Navigation Links
Molecule acts as umpire to make tough life-or-death calls
Date:5/22/2014

(MEMPHIS, Tenn. May 20, 2014) Researchers have demonstrated that an enzyme required for animal survival after birth functions like an umpire, making the tough calls required for a balanced response to signals that determine if cells live or die. St. Jude Children's Research Hospital scientists led the study, which was published online and appears in the May 22 edition of the scientific journal Cell.

The work involved the enzyme receptor-interacting protein kinase 1 (RIPK1). While RIPK1 is known to be involved in many vital cell processes, this study shows that its pivotal role in survival after birth is as an inhibitor of two different pathways that lead to the death of cells. Functioning properly, the pathways provide a way to get rid of dangerous, damaged or unneeded cells.

By removing different components of each pathway in different combinations, researchers demonstrated that after birth RIPK1 helps cells maintain a balanced response to signals that promote either pathway. "We are learning that in disease this balancing act can be perturbed to produce damage and cell death," said the study's corresponding author Douglas Green, Ph.D., chair of the St. Jude Department of Immunology.

The results resolve long-standing questions about RIPK1's role in cell survival and provide clues about how the disease-fighting immune system might use these pathways to contain infections. The findings have also prompted researchers to launch an investigation into whether RIPK1 could be harnessed to kill cancer cells or provide insight into tumor development. RIPK1 is already the focus of drug development efforts designed to limit cell damage following heart attack, stroke or kidney injury.

"This study fundamentally changes the way we think about RIPK1, a molecule that we care about because it is required for life," Green said. "The results helped us identify new pathways involved in regulating programmed cell death and suggest that
'/>"/>

Contact: Carrie Strehlau
carrie.strehlau@stjude.org
901-595-2295
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Molecule linked to aggressive pancreatic cancer offers potential clinical advances
2. Molecules involved in rheumatoid arthritis angiogenesis identified
3. Protein molecule may improve survival in deadly lung disease
4. Faster dental treatment with new photoactive molecule
5. Discovery of anti-appetite molecule released by fiber could help tackle obesity
6. Alcohol-breakdown molecule may play a role in breast cancer development
7. Designer swiss-army-knife molecule captures RNA in single cells in their natural tissue environment
8. Molecule discovered that protects the brain from cannabis intoxication
9. Molecule common in some cancers, rheumatoid arthritis leads to potential therapy for both
10. Immune system molecule promotes tumor resistance to anti-angiogenic therapy
11. A new method for clicking molecules together
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/30/2015)... ... August 31, 2015 , ... The acknowledgement from Caribbean Journal comes after Grace ... 2015. The island of Providenciales itself received a TripAdvisor Traveller's Choice Award in ... Bay is offering a special promotion for newlyweds and honeymooners to celebrate this amazing ...
(Date:8/30/2015)... ... August 31, 2015 , ... Although middle ... tax receipts, issues that are critically important to them are often overlooked when ... lobbyists monitoring proposed legislation and changing tax and regulatory policies. Smaller companies, which ...
(Date:8/30/2015)... , ... August 31, 2015 , ... Negotiating an FDA ... 1:30 p.m. – 3:00 p.m. EDT, http://www.fdanews.com/importholdcrisis , US authorities are holding ... products, and imports from India. , With alerts on an uptick and a new ...
(Date:8/30/2015)... ... August 31, 2015 , ... Intellitec ... Annual Convention & Expo October 5th & 6th in San Antonio, TX. Dedicated ... convention brings industry professionals from all over the country come to share the ...
(Date:8/30/2015)... ... 31, 2015 , ... ChopChop Kids, the nonprofit publisher of ... elected two new officers to serve on the organization’s Board of Directors in ... teaching kids to cook real food with their families and help continue to ...
Breaking Medicine News(10 mins):Health News:Grace Bay Beach Named a Top Beach Destination for Weddings 2Health News:Newport Board Group, an Advisory Firm Serving the Middle Market, Issues Five Tips on Selling Services to the Government 2Health News:Newport Board Group, an Advisory Firm Serving the Middle Market, Issues Five Tips on Selling Services to the Government 3Health News:Newport Board Group, an Advisory Firm Serving the Middle Market, Issues Five Tips on Selling Services to the Government 4Health News:FDAnews Announces — Negotiating an FDA Import Hold Crisis: Strategies for Challenging FDA Findings Webinar, Sept. 22, 2015 2Health News:FDAnews Announces — Negotiating an FDA Import Hold Crisis: Strategies for Challenging FDA Findings Webinar, Sept. 22, 2015 3Health News:Intellitec Solutions to feature Microsoft Dynamics GP at AHCA/NCAL 66th Annual Convention & Expo 2Health News:ChopChop Kids Appoints New Chair and Vice-Chair to Board of Directors 2Health News:ChopChop Kids Appoints New Chair and Vice-Chair to Board of Directors 3
... will soon have the opportunity to take part in ... the autoimmune disease, ankylosing spondylitis. Approximately 200 patients will ... aims to merge the latest molecular discoveries published by ... medical expertise of physicians and researchers at West China ...
... glaucoma and other conditions , , ... times a day can be difficult for patients to do, and because ... the dose is actually absorbed by the eye. Now, researchers led by ... Delivery at Children,s Hospital Boston, have developed special contact lenses that can ...
... , , , ... Allscripts (Nasdaq: MDRX ), the leader in software, ... Medfusion, the leader in patient-to-provider online communication solutions, today announced ... for Allscripts Electronic Health Record (EHR) and Practice Management clients ...
... 21 /PRNewswire-USNewswire / -- Representatives from leading national ... to honor the 2009 winners of the National Family ... and MetLife Foundation. The event recognized community-based programs supporting ... responsiveness to caregiver needs. , ...
... they,d prefer more flex time and balance in life, , TUESDAY, ... all again, most female surgeons would choose the same career path, ... in the July issue of Archives of Surgery , revealed ... because of their rigorous training and work schedule. , Few female ...
... combined with air pollution, smoking, it raises chances of condition, ... pollution from cars can increase a child,s chances of developing ... get even higher, a new study finds. , For children ... risk, parental stress also increases the risk for asthma, the ...
Cached Medicine News:Health News:Study aims to induce recovery from ankylosing spondylitis 2Health News:A Drug-Dispensing Contact Lens 2Health News:A Drug-Dispensing Contact Lens 3Health News:Allscripts and Medfusion Partner to Provide Patient Portal to Physician Practices Nationwide 2Health News:Allscripts and Medfusion Partner to Provide Patient Portal to Physician Practices Nationwide 3Health News:Allscripts and Medfusion Partner to Provide Patient Portal to Physician Practices Nationwide 4Health News:The National Alliance for Caregiving and MetLife Foundation Honor Innovators Making a Difference in the Lives of Caregivers 2Health News:The National Alliance for Caregiving and MetLife Foundation Honor Innovators Making a Difference in the Lives of Caregivers 3Health News:The National Alliance for Caregiving and MetLife Foundation Honor Innovators Making a Difference in the Lives of Caregivers 4Health News:The National Alliance for Caregiving and MetLife Foundation Honor Innovators Making a Difference in the Lives of Caregivers 5Health News:Female Surgeons Like What They Do, Survey Finds 2Health News:Parental Stress Boosts Kids' Asthma Risk 2Health News:Parental Stress Boosts Kids' Asthma Risk 3
(Date:8/30/2015)... 31, 2015 Noser Health ... to deliver new platform ... citizen-owned health data transaction platform, announced today strategic partnerships ... to engineer and bring to market its global health ... "Our business model is built on trust, ...
(Date:8/30/2015)... August 30, 2015 La ... l cuidado al paciente ...   Royal Philips  (NYSE: PHG, ... IntelliSpace Cardiovascular , un sistema web de gestión ... acceder, analizar y compartir imágenes cardiovasculares e información en ...
(Date:8/29/2015)... y LONDRES, August 29, 2015 ... para los sistemas de imagen por Ultrasonidos ... Ecografía, tiempos de examen rápidos y un flujo de ... confianza diagnóstica en el proceso de detección de Cardiopatías ... PHIA) ha anunciado hoy el lanzamiento europeo de ...
Breaking Medicine Technology:healthbank Announces Strategic Partnerships to Bring to Market Global Health Data Transaction Platform 2healthbank Announces Strategic Partnerships to Bring to Market Global Health Data Transaction Platform 3healthbank Announces Strategic Partnerships to Bring to Market Global Health Data Transaction Platform 4Philips presenta IntelliSpace Cardiovascular en el Congreso ESC 2015 2Philips presenta IntelliSpace Cardiovascular en el Congreso ESC 2015 3Philips presenta HeartModel A.I en el Congreso ESC 2015 2Philips presenta HeartModel A.I en el Congreso ESC 2015 3Philips presenta HeartModel A.I en el Congreso ESC 2015 4Philips presenta HeartModel A.I en el Congreso ESC 2015 5
... Inc. (NYSE: PFE ) today announced ... Innovation, an entrepreneurial network of partnerships with leading ... by accessing leading translational researchers.  The University of ... the network. (Logo: http://photos.prnewswire.com/prnh/20100416/PFIZERLOGO) ...
... 16, 2010 Baxa Corporation , a leading ... operations, today announced significant upgrades to its DoseEdge ... workflow management tool that verifies the use of correct ... chemo, TPN and oral liquid doses.  This release includes ...
Cached Medicine Technology:Pfizer Launches Global Centers for Therapeutic Innovation, a Network of Research Partnerships, With University of California, San Francisco 2Pfizer Launches Global Centers for Therapeutic Innovation, a Network of Research Partnerships, With University of California, San Francisco 3Pfizer Launches Global Centers for Therapeutic Innovation, a Network of Research Partnerships, With University of California, San Francisco 4Baxa Releases Upgrade for DoseEdge™ - the Only Dose Management System With Comprehensive Formulary Management Functionality 2Baxa Releases Upgrade for DoseEdge™ - the Only Dose Management System With Comprehensive Formulary Management Functionality 3Baxa Releases Upgrade for DoseEdge™ - the Only Dose Management System With Comprehensive Formulary Management Functionality 4
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: