Navigation Links
Molecular motor works by detecting minute changes in force
Date:7/9/2008

PHILADELPHIA - Researchers at the University of Pennsylvania School of Medicine discovered that the activity of a specific family of nanometer-sized molecular motors called myosin-I is regulated by force. The motor puts tension on cellular springs that allow vibrations to be detected within the body. This finely tuned regulation has important implications for understanding a wide variety of basic cellular processes, including hearing and balance and glucose uptake in response to insulin. The findings appear in the most recent issue of Science.

"This is the first demonstration that myosin-I shows such dramatic sensitivity to tension," says senior author E. Michael Ostap, Ph.D., Associate Director, Pennsylvania Muscle Institute and Associate Professor of Physiology. "It is surprising that a molecular motor can sense such small changes in force."

Myosin-I is a biological motor that uses the chemical energy made by cells to ferry proteins within cells and to generate force, powering the movement of molecular cargos in nearly all cells.

In two specific cases, myosin I puts tension on the specialized spring-like structures in human ears that enable hearing and maintenance of balance, and also has a role in delivering the proteins that pump glucose into cells in response to insulin. "However, why a tension-sensing molecular motor is needed for this function is unknown," says Ostap.

In collaboration with Henry Shuman, PhD, Associate Professor of Physiology, the research team used optical tweezers -- a combination focused laser beam and microscope, of sorts -- to measure incredibly small forces and movements (on the piconewton and nanometer level) to discover that myosin I motors are regulated by force. The motors pull on their cellular cargos until a certain tension is attained, after which they stop moving, but will hold the tension. If something happens in the cell to decrease this tension, the motor will restart its activit
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. A new molecular zip code, and a new drug target for Huntingtons disease
2. New knock-out gene model provides molecular clues to breast cancer
3. Molecular probe paints cancer cells in living animals, Stanford researchers find
4. Story ideas from molecular & cellular proteomics
5. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
6. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
7. Molecular fingerprint of breast-cancer drug resistance can predict response to treatment
8. Molecular profiling can accurately predict survival in colon cancer patients
9. Xceed Molecular Names Fran Tuttle to Its Board of Trustees
10. Virginia G. Piper Charitable Trust and Flinn Foundation launch molecular diagnostics initiative
11. Xceed Molecular Launches Ziplex(R) Automated Gene-Expression System at the Association for Molecular Pathology, Booth 84/85
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... City, UT (PRWEB) September 17, 2014 ... America 2015 Kira Kazantsev and ushered in a ... charitable support. As Miss America Organization’s official national ... welcoming Kazantsev as its newest National Goodwill Ambassador. ... at member Children’s Miracle Network Hospitals across the ...
(Date:9/17/2014)... may be preventable with a vaccine, new research in ... at Washington University School of Medicine in St. Louis, ... used in hospitals and other care facilities to drain ... a catheter is present in the urethra and the ... every patient who has a catheter for more than ...
(Date:9/17/2014)... 17, 2014 People who struggle to distinguish ... to http://www.perwickstrom.com and get the answer by reading ... point out, is that a business plan and a business ... together, commented Per Wickstrom. “The way I view it is ... business strategy which is part two.” , According to ...
(Date:9/17/2014)... guard against damage to the ends of chromosomes could hold ... the deadliest form of skin cancer according to new ... has uncovered an important new genetic risk factor for melanoma. ... are the strongest indicators of those most at risk of ... in the sun, as they burn more easily. , It ...
(Date:9/17/2014)... Dallas, TX (PRWEB) September 17, 2014 ... they were recently granted several awards for their top-notch ... regarding patient experience, orthopedic care and GYN surgery. , ... Patient Safety Excellence Award™. They have received this award ... ranked among the top 5 percent in the nation ...
Breaking Medicine News(10 mins):Health News:Miss America 2015 Kira Kazantsev Takes On Role as Children’s Miracle Network Hospitals National Goodwill Ambassador 2Health News:Miss America 2015 Kira Kazantsev Takes On Role as Children’s Miracle Network Hospitals National Goodwill Ambassador 3Health News:In mice, vaccine stops urinary tract infections linked to catheters 2Health News:In mice, vaccine stops urinary tract infections linked to catheters 3Health News:Per Wickstrom’s Latest Blog Explores the Difference Between a Business Plan and a Business Strategy 2Health News:Chromosome buffers hold key to better melanoma understanding 2Health News:North Central Surgical Center Receives Several Accolades 2
... expectancy increasing in Latin America, age-related disease has become ... epidemiological study conducted by researchers at the Jean Mayer ... at Tufts University and the Corporacion Ecuatoriana de Biotecnologia ... a person,s risk of developing cardiovascular disease and type ...
... little-known morphinelike drug is potentially more potent, longer ... standard morphine, a study led by a Loyola ... drug, morphine-6-0-sulfate, has a similar chemical structure to ... reported that a study they performed in rats ...
... payments for non-invasive medical imaging, including magnetic resonance imaging ... to non-radiologists than to radiologists, according to a study ... the American College of Radiology ( www.jacr.org ). ... who "control" non-invasive diagnostic imaging (NDI) and are primarily ...
... News) -- Post-traumatic stress disorder may have long-term effects ... -- while those who suffer from concussions and mild ... the long haul, a new study suggests. ... Enduring Freedom and Operation Iraqi Freedom since 2001," according ...
... , MONDAY, Jan. 3 (HealthDay News) -- Starting this year, first-time ... new Affordable Care Act. The "Welcome to Medicare" benefit will ... Part B, and the doctor must agree to be paid directly ... part of an effort to focus on preventive medicine, rather than ...
... MONDAY, Jan. 3 (HealthDay News) People at higher risk ... new study findings show. Researchers at Washington University School ... U.S. alcoholism surveys conducted in 1991-1992 and 2001-2002. According to ... family history of alcoholism were 49 percent more likely to ...
Cached Medicine News:Health News:Vitamins C and E linked to metabolic syndrome in low-income Ecuadorians 2Health News:Vitamins C and E linked to metabolic syndrome in low-income Ecuadorians 3Health News:Experimental drug more potent, longer lasting than morphine 2Health News:Soldiers' PTSD Tied to Lasting Psychosocial Effects 2Health News:First Physical With Medicare Now Free 2Health News:Family History of Alcoholism May Raise Obesity Risk 2
(Date:9/17/2014)... 17, 2014 The ambulance equipment ... decade due to the recession, an unstable ... advancements. This BCC Research report analyzes present ... the ambulance and emergency medical services equipment ... hemorrhage control devices, equipment used for burn ...
(Date:9/17/2014)... , Sept. 17, 2014  Dr. Stephen ... the White House today for National Recovery Month, stars ... consumer advocates released today. Consumer advocates were also joined ... who spoke out after losing her fiancée because of ... the doctor had a history of crack cocaine abuse. ...
(Date:9/17/2014)... Sept. 17, 2014 /PRNewswire-iReach/ -- ChemImage announced ... discussing improvements in the development of imaging ... both normal and diseased tissue that minimizes ... surgical procedures, lowers surgical costs and potentially ... The clinical and scientific ...
Breaking Medicine Technology:Ambulance and Emergency Equipment: Global Markets 2Ambulance and Emergency Equipment: Global Markets 3Ambulance and Emergency Equipment: Global Markets 4Doctor Recovering From 100-Pill-A-Day Addiction Stars In New Ad Supporting Prop 46; Appears At White House for National Recovery Month, Says Consumer Watchdog Campaign 2Doctor Recovering From 100-Pill-A-Day Addiction Stars In New Ad Supporting Prop 46; Appears At White House for National Recovery Month, Says Consumer Watchdog Campaign 3Patient Outcomes Improve When Molecular Chemical Imaging Technology Is Used to Aid Robotic Surgical Procedures, According to New White Paper 2
... 4 Novartis Vaccines & Diagnostics Inc. and Novartis ... to resolve civil False Claims Act allegations arising from the ... announced today. The settlement resolves allegations that, between Jan. ... and its predecessor, Chiron Corporation, caused false claims to be ...
... Joseph F. Finn, Jr. , C.P.A. ("Finn"),  Assignee for ... that the MRI imaging intellectual properties of the EP-3600 MRI imaging ... assets of Epix were transferred to him on July 20, ... Epix creditors.  He recently reached an agreement with Bayer Schering Pharma ...
Cached Medicine Technology:Novartis Vaccines & Diagnostics to Pay More Than $72 Million to Resolve False Claims Act Allegations Concerning TOBI 2Novartis Vaccines & Diagnostics to Pay More Than $72 Million to Resolve False Claims Act Allegations Concerning TOBI 3Epix Pharmaceuticals, Inc. Announces the May 28, 2010 Auction Sale of EP-3600 MRI Imaging Agent 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: