Navigation Links
Molecular profiling can accurately predict survival in colon cancer patients
Date:9/25/2007

ver three times (3.2) more likely to develop metastases than the patients in the good outcome group. This method of identifying poor outcome patients was better at predicting which patients should have adjuvant chemotherapy than the commonly-used method that follows recommendations from the American Society of Clinical Oncology (ASCO).

The researchers checked their findings against information from another set of colon cancer patients that had been published in the Journal of Clinical Oncology in 2005. Prof Tollenaar said: In these stage II colon cancer patients, the five-year metastasis-free survival prediction was confirmed; for the good outcome group, five-year survival was 90% and for the poor outcome group it was 40%. This was important validation of our own results.

From the genome-wide analysis, the researchers identified a subset of 100 genes that were able to predict outcome equally as well as the full-genome molecular expression profile. Many of these genes are know to regulate the Epithelial-Mesenchymal transition (EMT) a programme of cell development that is thought to be a driving force behind the development of metastases in colorectal cancer.

Prof Tollenaar said that although his research predicted outcome of disease in patients who had not received adjuvant chemotherapy, more work would need to be done to identify the molecular profile for those patients who would actually benefit from chemotherapy.

Before the results of this research could start to be used in the clinic, Prof Tollenaar said two things needed to happen: Current, ongoing validation studies required to confirm our findings have to be completed, and the test needs to be developed into a robust diagnostic device. The molecular profiling company Agendia BV of Amsterdam has taken this up and it is likely to be available in early 2008.

As to whether these findings would save large numbers of colon cancer patients from unnecessary chemotherapy,
'/>"/>

Contact: Emma Mason
wordmason@mac.com
34-932-308-834
ECCO-the European CanCer Conference
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Molecular markers for early diagnosis of breast and ovarian cancer
2. Scientists Developed Map For Brain Molecular Communities
3. Molecular Mechanism Of HIV Infecting The Healthy Cells Discovered.
4. Molecular Flaw Detected in Aggressive Breast Cancers
5. Molecular Computer Developed To perform Calculations From Within Human Body
6. Lung cancer molecular profile discovered by researchers.
7. Molecular Imaging Of Cancer Now Possible, New Hybrid Virus Produced
8. Molecular Basis Of ALS Found
9. New Molecular Treatment Identified To Treat Blood Cell Cancers
10. Researchers Find Molecular "Brake" to Cell Death
11. Solitons Could Power Molecular Electronics, Artificial Muscles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2015)... It’s not all about the law at the ... a civil litigation and plaintiff’s personal injury lawyer that has ... networks, it’s also about giving back to the community. ... Hutchinson Cancer Research Center Innovator’s Network. , “I believe there ... and lawyers can and do good community-focused work in their ...
(Date:4/28/2015)... April 28, 2015 Wimbledon Health ... provides vascular, electrocardiogram, echocardiogram, and NCV testing, has ... testing to help podiatrists diagnose peripheral arterial disease ... diagnose PAD without the aid of vascular testing,” ... Officer at Wimbledon Health Partners. “Diminished peripheral ...
(Date:4/28/2015)... April 28, 2015 “ Gwee ” ... Tech Report, which features the latest and coolest technology ... and special reporter for NewsWatch, conducted the review and ... iPad case. , As much as everyone loves their ... screen. Aside from looking at them, it's even more ...
(Date:4/28/2015)... Henderson, NV (PRWEB) April 28, 2015 ... University's Center for Ethics (June 27, 2014), prescription ... the world. Medical Science is becoming increasingly aware of ... on the market, such as chemotherapy drugs to treat ... bacteria that are quickly evolving to become increasingly resistant ...
(Date:4/28/2015)... PREVENT Life Safety, Inc., America’s premier ... of their Southern California offices from Orange, California to ... Unit I (letter I), Rancho Cucamonga, CA, 91730, is ... by the significant growth the company has realized in ... continue to provide superior life safety services, including fire ...
Breaking Medicine News(10 mins):Health News:Seattle Attorney Paul Schneiderman Helping to Combat Cancer 2Health News:Podiatrists Affiliate with Wimbledon Health Partners to Diagnose Peripheral Arterial Disease 2Health News:The Most Innovative iPad Case was Featured on NewsWatch Television 2Health News:Trivedi Science™ Announces the Beginning of Their Science Research to Create Highly Effective Pharmaceutical Drugs with Minimal Side Effects 2Health News:Trivedi Science™ Announces the Beginning of Their Science Research to Create Highly Effective Pharmaceutical Drugs with Minimal Side Effects 3Health News:Trivedi Science™ Announces the Beginning of Their Science Research to Create Highly Effective Pharmaceutical Drugs with Minimal Side Effects 4Health News:PREVENT Life Safety Moves to New Office in Rancho Cucamonga 2
... 15, 2010) -- Next week the city of Philadelphia ... Association of Physicists in Medicine (AAPM), the premier organization ... encompassing physics principles and applications in medicine and biology. ... meeting are focused on patient safety -- tailoring therapy ...
... as soldiers in 86 countries across the globe, almost ... how these children adjust after they return to their ... the characteristics of the communities to which the children ... former child soldiers from Sierra Leone who lived in ...
... Barcelona, Spain Today during the 88th General Session ... in Barcelona, Spain, presenting author S. Pradhani, University of ... Acinar Cells Regenerate Functional Glandular Structures in Modified Hydrogels." ... an ECM modified hyaluronic acid (HA) based hydrogel culture ...
... CHAPEL HILL Dozens of UNC researchers are heading ... AIDS conference this week. The International AIDS Society ... to discuss progress and chart a course for stemming ... Bill Clinton will address an estimated 25,000 attendees at ...
... By Karen Pallarito HealthDay Reporter , ... readmitted within 30 days of a hospital stay, it ... and wasteful spending on the hospital,s part. ... Cleveland Clinic researchers challenge that conventional wisdom. Their calculations ...
... has selected five physicians as recipients of two ... the Junior Faculty Career Research Training Award and ... Award. Winners were selected by ASTRO,s Research Evaluation ... Award is awarded to stimulate interest in radiation ...
Cached Medicine News:Health News:Patient safety highlights American Association of Physicists in Medicine 2Health News:Patient safety highlights American Association of Physicists in Medicine 3Health News:Patient safety highlights American Association of Physicists in Medicine 4Health News:Patient safety highlights American Association of Physicists in Medicine 5Health News:Patient safety highlights American Association of Physicists in Medicine 6Health News:Patient safety highlights American Association of Physicists in Medicine 7Health News:Patient safety highlights American Association of Physicists in Medicine 8Health News:Patient safety highlights American Association of Physicists in Medicine 9Health News:Patient safety highlights American Association of Physicists in Medicine 10Health News:Patient safety highlights American Association of Physicists in Medicine 11Health News:Patient safety highlights American Association of Physicists in Medicine 12Health News:Patient safety highlights American Association of Physicists in Medicine 13Health News:Patient safety highlights American Association of Physicists in Medicine 14Health News:Patient safety highlights American Association of Physicists in Medicine 15Health News:Patient safety highlights American Association of Physicists in Medicine 16Health News:Studies explore effects of war on former child soldiers 2Health News:Studies explore effects of war on former child soldiers 3Health News:Studies explore effects of war on former child soldiers 4Health News:New research explores relief for xerostomia cancer patients 2Health News:International AIDS conference features UNC work 2Health News:High Readmission Rates May Not Mean Worse Hospital Care 2Health News:High Readmission Rates May Not Mean Worse Hospital Care 3Health News:5 awarded ASTRO research grants 2
(Date:4/28/2015)... , April 28, 2015 /CNW/ - The group representing the ... drug tragedy left a two-hour meeting with Health Canada ... March 6th, Health Canada announced a $180 million support ... than six weeks after the Health Canada announcement and ... fully support the victims, the group representing ...
(Date:4/28/2015)... Israel , April 28, 2015 ... in its sixth funding cycle for U.S.- Israel ... and Energy Efficiency. To be considered, a project ... between a company and a university/research institution (one from the ... proposal should have significant commercial potential and the project outcome ...
(Date:4/27/2015)... Intarcia Therapeutics, Inc. today announced the closing of ... conversion option at a $5.5 billion Company valuation. Plans ... of additional head-to-head comparative and switch studies of ITCA ... therapies. In addition, proceeds from the financing will fund ... 650 in the United States , ...
Breaking Medicine Technology:Thalidomide Victims Gravely Concerned by Health Canada's Silence 2Opportunities for Funding U.S.-Israel Cooperation for Renewable Energy and Efficiency 2Intarcia Therapeutics Closes Novel $225 Million Synthetic Royalty Financing With Equity Conversion Option At $5.5 Billion Valuation 2Intarcia Therapeutics Closes Novel $225 Million Synthetic Royalty Financing With Equity Conversion Option At $5.5 Billion Valuation 3
... , , PITTSBURGH, Jan. 11 ... global, private High-Definition broadcasting network, has engineered a ... for world-renowned pharmaceutical and medical device companies. ... Novartis, Shire, Schering-Plough, Bristol-Myers Squib, Cardiovascular Research Foundation ...
... Maine, Jan. 11 IDEXX Laboratories, Inc. (Nasdaq: ... of 2,000 Catalyst Dx® chemistry analyzers in 2009, bringing ... in the first quarter of 2008, is a next ... integrated suite of analyzers and significantly expands the range ...
Cached Medicine Technology:VELOCITY Broadcasting Injects ROI into Pharmaceutical Sector by Engaging Medical Professionals with Experiential High-Definition Broadcast Events 2VELOCITY Broadcasting Injects ROI into Pharmaceutical Sector by Engaging Medical Professionals with Experiential High-Definition Broadcast Events 3IDEXX Laboratories Announces Catalyst Dx(R) Placement Total for 2009 and Installed Base of SmartService(TM) Customers 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
Medicine Products: