Navigation Links
Molecule Helps Leukemia Cells Hide From Immune System
Date:7/23/2009

Discovery might lead to new strategies to fight the disease, researchers say

THURSDAY, July 23 (HealthDay News) -- Leukemia stem cells cleverly cloak themselves to avoid detection by a person's immune system, according to a pair of studies by researchers at Stanford University Medical School.

The cells co-opt a protective molecular badge that is used by normal blood stem cells, and this badge helps them travel throughout the body undetected, the investigators found.

Patients who had cancer stem cells with higher levels of this molecule have a poorer prognosis than those whose cells express lower levels, the researchers report in the July 24 issue of the journal Cell.

"We call it the 'Don't eat me signal,'" said Dr. Ravindra Majeti, assistant professor of hematology at Stanford, co-first author of the studies, which focused on acute myeloid leukemia.

"When we blocked this signal in mice with established human leukemia, the cancer cells were more easily removed by the body's natural defenses," Majeti said in a news release from Stanford.

The study findings show that the molecule could be a prognostic factor and a valuable therapeutic target for treatment of the malignancy.

The researchers found that the molecule, CD47, protects the leukemia stem cells from macrophages by binding to a molecule on the macrophage's surface. The macrophages are part of a group of cells that travel around in an effort to find and engulf diseased or dying cells. The interaction between the two proteins gets in the way of the macrophage's instinct to kill and allows the cancer cells to escape.

In the study, the high-CD47-expressing cancer stem cells were put in a culture dish with an antibody that blocks the interaction of the cancer cells with macrophages, essentially hiding the protective badge. This allowed the macrophages to "see" and engulf the cancer cells. In the study in mice, a similar treatment prevented human cancer cells from causing leukemia in the animals, and even helped mice that already had leukemia to survive longer.

"This was the real kicker," Majeti said. "These mice showed a profound clinical response."

The next step for the researchers is to go forward with plans to test a similar treatment in humans.

More information

Learn more about leukemia from the American Cancer Society.



--Dennis Thompson



SOURCE: Stanford University, news release, July 23, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New class of RNA molecules may be important in human cancer
2. Molecule Promising Against Huntingtons Disease
3. Free Access to Literature Data on Chagas Disease Offered Online: Collaborative Drug Discovery, Inc. provides Neglected Disease researchers with archive mine and collaborate access to small molecule bioactivity SAR data on parasitic disease
4. Vulnerability to Stress Linked to Brain Molecule
5. Amira Pharmaceuticals Announces Favorable Phase 1 Clinical Trial Results for Lead Product Candidate AM103 and Initiates Clinical Studies for the 2nd Entry Molecule for the Treatment of Respiratory and Cardiovascular Disease
6. Study Describes Molecules That Control Blood Pressure
7. Researchers identify molecules with interesting anti-clotting properties
8. Jefferson neuroscientists show anti-inflammation molecule helps fight MS-like disease
9. St. Jude finds molecule that could improve cancer vaccines and therapy for other diseases
10. Major Advance in the Observation of DNA Molecules
11. Molecules can block breast cancers ability to spread
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecule Helps Leukemia Cells Hide From Immune System
(Date:8/18/2017)... ... August 18, 2017 , ... ... a highly specialized asset-light logistics provider of complex transport solutions for mission-critical ... to purchase Unitrans International Corporation, a division of Roadrunner Transportation Systems, Inc. ...
(Date:8/18/2017)... ... August 18, 2017 , ... The Dawn Johnson Insurance Group, a Missouri-based insurance ... to generate community support for efforts to educate the local population on cancer realities ... types of cancer. , Each day in America, roughly 4,600 new cases of ...
(Date:8/18/2017)... ... August 18, 2017 , ... The Brian Gifford Agency, an Indiana-based firm providing ... support of Campagna Academy in a charity drive to provide for at-risk children and ... Indiana,” Campagna Academy is a nonprofit organization that has offered critical programs to at-risk ...
(Date:8/18/2017)... ... August 18, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh in ... veil on false teachings pertaining to the mother of the Savior whom the world calls ... far different picture of the role of this historical woman. , “The world bows, ...
(Date:8/18/2017)... ... 18, 2017 , ... “Dangerous Inheritance”: a mystery about saving the family farm. ... from Southwest Nebraska where she was raised on a farm. As Diane wrote ... fictional, but the friendships and mantra of ‘neighbors helping neighbors’ have always been a ...
Breaking Medicine News(10 mins):
(Date:8/4/2017)... -- The search for test results that can be ... long been the goal of healthcare providers and the ... largest meeting of lab professionals and IVD firms this ... Kalorama Information.  The firm said scores of companies with ... and software were at the American Association for Clinical ...
(Date:8/2/2017)... Fenita J. Caldwell is ... Lifetime Professional in the Field of Healthcare. Caldwell ... Pharmaceuticals, AG. Her skills and areas of expertise ... Fenita ... experience as a highly successful sales specialist in ...
(Date:8/2/2017)... Aug. 2, 2017 CaryRx, a next-generation full-service pharmacy, ... service for patients in the Washington D.C. ... pharmacy by providing delivery of medications through the convenience of ... delivery or delivered within one hour to any location in ... to bring this invaluable service to Washington D.C. ...
Breaking Medicine Technology: