Navigation Links
Molecule Disrupts DNA Sequence in Ewing's Sarcoma

Finding could yield first targeted therapy for the rare disease, researchers say

MONDAY, April 14 (HealthDay News) -- A molecule that disrupts the oncogene that causes Ewing's sarcoma has been identified by Georgetown University Medical Center researchers.

Ewing's sarcoma is a rare cancer that strikes children and young adults and can cause tumors to grow anywhere in the body. About 500 cases are diagnosed each year in the United States. Treatment involves a combination of five different chemotherapy drugs. An estimated 60 percent to 70 percent of patients survive over time, but many experience lingering effects from the chemotherapy.

Ewing's sarcoma occurs when there's an exchange of DNA between two chromosomes, a process called translocation. The EWS gene on chromosome 22 fuses to the FLI1 gene on chromosome 11, creating a new gene called EWS-FLI1, which produces the fusion protein that's causes cancer.

If further research shows that this newly identified molecule is effective, it could offer the first targeted therapy to treat Ewing's sarcoma, the researchers said. The molecule works through a so-called protein-protein interaction and could provide a model upon which to design other therapies.

"I think this holds really wonderful promise as a unique way of targeting fusion proteins," lead investigator Dr. Jeffrey Toretsky, a pediatric oncology physician and researcher at Georgetown University's Lombardi Comprehensive Cancer Center, said in a prepared statement.

"People thought it wasn't possible to have a small molecule that can bind between flexible proteins, but we have shown that it can be done," Toretsky said.

He noted that the study was conducted in laboratory cells, so further research is needed before the molecule can be tested in humans.

The study was to be presented Sunday at the annual meeting of the American Association for Cancer Research, in San Diego.

More information

The U.S. National Library of Medicine has more about Ewing's sarcoma.

-- Robert Preidt

SOURCE: Georgetown University Medical Center, news release, April 13, 2008

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers learn how signaling molecule orchestrates breast cancers spread
2. Molecules that changed the world
3. Pain in fibromyalgia is linked to changes in brain molecule
4. Allergic response tied to lipid molecules in cell membrane
5. New understanding of how big molecules bind will lead to better drugs, synthetic organic materials
6. Novel molecules developed at UB can boost vaccine potency
7. Novel small molecule therapy shows benefit for anemic patients via hydration of red blood cells
8. Molecules may help predict survival in liver cancer
9. Synthesis of natural molecule could lead to better anti-cancer drugs
10. Molecule May Trigger Psoriasis
11. Alzheimers molecule is a smart speed bump on the nerve-cell transport highway
Post Your Comments:
Related Image:
Molecule Disrupts DNA Sequence in Ewing's Sarcoma
(Date:11/30/2015)... ... November 30, 2015 , ... Cycling, running, and walking are regular ... meaning the morning of February 28, 2016. , That’s when the 7th annual ... will exercise to help children and families at Joe DiMaggio Children’s Hospital. ...
(Date:11/30/2015)... Baltimore, MD (PRWEB) , ... November 30, 2015 , ... ... has teamed up with Public Television’s Travel With Kids to promote ... follows the Simmons family as they explore international destinations and educate families about the ...
(Date:11/30/2015)... ... 30, 2015 , ... A novel class of antimicrobials that ... in fighting methicillin-resistant Staphylococcus aureus (MRSA), one of the major drug-resistant bacterial pathogens, ... molecule analogs that target the functions of SecA, a central part of the ...
(Date:11/30/2015)... ... November 30, 2015 , ... At Grand Dental PC, their ... setting. , When you have dental problems, you need to turn to a dentist ... diagnose and treat your needs, a friendly dentist who counsels you on the best ...
(Date:11/30/2015)... ... ... Using a combination of two blood sugar tests rather than a single test ... study by researchers at the School of Public Health at Georgia State University. , ... Glucose Tests ,” published in Frontiers in Public Health, the researchers noted that 24 ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... FRANCISCO , Nov. 30, 2015 Next ... Designers of Things (DoT ) co-located events covering ... and the Internet of Things, will draw more than ... Jose Convention Center. The events, combined show ... latest technologies. --> ...
(Date:11/30/2015)... 2015 Nautilus Medical Inc. today announced worldwide ... ( ). The release of MatrixRay to the ... (Radiology Society North America) in Chicago ... --> --> MatrixRay ... to radiology studies worldwide via a peer-to-peer exchange network ...
(Date:11/30/2015)... 30, 2015 ... adds a 2015 publication on ... 2015 with comprehensive analysis of recent ... deal types, such as Mergers & ... . --> ...
Breaking Medicine Technology: