Navigation Links
Molecule Disrupts DNA Sequence in Ewing's Sarcoma
Date:4/14/2008

Finding could yield first targeted therapy for the rare disease, researchers say

MONDAY, April 14 (HealthDay News) -- A molecule that disrupts the oncogene that causes Ewing's sarcoma has been identified by Georgetown University Medical Center researchers.

Ewing's sarcoma is a rare cancer that strikes children and young adults and can cause tumors to grow anywhere in the body. About 500 cases are diagnosed each year in the United States. Treatment involves a combination of five different chemotherapy drugs. An estimated 60 percent to 70 percent of patients survive over time, but many experience lingering effects from the chemotherapy.

Ewing's sarcoma occurs when there's an exchange of DNA between two chromosomes, a process called translocation. The EWS gene on chromosome 22 fuses to the FLI1 gene on chromosome 11, creating a new gene called EWS-FLI1, which produces the fusion protein that's causes cancer.

If further research shows that this newly identified molecule is effective, it could offer the first targeted therapy to treat Ewing's sarcoma, the researchers said. The molecule works through a so-called protein-protein interaction and could provide a model upon which to design other therapies.

"I think this holds really wonderful promise as a unique way of targeting fusion proteins," lead investigator Dr. Jeffrey Toretsky, a pediatric oncology physician and researcher at Georgetown University's Lombardi Comprehensive Cancer Center, said in a prepared statement.

"People thought it wasn't possible to have a small molecule that can bind between flexible proteins, but we have shown that it can be done," Toretsky said.

He noted that the study was conducted in laboratory cells, so further research is needed before the molecule can be tested in humans.

The study was to be presented Sunday at the annual meeting of the American Association for Cancer Research, in San Diego.

More information

The U.S. National Library of Medicine has more about Ewing's sarcoma.



-- Robert Preidt



SOURCE: Georgetown University Medical Center, news release, April 13, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Researchers learn how signaling molecule orchestrates breast cancers spread
2. Molecules that changed the world
3. Pain in fibromyalgia is linked to changes in brain molecule
4. Allergic response tied to lipid molecules in cell membrane
5. New understanding of how big molecules bind will lead to better drugs, synthetic organic materials
6. Novel molecules developed at UB can boost vaccine potency
7. Novel small molecule therapy shows benefit for anemic patients via hydration of red blood cells
8. Molecules may help predict survival in liver cancer
9. Synthesis of natural molecule could lead to better anti-cancer drugs
10. Molecule May Trigger Psoriasis
11. Alzheimers molecule is a smart speed bump on the nerve-cell transport highway
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecule Disrupts DNA Sequence in Ewing's Sarcoma
(Date:3/22/2017)... ... March 22, 2017 , ... Drs. Jennifer Houck, Lauren ... base to accept new patients in need of skilled pediatric dentistry in ... Dental Care offers pediatric patients routine treatments, including cavities, sealants and fluoride applications, in ...
(Date:3/22/2017)... ... March 22, 2017 , ... Intrinsic Imaging, ... therapeutic experience and operational excellence in oncology clinical trials, proudly announces today that ... treatment of non-small cell lung cancer and small cell lung cancer. , Throughout ...
(Date:3/22/2017)... (PRWEB) , ... March 22, 2017 , ... ... consultation, financial planning, and related services to communities across eastern Texas, is announcing ... goal of providing meals to hungry children and adults. , Consistently a ...
(Date:3/22/2017)... ... March 22, 2017 , ... Chris Humphrey Insurance Agency, a North Carolina firm ... the coastal plains region, is initiating a charity event to raise support for five ... diagnosed with leukemia on a Friday evening in September 2014. At the time, Dillyn ...
(Date:3/22/2017)... ... March 22, 2017 , ... HumanHaus is proud to announce ... The conventional broom was great when it was invented, but our customers today are ... parents, the social young couple, the empty nesters and retired that want to travel. ...
Breaking Medicine News(10 mins):
(Date:3/22/2017)... LEXINGTON, Kentucky , March 22, 2017 ... Development and Manufacturing Organization (CDMO), held a special event ... its facilities in Lexington, Kentucky . ... Bevin , Piramal Group Chairman Ajay Piramal, and ... ...
(Date:3/22/2017)... 22, 2017 FinancialBuzz.com News Commentary  ... According to a report by ... estimated $6.6 billion in 2016, and is projected to grow at ... than $24 billion by 2025. The medical cannabis market is projected ... billion in 2016, to an estimated $13.3 billion in 2025. These ...
(Date:3/22/2017)... -- EMD Serono, the biopharmaceutical business of Merck KGaA, Darmstadt, ... Canada , today announced two new real-world data ... the 65 th Annual Pacific Coast Reproductive Society (PCRS) ... March 24 th .   The results being presented ... July 2009 to December 2015 containing data from 15 fertility ...
Breaking Medicine Technology: