Navigation Links
Molecular switch controls the destiny of self-eating cells
Date:7/17/2013

The study is the result of a collaboration of scientists at Karolinska Institutet in Sweden, University of Michigan, and University of California San Diego, USA, who were interested in finding out whether autophagy can be affected by events in the cell nucleus. Surprisingly, they discovered that a signal chain in the nucleus serves as a kind of molecular switch that determines whether the cell dies or survives.

Put simply autophagy is a process whereby the cell consumes parts of itself, and is a way for it to clean up abnormal lumps of proteins and rid itself of damaged organelles (the cell's 'organs') by breaking them down. The cell also uses the process when stressed by external circumstances, such as starvation, to keep itself alive until better times. So while autophagy can protect the cell, it can also lead to its death. However, just how the choice between life and death is controlled has remained a mystery.

Autophagy is involved in numerous diseases, such as cancer, diabetes, obesity, cardiovascular disease, chronic inflammations, Alzheimer's and Parkinson's diseases, as well as in physiological adaptation to exercise, the development of the immune system and ageing.

"Given the role of autophagy in human disease, all we have to do is select a disease model and test whether there's anything to be gained from influencing the new signal network that we've identified," says Dr Bertrand Joseph at Karolinska Institutet's Department of Oncology-Pathology, who headed the study.

To date, autophagy has mainly been considered a process in the cell's cytoplasm; the present study can completely overturn this view since the results indicate that events in the cell nucleus play an essential part in controlling the process once it has started. The DNA in the cell nucleus is packed around so-called histone proteins, on which different enzymes can attach acetyl groups. Such histone modification is a type of epigenetic regulation, whic
'/>"/>

Contact: Dr. Bertrand Joseph
bertrand.joseph@ki.se
46-073-073-0223
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related medicine news :

1. The Association for Molecular Pathology announces 2013 Leadership Award recipient
2. Abnormalities in new molecular pathway may increase breast cancer risk
3. Researchers gain new molecular-level understanding of the brains recovery after stroke
4. Molecular imaging enlists prostate enzyme to detect metastases
5. Molecular imaging improves care for children with brain cancer
6. Impact with Martin Sheen Exploring Molecular Medicine in a New Report
7. A molecular chain reaction in Alzheimers disease
8. Molecular Diagnostics Market - US, UK, Spain, Japan, Italy, Germany & France Analysis in New Research Report at ReportsnReports.com
9. The Institute of Regenerative & Molecular Orthopedics Applauds Newly Released Study on Platelet-Rich Plasma
10. First prospective trial shows molecular profiling timely for tailoring therapy
11. MarketResearch.com Announces the Release of New Report Called The World Market for Molecular Diagnostics, 5th Edition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2015)... ... August 29, 2015 , ... Next weekend is Labor ... (which astronomically, officially ends on September 22nd this year). For IT security personnel, it ... linger on which could prove far more costly than a simple headache. , Joe ...
(Date:8/29/2015)... ... August 29, 2015 , ... Vascular Health ... and sell Arterosil and Arterosil HP, and that all claims and counterclaims have ... Health Sciences, LLC (VHS) in the United States District Court for the Southern ...
(Date:8/28/2015)... FL (PRWEB) , ... August 28, 2015 , ... The ... potential workers are qualified for the position they are applying for, they are unable ... this, many employers are considering altering drug testing policies in order to be able ...
(Date:8/28/2015)... ... August 28, 2015 , ... As reported by Medical Daily on ... clearance for results that last for two years, the longest of any cellulite reduction ... are looking for a long-lasting, effective solution for their cellulite, according to Dr. Robert ...
(Date:8/28/2015)... , ... August 28, 2015 , ... “ Frequentz ” ... at the latest and coolest applications on the market for iOS, Android, and Windows. ... shared with viewers how this software allows businesses to track product movement from beginning ...
Breaking Medicine News(10 mins):Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 2Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 3Health News:Business Cyber Security – Come Out of the Summer with a Clean Slate 4Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 2Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 3Health News:Hiring Obstacles: Drug Abuse a Problem for Workforce 4Health News:Maryland Dermatologists Discuss Non-Invasive Cellulite Reduction System Cellfina Receiving 2-Year FDA Clearance 2Health News:Maryland Dermatologists Discuss Non-Invasive Cellulite Reduction System Cellfina Receiving 2-Year FDA Clearance 3Health News:Track Product Movement from Beginning to End with Frequentz 2
... study, a multivitamin pill should be taken daily by ... having a child with birth defects.// , ... range of severe birth defects like neural tube defects ... or missing limbs, urinary-tract abnormalities and cleft palate can ...
... has revealed that most people are eating and drinking more today ... even the extra orange juice we consume could add five pounds ... the idea of replicating a portion-size study from 20 years ago ... of meal items from a buffet table. The responses of 177 ...
... are divided on the effects of junk-food advertising.While a social ... still not be expected at any time in the near ... clear a ban is out of the question and also ... "surprisingly weak" according to public health researcher Owen Carter. ...
... in former industrial towns, like Easington in England are the ... conducted by a credit reference company ‘Experion’ and analysts Dr ... are 22% more likely to become obese than the average ... the east Midlands were second with 21% more at risk ...
... Over Estimated,A UK doctor, and a leading expert warned ... are being overstated, leading to unnecessary panic. // ... Tyne said there was very little evidence suggesting that ... nut allergies had saved lives. ,Writing in ...
... report in The New York Times says that breastfeeding in ... mothers from professional backgrounds// are allowed to breastfeed their babies, ... I had to choose between feeding my baby the best ... cashier at Resorts Atlantic City Casino. She said she had ...
Cached Medicine News:Health News:Prenatal multivitamins reduce birth defects 2Health News:Prenatal multivitamins reduce birth defects 3Health News:Should Junk Food Ads be Banned or Not? 2
(Date:8/28/2015)... , August 28, 2015 Insights- ... seamlessly connects people, technologies and care protoc ols across ... and the cost of healthcare delivery   ... presence at  ESC Congress 2015 , where the company is ... EchoNavigator and IntelliSpace Cardiovascular, that connect people and technology with ...
(Date:8/27/2015)... Aug. 27, 2015 Biosimilars are not ... the U.S. Food and Drug Administration (FDA) for ... in its draft guidance issued today. The FDA,s ... proposes distinguishable names, calling for biological products to ... suffix. This proposal reflects the agency,s thinking that ...
(Date:8/27/2015)... Women Grow , the fastest-growing professional networking organization for women ... Cannabis World Congress & Business Exposition (CWCBExpo) in ... sessions. CWCBExpo in LA will take place September 16-18, 2015 ... in Los Angeles, CA , and is ... marijuana industry. The Women Grow tracks at ...
Breaking Medicine Technology:Philips Showcases New Integrated Cardiology Solutions to Advance Minimally Invasive Procedures at ESC Congress 2015 2Philips Showcases New Integrated Cardiology Solutions to Advance Minimally Invasive Procedures at ESC Congress 2015 3Philips Showcases New Integrated Cardiology Solutions to Advance Minimally Invasive Procedures at ESC Congress 2015 4Biologics Prescribers Collaborative (BPC) Statement on FDA Draft Guidance entitled "Nonproprietary Naming of Biological Products" 2Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 2Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 3Cannabis World Congress in Los Angeles Boasts Women Grow Sponsored Education 4
... is money, and time that is wasted looking for the right ... mobile and HTML5 app released by Providian Medical Equipment LLC is ... money. With just a few quick and easy steps, the app ... machines based on their individual needs. The app allows a user ...
... 2011 Unilife Corporation ("Unilife" or the ... announced strategic additions to its management team. These senior ... the Unifill ® ready-to-fill (prefilled) syringe to a ... accelerate the commercialization of other pipeline devices within the ...
Cached Medicine Technology:Providian Medical Launches New Tool to Make Finding the Right Ultrasound Machine Easier Than Ever 2Unilife Expands Management Team to Support Business Growth 2Unilife Expands Management Team to Support Business Growth 3Unilife Expands Management Team to Support Business Growth 4Unilife Expands Management Team to Support Business Growth 5Unilife Expands Management Team to Support Business Growth 6
Distinct male and female designs for proper anatomical fit. Hip and pelvic components sized independently. Rigid posterior tongue minimizes pelvic rotation. Available in black or white plastic. Aggre...
Modular hip abduction system designed to provide superior fit, adjustability and functionality for optimum patient stability, comfort and compliance...
... Stabilizer Abduction and rotation ... revisions and fractures. Preset ... with adjustable flexion and ... Adjustabelt back panel. Available ...
... contact casting for the treatment of ... plantar surface of the foot. Other ... plantar fasciitis or other foot conditions ... even distribution of body weight on ...
Medicine Products: