Navigation Links
Molecule Helps Leukemia Cells Hide From Immune System
Date:7/23/2009

Discovery might lead to new strategies to fight the disease, researchers say

THURSDAY, July 23 (HealthDay News) -- Leukemia stem cells cleverly cloak themselves to avoid detection by a person's immune system, according to a pair of studies by researchers at Stanford University Medical School.

The cells co-opt a protective molecular badge that is used by normal blood stem cells, and this badge helps them travel throughout the body undetected, the investigators found.

Patients who had cancer stem cells with higher levels of this molecule have a poorer prognosis than those whose cells express lower levels, the researchers report in the July 24 issue of the journal Cell.

"We call it the 'Don't eat me signal,'" said Dr. Ravindra Majeti, assistant professor of hematology at Stanford, co-first author of the studies, which focused on acute myeloid leukemia.

"When we blocked this signal in mice with established human leukemia, the cancer cells were more easily removed by the body's natural defenses," Majeti said in a news release from Stanford.

The study findings show that the molecule could be a prognostic factor and a valuable therapeutic target for treatment of the malignancy.

The researchers found that the molecule, CD47, protects the leukemia stem cells from macrophages by binding to a molecule on the macrophage's surface. The macrophages are part of a group of cells that travel around in an effort to find and engulf diseased or dying cells. The interaction between the two proteins gets in the way of the macrophage's instinct to kill and allows the cancer cells to escape.

In the study, the high-CD47-expressing cancer stem cells were put in a culture dish with an antibody that blocks the interaction of the cancer cells with macrophages, essentially hiding the protective badge. This allowed the macrophages to "see" and engulf the cancer cells. In the study in mice, a similar treatment prevented human cancer cells from causing leukemia in the animals, and even helped mice that already had leukemia to survive longer.

"This was the real kicker," Majeti said. "These mice showed a profound clinical response."

The next step for the researchers is to go forward with plans to test a similar treatment in humans.

More information

Learn more about leukemia from the American Cancer Society.



--Dennis Thompson



SOURCE: Stanford University, news release, July 23, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New class of RNA molecules may be important in human cancer
2. Molecule Promising Against Huntingtons Disease
3. Free Access to Literature Data on Chagas Disease Offered Online: Collaborative Drug Discovery, Inc. provides Neglected Disease researchers with archive mine and collaborate access to small molecule bioactivity SAR data on parasitic disease
4. Vulnerability to Stress Linked to Brain Molecule
5. Amira Pharmaceuticals Announces Favorable Phase 1 Clinical Trial Results for Lead Product Candidate AM103 and Initiates Clinical Studies for the 2nd Entry Molecule for the Treatment of Respiratory and Cardiovascular Disease
6. Study Describes Molecules That Control Blood Pressure
7. Researchers identify molecules with interesting anti-clotting properties
8. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
9. St. Jude finds molecule that could improve cancer vaccines and therapy for other diseases
10. Major Advance in the Observation of DNA Molecules
11. Molecules can block breast cancers ability to spread
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecule Helps Leukemia Cells Hide From Immune System
(Date:6/26/2016)... ... , ... Brent Kasmer, a legally blind and certified personal trainer is helping to develop a ... fitness app plans to fix the two major problems leading the fitness industry today:, ... type program , They don’t eliminate all the reasons people quit their exercise ...
(Date:6/25/2016)... ... 2016 , ... Austin residents seeking Mohs surgery services, can now turn to ... Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization to ... fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction of ...
(Date:6/25/2016)... ... 2016 , ... First Choice Emergency Room , the largest network of ... Medical Director of its new Mesquite-Samuell Farm facility. , “We are pleased to ... said Dr. James M. Muzzarelli, Executive Medical Director of First Choice Emergency Room. ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health and ... their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards took ... the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to receive ...
(Date:6/24/2016)... ... ... Those who have experienced traumatic events may suffer from a complex set ... drug or alcohol abuse, as a coping mechanism. To avoid this pain and suffering, ... traumatic event. , Trauma sufferers tend to feel a range of emotions, from depression, ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...   Bay Area Lyme Foundation , collaborating ... for Tick Borne Illness , Harvard Medical School ... Medicine, University of California, Berkeley, and the Veterans ... finalists of Lyme Innovation , the first ... scientists, clinicians, researchers, entrepreneurs, and investors from several ...
(Date:6/24/2016)... Research and Markets has ... 2015-2025: Applications, Technologies, Forecasts" report to their ... Electronics, Smart Skin, Structural Health Monitoring, Composite Smart ... electronics involves electronic and/or electrical components and circuits ... structures such as vehicle bodies or conformally placed ...
(Date:6/24/2016)... Dehaier Medical Systems Ltd. (NASDAQ: DHRM ) ... medical devices and wearable sleep respiratory products in ... with Hongyuan Supply Chain Management Co., Ltd. (hereinafter referred ... to develop Dehaier,s new Internet medical technology business. ... Hongyuan Supply Chain,s sales platform to reach Dehaier,s dealers ...
Breaking Medicine Technology: