Navigation Links
Molecule common in some cancers, rheumatoid arthritis leads to potential therapy for both
Date:11/13/2013

WASHINGTON A molecule that helps cells stick together is significantly over-produced in two very different diseases rheumatoid arthritis and a variety of cancers, including breast and brain tumors, concludes a new study. The scientists who made the discovery also found candidate drugs to inhibit the molecule, cadherin-11, one of which is already in a clinical trial.

The study, published in Oncotarget, was led by investigators at Georgetown University Medical Center, and included collaborators from Harvard and Columbia Universities, Mayo Clinic and Queen's University in Belfast, Northern Ireland.

"Our findings suggest that cadherin-11 is important for cancer progression as well as rheumatoid arthritis for reasons we do not fully understand. Nevertheless, we are rapidly translating this discovery for use in the clinic," says the study's senior investigator, Stephen Byers, PhD, a professor and molecular oncologist at Georgetown Lombardi Comprehensive Cancer Center.

Byers and his Georgetown colleagues, Shahin Assefnia DVM, Siva Dakshanurthy PhD, and Jaime Guidry Auvil, PhD, have found that cadherin-11 is over-expressed in 15 percent of breast cancers, and in many glioblastomas. He believes the molecule also contributes to pancreatic cancer.

"What most of these cancers all have in common is cadherin-11 and a poor prognosis, with no effective therapies," Byers says. "Cadherin-11 expression is required for tumors to grow. If it is blocked, the cancers in cell line studies and in animals just stop growing which is really quite striking."

The Georgetown team has developed a small molecule agent to shut down cadherin-11 in cancer, and, by screening drugs now on the market, found that the well known arthritis drug Celebrex acts in a similar way. While it is unlikely that Celebrex could be used as a single agent against cancer because it would be too toxic at the level needed to impair cadherin-11, a Celebrex-related molecule works the same way, and may potentially be less toxic.

Co-author Michael Brenner, MD, at Harvard University, has designed an antibody that can shut down cadherin-11 in rheumatoid arthritis. The Oncotarget study demonstrated that Brenner's antibody worked in animal models of tumors that made cadherin-11.

It was chance that he and Brenner were working on the same molecule at the same time and came to know of each other's work. Coincidentally, co-author Lawrence Shapiro, PhD, at Columbia, was building a crystal structure of cadherin-11 and is now working with Byers and Brenner to show how the molecule binds to Celebrex and other small molecule drug cadherin-11 inhibitors.

This close collaboration led Byers, Brenner and Shapiro to apply for a grant last year from the National Cancer Institute's Provocative Questions project. They proposed answering the question related to the connection between drugs, such as anti-inflammatory agents, that can protect against cancer and other conditions.


'/>"/>

Contact: Karen Mallet
km463@georgetown.edu
Georgetown University Medical Center
Source:Eurekalert

Related medicine news :

1. Immune system molecule promotes tumor resistance to anti-angiogenic therapy
2. A new method for clicking molecules together
3. Metabolic molecule drives growth of aggressive brain cancer
4. Small molecule could have big impact on cancer
5. Molecule treats leukemia by preventing cancer cell repair, Jackson Laboratory scientists report
6. Moffitt Cancer Center researchers design small molecule to disrupt cancer-causing protein
7. Tiny RNA molecule may have role in polycystic ovary syndrome, insulin resistance
8. Signaling molecule may help stem cells focus on making bone despite age, disease
9. Novel small molecules used to visualize prostate cancer
10. Small molecules in the blood might gauge radiation effects after exposure
11. Molecules generated that can halt metastasis of colon cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/28/2017)... ... June 28, 2017 , ... The Dianne Michael Insurance ... Cincinnati metropolitan area, is teaming up with the local chapter of the Ronald ... treatment in nearby hospitals. , Ronald McDonald House of Greater Cincinnati, one of ...
(Date:6/27/2017)... ... June 27, 2017 , ... Harbour , a DAO (decentralized ... the Ethereum blockchain, has released their technical specifications . , 2017 has seen ... little systematic approach for determining which offerings will garner the greatest ROI. Dean Eigenmann, ...
(Date:6/27/2017)... ... June 27, 2017 , ... From June 20-22, EarQ and Widex ... Syracuse, New York, where EarQ is headquartered. , Together, the organizations educate hearing ... today’s savvy consumer, and the latest in hearing technology. At the event, EarQ ...
(Date:6/27/2017)... ... June 27, 2017 , ... ... contribute to an upcoming case studies guidebook. This guidebook offers an excellent branding ... book will include articles, case studies and how-to’s that fall into the following ...
(Date:6/27/2017)... ... June 27, 2017 , ... Hammer Strength, the world’s leading ... named Javair Gillett of the Houston Rockets the NBSCA Strength & Conditioning Coach of ... decided by NBSCA members who vote to select the coach who embodies the highest ...
Breaking Medicine News(10 mins):
(Date:6/9/2017)... , June 9, 2017 More than 400 ... effort to help spread lessons learned from clinical research ... Diabetes Federation (IDF) and Eli Lilly and Company (NYSE: ... second phase of the Bringing Research in Diabetes to ... commitment to helping people with diabetes effectively manage their ...
(Date:6/7/2017)... , June 7, 2017  Novavax, Inc., (Nasdaq: ... of two Phase 2 trials of its RSV F protein ... child bearing age have been published in the journal ... have been shared in prior scientific conferences). The Company previously ... April 2014. Novavax is developing the RSV F Vaccine with ...
(Date:6/2/2017)... , June 2, 2017  NxStage Medical, Inc. (Nasdaq: ... care, today announced new findings demonstrating positive biochemical outcomes ... System One™. The data will be presented at ... Madrid, Spain . ... Improve Home Dialysis Network in Europe ...
Breaking Medicine Technology: