Navigation Links
Molecule Disrupts DNA Sequence in Ewing's Sarcoma
Date:4/14/2008

Finding could yield first targeted therapy for the rare disease, researchers say

MONDAY, April 14 (HealthDay News) -- A molecule that disrupts the oncogene that causes Ewing's sarcoma has been identified by Georgetown University Medical Center researchers.

Ewing's sarcoma is a rare cancer that strikes children and young adults and can cause tumors to grow anywhere in the body. About 500 cases are diagnosed each year in the United States. Treatment involves a combination of five different chemotherapy drugs. An estimated 60 percent to 70 percent of patients survive over time, but many experience lingering effects from the chemotherapy.

Ewing's sarcoma occurs when there's an exchange of DNA between two chromosomes, a process called translocation. The EWS gene on chromosome 22 fuses to the FLI1 gene on chromosome 11, creating a new gene called EWS-FLI1, which produces the fusion protein that's causes cancer.

If further research shows that this newly identified molecule is effective, it could offer the first targeted therapy to treat Ewing's sarcoma, the researchers said. The molecule works through a so-called protein-protein interaction and could provide a model upon which to design other therapies.

"I think this holds really wonderful promise as a unique way of targeting fusion proteins," lead investigator Dr. Jeffrey Toretsky, a pediatric oncology physician and researcher at Georgetown University's Lombardi Comprehensive Cancer Center, said in a prepared statement.

"People thought it wasn't possible to have a small molecule that can bind between flexible proteins, but we have shown that it can be done," Toretsky said.

He noted that the study was conducted in laboratory cells, so further research is needed before the molecule can be tested in humans.

The study was to be presented Sunday at the annual meeting of the American Association for Cancer Research, in San Diego.

More information

The U.S. National Library of Medicine has more about Ewing's sarcoma.



-- Robert Preidt



SOURCE: Georgetown University Medical Center, news release, April 13, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers learn how signaling molecule orchestrates breast cancers spread
2. Molecules that changed the world
3. Pain in fibromyalgia is linked to changes in brain molecule
4. Allergic response tied to lipid molecules in cell membrane
5. New understanding of how big molecules bind will lead to better drugs, synthetic organic materials
6. Novel molecules developed at UB can boost vaccine potency
7. Novel small molecule therapy shows benefit for anemic patients via hydration of red blood cells
8. Molecules may help predict survival in liver cancer
9. Synthesis of natural molecule could lead to better anti-cancer drugs
10. Molecule May Trigger Psoriasis
11. Alzheimers molecule is a smart speed bump on the nerve-cell transport highway
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecule Disrupts DNA Sequence in Ewing's Sarcoma
(Date:2/8/2016)... ... February 08, 2016 , ... Stephanie Hebert Insurance Agency, ... of a new charity campaign. As part of their ongoing community involvement program, ... the belief that children deserve a voice, and in the spirit of neighbors ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... A man who has struggled to quit ... Freedom Laser Therapy , was determined to find solutions to his problems – and he ... Inventors Digest is ready to introduce his breakthrough inventions to the world and better ...
(Date:2/8/2016)... York, NY (PRWEB) , ... February 08, 2016 , ... ... are too much to handle, you are not alone. According to the Center for ... include heart disease, stroke, type 2 diabetes and certain types of cancer, some of ...
(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... Steve Helwig ... with a vital new community enrichment program, has teamed up with Citizens Opposed to ... children suffering from intimate abuse. To support all those victimized by the fear of ...
(Date:2/8/2016)... ... February 08, 2016 , ... Local insurance agency Dennis ... FL area, has initiated a fundraiser for a two year old little girl ... after Christmas. To support this beautiful child who is facing life’s journey without ...
Breaking Medicine News(10 mins):
(Date:2/9/2016)... new report "Global Diagnostic Ultrasound Devices Market Assessment & Forecast: 2015-2019" ... diagnostic ultrasound devices market was valued at US$ 5,381.1 million in ... at a CAGR of 6.8% from 2015 to 2019. The ... for six geographies of North America , ... Latin America , Middle-East and ...
(Date:2/9/2016)... The global prefilled syringes market accounted for $3,905.1 million ... with a CAGR of 12.9% during 2015-2020. Among the ... global prefilled syringes market, with 90.1% share in 2014. ... global market of prefilled syringes is up surging with ... demand for vaccines, increasing prevalence of chronic and lifestyle ...
(Date:2/9/2016)... report "Global Blood Monitoring & Cardiac Monitoring Devices Market Assessment & ... that global market for blood monitoring & cardiac monitoring devices was ... to US$ 24,830.1 million by 2019 at a CAGR of 6.8% ... Europe , Asia-Pacific , ... Africa . The three major factors determining growth ...
Breaking Medicine Technology: