Navigation Links
Molecular signatures may aid fight against pediatric liver disease

Researchers have identified a set of "molecular signatures" for biliary atresia the most common diagnosis leading to liver transplant in children that can help identify the progression of disease at diagnosis and predict clinical outcomes.

The Cincinnati Children's Hospital Medical Center scientists found that using traditional methods to analyze liver biopsies, only 14 of 47 infants with biliary atresia could be identified as having either inflammation or fibrosis (development of excess fibrous connective tissue). By examining the expression of the entire genome in the liver, the researchers developed a molecular signature that could classify the vast majority of the patients as inflamed or fibrotic.

"This suggests that the molecular profile at diagnosis may determine the 'stage' of liver disease through specific biological pathways that are not easily distinguishable by standard approaches," says Jorge Bezerra, M.D., a gastroenterologist at Cincinnati Children's and senior author of the study. "Infants with inflammation were younger, indicating that inflammation may reflect an earlier stage of disease particularly given that those with fibrosis had decreased survival without transplant."

The researchers hope that, given the ability to identify how disease will progress, current treatments can be tailored to the stage of the liver disease and that new treatments can be developed.

Biliary atresia is a rare disease of the liver and bile ducts that occurs in infants. Symptoms of the disease appear or develop about two to eight weeks after birth. When a baby has biliary atresia, bile flow from the liver to the gallbladder is blocked. This causes the bile to be trapped inside the liver, eventually causing liver failure.


Contact: Jim Feuer
Cincinnati Children's Hospital Medical Center

Page: 1

Related medicine news :

1. Smoking-related colorectal cancer in older women is associated with molecularly-defined DNA changes
2. SNMs 2010 Annual Meeting reveals latest developments in molecular imaging and nuclear medicine
3. SNM 2010 image of the year: Molecular imaging shows parathyroid disease in greater detail
4. Molecular Devices Relaunches with HiveMind Marketing
5. Molecular imaging detects recurrent prostate cancer
6. Molecular Signatures in Post-Mortem Brain Tissue of Younger Individuals at High Risk for Alzheimer's Disease
7. Molecular imaging and CT colonography team up to bring comfort to patients
8. Acupunctures molecular effects pinned down
9. Salt Lake City proclaims Molecular Imaging Days during SNMs Annual Meeting in June
10. Scientists discover the molecular heart of collective behavior
11. News from Molecular Medicine
Post Your Comments:
(Date:11/24/2015)... Los Angeles, CA (PRWEB) , ... November 24, 2015 , ... ... author explored the different restrictions and variables that determine which patients are or are ... are those patients that have a BMI over 40, are more than 100 pounds ...
(Date:11/24/2015)... ... November 24, 2015 , ... It takes only three to five seconds to ... that the first impression be positive and reflects business values. If a client starts ... or want to return. They will also share their thoughts about a business with ...
(Date:11/24/2015)... ... November 24, 2015 , ... Cancer patients, survivors, caregivers, ... at a live taping of the next CURE Connections® video series ... Cancers 2015 Symposium at Georgetown University Hotel & Conference Center in Washington, D.C. ...
(Date:11/24/2015)... ... November 24, 2015 , ... Aided by seed funding ... an innovative study designed to yield insights into how to detect and treat pancreatic ... for pancreatic cancer from small, non-coding RNA molecules (ncRNA), genetic material that is present ...
(Date:11/24/2015)... ... 24, 2015 , ... Sir Grout of Baltimore is proud ... The award recognizes good companies for excellence in service and a commitment to ... hard surface restoration company earned this recognition after a thorough review by the ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... LONDON , November 24, 2015 ... PCSK9 Inhibitors, CETP Inhibitors, MTTP Inhibitors, ApoB Inhibitors and ... areas are going to grow at the fastest rates? ... to 2025, assessing data, trends, opportunities and prospects there. ... graphs. Discover the most lucrative areas in the industry ...
(Date:11/24/2015)... , UAE, November 24, 2015   ... and dietician deliver s advice and ...   More than 50% of ... to keep themselves healthy according to the DHA   femMED ... in the UAE    Dubai residents are not ...
(Date:11/24/2015)... , Nov. 24, 2015  Eyewear brand Revo ... collaboration with U2 lead singer and activist Bono as part ... prevent vision impairment and blindness in more than 5 million ... Revo will donate $10 from the sale of every ... up to a total of $10 million to the "Buy ...
Breaking Medicine Technology: