Navigation Links
Molecule Discovery Might Help ALS Patients
Date:12/10/2009

Finding in mouse study could lead to treatment for the disease, researchers say

THURSDAY, Dec. 10 (HealthDay News) -- Researchers have identified a molecule that can reduce symptoms and prolong the life of mice with a type of amyotrophic lateral sclerosis (ALS).

The molecule, called microRNA-206 (miR-206), is produced naturally by skeletal muscles in response to nerve damage caused by ALS, also known as Lou Gehrig's disease. The molecule acts as a chemical signal to guide new nerve endings and maintain their interactions with muscles.

However, this research in mice suggests that miR-206 only works for a limited period of time. As nerves continue to die because of ALS, eventually surviving nerves can no longer compensate and symptoms such as muscle weakness begin to develop.

"While miR-206 initially prompts nearby surviving nerves to send new branches to the muscles, it only delays the inevitable," study senior author Eric Olson, chairman of molecular biology at the University of Texas Southwestern Medical Center, said in a university news release.

"Our findings correlate with the observation in ALS patients that the disease is nearly asymptomatic until a large fraction of motor neurons has died, at which point the few remaining ones can't compensate sufficiently," he explained. "These results provide a new perspective on the mechanisms of ALS. MiR-206 seems to sense nerve injury and promote regeneration."

These findings may help in efforts to develop drugs to treat ALS. Currently there is no cure or treatment to slow progression of the disease, which causes muscle weakness, paralysis and death.

"Because miR-206 only exists in skeletal muscle, a drug based on it might not affect other tissues. That limits its risk of side effects and is a key part of its appeal as a potential therapy," Olson added.

The study appears in the Dec. 11 issue of the journal Science.

More information

The ALS Association has more about amyotrophic lateral sclerosis.



-- Robert Preidt



SOURCE: University of Texas Southwestern Medical Center, news release, Dec. 10, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Wayne State Researchers Report a Possible Proofreading Step in DNA Synthesis by Observing Single Molecules of DNA Polymerase
2. Molecules wrestle for supremacy in creation of superstructures
3. Molecule plays early role in nonsmoking lung cancer
4. Molecule Helps Leukemia Cells Hide From Immune System
5. Small Molecule Might Play Big Part in Lung Cancer
6. New role discovered for molecule important in development of the pancreas
7. Fate Therapeutics to Present Data on Stimulation of Osteogenic Activity Using Small Molecule Modulators of Wnt Pathway
8. Ready for relapse: Molecule helps breast cancer cells to survive in the bone marrow
9. LSUHSC research identifies enzyme that makes survival molecule for key vision cells
10. Ludwig Institute of Cancer Research Ltd., Brussels Branch, Issues Statement Concerning Prospect Therapeutics Incs. GCS-100 Molecule
11. Small molecule inhibitor shows promise in trastuzumab-resistant metastatic breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified personal ... personalized through a fitness app. The fitness app plans to fix the two major problems ... offer a one size fits all type program , They don’t eliminate all ...
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand ... project," said Christina Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s ... within Final Cut Pro X . Simply select a ProHand generator and drag ...
(Date:6/25/2016)... ... 25, 2016 , ... Conventional wisdom preaches the benefits of moderation, whether it’s ... setting the bar too high can result in disappointment, perhaps even self-loathing. However, those ... goal. , Research from PsychTests.com reveals that behind the tendency to ...
(Date:6/24/2016)... ... 24, 2016 , ... The Pulmonary Hypertension Association (PHA) learned ... receive two significant new grants to support its work to advance research and ... by recognizing patients, medical professionals and scientists for their work in fighting pulmonary ...
(Date:6/24/2016)... TX (PRWEB) , ... June 24, 2016 , ... People ... part in Genome magazine’s Code Talker Award, an essay contest in which patients and ... an award to be presented at the 2016 National Society of Genetic Counselors (NSGC) ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... ANDOVER, Mass. and SAN CLEMENTE, Calif. ... California -based mobile pulmonary function testing company, is now ... portable PFT devices developed by ndd Medical Technologies , Inc. ... PFT testing done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ... CA , can get any needed testing done in the ...
(Date:6/24/2016)... India , June 24, 2016 ... Needles Market by Type (Standard Pen Needles, Safety Pen ... Therapy (Insulin, GLP-1, Growth Hormone), Mode of Purchase (Retail, ... by MarketsandMarkets, This report studies the market for the ... expected to reach USD 2.81 Billion by 2021 from ...
(Date:6/24/2016)... Belgium , June 24, 2016 ... the appointment of Dr. Edward Futcher ... Non-Executive Director, effective June 23, 2016.Dr. Futcher was ... Nominations and Governance Committees.  As a non-executive member ... independent expertise and strategic counsel to VolitionRx in ...
Breaking Medicine Technology: