Navigation Links
Molecule Promising Against Huntington's Disease
Date:10/9/2007

C2-8 battles the brain illness, mouse study shows

TUESDAY, Oct. 9 (HealthDay News) -- U.S. researchers say they've found a compound that may lead to a treatment for the hereditary, progressive neurological disorder known as Huntington's disease (HD).

In mice, a molecule called C2-8 appears to reduce HD-related neurological damage and delay the loss of motor control, said the team from the MassGeneral Institute for Neurological Disorders (MIND), Boston. Their study appears in the journal Proceedings of the National Academy of Sciences.

"We found that C2-8 slows the progress of HD in a mouse model and might do the same thing in human patients, if it or its biochemical relatives can be translated into a drug," study leader Dr. Steven Hersch said in a prepared statement. "What we don't know yet is precisely how it works, what molecules it interacts with in cells and how potent it might be."

His team first confirmed that oral doses of C2-8 can cross the blood-brain barrier and are nontoxic in mice. They also found that C2-8 doesn't interact with a number of molecules predictive of negative side effects.

HD mice that started receiving C2-8 when they were 24 days old did much better on tests of strength, endurance and coordination than HD mice that did not receive C2-8. The treated mice had less HD-related brain cell shrinkage and smaller aggregates of disease-related protein than untreated mice, the Boston group found.

The results suggest that C2-8 "has potential as the basis of a neuroprotective treatment," said Hersch, who is also an associate professor of neurology at Harvard Medical School. "We now need to confirm those results in a different mouse model, see whether similar compounds may be more potent than C2-8 and search for the enzyme or receptor that it is binding to."

More information

For more on Huntington's disease, head to WeMove.



-- Robert Preidt



SOURCE: MassGeneral Institute for Neurological Disorders, news release, Oct. 8, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New molecule to treat brain disorders found
2. Poisonous Parkinsons molecule discovered
3. Glenmark’s new molecule to go through trial
4. Resistant tumors could be treated with the discovery of a new molecule within cancer cells
5. Ways to counter radiation effects with new molecule discovery
6. Same molecule found in meat, milk, tumors
7. New Molecule that can stop the growth of Viruses
8. Puberty may be due to GPR54 gene and KiSS-1 Molecule
9. Molecule responsible for muscle repair identified
10. Molecule aids fight E. Coli Infections
11. Molecule That Aids Bacterial Infections Identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... ... February 09, 2016 , ... A new leadership team for Mid-South Youth ... Joe Wiley made the announcement Monday night, Feb. 8, prior to the evening session ... FHU and the creator of GO! Camp, has been named director. Gayle McDonald, currently ...
(Date:2/10/2016)... ... February 09, 2016 , ... Ross ... Specialists are delighted to welcome a new addition to their growing practice. Beginning ... Specialists as a nurse practitioner performing cosmetic procedures including injectables, fillers ...
(Date:2/10/2016)... , ... February 09, 2016 , ... ... concussion, yet the cause of injury may be one of many possible sources: ... PT Continuing Education Course , Mastering Rehab Solutions for the Complexities ...
(Date:2/9/2016)... , ... February 09, 2016 , ... Steven Douglas Associates ... of South Florida Event, an upscale fundraiser held in South Florida. The Inaugural What’s ... guests alike. This year the event will be held in a new, more causal ...
(Date:2/9/2016)... ... 09, 2016 , ... Interstate Restoration LLC, a full service ... the acquisition of Hawaii DKI. Hawaii DKI is one of the more recognized ... who excel at service and response helps support our goal of becoming the ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)...  Bluestar Silicones will promote its Silbione® Biomedical ... implant applications and announce certification of its clean ... West Conference (Booth #1759), February 9-10, at the ... --> Available in 01 through 70 ... physical properties enabling our customers to optimize their ...
(Date:2/8/2016)... -- Alzheimer Diagnostic Tests - Medical Devices Pipeline ... sector report , "Alzheimer Diagnostic Tests - Medical ... Alzheimer Diagnostic Tests currently in pipeline stage. ... products with comparative analysis of the products at ... players involved in the pipeline product development. It ...
(Date:2/8/2016)... Devices - Medical Devices Pipeline Assessment, 2015 Summary ... Medical Devices Pipeline Assessment, 2015" provides an overview of ... This report is prepared using data sourced from in-house ... industry experts. *Note: Certain sections in the report ... and relevance of data in relation to the equipment ...
Breaking Medicine Technology: