Navigation Links
Molecule Nutlin-3a activates a signal inducing cell death and senescence in primary brain tumors
Date:4/20/2011

Researchers of Apoptosis and Cancer Group of the Bellvitge Biomedical Research Institute (IDIBELL) have found that a small molecule, Nutlin-3a, an antagonist of MDM2 protein, stimulates the signalling pathway of another protein, p53. By this way, it induces cell death and senescence (loss of proliferative capacity) in brain cancer, a fact that slows its growth. These results open the door for MDM2 agonists as new treatments for glioblastomas. The study has been published at the journal PLoS ONE.

Glioblastoma multiforme is the most common brain tumour in adults and the most aggressive. Despite efforts on new treatments and technological innovation in neurosurgery, radiation therapy and clinical trials of new therapeutic agents, most patients die two years after diagnosis. Avelina Tortosa, IDIBELL and University of Barcelona (UB) researcher, coordinator of the study, explained that one objective of her group is "to find substances that sensitize tumour cells to radiotherapy for more efficient treatments".

New therapeutic targets

There is evidence that several genetic alterations promote the growth, invasion and resistance to stimuli that induce programmed cell death (apoptosis). In this sense, the pilot project TCGA (The Cancer Genome Atlas) has sequenced the genome of up to 25 glioblastomas noting that 14% of patients have an increased expression of MDM2 and 35% had alterations in p53 expression (apoptosis-inducing). That is why research is now focused on the development of new therapeutic strategies that target the apoptosis in gliomas.

The aim of this study was to investigate the antitumor activity of Nutlin-3a in cell lines and primary cultures of glioblastoma. Researchers have shown that Nutlin-3a induces apoptosis and cellular senescence by stimulating the p53 pathway in cells, because cells with mutations in this protein don't produce this response. They have also discovered that the use of Nutlin-3a enhances the response of glioblastoma cells to radiotherapy. "The radiation induced DNA damage of tumour cells", explained Tortosa, "the cells activate repairing mechanisms and, if they are unable to repair, they destruct themselves (a mechanism known as apoptosis). With Nutlin-3a we have seen that increases tumour cell death and therefore increases the effectiveness of radiotherapy treatment. "

In conclusion, the results suggest that the MDM2 antagonists may be new therapeutic options for the treatment of glioblastoma patients.


'/>"/>

Contact: Arantxa Mena
comunicacio@idibell.cat
IDIBELL-Bellvitge Biomedical Research Institute
Source:Eurekalert

Related medicine news :

1. Small molecules inhibit growth of human tumor cells
2. Molecules identified that help propel cancer metastasis
3. Scientists identify molecule that can increase blood flow in vascular disease
4. New role for an old molecule: protecting the brain from epileptic seizures
5. Study Links Brain Molecule to Risk of Major Depression
6. Membrane molecule keeps nerve impulses hopping
7. Researchers reveal function of novel molecule that underlies human deafness
8. Small molecules may prevent ebola infection
9. Molecules made by IUPUI students may have potential to cure diseases
10. Link between signaling molecules could point way to therapies for epilepsy, stroke, other diseases
11. Structure of key molecule in immune system provides clues for designing drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/23/2017)... CO (PRWEB) , ... March 23, 2017 , ... ... serving the families and businesses of the greater Fort Collins area, has unveiled ... in their ongoing community involvement program. Donations to this worthy cause may now ...
(Date:3/23/2017)... ... 2017 , ... ChenMed, a privately owned medical, management and ... executive team expansion needed to further optimize growth and performance. , “We are ... Chen, MD, ChenMed Chief Executive Officer. “George Wheeler and Donald Trexler round-out ...
(Date:3/23/2017)... ... 23, 2017 , ... Inflow IQ & Inflownomics of Raleigh, NC introduce a ... solid foundation. As experts in dangerous situations the Inflow IQ team can help ... deliver ripe, fresh, clean & refreshing knowledge systems that enhance life. , ...
(Date:3/23/2017)... (PRWEB) , ... March 23, 2017 , ... ... (USSOCOM) awarded Task Force Dagger Foundation the US Special Operations Command’s Patriot Award. ... the presentation, General Thomas thanked Task Force Dagger Foundation for its significant and ...
(Date:3/23/2017)... ... March 23, 2017 , ... “Beyond and Back”: a true-life testimony of tragedy ... of published author Bonetta Rose, a wife, mother and grandmother committed to sharing her ... Faith Publishing, Bonetta Rose‘s new book presents actual events in the life of her ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... March 23, 2017  Interpace Diagnostics Group, Inc. ... fully integrated commercial company that provides clinically useful ... that it has entered into agreements to successfully ... Shareholders ("RedPath") and concurrently terminate its royalty and ... secured debt to RedPath amounting to $9.34 million ...
(Date:3/23/2017)... 23, 2017 A research report by ... expected to reach USD 7.2 billion by the end of ... is a procedure in which a sample is preserved prior ... analytical procedures since the methods are often allowing repeated testing. ... the most shared procedures in the lab. In many life ...
(Date:3/23/2017)... , March 23, 2017 CENTRO DE IMAGEM ... 157, paragraph 4 of Law 6,404/76 and Instruction 358/02 ... informs its shareholders and the market in general that ... subsidiary Centro de Diagnosticos por Imagem Ltda. (" CDI ... interest in RADIOLOGISTAS ASSOCIADOS LTDA. (" Partnership " and ...
Breaking Medicine Technology: