Navigation Links
Molecule Discovery Might Help ALS Patients
Date:12/10/2009

Finding in mouse study could lead to treatment for the disease, researchers say

THURSDAY, Dec. 10 (HealthDay News) -- Researchers have identified a molecule that can reduce symptoms and prolong the life of mice with a type of amyotrophic lateral sclerosis (ALS).

The molecule, called microRNA-206 (miR-206), is produced naturally by skeletal muscles in response to nerve damage caused by ALS, also known as Lou Gehrig's disease. The molecule acts as a chemical signal to guide new nerve endings and maintain their interactions with muscles.

However, this research in mice suggests that miR-206 only works for a limited period of time. As nerves continue to die because of ALS, eventually surviving nerves can no longer compensate and symptoms such as muscle weakness begin to develop.

"While miR-206 initially prompts nearby surviving nerves to send new branches to the muscles, it only delays the inevitable," study senior author Eric Olson, chairman of molecular biology at the University of Texas Southwestern Medical Center, said in a university news release.

"Our findings correlate with the observation in ALS patients that the disease is nearly asymptomatic until a large fraction of motor neurons has died, at which point the few remaining ones can't compensate sufficiently," he explained. "These results provide a new perspective on the mechanisms of ALS. MiR-206 seems to sense nerve injury and promote regeneration."

These findings may help in efforts to develop drugs to treat ALS. Currently there is no cure or treatment to slow progression of the disease, which causes muscle weakness, paralysis and death.

"Because miR-206 only exists in skeletal muscle, a drug based on it might not affect other tissues. That limits its risk of side effects and is a key part of its appeal as a potential therapy," Olson added.

The study appears in the Dec. 11 issue of the journal Science.

'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1 2

Related medicine news :

1. Wayne State Researchers Report a Possible Proofreading Step in DNA Synthesis by Observing Single Molecules of DNA Polymerase
2. Molecules wrestle for supremacy in creation of superstructures
3. Molecule plays early role in nonsmoking lung cancer
4. Molecule Helps Leukemia Cells Hide From Immune System
5. Small Molecule Might Play Big Part in Lung Cancer
6. New role discovered for molecule important in development of the pancreas
7. Fate Therapeutics to Present Data on Stimulation of Osteogenic Activity Using Small Molecule Modulators of Wnt Pathway
8. Ready for relapse: Molecule helps breast cancer cells to survive in the bone marrow
9. LSUHSC research identifies enzyme that makes survival molecule for key vision cells
10. Ludwig Institute of Cancer Research Ltd., Brussels Branch, Issues Statement Concerning Prospect Therapeutics Incs. GCS-100 Molecule
11. Small molecule inhibitor shows promise in trastuzumab-resistant metastatic breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/13/2014)... type-1 diabetes could improve patient care worldwide and ... the device,s inventors at the Stanford University School ... be published online July 13 in Nature ... type-1 diabetes outside hospital settings. The handheld microchips ... mellitus, which are both characterized by high blood-sugar ...
(Date:7/13/2014)... American water storage systems market is estimated to grow from ... a CAGR of 21.0%, from 2013 to 2018. The water ... North America. The U.S. is experiencing high growth on account ... collection, and the increased spending on modernization and upgradation of ... in Canada, and is rising at a rapid pace in ...
(Date:7/13/2014)... 13, 2014 Fuel additives are chemicals, ... diesel, jet fuel, kerosene, and so on, in order ... for reducing the corrosion effects caused by fuels and ... to any fuel, provide economies of scale in the ... the overall cost of the fuel products. , The ...
(Date:7/13/2014)... HealthDay Reporter FRIDAY, July 11, ... for people with diabetes is being developed to measure sugar ... report. Scientists at Brown University in Providence, R.I., created ... uses light, metal and a special enzyme that changes color ... have to prick their fingers to draw blood to check ...
(Date:7/13/2014)... (PRWEB) July 13, 2014 Recently, ... retailer, has unveiled its new range of gorgeous ... current market, the demand for elegant Quinceanera outfits ... more beautiful items. All the company’s newly released ... trends. They are all elegant and vivid. ...
Breaking Medicine News(10 mins):Health News:Stanford researchers invent nanotech microchip to diagnose type-1 diabetes 2Health News:Stanford researchers invent nanotech microchip to diagnose type-1 diabetes 3Health News:Stanford researchers invent nanotech microchip to diagnose type-1 diabetes 4Health News:North American Water Storage Systems Market is Expected to Reach $5,450 million by 2018 - New Report by MicroMarket Monitor 2Health News:North American Water Storage Systems Market is Expected to Reach $5,450 million by 2018 - New Report by MicroMarket Monitor 3Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 2Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 3Health News:North America Fuel Additives Market is Expected to Reach $8,100 Million by 2017 - New Report by MicroMarket Monitor 4Health News:Saliva Test Might Someday Replace Needle Prick for Diabetics 2Health News:Saliva Test Might Someday Replace Needle Prick for Diabetics 3Health News:2014QuinceaneraDresses.com Releases Its New Quinceanera Dresses 2
... presented innovative, early-stage research at the 16th Annual ... AUA Foundation and the Society for Basic Urologic ... Foundation hosted the forum for young investigators to ... sexual medicine. These investigators represent the future ...
... Clinical Team Conference on October 23,2008, ALEXANDRIA, ... to improving America,s future. A strong advocate for,children ... vocal advocate and,tireless worker on behalf of important ... Mrs. Edwards will be the opening speaker at,the ...
... men with enlarged prostates, daily Cialis showed benefit without ... -- A daily dose of the erectile dysfunction drug ... men with signs of enlarged prostates, according to a ... age 50 and older have lower urinary tract symptoms, ...
... saves hospital money, enables more wide-spread ... authentication for network access, DALLAS, ... Medical Center already was,leveraging two-factor authentication via hardware tokens in ... The,solution, however, was cost-prohibitive to deploy to a wider audience ...
... ... Practitioners, NEWPORT BEACH, Calif., ... a Managed Compliance Services,Program (MCSP) for small healthcare practitioners -- the ... Program is tailored to meet the HIPAA compliance,requirements of small healthcare ...
... reach 210,000 cups sold by Labor Day ... 2008, First-of-its-kind virtual lemonade stand ... ... the,fight to eliminate pediatric cancer charges ahead. The world,s first,virtual lemonade stand, http://www.lemonadestandforlife.com ...
Cached Medicine News:Health News:New research on sexual function 2Health News:Elizabeth Edwards to be Opening Speaker at National Hospice Conference in Dallas 2Health News:ED Drug Relieves Lower Urinary Tract Symptoms 2Health News:Entrust IdentityGuard Enables Georgia-based Hospital Network to Deploy Strong Authentication for Remote Access 2Health News:Entrust IdentityGuard Enables Georgia-based Hospital Network to Deploy Strong Authentication for Remote Access 3Health News:Managed Compliance Services Program (MCSP) Introduced for Small Healthcare Practitioners 2Health News:Managed Compliance Services Program (MCSP) Introduced for Small Healthcare Practitioners 3Health News:Make an Impact on Pediatric Cancer Research Before Summer's End: Try Some Virtual Lemonade! 2Health News:Make an Impact on Pediatric Cancer Research Before Summer's End: Try Some Virtual Lemonade! 3
(Date:7/10/2014)...  Valeant Pharmaceuticals International, Inc. (NYSE: VRX ... the sale to Galderma of all rights to Restylane, ... Valeant for $1.4 billion in cash, pursuant to the ... its acquisition of Galderma. "We are ... a company that is firmly committed to the aesthetic ...
(Date:7/10/2014)... July 10, 2014   LabStyle Innovations Corp ... today announced the appointment of Professor Richard ... its Board of Directors. Prof. Stone ... experience to LabStyle as an entrepreneur, venture capitalist ... corporate governance expert. He currently serves on the ...
(Date:1/15/2014)... , Jan. 15, 2014 Sono-Tek Corporation (OTC BB: SOTK) ... November 30, 2013, compared to sales of $2,202,000 for the ... again, this quarter has also shown growth over the preceding ... quarter of this fiscal year. Markets that experienced sales increases ...
Breaking Medicine Technology:LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 2LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 3LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 4Sono-Tek Announces Third Quarter Results 2Sono-Tek Announces Third Quarter Results 3Sono-Tek Announces Third Quarter Results 4
The Bair Hugger outpatient blanket makes it easy to give your patients the benefit of prewarming and enhance patient comfort during outpatient procedures....
Cocoon Disposable Patient Warming Blankets are specially designed to prevent hypothermia and maintain normothermia in your patients. The soft warm coloured material is strong and resists tearing and ...
2-ply material consisting of polyethylene film inner layer and non-woven outer layers....
The upper body blanket is typically used for abdominal or lower body procedures. The upper body blankets warms the upper torso and arms. A clear drape is included to cover and warm the intubated pati...
Medicine Products: