Navigation Links
Molecule Nutlin-3a activates a signal inducing cell death and senescence in primary brain tumors
Date:4/20/2011

Researchers of Apoptosis and Cancer Group of the Bellvitge Biomedical Research Institute (IDIBELL) have found that a small molecule, Nutlin-3a, an antagonist of MDM2 protein, stimulates the signalling pathway of another protein, p53. By this way, it induces cell death and senescence (loss of proliferative capacity) in brain cancer, a fact that slows its growth. These results open the door for MDM2 agonists as new treatments for glioblastomas. The study has been published at the journal PLoS ONE.

Glioblastoma multiforme is the most common brain tumour in adults and the most aggressive. Despite efforts on new treatments and technological innovation in neurosurgery, radiation therapy and clinical trials of new therapeutic agents, most patients die two years after diagnosis. Avelina Tortosa, IDIBELL and University of Barcelona (UB) researcher, coordinator of the study, explained that one objective of her group is "to find substances that sensitize tumour cells to radiotherapy for more efficient treatments".

New therapeutic targets

There is evidence that several genetic alterations promote the growth, invasion and resistance to stimuli that induce programmed cell death (apoptosis). In this sense, the pilot project TCGA (The Cancer Genome Atlas) has sequenced the genome of up to 25 glioblastomas noting that 14% of patients have an increased expression of MDM2 and 35% had alterations in p53 expression (apoptosis-inducing). That is why research is now focused on the development of new therapeutic strategies that target the apoptosis in gliomas.

The aim of this study was to investigate the antitumor activity of Nutlin-3a in cell lines and primary cultures of glioblastoma. Researchers have shown that Nutlin-3a induces apoptosis and cellular senescence by stimulating the p53 pathway in cells, because cells with mutations in this protein don't produce this response. They have also discovered that the use of Nutlin-3a enhances the response of glioblastoma cells to radiotherapy. "The radiation induced DNA damage of tumour cells", explained Tortosa, "the cells activate repairing mechanisms and, if they are unable to repair, they destruct themselves (a mechanism known as apoptosis). With Nutlin-3a we have seen that increases tumour cell death and therefore increases the effectiveness of radiotherapy treatment. "

In conclusion, the results suggest that the MDM2 antagonists may be new therapeutic options for the treatment of glioblastoma patients.


'/>"/>

Contact: Arantxa Mena
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Related medicine news :

1. Small molecules inhibit growth of human tumor cells
2. Molecules identified that help propel cancer metastasis
3. Scientists identify molecule that can increase blood flow in vascular disease
4. New role for an old molecule: protecting the brain from epileptic seizures
5. Study Links Brain Molecule to Risk of Major Depression
6. Membrane molecule keeps nerve impulses hopping
7. Researchers reveal function of novel molecule that underlies human deafness
8. Small molecules may prevent ebola infection
9. Molecules made by IUPUI students may have potential to cure diseases
10. Link between signaling molecules could point way to therapies for epilepsy, stroke, other diseases
11. Structure of key molecule in immune system provides clues for designing drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2017)... ... September 22, 2017 , ... Silicon Valley ... even on the go. Their electric toothbrushes aggressively attack oral bacteria by reducing ... sanitizing technology. Combining leading edge Enke technology with a premium timeless design, they ...
(Date:9/22/2017)... ... September 22, 2017 , ... “Letters From Home”: a moving ... lost, have value to God. “Letters From Home” is the creation of published author, ... the President’s Cabinet of Jerry Savelle Ministries International, who has traveled and ministered on ...
(Date:9/22/2017)... ... September 22, 2017 , ... ... and create life. Although frozen embryos have a slight statistical advantage for live ... freezing is a wonderful opportunity for women undergoing medical treatment or who are ...
(Date:9/21/2017)... ... 21, 2017 , ... With ProSlideshow Portrait from Pixel Film Studios creating a ... select from up to two layers of subject matter along with fully customizable backdrop ... Final Cut Pro X. , With ProSlideshow Portrait each user are given ...
(Date:9/21/2017)... ... 21, 2017 , ... Process Capability Indices for Medical Device ... ET, http://www.fdanews.com/processcapabilityindices      , Quality in device manufacturing is ... Quality System Regulation (§820.250), and Devicemakers find themselves staring at a warning letter. ...
Breaking Medicine News(10 mins):
(Date:9/9/2017)... ... ... – Monday, September 18 th .The Brain Tumor Foundation (BTF) begins ... the public.Where:  BTF,s Mobile MRI Unit – a ... Washington, D.C.What:BTF brings its nationwide initiative, the Road to Early Detection Sponsor-A-City ...
(Date:9/9/2017)... Lilly and Company (NYSE: LLY ) will ... an investigational, oral, first-in-class molecule for the acute treatment ... placebo in the Phase 3 SPARTAN study. Detailed results ... the International Headache Society (IHC) in Vancouver ... lasmiditan,s potential to reduce pain and provide freedom from ...
(Date:9/7/2017)... MIRAGE, Calif. , Sept. 7, 2017  For nearly two decades, ... service in the Assisted Reproduction Insurance industry. Today, New Life Agency announces ... fertility medications. ... http://pharmacarecard.com/ (PRNewsfoto/PharmaCareCard) ... ...
Breaking Medicine Technology: