Navigation Links
Molecule Promising Against Huntington's Disease
Date:10/9/2007

C2-8 battles the brain illness, mouse study shows

TUESDAY, Oct. 9 (HealthDay News) -- U.S. researchers say they've found a compound that may lead to a treatment for the hereditary, progressive neurological disorder known as Huntington's disease (HD).

In mice, a molecule called C2-8 appears to reduce HD-related neurological damage and delay the loss of motor control, said the team from the MassGeneral Institute for Neurological Disorders (MIND), Boston. Their study appears in the journal Proceedings of the National Academy of Sciences.

"We found that C2-8 slows the progress of HD in a mouse model and might do the same thing in human patients, if it or its biochemical relatives can be translated into a drug," study leader Dr. Steven Hersch said in a prepared statement. "What we don't know yet is precisely how it works, what molecules it interacts with in cells and how potent it might be."

His team first confirmed that oral doses of C2-8 can cross the blood-brain barrier and are nontoxic in mice. They also found that C2-8 doesn't interact with a number of molecules predictive of negative side effects.

HD mice that started receiving C2-8 when they were 24 days old did much better on tests of strength, endurance and coordination than HD mice that did not receive C2-8. The treated mice had less HD-related brain cell shrinkage and smaller aggregates of disease-related protein than untreated mice, the Boston group found.

The results suggest that C2-8 "has potential as the basis of a neuroprotective treatment," said Hersch, who is also an associate professor of neurology at Harvard Medical School. "We now need to confirm those results in a different mouse model, see whether similar compounds may be more potent than C2-8 and search for the enzyme or receptor that it is binding to."

More information

For more on Huntington's disease, head to WeMove.



-- Robert Preidt



SOURCE: MassGeneral Institute for Neurological Disorders, news release, Oct. 8, 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. New molecule to treat brain disorders found
2. Poisonous Parkinsons molecule discovered
3. Glenmark’s new molecule to go through trial
4. Resistant tumors could be treated with the discovery of a new molecule within cancer cells
5. Ways to counter radiation effects with new molecule discovery
6. Same molecule found in meat, milk, tumors
7. New Molecule that can stop the growth of Viruses
8. Puberty may be due to GPR54 gene and KiSS-1 Molecule
9. Molecule responsible for muscle repair identified
10. Molecule aids fight E. Coli Infections
11. Molecule That Aids Bacterial Infections Identified
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/27/2016)... ... June 27, 2016 , ... TherapySites, the ... affiliation with Tennessee Counseling Association. This new relationship allows TherapySites to ... Counseling Association, adding exclusive benefits and promotional offers. , "TCA is extremely excited ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... to revolutionize the emergency ambulance transport experience for the millions of people who ... Uber has disrupted the taxi industry through the use of technology. Now, SmartEMS ...
(Date:6/26/2016)... N.J. (PRWEB) , ... June 27, 2016 , ... Quality ... sources, yet in many ways they remain in the eye of the beholder, according ... (EBO), a publication of The American Journal of Managed Care. For the full issue, ...
(Date:6/26/2016)... ... ... Pixel Film Studios Released ProSlice Levels, a Media Slicing Effect Plugin ... whole new perspective by using the title layers in ProSlice Levels to split-up ... Levels contains over 30 Different presets to choose from. FCPX users can ...
(Date:6/26/2016)... NC (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind and ... to be personalized through a fitness app. The fitness app plans to fix the two ... currently only offer a one size fits all type program , They don’t ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... a startling report released today, National Safety Council research ... proven plan to eliminate prescription opioid overdoses. Prescription Nation ... tackling the worst drug crisis in recorded U.S. history, assigned a ... , New Mexico , Tennessee ... failing states, three – Michigan , ...
(Date:6/23/2016)... June 23, 2016 Research and Markets ... Medical Market Analysis 2016 - Forecast to 2022" report ... The report contains up to date financial data derived from ... of major trends with potential impact on the market during ... market segmentation which comprises of sub markets, regional and country ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... their offering. The current ... environment for MedImmune to enter. The US ageing population creates ... drive considerable growth for effective anti-influenza medications. The introduction of ... but development is still in its infancy. ...
Breaking Medicine Technology: