Navigation Links
Molecular pathways linked to sex, age affect outcomes in lung cancer
Date:2/9/2010

in the tumors, then selected twelve of the most common molecular pathways that become dysregulated in NSCLC. The goal was to identify any patterns linking the pathways to age, sex and time to recurrence. They sorted the patients by age and sex and then again into low- and high-risk groups, based on five-year, recurrence-free survival.

They found that certain molecular pathways were more frequently activated in some groups than others and that certain pathway patterns were associated with better long-term survival in patients with lung cancer. Specifically, they found that:

  • High-risk patients those with the shortest time to recurrence were significantly more likely to have increased activation of the pathways responsible for tumor metastasis and necrosis, when compared with low-risk patients.
  • High-risk patients 70 or older were found to have higher activation of pathways regulating blood supply and invasiveness.
  • In comparing high-risk women to high-risk men, they found that men were more likely to have a much more complex pattern of multiple pathways being activated than women with the same type of lung cancer.

The study also identified a subset of patients over age 70 who had a low-risk profile, meaning the molecular pathways activated in their tumors would likely give them a better chance at long-term survival. Potti says that's important because people over age 70 are generally not included in many clinical trials and physicians often hesitate to offer them the option of conventional chemotherapy. "The thinking has been that they may not withstand the treatment or benefit from it much. But now we know that it probably makes sense to consider treating this population, by risk-stratifying the disease," says Potti.

Potti says it is likely that there are additional cancer-promoting pathways that are involved in the development and progression of NSCLC and adds that these findings must be validated in oth
'/>"/>

Contact: Michelle Gailiun
michelle.gailiun@duke.edu
919-660-1306
Duke University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Ground Breaking Molecular Diagnostics Business Appoints New CEO
2. Select Topics in ALL: Molecular Characterization, Approaches to CNS Disease, and Post-remission Transplantation
3. Scientists show how molecular switch helps pancreatic cancer beat drugs
4. News from the Latest Issue of Molecular Medicine
5. The Institut Curie and Ipsogen Sign a Scientific Collaboration Agreement Relating to the Genomic Grade, a Molecular Diagnostic Tool for Breast Cancer
6. Scientists Find Molecular Switch Related to Huntingtons
7. Seven World Leading IT Companies to Sponsor and Speak at CHI's Adopting R&D Informatics Systems, part of 17th International Molecular Medicine Tri-Conference
8. New England Journal of Medicine publishes CWRU review of the molecular basis of colorectal cancer
9. Scientists find molecular trigger that helps prevent aging and disease
10. CHI's Molecular Medicine Tri-Conference Keynote John Crowley Inspires Feature Film Starring Harrison Ford
11. News from the November/December Issue of Molecular Medicine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... FRIDAY, Dec. 19, 2014 (HealthDay News) -- U.S. and ... to caramel apples that has killed at least four ... Consumers should not eat any commercially produced, prepackaged caramel ... for Disease Control and Prevention said in a news ... 28 people had been infected with the outbreak strains ...
(Date:12/22/2014)... 2014 Physicians in China are most ... treatment of non-Hodgkin’s lymphoma (NHL), according to a new ... healthcare consulting firm. MabThera is the only biologic available ... common form of NHL. , According to Kantar Health’s ... incidence of NHL in China has been growing and ...
(Date:12/22/2014)... Colorado (PRWEB) December 22, 2014 Super ... Black Friday this year as the busiest day in ... other retailers, The Grass Station had a steady pre-Christmas ... holiday gifts, this past Saturday. , “I definitely intend ... 33-year-old Robert, a Denver resident who was enjoying The ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 Only weeks ... southern and mid-western cities to have a battery manufacturer ... TalkLocal ( http://www.talklocal.com ) is launching in Henderson ... economy. , “A strong manufacturing sector is going ... founder Gurpreet Singh explained, “and TalkLocal works with small ...
(Date:12/22/2014)... In recognition of Veteran’s Day, Discount Labels ... a local organization that provides services to veterans and ... on a couple hundred acres in the hills of ... class fishing, hunting, hiking, horseback riding, 4-wheeling, skeet shooting, ... ago to support U.S. Service men and women, police ...
Breaking Medicine News(10 mins):Health News:CDC Warns of Listeria Danger From Caramel Apples 2Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 2Health News:Physicians in China See Most Significant Demand for MabThera Biosimilar 3Health News:Customers at Colorado’s Grass Station Say They’re Enjoying the Experience of Legally Purchasing Marijuana this Year to Give as Christmas Presents to Friends and Family 2Health News:TalkLocal Launches in Henderson Weeks Following New Megafactory, New Jobs Announcement 2Health News:Discount Labels Donates Portion of November Sales to Hero Reward Program 2
... Capital BlueCross announced today that it will cover an ... and those with individual coverage during the upcoming 2009-2010 flu ... to include this benefit. , , A ... October. Various clinical vaccine trials have begun, some under the ...
... NEW YORK, Sept. 16 Dr. Mark Hasten, chairman of the ... Kadish, M.D., as senior provost and chief operating officer for Touro ... http://www.flickr.com/photos/tourocollege/3923514965/ , , Touro is ... college was founded by Dr. Bernard Lander in 1970, originally as ...
... , FARMINGTON HILLS, Mich., Sept. ... stock and assets of GTL, Inc. dba as "Link to ... product and service offerings into CST to provide cost-effective personal ... and quality of life for older adults, the disabled and ...
... 20% of emergency room visits and 5% of ... first-line treatment option in patients with gastrointestinal bleeding, ... diagnostic and treatment method in patients with gastrointestinal ... incidence of rebleeding in patients with negative initial ...
... HEATHROW, Fla., Sept. 16 Cozmix, Inc., a sales ... beta release of SizeMix, the sales industry,s first point and ... forms a core component of Cozmix, SizeMix Process. , ... components necessary to complete a full internal review of a ...
... , BALTIMORE, Sept. 16 While most men ... likely unaware of other important statistics that could one day save ... and the National Football League (NFL) are teaming to encourage men ... of cancer death for American men. Men and their loved ones ...
Cached Medicine News:Health News:Capital BlueCross to Cover Administration Costs of H1N1 Vaccine for Fully-Insured Groups, Individuals This Flu Season 2Health News:Touro Appoints Alan Kadish, M.D., Senior Provost and Chief Operating Officer 2Health News:Touro Appoints Alan Kadish, M.D., Senior Provost and Chief Operating Officer 3Health News:Touro Appoints Alan Kadish, M.D., Senior Provost and Chief Operating Officer 4Health News:Critical Signal Technologies Acquires Link to Life to Grow Depth and Expertise in TeleHealth, Personal Emergency Response and Medical Monitoring Systems 2Health News:Critical Signal Technologies Acquires Link to Life to Grow Depth and Expertise in TeleHealth, Personal Emergency Response and Medical Monitoring Systems 3Health News:Sales Force Sizing and Resource Optimization Software Is the First of Its Kind to Enter the Market (Beta Release) 2Health News:Video: NFL Season Kicks Off With Campaign to 'Know Your Stats About Prostate Cancer' 2Health News:Video: NFL Season Kicks Off With Campaign to 'Know Your Stats About Prostate Cancer' 3Health News:Video: NFL Season Kicks Off With Campaign to 'Know Your Stats About Prostate Cancer' 4
(Date:12/19/2014)... December 19, 2014 TODAY, AEGATE, ... the World announced the appointment of Peter Fox ... as Chief Channels and Partner Officer. Peter ... through to its acquisition by Oracle in 2011. ... Geneva and subsequently Convergys, a ...
(Date:12/19/2014)... , Dec. 19, 2014   Hospira, Inc. ... of injectable drugs and infusion technologies, today announced that ... Annual Healthcare Conference on Wednesday, Jan. 14, 2015, in ... scheduled to begin at 10:30 a.m. Pacific time on ... all interested parties through a live audiocast accessible via ...
(Date:12/19/2014)... WORTH, Texas , December 18, 2014 /PRNewswire/ ... a networked software application/module that is used to ... related images. RIS comprises a patient tracking and ... system. The integration of RIS with HIS and ... used for patient registration and patient scheduling, patient ...
Breaking Medicine Technology:Aegate Appoints new CTO and Chief Channels & Partner Officer 2Aegate Appoints new CTO and Chief Channels & Partner Officer 3Aegate Appoints new CTO and Chief Channels & Partner Officer 4The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 2The Global Radiology Information Systems Market is Expected to Grow at a CAGR of 7.5% from 2014 to 2019 3
... NEW YORK, May 2, 2011 Reportlinker.com announces ... in its catalogue: Drug Delivery ... companies http://www.reportlinker.com/p0203542/Drug-Delivery-in-Central-Nervous-System-Diseases---technologiesmarkets-and-companies.html ... nervous system (CNS) is a challenge in the ...
... PARSIPPANY, N.J., April 29, 2011 Watson Pharmaceuticals, Inc. (NYSE: ... announced today that the Company will conduct a live webcast ... 13, 2011 beginning at 9:00 AM Eastern Daylight Time. As ... executive officer, will provide an overview and update of the ...
Cached Medicine Technology:Reportlinker Adds Drug Delivery in Central Nervous System Diseases - Technologies, Markets and Companies 2Reportlinker Adds Drug Delivery in Central Nervous System Diseases - Technologies, Markets and Companies 3Reportlinker Adds Drug Delivery in Central Nervous System Diseases - Technologies, Markets and Companies 4
Fine 3.0 mm platformed angled 60 degrees 10 mm from angle to tip. Serrated handle with dull finish....
Tennant straight tying forceps, 6.0 mm tying platforms, with pin, extra delicate smooth jaws....
Sinskey tying forceps, straight, fine, 7 mm tying platforms....
O'Gawa-Castroviejo tying forceps, straight shafts, 6 mm tying platforms, wide handle....
Medicine Products: