Navigation Links
Molecule Disrupts DNA Sequence in Ewing's Sarcoma
Date:4/14/2008

Finding could yield first targeted therapy for the rare disease, researchers say

MONDAY, April 14 (HealthDay News) -- A molecule that disrupts the oncogene that causes Ewing's sarcoma has been identified by Georgetown University Medical Center researchers.

Ewing's sarcoma is a rare cancer that strikes children and young adults and can cause tumors to grow anywhere in the body. About 500 cases are diagnosed each year in the United States. Treatment involves a combination of five different chemotherapy drugs. An estimated 60 percent to 70 percent of patients survive over time, but many experience lingering effects from the chemotherapy.

Ewing's sarcoma occurs when there's an exchange of DNA between two chromosomes, a process called translocation. The EWS gene on chromosome 22 fuses to the FLI1 gene on chromosome 11, creating a new gene called EWS-FLI1, which produces the fusion protein that's causes cancer.

If further research shows that this newly identified molecule is effective, it could offer the first targeted therapy to treat Ewing's sarcoma, the researchers said. The molecule works through a so-called protein-protein interaction and could provide a model upon which to design other therapies.

"I think this holds really wonderful promise as a unique way of targeting fusion proteins," lead investigator Dr. Jeffrey Toretsky, a pediatric oncology physician and researcher at Georgetown University's Lombardi Comprehensive Cancer Center, said in a prepared statement.

"People thought it wasn't possible to have a small molecule that can bind between flexible proteins, but we have shown that it can be done," Toretsky said.

He noted that the study was conducted in laboratory cells, so further research is needed before the molecule can be tested in humans.

The study was to be presented Sunday at the annual meeting of the American Association for Cancer Research, in San Diego.

More information

The U.S. National Library of Medicine has more about Ewing's sarcoma.



-- Robert Preidt



SOURCE: Georgetown University Medical Center, news release, April 13, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers learn how signaling molecule orchestrates breast cancers spread
2. Molecules that changed the world
3. Pain in fibromyalgia is linked to changes in brain molecule
4. Allergic response tied to lipid molecules in cell membrane
5. New understanding of how big molecules bind will lead to better drugs, synthetic organic materials
6. Novel molecules developed at UB can boost vaccine potency
7. Novel small molecule therapy shows benefit for anemic patients via hydration of red blood cells
8. Molecules may help predict survival in liver cancer
9. Synthesis of natural molecule could lead to better anti-cancer drugs
10. Molecule May Trigger Psoriasis
11. Alzheimers molecule is a smart speed bump on the nerve-cell transport highway
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecule Disrupts DNA Sequence in Ewing's Sarcoma
(Date:8/16/2017)... ... 2017 , ... LabRoots , the leading provider of educational and interactive ... to announce Andrew Ly as the winner of the LabRoots Summer Textbook scholarship, awarding ... Ly, who is in his third year at the University of California, Los Angeles ...
(Date:8/16/2017)... ... 2017 , ... SGNA Standards of Infection Control in Reprocessing ... between patient procedures and before storage, is a requisite practice crucial to the ... prevention of disease transmission and nosocomial infection as cleaning and HLD.” The ...
(Date:8/16/2017)... VERO BEACH, Fla. (PRWEB) , ... August 16, ... ... living development and management company based in Vero Beach, announced today that two ... Florida Argentum, an organization that represents professionally managed senior living communities in Florida. ...
(Date:8/16/2017)... , ... August 16, 2017 , ... TopConsumerReviews.com recently gave ... Lab Testing . , The healthcare industry in the United States has undergone major ... the days of needing to have a doctor’s order to get a blood test ...
(Date:8/16/2017)... ... August 16, 2017 , ... Women’s ... chronic pelvic pain. In addition to oncology services, the new center will ... menorrhagia (abnormal heavy bleeding during menstruation), uterine fibroids, and uterine and pelvic adhesions ...
Breaking Medicine News(10 mins):
(Date:8/7/2017)... Aug. 7, 2017  Endo International plc (NASDAQ: ... to resolve virtually all known U.S. mesh product liability ... resolve the known remaining U.S. claims at reasonable values. ... in the fourth quarter of 2017 and continuing through ... second quarter 2017 results, the Company intends to increase ...
(Date:8/3/2017)... DIEGO , Aug. 3, 2017  Opioid addiction ... diseases driving up healthcare costs and threatening outcomes, were ... lab supply and IVD industry that support them, met ... care market researcher said that drugs of abuse, procalcitonin ... and sessions at the organization,s 69th meeting in ...
(Date:8/2/2017)... , Aug. 2, 2017  Life Flight Network and ... The agreement improves patient care and operational efficiency for patients ... Springfield , Cottage Grove , and ... medical transportation. PeaceHealth and Life Flight Network work collaboratively to ... during transport, or when a time sensitive emergency exists. ...
Breaking Medicine Technology: