Navigation Links
Molecular switch controls the destiny of self-eating cells
Date:7/17/2013

The study is the result of a collaboration of scientists at Karolinska Institutet in Sweden, University of Michigan, and University of California San Diego, USA, who were interested in finding out whether autophagy can be affected by events in the cell nucleus. Surprisingly, they discovered that a signal chain in the nucleus serves as a kind of molecular switch that determines whether the cell dies or survives.

Put simply autophagy is a process whereby the cell consumes parts of itself, and is a way for it to clean up abnormal lumps of proteins and rid itself of damaged organelles (the cell's 'organs') by breaking them down. The cell also uses the process when stressed by external circumstances, such as starvation, to keep itself alive until better times. So while autophagy can protect the cell, it can also lead to its death. However, just how the choice between life and death is controlled has remained a mystery.

Autophagy is involved in numerous diseases, such as cancer, diabetes, obesity, cardiovascular disease, chronic inflammations, Alzheimer's and Parkinson's diseases, as well as in physiological adaptation to exercise, the development of the immune system and ageing.

"Given the role of autophagy in human disease, all we have to do is select a disease model and test whether there's anything to be gained from influencing the new signal network that we've identified," says Dr Bertrand Joseph at Karolinska Institutet's Department of Oncology-Pathology, who headed the study.

To date, autophagy has mainly been considered a process in the cell's cytoplasm; the present study can completely overturn this view since the results indicate that events in the cell nucleus play an essential part in controlling the process once it has started. The DNA in the cell nucleus is packed around so-called histone proteins, on which different enzymes can attach acetyl groups. Such histone modification is a type of epigenetic regulation, which can influence gene expression without changing the DNA sequence. The modification of histones is a dynamic process, since some enzymes add the acetyl groups and other enzymes remove them.

The researchers studied how the outcome of the autophagy was affected by the acetylation of histone H4, and found that during the processes the acetylation of H4 decreased, which led to a reduction in the expression of autophagy-related genes. If this specific histone modification was blocked, the autophagic cells died.

"Our findings open up avenues for influencing autophagy," says Dr Joseph.


'/>"/>

Contact: Dr. Bertrand Joseph
bertrand.joseph@ki.se
46-073-073-0223
Karolinska Institutet
Source:Eurekalert

Related medicine news :

1. The Association for Molecular Pathology announces 2013 Leadership Award recipient
2. Abnormalities in new molecular pathway may increase breast cancer risk
3. Researchers gain new molecular-level understanding of the brains recovery after stroke
4. Molecular imaging enlists prostate enzyme to detect metastases
5. Molecular imaging improves care for children with brain cancer
6. Impact with Martin Sheen Exploring Molecular Medicine in a New Report
7. A molecular chain reaction in Alzheimers disease
8. Molecular Diagnostics Market - US, UK, Spain, Japan, Italy, Germany & France Analysis in New Research Report at ReportsnReports.com
9. The Institute of Regenerative & Molecular Orthopedics Applauds Newly Released Study on Platelet-Rich Plasma
10. First prospective trial shows molecular profiling timely for tailoring therapy
11. MarketResearch.com Announces the Release of New Report Called The World Market for Molecular Diagnostics, 5th Edition
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... Milwaukee, WI (PRWEB) , ... October 13, 2017 , ... ... movement in medicine known as “patient engagement.” The patient is doing more than filling ... research partners. , “There is an increasing emphasis in health care and research ...
(Date:10/13/2017)... IL (PRWEB) , ... October 13, 2017 , ... ... which established the certification process to promote standards of excellence for the field ... Symposium, scheduled for March 22 – 25, 2018 in Orlando, Florida at the ...
(Date:10/13/2017)... ... ... Lori R. Somekh, founder of the Law Office of Somekh & ... and special needs planning attorneys. “Membership in ElderCounsel helps our office remain up to ... with elder law attorneys nationwide,” said Somekh. , ElderCounsel was founded ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills ... specialty vendors and unique items from across the nation, this holiday-themed event will raise ... offered by the VNA. The boutique will be open Saturday, November 4 (10:00 ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The ... the most popular and least understood books in the Holy Scriptures, Revelation. The Book ... have baffled scholars for centuries. Many have tossed it off as mere rubbish, but ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... 27, 2017  Commended for their devotion to personalized service, ... as number one in the South Florida Business Journal,s 50 ... 5000 yearly list, the national specialty pharmacy has found its ... will soon be honored by SFBJ as the 2017 ... Set to receive his award in October, Bardisa said ...
(Date:9/23/2017)... Sept. 22, 2017 Janssen Biotech, Inc. (Janssen) ... letter from the U.S. Food and Drug Administration (FDA) ... sirukumab for the treatment of moderately to severely active ... clinical data are needed to further evaluate the safety ... active RA. ...
(Date:9/19/2017)... 19, 2017   ZirMed Inc ., a recognized leader ... that it has been ranked #1 by its users for ... Rankings 2017 User Survey. ZirMed was recognized as the top-ranked ... and medical centers over 200 beds and holds one of ... user survey history. ...
Breaking Medicine Technology: