Navigation Links
Molecular meet and greet
Date:8/18/2011

Boston, Mass. (Aug. 19, 2011)Researchers at Harvard Medical School have discovered that structural elements in the cell play a crucial role in organizing the motion of cell-surface receptors, proteins that enable cells to receive signals from other parts of the organism.

This discovery, published in the Aug. 19 issue of the journal Cell, fills a fundamental gap in the understanding of how cells relate to biochemical signals, including pharmaceuticals, and could have profound implications for drug development and the treatment of cancer and other diseases.

The findings are already prompting the design of a new lecture on cell signaling in one basic biochemistry course at HMS.

"We found that the way the receptors are organized in the membrane and the way they move around are controlled by the cytoskeleton," said Khuloud Jaqaman, instructor in the Department of Systems Biology at HMS and first author of the study. This dynamic organization promotes signaling function by encouraging receptors to cluster, even if briefly, she said.

Jaqaman and Gaudenz Danuser, HMS professor of cell biology, working with Sergio Grinstein from the Hospital for Sick Children in Toronto as well as colleagues at the University of Alberta, Edmonton, studied the motion of CD36, a receptor in human macrophages, a type of white blood cell that plays a role in immune response. CD36 detects oxidized LDL (oxLDL), a lipoprotein implicated in atherosclerosis.

Receptors are like the antennas in a cell's communication system with the world outside their membrane. The cytoskeleton, which includes a fine meshwork of actin fibers and an array of radiating microtubules, gives the cell its shape.

Like many receptors, CD36 can't work alone; a group of receptors must cluster together to send a signal into the cell. Until now, very little was known about how those functional groups of receptors formed. The cell and receptors were thought to wait
'/>"/>

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Hebrew U. scientists identify molecular basis for DNA breakage
2. Blocking molecular target could make more cancers treatable with PARP inhibitors
3. Scientists discover new molecular pathway involved in wound-healing and temperature sensation
4. Molecular glue sticks it to cancer
5. Molecular movements could lead to new way to treat cancer
6. Scientists Find Molecular Similarities in Brains of Those With Autism
7. Autism changes molecular structure of the brain, UCLA study finds
8. Finding molecular targets of an HIV drug used in cancer therapy
9. Researchers publish molecular disease model for melanoma
10. Stanford researchers discover molecular determinant of cell identity
11. Using a molecular switch to turn on cancer vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... Researchers at the Perelman School of Medicine at the ... Cancer Institute have received an $8 million grant from ... of photodynamic light therapy (PDT) in patients with malignant ... most often manifests itself in the lining of the ... asbestos. The grant will fund a clinical trial and ...
(Date:7/9/2014)... metabolism of stromal support cells and immune cells ... types in the development of diseases could open ... That was the conclusion of a review article by ... journal Nature . , Prof. Peter Carmeliet: "Consider ... metabolism of cancer cells has been examined in minute ...
(Date:7/9/2014)... N.Y. Although feelings are personal and subjective, ... code that objectively represents emotions across different senses, ... by Cornell University neuroscientist Adam Anderson. , "We ... the orbitofrontal cortex, an area of the brain ... code which captures an individual,s subjective feeling," says ...
(Date:7/9/2014)... Cup highlights, Brian Williams refreshing old school rap classics, ... railings. A University of Colorado Cancer Center study published ... YouTube also allows researchers, journals, and health advocates to ... cancer and prevention. , "No matter what field you,re ... communicate around the world," says Chante Karimkhani, MD candidate ...
(Date:7/9/2014)... labels handed out by pharmacists may be misread ... according to new research by the University of ... Blind)., The study, published recently in the ... prescription medications dispensed by pharmacies do not consistently ... simply following recommended guidelines for font size, use ...
Breaking Medicine News(10 mins):Health News:Penn mesothelioma program receives $8 million NCI grant 2Health News:Wake-up call for more research into cell metabolism 2Health News:Study cracks how the brain processes emotions 2Health News:Study of dermatology on YouTube shows new ways science reaches public 2Health News:Most prescription labels fail to meet guidelines, risking dosage errors 2
... , MINNEAPOLIS, June 9 Nonin Medical, Inc., ... history today by announcing the world,s first Bluetooth(R)-enabled ... now certified as compliant to the Continua(TM) Version ... Device Profile (HDP) and ISO/IEEE 11073 data protocol, ...
... from the Virginia Bioinformatics Institute (VBI) at Virginia Tech ... that allows them to profile in detail complex cellular ... to look at how the levels of proteins change ... hormones or cancer drugs like tamoxifen. VBI Assistant ...
... June 9 /PRNewswire-FirstCall/ -- Apria Healthcare Group ... ) (NYSE: PER ) today announced an ... to Apria Healthcare a range of healthcare information technology solutions, ... as well as consulting services. The term of the ...
... Resort Sponsors Scottish-Themed Charity Event , , OAK BROOK, Ill., June 9 ... night at the Oak Brook Hills Marriott Resort in Illinois. From 4:30 p.m. ... will be hosting the Oak Brook Hills Golf Classic to benefit the ... will feature: , , , ...
... you are getting full when eating a large meal? New ... may partially explain why severely obese individuals may not feel ... of food they consume during a meal. Researchers led ... and Diabetes Research Center focused on habituation, or the idea ...
... researchers determine that race has no bearing on life expectancy ... Older adults with mild cognitive impairment or Alzheimer,s disease have ... risk of death is no greater for whites or blacks, ... at Rush University Medical Center in Chicago, contradicts earlier information ...
Cached Medicine News:Health News:Nonin Medical, Inc. Announces the First Bluetooth(R) Continua(TM) Certified Product 2Health News:VBI researchers develop new method for breast cancer biomarker discovery 2Health News:Apria Healthcare Awards Technology Solutions Contract to Perot Systems 2Health News:Apria Healthcare Awards Technology Solutions Contract to Perot Systems 3Health News:Oak Brook Hills Golf Classic to Benefit the Children's Miracle Network 2Health News:Physiological response may explain why some severely obese patients overeat 2Health News:Alzheimer's and Even Mild Dementia Hasten Death 2
(Date:1/15/2014)... YORK , Jan. 15, 2014 ... report is available in its catalogue: ... for Advanced Drug Delivery Systems -- Focus ... STUDY OBJECTIVES ...
(Date:1/14/2014)... Corporation (Nasdaq: LMNX ) today announced that it ... on Monday, February 3, 2014. A press release announcing the ... (Logo: http://photos.prnewswire.com/prnh/20100104/LUMINEXLOGO ) Management ... and financial results for the fourth quarter and twelve months ...
(Date:1/14/2014)... , Jan. 14, 2014 Animal Emergency Critical Care, a ... Leesburg, Virginia is the first in ... chamber. Dr. Susan M. Barnes , Medical ... Barnes and husband, Dr. Cole Taylor , are avid scuba ...
Breaking Medicine Technology:Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 2Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 3Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 4Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 5Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 6Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 7Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 8Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 9Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 10Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 11Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 12Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 13Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 14Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 15Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 16Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 17Global Markets and Technologies for Advanced Drug Delivery Systems -- Focus on End Users 18Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 2Luminex Corporation Fourth Quarter Earnings Release Scheduled for February 3, 2014 3Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2
... Amarin Corporation plc (Nasdaq: AMRN ), a clinical-stage ... positive, statistically significant top-line results from its ANCHOR trial for ... met its primary and secondary efficacy endpoints for both the ... The purpose of the ANCHOR trial was to demonstrate that ...
... and SYDNEY, April 15, 2011 HeartWare International, ... a leading innovator of less invasive, miniaturized circulatory ... advanced heart failure, today announced the presentation of ... transplantation (BTT) study, ADVANCE, showing 180-day survival, using ...
Cached Medicine Technology:Amarin's AMR101 Phase 3 ANCHOR Trial Meets all Primary and Secondary Endpoints with Statistically Significant Reductions in Triglycerides at Both 4 Gram and 2 Gram Doses and Statistically Significant Decrease in LDL-C 2Amarin's AMR101 Phase 3 ANCHOR Trial Meets all Primary and Secondary Endpoints with Statistically Significant Reductions in Triglycerides at Both 4 Gram and 2 Gram Doses and Statistically Significant Decrease in LDL-C 3Amarin's AMR101 Phase 3 ANCHOR Trial Meets all Primary and Secondary Endpoints with Statistically Significant Reductions in Triglycerides at Both 4 Gram and 2 Gram Doses and Statistically Significant Decrease in LDL-C 4Amarin's AMR101 Phase 3 ANCHOR Trial Meets all Primary and Secondary Endpoints with Statistically Significant Reductions in Triglycerides at Both 4 Gram and 2 Gram Doses and Statistically Significant Decrease in LDL-C 5Amarin's AMR101 Phase 3 ANCHOR Trial Meets all Primary and Secondary Endpoints with Statistically Significant Reductions in Triglycerides at Both 4 Gram and 2 Gram Doses and Statistically Significant Decrease in LDL-C 6Amarin's AMR101 Phase 3 ANCHOR Trial Meets all Primary and Secondary Endpoints with Statistically Significant Reductions in Triglycerides at Both 4 Gram and 2 Gram Doses and Statistically Significant Decrease in LDL-C 7Amarin's AMR101 Phase 3 ANCHOR Trial Meets all Primary and Secondary Endpoints with Statistically Significant Reductions in Triglycerides at Both 4 Gram and 2 Gram Doses and Statistically Significant Decrease in LDL-C 8HeartWare Reports Additional Data from Bridge-to-Transplant Clinical Trial and Continued Access Patients 2HeartWare Reports Additional Data from Bridge-to-Transplant Clinical Trial and Continued Access Patients 3HeartWare Reports Additional Data from Bridge-to-Transplant Clinical Trial and Continued Access Patients 4HeartWare Reports Additional Data from Bridge-to-Transplant Clinical Trial and Continued Access Patients 5
West 2 periosteal elevators....
Semb periosteal elevators....
Williger periosteal elevators....
Lambotte periosteal elevators....
Medicine Products: