Navigation Links
Molecular subtypes and genetic alterations may determine response to lung cancer therapy
Date:5/11/2012

Cancer therapies targeting specific molecular subtypes of the disease allow physicians to tailor treatment to a patient's individual molecular profile. But scientists are finding that in many types of cancer the molecular subtypes are more varied than previously thought and contain further genetic alterations that can affect a patient's response to therapy.

A UNC-led team of scientists has shown for the first time that lung cancer molecular subtypes correlate with distinct genetic alterations and with patient response to therapy. These findings in pre-clinical models and patient tumor samples build on their previous report of three molecular subtypes of non-small cell lung cancer and refines their molecular analysis of tumors.

Their findings were published in the May 10, 2012 online edition of the Public Library of Science One.

Study senior author, Neil Hayes, MD, MPH, associate professor of medicine, says, "It has been known for about a decade of using gene expression arrays that "molecular subtypes" exist. These subtypes have molecular "fingerprints" and frequently have different clinical outcomes. However, the underlying etiologies of the subtypes have not been recognized. Why do tumors form subtypes?

"Our study shows that tumor subtypes have different underlying alterations of DNA as part of the difference. These differences are further evidence of the importance of subtypes and the way we will use them. For example, the mutations are different which may imply much more ability to target than previously recognized. Also, we are starting to get a suggestion that these subtypes may reflect different cells of origin that rely on different cancer pathways. This is further unlocking the diversity of this complex disease." Hayes is a member of UNC Lineberger Comprehensive Cancer Center.

The team first defined and reported in 2006 on three lung cancer molecular subtypes, named according to their genetic p
'/>"/>

Contact: Dianne G. Shaw
dgs@med.unc.edu
919-966-7834
University of North Carolina School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Small molecular bodyguards kill HPV-infected cancer cells by protecting tumor-suppressor
2. Molecular probes identify changes in fibronectin that may lead to disease
3. Coordinating the circadian clock: Molecular pair controls time-keeping and fat metabolism
4. Olson, noted UT Southwestern molecular biologist, wins 2012 Passano Award
5. Molecular profiling reveals differences between primary and recurrent ovarian cancers
6. ROCK off: Study establishes molecular link between genetic defect and heart malformation
7. Sanford-Burnham researchers find molecular switch that allows melanoma to resist therapy
8. Mutated Kras spins a molecular loop that launches pancreatic cancer
9. Molecular fingerprint discovered that may improve outcomes for head and neck cancer patients
10. Toronto researchers obtain detailed molecular signature for Tankyrase
11. Unlocking the genetic and molecular mystery of soft-tissue sarcoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... New York, NY (PRWEB) , ... July 01, 2015 , ... ... of $100,000 from the New York Community Trust. The grant will allow CCF to ... and sharing proven practices. , CCF was formed to respond to many changes in ...
(Date:7/1/2015)... PA (PRWEB) , ... July 01, 2015 , ... ... national sales training leaders Lora Posey (Manager, National Sales Training and Development) and ... and Educators Network (LTEN) Conference in Phoenix, AZ. LTEN brings together learning and ...
(Date:7/1/2015)... , ... July 01, 2015 , ... As if mood ... found in a significant number of women: leg pain. Northeast Houston Vein Center is ... pain, a symptom of venous reflux disease, is underdiagnosed and often overlooked. Many women ...
(Date:7/1/2015)... Louisville, KY (PRWEB) , ... July 01, 2015 ... ... Health Care Transformation Task Force, contributing to newly released white paper: “Pro-actively Identifying ... The paper was published July 1st and is available at: http://www.hcttf.org/resouces-tools . ...
(Date:7/1/2015)... FL (PRWEB) , ... July 01, 2015 , ... ... of premium delicatessen products, is helping families get ready for Independence Day celebrations ... sweet sliders, these easy and versatile options are perfect for any summertime get ...
Breaking Medicine News(10 mins):Health News:The Collaborative for Children and Families Receives a Grant From The New York Community Trust to Build Capacity for Comprehensive Child Welfare 2Health News:The Collaborative for Children and Families Receives a Grant From The New York Community Trust to Build Capacity for Comprehensive Child Welfare 3Health News:Mission Pharmacal Company: Alamo Pharma Services' Training Leaders Take Steps to Further Expand Capabilities for Mission Pharmacal and Other Clients 2Health News:Mission Pharmacal Company: Alamo Pharma Services' Training Leaders Take Steps to Further Expand Capabilities for Mission Pharmacal and Other Clients 3Health News:Mission Pharmacal Company: Alamo Pharma Services' Training Leaders Take Steps to Further Expand Capabilities for Mission Pharmacal and Other Clients 4Health News:Northeast Houston Vein Center Offers Tips for Women with Leg Pain 2Health News:Northeast Houston Vein Center Offers Tips for Women with Leg Pain 3Health News:A Population Based Approach to Pay for Value: RowdMap, Inc. Contributes to Health Care Transformation Task Force White Paper 2Health News:A Population Based Approach to Pay for Value: RowdMap, Inc. Contributes to Health Care Transformation Task Force White Paper 3Health News:Boar’s Head Helps Craft a Delicious Independence Day 2Health News:Boar’s Head Helps Craft a Delicious Independence Day 3
... well in certain people, without the risks , WEDNESDAY, ... renal arteries fare just as well when treated with ... opened and a stent implanted, British researchers report. , ... with severe hypertension -- there is no benefit from ...
... ... with an addiction to cocaine. They were also desperate pioneers whose drug use ... to a double-blind, placebo-controlled study to test whether an epilepsy drug could reduce ... were taking a medicine called vigabatrin spent the final three weeks of the ...
... USTeleradiology, LLC,s reaccreditation survey by The Joint Commission was ... Commission accreditation - the gold standard within the health ... "UST has experienced significant growth over the past few ... of our clients, the dedication of our physicians, and ...
... Ingenious Med is partnering with Children,s Restoration Network (CRN) to ... living in group homes and shelters. , CRN kicked ... stock 129 shelters with basic needs as well as holiday ... host these food drives throughout Atlanta. Ingenious Med has ...
... have devised an innovative way to disarm a key protein ... develop a drug against it have failed. Their discovery, published ... the foundation for a new kind of therapy aimed directly ... thousand so-called transcription factors that could someday be used ...
... or using wireless technologies might help, experts say , ... dyslexia may not be able to focus on the ... lockers, scraping chairs and other auditory distractions, a U.S. ... spelling skills in 5 to 10 percent of school-age ...
Cached Medicine News:Health News:Surgery Not Always Best for Narrowed Kidney Arteries 2Health News:Surgery Not Always Best for Narrowed Kidney Arteries 3Health News:Anti-Epileptic Drug Curbs Cocaine Use in First Study Comparing Placebo Dose 2Health News:Anti-Epileptic Drug Curbs Cocaine Use in First Study Comparing Placebo Dose 3Health News:Anti-Epileptic Drug Curbs Cocaine Use in First Study Comparing Placebo Dose 4Health News:USTeleradiology Retains Joint Commission Accreditation 2Health News:Ingenious Med Partners with Children's Restoration Network for Holiday Charity 2Health News:Researchers 'notch' a victory toward new kind of cancer drug 2Health News:Researchers 'notch' a victory toward new kind of cancer drug 3Health News:Dyslexia May Make It Tough to Tune Out School Noise 2
(Date:7/1/2015)... Pharma, Inc. (Nasdaq: MEIP ), an oncology company focused ... today that Daniel P. Gold , Ph.D., President and ... Healthcare Conference on Wednesday, July 8, 2015 at 8:30 a.m. ... New York . A live webcast of the ... will be available approximately one hour after the presentation. ...
(Date:7/1/2015)... , July 1, 2015 According ... Equipment Market by Method (Biochemical (Calcium Phosphate, Lipofection, Dendrimers), ... - Analysis & Global Forecast to 2020", published by ... to reach around $957.9 Million by 2020 with a ... Browse 116 market T ables and 33 ...
(Date:7/1/2015)... 1, 2015  Genoa has acquired West Bend Assisted ... another pharmacy location with a proven track record for ... residential settings, and those involved in their care. Both ... and delivering true value to their customers. ... provider of pharmacy services dedicated to the behavioral health ...
Breaking Medicine Technology:MEI Pharma to Present at Cantor Fitzgerald Healthcare Conference 2Transfection Reagents and Equipment Market Worth $957.9 Million by 2020 2Transfection Reagents and Equipment Market Worth $957.9 Million by 2020 3Transfection Reagents and Equipment Market Worth $957.9 Million by 2020 4Genoa, a QoL Healthcare Company Acquires West Bend Assisted Living Pharmacy 2
... 20, 2011 Reportlinker.com announces that ... available in its catalogue: ... (HRT) - Pipeline Assessment and Market ... http://www.reportlinker.com/p0617091/Post-Menopausal-Hormone-Replacement-Therapy-HRT---Pipeline-Assessment-and-Market-Forecasts-to-2018.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Therapy ...
... The American Pharmacists Association (APhA) is encouraging ... with their pharmacist about the options available at their ... in all 50 states, D.C. and Puerto Rico, and ... the practice of immunization administration. The CDC estimates that ...
Cached Medicine Technology:Post-Menopausal Hormone Replacement Therapy (HRT) - Pipeline Assessment and Market Forecasts to 2018 2Post-Menopausal Hormone Replacement Therapy (HRT) - Pipeline Assessment and Market Forecasts to 2018 3Post-Menopausal Hormone Replacement Therapy (HRT) - Pipeline Assessment and Market Forecasts to 2018 4Post-Menopausal Hormone Replacement Therapy (HRT) - Pipeline Assessment and Market Forecasts to 2018 5Post-Menopausal Hormone Replacement Therapy (HRT) - Pipeline Assessment and Market Forecasts to 2018 6Post-Menopausal Hormone Replacement Therapy (HRT) - Pipeline Assessment and Market Forecasts to 2018 7Post-Menopausal Hormone Replacement Therapy (HRT) - Pipeline Assessment and Market Forecasts to 2018 8Post-Menopausal Hormone Replacement Therapy (HRT) - Pipeline Assessment and Market Forecasts to 2018 9Nation's Pharmacists Ready to Administer Seasonal Flu Vaccines 2Nation's Pharmacists Ready to Administer Seasonal Flu Vaccines 3
... Mx8000 IDT 10 offers premium-level performance with a ... any other systems in the 8- and 10-slice ... second rotation time, and submillimeter isotropic imaging set ... and a simple upgrade to a 16-slice system ...
... The PLIF instrument set consists of ... with nerve root protectors, for bone ... allograft bone blocks of the Lumbar ... channel preparation which is important for ...
... The Pyrametrix Plus instrument system is ... space preparation and removal. The set is ... fusion (TLIF) procedure more reproducible by providing ... reamers to prepare the disc space. This ...
... insertion assembly incorporates slotted guides for ... The PathFinder MIS System uses an ... screw insertion assembly incorporates crescent-shaped slotted ... evolutionary Pathfinder MIS pedicle screw system ...
Medicine Products: