Navigation Links
Molecule Keeps Bacteria Like Salmonella in Check

Finding could also fight other pathogens before they develop resistance to antibiotics

FRIDAY, Aug. 22 (HealthDay News) -- A molecule that tames bacteria that cause gastroenteritis, tularemia and severe diarrhea has been identified by researchers at the University of Texas Southwestern Medical Center at Dallas.

The finding, they say, could help in the development of new drugs to combat increasing microbial resistance to antibiotics.

The molecule LED209 blocks a bacterial receptor, called QseC sensor kinase, from biochemical signals from the host that trigger bacteria to release toxins and cause illness.

"What we have here is a completely novel approach to combating illness," study senior author Dr. Vanessa Sperandio, an associate professor of microbiology and biochemistry, said in a UT Southwestern news release.

In studies in vitro, the researchers found that LED209 blocked the QseC sensors in E. coli, salmonella, and Francisella tularensis bacteria. In mice, LED209 prevented salmonella and F. tularensis from causing illness.

The findings were published online Aug. 21 in Science.

Conventional antibiotics kill bacteria. Killing or inhibiting the growth of some bacteria "angers" them and causes them to release toxins. LED209 allows bacteria to grow but prevents virulence that causes illness, according to the study.

"The sensors in bacteria are waiting for the right signal to initiate expression of virulent genes," Sperandio explained. "Using LED209, we blocked those sensing mechanisms and basically tricked the bacteria to not recognize that they were within the host. When we did that, the bacterial pathogens could not effectively cause disease in the treated animals."

Allowing the bacteria to survive also reduces the likelihood it will develop drug resistance.

The study looked at how LED209 affected three pathogens, but the researchers believe that drugs that target QseC could have wider use, because the sensor is present in at least 25 important animal and plant pathogens, including those that cause lung infections and Legionnaire's disease.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about bacteria and foodborne illness.

-- Robert Preidt

SOURCE: University of Texas Southwestern Medical Center at Dallas, news release, Aug. 21, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Tiny molecule helps control blood-vessel development, UT Southwestern researchers find
2. Mouse Study Finds Molecule That Tells Hair to Grow
3. How molecules out of balance lead to human multiple myeloma and other cancers
4. Molecule Uses Cellular Recycling to Treat Kidney Cancer
5. Stanford researchers find molecule that kills kidney cancer cells
6. Immune Molecule Key to Preventing Organ Rejection
7. Researchers confirm benzene-like electron delocalization of important molecule
8. Immune molecule that plays a powerful role in avoiding organ rejection identified
9. New Molecule Discovery Shows Promise Against Tamoxifen-Resistant Breast Cancers
10. Synthetic molecules hold promise for new family of anti-cancer drugs
11. VIDEO from Medialink and Johnson & Johnson: From Molecule to Medicine
Post Your Comments:
(Date:11/27/2015)... Angeles, CA (PRWEB) , ... November 27, 2015 , ... ... conversation at the recent 2015 American Dental Association meeting in Washington D.C. revolved around ... help protect a patient’s overall health. The talk stressed the link between periodontal disease ...
(Date:11/27/2015)... ... 27, 2015 , ... An inventor, from Hopkinsville, Ky., thought ... at home, so he invented the patent-pending ELECTRONIC M.D. , The ELECTRONIC M.D. ... doing so, it could help to prevent potential overdose situations. As a result, ...
(Date:11/27/2015)... ... November 27, 2015 , ... MPWH, the No.1 Herpes-only dating community in the world, revealed ... 1-1 ). More than 3.7 billion people under the age of 50 – or ... to WHO's first global estimates of HSV-1 infection . , "The data shocks us ...
(Date:11/27/2015)... ... November 27, 2015 , ... Keeping ... platform for mental health and wellness consultation, has collaborated with a leading web-based ... the knowledge gap experienced by parents and bring advice from parenting experts within ...
(Date:11/27/2015)... ... November 27, 2015 , ... Indosoft ... announces the incorporation of Asterisk 11 LTS (Long Term Support) into its Q-Suite ... LTS brings Q-Suite 5.10 up-to-date with a version of Asterisk that will receive ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... November 26, 2015 3D bioprinting market ... according to a new report by Grand View Research Inc. ... (CKD) which demands kidney transplantation is expected to boost the ... substitute for organ transplantation. --> 3D bioprinting market ... according to a new report by Grand View Research Inc. ...
(Date:11/26/2015)... 26, 2015 ... ser potential att använda SyMRI för att ... för patienter med multipel skleros (MS) eller ... SyntheticMR AB för att kunna använda SyMRI ... Med SyMRI kan man generera flera konstrastbilder ...
(Date:11/26/2015)... 2015 Research and Markets ( ... "2016 Future Horizons and Growth Strategies in the ... Country Segment Forecasts, Competitive Intelligence, Emerging Opportunities" ... --> --> This new 247-page ... therapeutic drug monitoring market, including emerging tests, technologies, ...
Breaking Medicine Technology: