new report, the HSE// said that any such ... by countless households in the country, could become too heavy ... ,These boxes also exceed the recommended weight limit. The ...
... releases a dose of nicotine and is one of ... quit smoking.// ,The federal government has announced ... The lozenges are to join nicotine patches, gums and ... was taken because the government said that the prescription ...
... avian influenza has clearly demonstrated that the New Zealand ... to Poultry Industry Association executive director Michael Brooks. ... of highly pathogenic notifiable avian influenza as well as ... samples from thousands of poultry meat birds. ...
Cached Medicine News:
(Date:5/4/2015)... , May 4, 2015  CytRx Corporation (Nasdaq: ... company specializing in oncology, today announced an interim ... combination studies pairing aldoxorubicin with either gemcitabine or ... or ifosfamide with escalating doses of aldoxorubicin. The ... at the lowest dose level of aldoxorubicin (170 ...
(Date:5/4/2015)... 4, 2015 Unchained Labs, a refreshingly new ... year,s PEGS conference and launches the UNit — the ... PEGS: The Essential Protein Engineering Summit takes place in ... The UNit lets drug discovery researchers look at ... there. Its 7 applications, 144 sample a day throughput ...
(Date:5/4/2015)... May 4, 2015  Geneia, a company of ... solutions to improve healthcare efficiencies, today announced a ... Center (BNRC) use Geneia,s advanced analytics solution ... the quality and lower the cost of patient ... outcomes, claims and utilization data from multiple sources ...
Breaking Medicine Technology:CytRx Reports Aldoxorubicin Demonstrates Both Tumor Shrinkage and Improved Quality of Life in Chemotherapy Resistant Cancers 2CytRx Reports Aldoxorubicin Demonstrates Both Tumor Shrinkage and Improved Quality of Life in Chemotherapy Resistant Cancers 3CytRx Reports Aldoxorubicin Demonstrates Both Tumor Shrinkage and Improved Quality of Life in Chemotherapy Resistant Cancers 4CytRx Reports Aldoxorubicin Demonstrates Both Tumor Shrinkage and Improved Quality of Life in Chemotherapy Resistant Cancers 5CytRx Reports Aldoxorubicin Demonstrates Both Tumor Shrinkage and Improved Quality of Life in Chemotherapy Resistant Cancers 6CytRx Reports Aldoxorubicin Demonstrates Both Tumor Shrinkage and Improved Quality of Life in Chemotherapy Resistant Cancers 7Unchained Labs Lets the UNit Loose 2Geneia Launches First-of-its-Kind Partnership to Use Advanced Analytics to Improve the Quality and Cost of Care for Skilled Nursing and Rehabilitation Patients 2Geneia Launches First-of-its-Kind Partnership to Use Advanced Analytics to Improve the Quality and Cost of Care for Skilled Nursing and Rehabilitation Patients 3
... MAQUET Cardiovascular, a global leading provider of ... U.S. Federal Trade Commission (FTC) approval to acquire ... technologies for interventional cardiology and radiology, chest trauma ... surgery, and has subsequently closed the previously announced ...
... YORK, Nov. 7, 2011 Reportlinker.com ... report is available in its catalogue: ... X-Ray, Digital X-Ray, CT and Other ... http://www.reportlinker.com/p0681346/Medical-Imaging-Markets-X-Ray-Digital-X-Ray-CT-and-Other-Radiography-Systems.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Medical_Imaging Radiography ...
Cached Medicine Technology:MAQUET Cardiovascular Completes Acquisition of Atrium Medical Corporation 2MAQUET Cardiovascular Completes Acquisition of Atrium Medical Corporation 3Medical Imaging Markets: X-Ray, Digital X-Ray, CT and Other Radiography Systems 2Medical Imaging Markets: X-Ray, Digital X-Ray, CT and Other Radiography Systems 3Medical Imaging Markets: X-Ray, Digital X-Ray, CT and Other Radiography Systems 4Medical Imaging Markets: X-Ray, Digital X-Ray, CT and Other Radiography Systems 5Medical Imaging Markets: X-Ray, Digital X-Ray, CT and Other Radiography Systems 6
... are designed exclusively for video endoscopy and ... Olympus endoscopy systems. When used in conjunction ... provides sharp, high-resolution images with excellent color ... - and details - necessary for accurate ...
... are designed specifically for medical environments. Resulting ... with professional monitors, the LMD-151MD offer uncompromising ... requirements and are ideal for use in ... Slim and light, they can be used ...
Resorbable fixation system 1.5/2.0....
... is intended for visualization of the anatomic ... shifts in the brain, evaluation of the ... use, the Sonomed-315 offers quick and reliable ... to identify the anatomic structures of the ...
Medicine Products: