Navigation Links
Molecular probe 'paints' cancer cells in living animals, Stanford researchers find
Date:9/9/2007

d.

And unlike most other molecular probes, this type identifies only active enzymes. "We went one step beyond just telling if the enzymes are there. We can answer the question, 'Are they active"' That's important because an accumulation of inactive enzymes doesn't necessarily indicate disease," Blum said.

Bogyo, Blum and colleagues designed the probe to bind to a subset of a family of proteases called cysteine cathepsins, which are more active in several types of cancer as well as other diseases. Now they are tinkering with the probe's configuration in an effort to create a variant that recognizes the enzymes involved in apoptosis, the process of cell death. This could ultimately allow researchers and doctors to visualize response to chemotherapy in tumors, Bogyo said.

And because other diseases besides cancer involve hyped-up proteases - such as Alzheimer's, arthritis, atherosclerosis and osteoporosis - the approach might be of use in diagnosing and treating them as well.

The work went surprisingly smoothly because of Blum's background in chemistry as well as biology. Using her chemistry skills, she created the probes. Then she switched to biology mode and tested them. When she discovered that an earlier version of the probe worked great in tissue culture but decomposed on contact with mouse blood, she was able to tweak the molecule's structure to survive inside a living animal.

In addition to the potential health-care applications, the approach provides a valuable research tool, the researchers said. "It allows you to see exactly where enzymes are active within living animals," said Bogyo.

The Stanford researchers' ultimate goal is to test it in humans, though they'll complete more testing in animals before requesting permission from the U.S. Food and Drug Administration to conduct a human trial. "Since there are currently no fluorescent imaging agents in use in humans, the approval process is likely to requir
'/>"/>

Contact: Rosanne Spector
manishma@stanford.edu
650-725-5374
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Molecular markers for early diagnosis of breast and ovarian cancer
2. Scientists Developed Map For Brain Molecular Communities
3. Molecular Mechanism Of HIV Infecting The Healthy Cells Discovered.
4. Molecular Flaw Detected in Aggressive Breast Cancers
5. Molecular Computer Developed To perform Calculations From Within Human Body
6. Lung cancer molecular profile discovered by researchers.
7. Molecular Imaging Of Cancer Now Possible, New Hybrid Virus Produced
8. Molecular Basis Of ALS Found
9. New Molecular Treatment Identified To Treat Blood Cell Cancers
10. Researchers Find Molecular "Brake" to Cell Death
11. Solitons Could Power Molecular Electronics, Artificial Muscles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/30/2015)... ... July 30, 2015 , ... In an effort to ... Dr. Aggarwal is making a change in his practice. , The decision will also ... 14, 2015, Dr. Aggarwal will be transferring his in-patient admissions to the hospitalists at ...
(Date:7/30/2015)... New York, NY (PRWEB) , ... July 30, ... ... with Setria®Glutathione and Sustamine® L-Alanyl-L-Glutamine for people on the go. With no water ... Zaca Recovery Chewable as a simple way to get the natural ingredients that ...
(Date:7/30/2015)... ... 30, 2015 , ... Mullin/Ashley Associates, Inc. , an ... in the Service Industry Advertising Awards 12th annual national competition. , The ... and University of Maryland Shore Regional Health. , A Gold Award was won ...
(Date:7/30/2015)... (PRWEB) , ... July 30, 2015 , ... ... consistently growing into one of the largest, family-owned low cost service and repair ... and commercial applications, as well as growing their company to meet the demands ...
(Date:7/30/2015)... (PRWEB) , ... July 30, 2015 , ... 24/7 Care ... Angeles, Riverside, and San Bernardino, recently announced that the Centers for Medicare and Medicaid ... system of home health care providers. 24/7 Care At Home’s agency is one of ...
Breaking Medicine News(10 mins):Health News:River Valley Physician Dr. Aggarwal is Making Changes to his Practice 2Health News:Zaca Life Introduces Recovery Chewable Packets with Setria® Glutathione and Sustamine® L-Alanyl-L-Glutamine 2Health News:Zaca Life Introduces Recovery Chewable Packets with Setria® Glutathione and Sustamine® L-Alanyl-L-Glutamine 3Health News:Zaca Life Introduces Recovery Chewable Packets with Setria® Glutathione and Sustamine® L-Alanyl-L-Glutamine 4Health News:Mullin/Ashley Associates Takes Home Wins for Three Clients in the Service Industry Advertising Awards Annual Competition 2Health News:Mullin/Ashley Associates Takes Home Wins for Three Clients in the Service Industry Advertising Awards Annual Competition 3Health News:Bill Howe Plumbing, Heating & Air Launches Online Application to Prospective Employees 2Health News:Bill Howe Plumbing, Heating & Air Launches Online Application to Prospective Employees 3Health News:24/7 Care At Home Earns a 5-Star Rating from the Centers for Medicare and Medicaid (CMS) 2
... 1 Edifecs announced today a ... that providers, payers, clearinghouses and other healthcare stakeholders will ... In these sessions, Edifecs will offer guidance and ... -- a comprehensive set of products, online services, resources ...
... climate change and semi-arid regions turn to desert, people ... to be displaced. A mathematical approach to planned relocation ... Operational Research . , Decision scientist Sajjad Zahir at ... Sarker of the University of New South Wales, Canberra, ...
... and TAMPA, Fla., April 1 Stem Cell Biotherapy ... Los Angeles County Superior Court against the Company,s Co-Founder ... among other things conduct by Nabavi giving rise to ... as a medical doctor, practiced medicine without a license, ...
... Independent Online Retailer of Beauty and Skin-Care Products ... Sandow Media, parent company of NewBeauty ... Salu Beauty, parent company of SkinStore.com, today announced ... for beauty product manufacturers. This powerful new alliance ...
... April is National STD Awareness Month , HARRISBURG, Pa., ... Pennsylvanians of the continuing need for men and women ... transmitted diseases, or STDs, as well as the importance ... care providers. "Although many STDs are treatable, screening and ...
... Inverness Medical Innovations, Inc. (NYSE: IMA ), ... their health at home through the merger of rapid diagnostics ... MS, FACOG, was elected to the company,s board of directors. ... in Health Care and in the Life Sciences was also ...
Cached Medicine News:Health News:Edifecs Launches First of a Series of Edifecs5010(TM) Migration Educational Webinars Addressing 5010 Migration Challenges, Opportunities and Solutions 2Health News:Edifecs Launches First of a Series of Edifecs5010(TM) Migration Educational Webinars Addressing 5010 Migration Challenges, Opportunities and Solutions 3Health News:Relocation, relocation, relocation 2Health News:Stem Cell Biotherapy Sues Casey Nabavi, Co-Founder and Former President, for Conduct Resulting in Claims by SCB Patients Against Nabavi, Embezzling Money and Converting Other Assets Belonging to SCB and for Wrongfully Establishing Cellulogix Biosciences t 2Health News:NewBeauty Magazine and SpaLook.com Create Strategic Alliance With Salu Beauty and SkinStore.com 2Health News:NewBeauty Magazine and SpaLook.com Create Strategic Alliance With Salu Beauty and SkinStore.com 3Health News:Pennsylvania Department of Health Urges Greater Awareness of, Testing for Sexually Transmitted Diseases 2Health News:Eli Y. Adashi, MD, MS, FACOG, Joins Inverness Medical Innovations' Board of Directors 2
(Date:7/30/2015)...  ResMed Inc. (NYSE: RMD ) today announced ... for the quarter was $453.1 million, a 9 percent ... (a 17 percent increase on a constant currency basis). ... ended June 30, 2014.  Diluted earnings per share for ... June 30, 2014.  The results for ...
(Date:7/30/2015)... bring you a special edition of #MedicareMonday on Medicare,s 50 th anniversary. As ... resources and continue highlighting the success of the prescription drug benefit, commonly referred to ... our latest infographics and videos here: http://onphr.ma/1INp9qQ ... ... ...
(Date:7/30/2015)... OAKS, Calif., July 30, 2015  Amgen (NASDAQ: ... the second quarter of 2015. Key results include: ... the second quarter of 2014 to $5,370 million, ... by Enbrel ® (etanercept), Prolia ® ... (carfilzomib) and XGEVA ® (denosumab). Unfavorable changes ...
Breaking Medicine Technology:ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 2ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 3ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 4ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 5ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 6ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 7ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 8ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 9ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 10ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 11ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 12ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 13ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 14ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 15ResMed Inc. Announces Results for the Fourth Quarter and Fiscal Year 2015 16Happy 50th Anniversary Medicare! 2Happy 50th Anniversary Medicare! 3Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 2Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 3Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 4Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 5Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 6Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 7Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 8Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 9Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 10Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 11Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 12Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 13Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 14Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 15Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 16Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 17Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 18Amgen's Second Quarter 2015 Revenues Increased 4 Percent To $5.4 Billion And Adjusted Earnings Per Share (EPS) Increased 8 Percent To $2.57 19
... and FARGO, N.D., Dec. 16, 2011  Crystal3 Labs, Inc., a ... FL, announced today that it has been acquired by ... Financial terms of the transaction were not disclosed. The ... Pharma Analytics. Founded in 2007, Global Pharma ...
... 2011 Ekahau Inc. the leading global provider ... and KARL STORZ GmbH & Co. KG, the endoscopy specialist, ... Clinic in Berlin has successfully deployed and is using the ... and Ekahau RTLS for automatic real-time management of ...
Cached Medicine Technology:Crystal3 Labs Acquired by Individual Investor, Vithalbhai Dhaduk, M.D. 2Hospital Operating Rooms are now Optimized in Real-time With a Joint Solution From Karl Storz and Ekahau 2Hospital Operating Rooms are now Optimized in Real-time With a Joint Solution From Karl Storz and Ekahau 3Hospital Operating Rooms are now Optimized in Real-time With a Joint Solution From Karl Storz and Ekahau 4
... Transfer an Entire Column of a 384 Well ... throughput with 384 well plates, you need a ... spacing. Thats exactly what you get with our ... software (see Impact/Impact2), this innovation was specifically designed ...
... CS and Alliance Catheter Delivery ... the introduction of catheters or ... from a superior approach. These ... outstanding peel-away introducer performance with ...
The AXIUS™ Blower/Mister provides controlled delivery of CO2 and saline to improve visibility during anastomosis....
... Biliary Self-Expanding Stent System combines low-profile, high radial ... .018" guide wire compatible stent system provides 6F ... diameters (5.0 - 10.0 mm). Now, with longer ... in five stent lengths (28, 38, 56, 80 ...
Medicine Products: