Navigation Links
Molecule Keeps Bacteria Like Salmonella in Check

Finding could also fight other pathogens before they develop resistance to antibiotics

FRIDAY, Aug. 22 (HealthDay News) -- A molecule that tames bacteria that cause gastroenteritis, tularemia and severe diarrhea has been identified by researchers at the University of Texas Southwestern Medical Center at Dallas.

The finding, they say, could help in the development of new drugs to combat increasing microbial resistance to antibiotics.

The molecule LED209 blocks a bacterial receptor, called QseC sensor kinase, from biochemical signals from the host that trigger bacteria to release toxins and cause illness.

"What we have here is a completely novel approach to combating illness," study senior author Dr. Vanessa Sperandio, an associate professor of microbiology and biochemistry, said in a UT Southwestern news release.

In studies in vitro, the researchers found that LED209 blocked the QseC sensors in E. coli, salmonella, and Francisella tularensis bacteria. In mice, LED209 prevented salmonella and F. tularensis from causing illness.

The findings were published online Aug. 21 in Science.

Conventional antibiotics kill bacteria. Killing or inhibiting the growth of some bacteria "angers" them and causes them to release toxins. LED209 allows bacteria to grow but prevents virulence that causes illness, according to the study.

"The sensors in bacteria are waiting for the right signal to initiate expression of virulent genes," Sperandio explained. "Using LED209, we blocked those sensing mechanisms and basically tricked the bacteria to not recognize that they were within the host. When we did that, the bacterial pathogens could not effectively cause disease in the treated animals."

Allowing the bacteria to survive also reduces the likelihood it will develop drug resistance.

The study looked at how LED209 affected three pathogens, but the researchers believe that drugs that target QseC could have wider use, because the sensor is present in at least 25 important animal and plant pathogens, including those that cause lung infections and Legionnaire's disease.

More information

The U.S. National Institute of Diabetes and Digestive and Kidney Diseases has more about bacteria and foodborne illness.

-- Robert Preidt

SOURCE: University of Texas Southwestern Medical Center at Dallas, news release, Aug. 21, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Tiny molecule helps control blood-vessel development, UT Southwestern researchers find
2. Mouse Study Finds Molecule That Tells Hair to Grow
3. How molecules out of balance lead to human multiple myeloma and other cancers
4. Molecule Uses Cellular Recycling to Treat Kidney Cancer
5. Stanford researchers find molecule that kills kidney cancer cells
6. Immune Molecule Key to Preventing Organ Rejection
7. Researchers confirm benzene-like electron delocalization of important molecule
8. Immune molecule that plays a powerful role in avoiding organ rejection identified
9. New Molecule Discovery Shows Promise Against Tamoxifen-Resistant Breast Cancers
10. Synthetic molecules hold promise for new family of anti-cancer drugs
11. VIDEO from Medialink and Johnson & Johnson: From Molecule to Medicine
Post Your Comments:
(Date:10/13/2017)... ... 13, 2017 , ... Apple Rehab Shelton Lakes , which specializes in ... the facility as part of a disaster drill on October 3rd. , Apple Rehab ... City Emergency Manager, as well as the Connecticut Long Term Care Mutual Aid ...
(Date:10/13/2017)... RIDGE, N.J. (PRWEB) , ... October 13, 2017 , ... ... annual Holly Day Market. Featuring a collection of specialty vendors and unique items from ... of personalized and quality-focused health and wellness services offered by the VNA. The ...
(Date:10/13/2017)... ... ... Global Healthcare Management’s 4th Annual Kids Fun Run brought out many kids this ... by Global Healthcare Management’s CEO, Jon Letko, is aimed at getting kids excited about ... ages; it is a non-competitive, non-timed event, which is all about having fun and ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... viewers the lowdown on sciatica in a new episode of "Success Files," which ... current events and innovation and investigates each subject in-depth with passion and integrity. ...
(Date:10/13/2017)... ... 2017 , ... “The Journey: From the Mountains to the Mission Field”: the ... in the Philippines. “The Journey: From the Mountains to the Mission Field” is the ... She has taught all ages and currently teaches a class of ladies at her ...
Breaking Medicine News(10 mins):
(Date:10/2/2017)... Halo Labs announces the European launch of their new ... at MIBio 2017 in Cambridge, U.K on ... in biopharmaceutical samples with unprecedented speed and sensitivity while using far ... Membrane Imaging. ... particle analysis system ...
(Date:9/28/2017)... -- Hill-Rom Holdings, Inc. (NYSE: HRC), will host its ... on Friday, November 3, 2017, beginning at 7:00 a.m. ... 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... and guidance for 2018, Hill-Rom executives will also highlight ... and long-range financial outlook through 2020. ...
(Date:9/27/2017)... , Sept. 27, 2017  Commended for their devotion ... notable awards. Ranked as number one in the South Florida ... time in Inc. 5000 yearly list, the national specialty pharmacy ... Armando Bardisa will soon be honored by SFBJ ... Set to receive his award in ...
Breaking Medicine Technology: