Navigation Links
Molecular signatures may aid fight against pediatric liver disease
Date:6/30/2010

Researchers have identified a set of "molecular signatures" for biliary atresia the most common diagnosis leading to liver transplant in children that can help identify the progression of disease at diagnosis and predict clinical outcomes.

The Cincinnati Children's Hospital Medical Center scientists found that using traditional methods to analyze liver biopsies, only 14 of 47 infants with biliary atresia could be identified as having either inflammation or fibrosis (development of excess fibrous connective tissue). By examining the expression of the entire genome in the liver, the researchers developed a molecular signature that could classify the vast majority of the patients as inflamed or fibrotic.

"This suggests that the molecular profile at diagnosis may determine the 'stage' of liver disease through specific biological pathways that are not easily distinguishable by standard approaches," says Jorge Bezerra, M.D., a gastroenterologist at Cincinnati Children's and senior author of the study. "Infants with inflammation were younger, indicating that inflammation may reflect an earlier stage of disease particularly given that those with fibrosis had decreased survival without transplant."

The researchers hope that, given the ability to identify how disease will progress, current treatments can be tailored to the stage of the liver disease and that new treatments can be developed.

Biliary atresia is a rare disease of the liver and bile ducts that occurs in infants. Symptoms of the disease appear or develop about two to eight weeks after birth. When a baby has biliary atresia, bile flow from the liver to the gallbladder is blocked. This causes the bile to be trapped inside the liver, eventually causing liver failure.


'/>"/>

Contact: Jim Feuer
jim.feuer@cchmc.org
513-636-4656
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1

Related medicine news :

1. Smoking-related colorectal cancer in older women is associated with molecularly-defined DNA changes
2. SNMs 2010 Annual Meeting reveals latest developments in molecular imaging and nuclear medicine
3. SNM 2010 image of the year: Molecular imaging shows parathyroid disease in greater detail
4. Molecular Devices Relaunches with HiveMind Marketing
5. Molecular imaging detects recurrent prostate cancer
6. Molecular Signatures in Post-Mortem Brain Tissue of Younger Individuals at High Risk for Alzheimer's Disease
7. Molecular imaging and CT colonography team up to bring comfort to patients
8. Acupunctures molecular effects pinned down
9. Salt Lake City proclaims Molecular Imaging Days during SNMs Annual Meeting in June
10. Scientists discover the molecular heart of collective behavior
11. News from Molecular Medicine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/17/2017)... ... ... Pot Valet is a leading provider of premium medical-grade cannabis in California. ... soon, every state in the country, the company offers patients safe, legal, and discreet ... , According to Pot Valet, all California patients have the legal right to ...
(Date:8/17/2017)... (PRWEB) , ... August 17, 2017 , ... ... Great Employers , an international competition, were announced today. The awards recognize the ... and suppliers who help to create and drive great places to work. , ...
(Date:8/16/2017)... , ... August 16, 2017 , ... The next Patient ... being accepted. , Students who successfully complete the seven-week long Patient Care Academy ... Assistant (CNA). The average starting salary for a CNA in Kalamazoo is $24,428.* , ...
(Date:8/16/2017)... Houston, Texas (PRWEB) , ... August 16, 2017 , ... ... Community Credit Union's Stars in the Classroom and will win a visit by a ... in grades K-12 who are at least five years old can visit texanschecking.com/stars to ...
(Date:8/16/2017)... ATLANTA, Georgia (PRWEB) , ... August 16, 2017 ... ... practice in Atlanta, opened their doors. They celebrate 30 years in business this ... to create an up-to-date, inviting, tranquil space to serve their patients. , ...
Breaking Medicine News(10 mins):
(Date:8/15/2017)... Inc., the creator of the drug Truveta for the treatment ... IPO. The United States spends approximately ... prescription epilepsy drug being $450.00-$1200.00 for a one month supply. ... AXIUM PHARMACEUTICALS, INC ... is the fact that Americans spent $42 billion on anxiety medications last ...
(Date:8/11/2017)... , Aug. 11, 2017 DarioHealth Corp. (NASDAQ: ... health and big data solutions, today announced that it ... August 14 and host a conference call at 9:00am ... operating and financial results and its strategy and outlook ... hosted by Erez Raphael , Chief Executive Officer, ...
(Date:8/7/2017)... 7, 2017 Insightin Health, provider of ... and engagement, announced the selection of Michael ... Development, effective as of February 2017. In this role, ... strategy for our clients. Wood brings with him ... and business analytics within the healthcare industry. Wood ...
Breaking Medicine Technology: