Navigation Links
Molecule Keeps Bacteria Like Salmonella in Check
Date:8/22/2008

Finding could also fight other pathogens before they develop resistance to antibiotics

FRIDAY, Aug. 22 (HealthDay News) -- A molecule that tames bacteria that cause gastroenteritis, tularemia and severe diarrhea has been identified by researchers at the University of Texas Southwestern Medical Center at Dallas.

The finding, they say, could help in the development of new drugs to combat increasing microbial resistance to antibiotics.

The molecule LED209 blocks a bacterial receptor, called QseC sensor kinase, from biochemical signals from the host that trigger bacteria to release toxins and cause illness.

"What we have here is a completely novel approach to combating illness," study senior author Dr. Vanessa Sperandio, an associate professor of microbiology and biochemistry, said in a UT Southwestern news release.

In studies in vitro, the researchers found that LED209 blocked the QseC sensors in E. coli, salmonella, and Francisella tularensis bacteria. In mice, LED209 prevented salmonella and F. tularensis from causing illness.

The findings were published online Aug. 21 in Science.

Conventional antibiotics kill bacteria. Killing or inhibiting the growth of some bacteria "angers" them and causes them to release toxins. LED209 allows bacteria to grow but prevents virulence that causes illness, according to the study.

"The sensors in bacteria are waiting for the right signal to initiate expression of virulent genes," Sperandio explained. "Using LED209, we blocked those sensing mechanisms and basically tricked the bacteria to not recognize that they were within the host. When we did that, the bacterial pathogens could not effectively cause disease in the treated animals."

Allowing the bacteria to survive also reduces the likelihood it will develop drug resistance.

The study looked at how LED209 affected three pathogens, but the researchers believe that drugs that target QseC could have wider use, because the sensor is present in at least 25 important animal and plant pathogens, including those that cause lung infections and Legionnaire's disease.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about bacteria and foodborne illness.



-- Robert Preidt



SOURCE: University of Texas Southwestern Medical Center at Dallas, news release, Aug. 21, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Tiny molecule helps control blood-vessel development, UT Southwestern researchers find
2. Mouse Study Finds Molecule That Tells Hair to Grow
3. How molecules out of balance lead to human multiple myeloma and other cancers
4. Molecule Uses Cellular Recycling to Treat Kidney Cancer
5. Stanford researchers find molecule that kills kidney cancer cells
6. Immune Molecule Key to Preventing Organ Rejection
7. Researchers confirm benzene-like electron delocalization of important molecule
8. Immune molecule that plays a powerful role in avoiding organ rejection identified
9. New Molecule Discovery Shows Promise Against Tamoxifen-Resistant Breast Cancers
10. Synthetic molecules hold promise for new family of anti-cancer drugs
11. VIDEO from Medialink and Johnson & Johnson: From Molecule to Medicine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2017)... ... June 24, 2017 , ... ... at 217 Portion Road in Lake Ronkonkoma, Dental365 offers patients high-quality and affordable ... that visits to the dentist fit into their patients’ busy lifestyles. Dental365 also ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... announced the launch of Care Management Alerts and Dashboards, an innovative new service ... Rhode Island. , RIQI’s Care Management Alerts and Dashboards provide near real-time data ...
(Date:6/23/2017)... MA (PRWEB) , ... June 23, 2017 , ... ... Care Reconciliation Act (BCRA), their proposed healthcare bill to repeal and replace the ... May, the Senate bill would make significant cuts to Medicaid, a public health ...
(Date:6/23/2017)... ... 23, 2017 , ... Dr. Ran Y. Rubinstein , ... begun offering three new minimally invasive procedures to patients who want a younger ... Dr. Rubinstein is excited to bring microneedling, microneedling facials, and platelet rich plasma ...
(Date:6/23/2017)... ... 2017 , ... Goodcents Deli Fresh Subs today announced the opening of a ... 21st St. Topeka, Kan. 66604 (near 21st and Gage). It is owned and operated ... other locations in the Topeka and Bonner Springs, Kan. area. , “Goodcents has ...
Breaking Medicine News(10 mins):
(Date:6/16/2017)... years ago today, the Monterey Pop Festival opened its gates ... Francisco "Summer of Love."  To celebrate the anniversary, Northern Light® ... market research portals that it will begin delivering to customers ... "Summer of Love (For Our Customers)."  ... Northern Light ...
(Date:6/13/2017)... , June 13, 2017 Zimmer Biomet Holdings, Inc. ... today announced that the U.S. Food and Drug Administration (FDA) ... 3, 2015 relating to its Zhejiang, China ... "The successful clearance of the Warning Letter ... manufacturing facility is a measure of the progress we have ...
(Date:6/9/2017)... 9, 2017 AirXpanders, Inc. (ASX: AXP) (AirXpanders ... design, manufacture, sale and distribution of the AeroForm® Tissue ... of its commercial roll-out in the United ... than one hundred (100) medical institutions and health systems, ... a needle-free alternative for women who choose reconstructive surgery ...
Breaking Medicine Technology: