Navigation Links
Molecular movements could lead to new way to treat cancer
Date:6/6/2011

Work by researchers at Queen Mary, University of London could point to a new way to treat aggressive types of cancer.

The scientists have found that a molecule called Met is responsible for stimulating the growth and spread of cancer because it is relocating to the wrong part of the cell.

Experiments in the lab suggest that moving Met molecules from the inside of the cell to the cell surface could halt the growth of cancer cells and even cause tumours to shrink.

Met molecules are involved in the growth of cells in the human body but they are usually only active in a growing embryo or in wound-healing.

However, Met has also been found in many different types of tumour, including breast and lung cancers, where cells are growing uncontrollably. And tumours with high levels of Met tend to be the most aggressive.

Previous research on Met and similar molecules has attempted to tackle the problem by completely blocking the molecule but this has only achieved limited results.

In this new study, published in the journal Nature Cell Biology, the researchers instead attempted to chemically relocate Met to a different part of the cancer cells. Using this approach they were able to halt the growth of cancer cells in the lab and shrink tumours in mice.

The researchers say the study is still in its very early stages but, in the future, it could point the way to a new treatment for cancers.

Dr Stphanie Kermorgant, who led the study, is a Lecturer in Cellular Oncology at Barts Cancer Institute, part of Queen Mary, University of London. She said: "Previous research has indicated that Met has a role in the development of cancer. We've made a fascinating discovery that, in some cancer cells, this molecule is not only present but it's located in the wrong part of the cell it would normally be on the outside of the cell and we've found it on the inside.

"Our study shows that it's not only the presence of the molecule but also where it is in the cell that may promote cancer. We've also shown that we may be able to take advantage of this discovery to design new types of drugs.

"Scientists have been trying to create new cancer drugs by testing chemicals that block Met, or other similar molecules, but results have been mixed.

"Our findings led us to try a new approach using a chemical to prevent Met molecules going to the wrong part of the cell. Importantly, this method works even when blocking Met does not work.

"It's early days but this approach looks promising and could eventually lead to new drugs for treating these aggressive types of cancer."


'/>"/>

Contact: Kerry Noble
k.noble@qmul.ac.uk
44-020-788-27943
Queen Mary, University of London
Source:Eurekalert

Related medicine news :

1. Molecular pathways linked to sex, age affect outcomes in lung cancer
2. SNMs Conjoint Mid-Winter Meetings continue to advance molecular imaging
3. Scientists Discover Molecular Pathway for Organ Tissue Regeneration and Repair
4. The Association for Molecular Pathology celebrates ruling in DNA patent case
5. USC researchers discover new molecular subtype of brain cancer
6. Molecular discovery points to new therapies for brain tumors
7. Molecular marker could help spot pancreatic cancer early
8. News from Molecular Medicine
9. Scientists discover the molecular heart of collective behavior
10. Salt Lake City proclaims Molecular Imaging Days during SNMs Annual Meeting in June
11. Acupunctures molecular effects pinned down
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... The ... MSC Cruises as part of the line’s 4th Annual MSC True Partnerships’ Awards. ... performing North American travel partners for the year based on overall business growth in ...
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... ... advance to the semi-final round of the 2017 Cupid's Cup Entrepreneurship Competition. Chaired ... its 12th year in 2017. The entrepreneurs will showcase their businesses on February ...
(Date:1/24/2017)... ... January 24, 2017 , ... West’s Health Advocate Solutions, ... Series of webinars will start January 31 with a session about understanding healthcare ... health and benefits topics, including employee engagement, pricing transparency, population health and wellness, ...
(Date:1/24/2017)... ... ... His message has been heard by more than 100,000 students and adults ... Joel Feldman, has reached his biggest national audience yet: the three million daily readers ... in circulation in the country, and he hopes it will help spread his message ...
(Date:1/24/2017)... Santa Margarita, CA (PRWEB) , ... January 24, 2017 , ... ... advancement platform for 21st century leadership, has named Hector M. Chavez, Manager, Employee & ... and diabetes treatment center - as its Hispanic Leader of the Month. City of ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... -- Trifecta Clinical , a leading global provider ... Ward to Vice President of Commercial Operations.  Rick ... the promotion of Ericka Atkinson to Vice ... joins Trifecta from Greenphire where he was Vice President ... positions within the healthcare industry throughout his career.  "Rick ...
(Date:1/24/2017)... Research and Markets has announced the addition of the "Implantable ... to 2025" report to their offering. ... The Global Implantable Medical Devices Market ... the next decade to reach approximately $54.28 billion by 2025 ... include 3D medical printing is expected to develop and find in ...
(Date:1/24/2017)... , and GAITHERSBURG, Md. , Jan. 24, ... ), a leader in the engineering and industrialization of biology ... planet, today announced that it has entered into a definitive ... GNVC ), a clinical-stage company and pioneer in the development ... to integrate and expand upon GenVec,s expertise in adenoviral vectors ...
Breaking Medicine Technology: