Navigation Links
Molecular switch identified that controls key cellular process
Date:8/1/2012

New York, NY and Oxford, UK, August 1, 2012 The body has a built-in system known as autophagy, or 'self-eating,' that controls how cells live or die. Deregulation of autophagy is linked to the development of human diseases, including neural degeneration and cancer.

In a study published online this week in the Proceedings of the National Academy of Sciences, scientists at the Ludwig Institute for Cancer Research in Oxford discovered a critical molecular switch that regulates autophagy. They also studied the links between autophagy and a cellular process called senescence that stops cell growth permanently.

The researchers identified ASPP2, a tumor suppressor, as a molecular switch that can dictate the ability of a common cancer gene, known as the RAS oncogene, to either stop or promote senescence.

As Yihua Wang and researchers in Xin Lu's group at the Ludwig Institute investigated the life cycle of fibroblast cells the most common connective tissue cells in animals they found that reduced levels of the ASPP2 protein increase RAS oncogene-induced autophagic activity. This in turn prevented cells from entering senescence. Without ASPP2, the cells continued to proliferate unchecked, thereby promoting tumor growth.

ASPP2 is known to play a role in suppressing tumor development. Mice that have a deficiency or malfunction in this protein have a predisposition to developing tumors. And low ASPP2 levels in patients are linked to poor prognoses in cancers, such as large B-cell lymphomas. Reduced ASPP2 expression has also been observed in highly metastatic breast tumors. But until now, researchers did not understand why.

"We found that in the presence of the common cancer-causing RAS oncogene, ASPP2 interacted with a protein complex that is responsible for deciding cell fate via autophagy," said Yihua Wang, PhD, Ludwig researcher in Oxford.

"What this means is that the cell's emergency stop button is d
'/>"/>

Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Researchers unveil molecular details of how bacteria propagate antibiotic resistance
2. Media alert: 24th EORTC - NCI - AACR Symposium Molecular Targets and Cancer Therapeutics
3. Better treatment for brain cancer revealed by new molecular insights
4. Grb2 holds powerful molecular signaling pathway in check
5. New molecular structure offers first picture of a protein family vital to human health
6. Scientists discover distinct molecular subtype of prostate cancer
7. Molecular subtypes and genetic alterations may determine response to lung cancer therapy
8. Small molecular bodyguards kill HPV-infected cancer cells by protecting tumor-suppressor
9. Molecular probes identify changes in fibronectin that may lead to disease
10. Coordinating the circadian clock: Molecular pair controls time-keeping and fat metabolism
11. Force of habit: Stress hormones switch off areas of the brain for goal-directed behaviour
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/27/2015)... May 27, 2015 The BBB Code ... service practices that enhance customer trust and confidence in ... for Trust, eight principles that summarize important elements of ... represents standards for business accreditation by BBB. Businesses based ... standards and complete application procedures will be accredited by ...
(Date:5/27/2015)... With the launch of the Centers for Medicare ... (NMM) tool, monitoring provider-network adequacy will take a technological ... Services, Inc.’s (AIS) Medicare Advantage News (MAN) offers in-depth ... analysis from industry experts on why CMS is moving ... NMM were announced at CMS’s recently held annual spring ...
(Date:5/27/2015)... The new http://www.carsonenergy.com includes extensive oil ... oil and gas investing, the substantial tax benefits available ... news, IRA investing, definitions and acronyms, info-graphics and educational ... experience is now in one central location, for the ... access 24 hours a day, 7 days a week. ...
(Date:5/27/2015)... Rock, AR (PRWEB) May 27, 2015 ... Medix today announce a partnership to provide CMSA's ... Medix community. This collaboration seeks to strengthen the ... measurement through CMSA’s CKP program. The mutually beneficial ... on identifying individual skills of talent in the ...
(Date:5/27/2015)... 27, 2015 Coco Libre announced today that ... to reach for Organic Coconut Water to quench their thirst ... available at VIP areas, artist greenrooms, corporate skyboxes and concessions ... area hotels and on festival shuttle buses. , “We’re ... said Noa Elan, Director of Strategic Partnerships for Latitude 38 ...
Breaking Medicine News(10 mins):Health News:Carson Energy Receives A+ Accredited Rating For 19 Consecutive Years 2Health News:AIS Newsletter Offers Coverage, Analysis of New CMS Strategy on Monitoring MA Provider Access 2Health News:AIS Newsletter Offers Coverage, Analysis of New CMS Strategy on Monitoring MA Provider Access 3Health News:Carson Energy Launches Next Generation Investor Website 2Health News:Case Management Society of America Partners with Medix to Offer Career and Knowledge Pathways 2Health News:Case Management Society of America Partners with Medix to Offer Career and Knowledge Pathways 3Health News:Coco Libre Puts Organic Coconut Water on the Line-up at BottleRock Napa 2
... CHICAGO, Sept. 1 In response to a rising number ... repeated brain injuries are at great risk for future neurological ... Institute of Neurosurgery and Neuroresearch (CINN) are offering a wallet-sized ... card is an educational tool for parents, coaches and others ...
... , PHILADELPHIA, Sept. 1 In ... Independence Blue Cross (IBC) will offer coverage for the administration costs ... addition IBC will continue to cover seasonal flu vaccine. , ... and customers to be prepared with everything they need to know ...
... , , , ... , , SACRAMENTO, Calif., Sept. 1 According to ... polls (conducted in April 2006, Sept. 2006 and July 2009), Democrats have ... reform and jobs and the economy. , , ...
... take all measurements into account , TUESDAY, Sept. 1 (HealthDay ... U.S. News & World Report list of best hospitals ... regarding heart failure, researchers say. , "If you really want ... heart failure mortality and readmission, you should look directly at ...
... hours later with milder heart attacks, study shows , TUESDAY, ... hospital emergency rooms with chest pains can wait as long ... (EKG) shows evidence of a heart attack, a new French ... measures of heart damage and one-month death rates in the ...
... Sept. 1 Zimmer Holdings, Inc. (NYSE: ZMH ; SWX: ZMH) ... month of September: , , , ... at 11:30 a.m. Eastern Time; , Morgan Stanley Healthcare ... a.m. Eastern Time; and , UBS Global Life Sciences ...
Cached Medicine News:Health News:Illinois Athletic Trainers and Physicians Offer Handy Wallet Card to Tackle Concussions 'Head On' 2Health News:Independence Blue Cross Takes Steps to Prepare for H1N1 and Seasonal Flu 2Health News:Independence Blue Cross Takes Steps to Prepare for H1N1 and Seasonal Flu 3Health News:Independence Blue Cross Takes Steps to Prepare for H1N1 and Seasonal Flu 4Health News:Congressional Democrats Achieve Credibility With Latino Voters 2Health News:Government Best Source for U.S. Hospital Data, Study Finds 2Health News:Sometimes Angioplasty Can Wait 2
(Date:5/27/2015)... -- Research and Markets ( http://www.researchandmarkets.com/research/s9qx9j/asia_pacific_open ) ... Open System MRI Market - Growth, Trends And ... offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , , ... the fastest growing market for Open System MRI. ... replacing CT because of its higher sensitivity and ...
(Date:5/27/2015)... May 27, 2015 ... the addition of the  "US Cancer Vaccine ... offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ... to two broad categories of prophylactic (preventive) ... vaccines belong to both of these groups ...
(Date:5/27/2015)...  With all the daily obstacles facing physicians these ... keep patients healthy should be easy. Unfortunately, it isn,t ... Care Act continues to affect the way physicians are ... more important than ever that medical practices have open ... with for patient care. Each year, cloud-based ...
Breaking Medicine Technology:Asia Pacific Open System MRI Market Trends and Forecasts 2015-2019 2US Cancer Vaccine Market Outlook 2020 2US Cancer Vaccine Market Outlook 2020 3Physicians Seek Payer Inclusion, Not Impediment 2Physicians Seek Payer Inclusion, Not Impediment 3
Architect i2000SR provides high productivity. Seamless integration optimize performance....
... delivers a new level of ... flexibility to integrate with any ... in the future. Most importantly, ... menu of immunoassays - a ...
The UniCel DxI 800 with its exceptional throughput, proven chemiluminescent technology, assay protocols like Access, Access 2, Synchron LXi 725 and load "on-the-fly" capability simplifies and automat...
...
Medicine Products: