Navigation Links
Molecule Promising Against Huntington's Disease
Date:10/9/2007

C2-8 battles the brain illness, mouse study shows

TUESDAY, Oct. 9 (HealthDay News) -- U.S. researchers say they've found a compound that may lead to a treatment for the hereditary, progressive neurological disorder known as Huntington's disease (HD).

In mice, a molecule called C2-8 appears to reduce HD-related neurological damage and delay the loss of motor control, said the team from the MassGeneral Institute for Neurological Disorders (MIND), Boston. Their study appears in the journal Proceedings of the National Academy of Sciences.

"We found that C2-8 slows the progress of HD in a mouse model and might do the same thing in human patients, if it or its biochemical relatives can be translated into a drug," study leader Dr. Steven Hersch said in a prepared statement. "What we don't know yet is precisely how it works, what molecules it interacts with in cells and how potent it might be."

His team first confirmed that oral doses of C2-8 can cross the blood-brain barrier and are nontoxic in mice. They also found that C2-8 doesn't interact with a number of molecules predictive of negative side effects.

HD mice that started receiving C2-8 when they were 24 days old did much better on tests of strength, endurance and coordination than HD mice that did not receive C2-8. The treated mice had less HD-related brain cell shrinkage and smaller aggregates of disease-related protein than untreated mice, the Boston group found.

The results suggest that C2-8 "has potential as the basis of a neuroprotective treatment," said Hersch, who is also an associate professor of neurology at Harvard Medical School. "We now need to confirm those results in a different mouse model, see whether similar compounds may be more potent than C2-8 and search for the enzyme or receptor that it is binding to."

More information

For more on Huntington's disease, head to WeMove.



-- Robert Preidt



SOURCE: MassGeneral Institute for Neurological Disorders, news release, Oct. 8, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New molecule to treat brain disorders found
2. Poisonous Parkinsons molecule discovered
3. Glenmark’s new molecule to go through trial
4. Resistant tumors could be treated with the discovery of a new molecule within cancer cells
5. Ways to counter radiation effects with new molecule discovery
6. Same molecule found in meat, milk, tumors
7. New Molecule that can stop the growth of Viruses
8. Puberty may be due to GPR54 gene and KiSS-1 Molecule
9. Molecule responsible for muscle repair identified
10. Molecule aids fight E. Coli Infections
11. Molecule That Aids Bacterial Infections Identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... 24, 2016 , ... June 19, 2016 is World Sickle Cell Observance Day. ... the benefits of holistic treatments, Serenity Recovery Center of Marne, Michigan, has ... , Sickle Cell Disease (SCD) is a disorder of the red blood cells, which ...
(Date:6/24/2016)... ... ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys are ... for this recognition are considered among the top 2 percent of lawyers practicing within ... of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. Bloom, ...
(Date:6/24/2016)... ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and MyPainAway Pain Relief ... a minimum wage raise to $12 an hour by 2020 and then adjusting it yearly ... lost value of the minimum wage, assure the wage floor does not erode again, and ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Living, is proud to recognize Dr. Barry M. Weintraub as a prominent plastic ... most beautiful women in the world, and the most handsome men, look naturally ...
(Date:6/24/2016)... ... 2016 , ... National recruitment firm Slone Partners is pleased to ... genomics experience, as Vice President of North American Capital Sales at HTG Molecular ... the sales team in the commercialization of the HTG EdgeSeq system and associated reagents ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016 VolitionRx ... of Dr. Edward Futcher to the ... effective June 23, 2016.Dr. Futcher was also appointed ... Governance Committees.  As a non-executive member of the ... and strategic counsel to VolitionRx in connection with ...
(Date:6/23/2016)... , June 23, 2016 Any dentist who ... challenges of the current process. Many of them do not ... the technical difficulties and high laboratory costs involved. And those ... offer it at such a high cost that the majority ... Dr. Parsa Zadeh , founder of Dental ...
(Date:6/23/2016)... 2016 Research and Markets has announced ... Analysis 2016 - Forecast to 2022" report to their ... contains up to date financial data derived from varied research ... trends with potential impact on the market during the next ... which comprises of sub markets, regional and country level analysis. ...
Breaking Medicine Technology: