Navigation Links
Molecular marker predicts patients most likely to benefit longest from 2 popular cancer drugs
Date:9/5/2013

Johns Hopkins scientists have identified a molecular marker called "Mig 6" that appears to accurately predict longer survival -- up to two years -- among patients prescribed two of the most widely used drugs in a class of anticancer agents called EGFR inhibitors.

The U.S. Food and Drug Administration-approved drugs, gefitinib (Iressa) and erlotinib (Tarceva), are prescribed for lung and pancreatic cancer patients but only a few who have mutations in the EGFR gene usually benefit with a prolonged reduction of tumor size. The two drugs block the gene's ramped-up protein production, but patients' response to the drug varies widely from no survival benefit to several years. The average is several months.

"Clinicians have had no reliable method for distinguishing patients who are not likely to respond to EGFR inhibitors and those who will respond very well," says David Sidransky, M.D., professor of otolaryngology, oncology, pathology, urology, and genetics at Johns Hopkins. Looking at the precise level of protein production from the EGFR gene alone in specific patients was not proven to be a good indicator of patients' response to EGFR-blocking drugs, but the presence or absence of Mig 6 might be, he adds.

In a preliminary study, described July 31 in the online journal, PLoS ONE, the Johns Hopkins scientists found the genetic marker in a series of experiments that began with laboratory-derived lung and head and neck cancer cell lines resistant to EGFR-inhibitor drugs. In the cell lines, the team found very high levels of protein production from the Mig 6 gene -- up to three times the level in sensitive cell lines. Mig 6 is one of the molecules that controls the activity of the EGFR protein.

"In the first set of experiments, we found that higher levels of Mig 6 occur often in cells that don't respond to EGFR inhibitors," says Sidransky. "Most tumors are known to have high Mig 6 levels and are not expected to respond to EG
'/>"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-614-2916
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Molecular Imaging, Inc. Announces New Webinar: Advancing Discovery and Development of Biologics Through Non-Invasive Biodistribution Imaging
2. Janina A. Longtine, MD of the Icahn School of Medicine at Mount Sinai Elected President of the Association for Molecular Pathology
3. Dartmouth researchers develop molecular switch that changes liquid crystal colors
4. Mount Sinai and Exosome Partner to Accelerate Translation of Body Fluid Molecular Diagnostics to Overcome Limitations of Tissue Biopsy in Areas of Unmet Medical Needs
5. Molecular Diagnostics Market - New Industry Research Report is Now Available for Pre-Order at Transparency Market Research
6. New study shows vitamin D-related molecular switches predict childhood bone mass
7. EurekaMag.com Publishes 64 Thousand New Animal Science References and Bibliography on Molecular Cloning
8. Molecular switch controls the destiny of self-eating cells
9. The Association for Molecular Pathology announces 2013 Leadership Award recipient
10. Abnormalities in new molecular pathway may increase breast cancer risk
11. Researchers gain new molecular-level understanding of the brains recovery after stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2015)... 2015 TROY Healthcare Solutions is proud ... Regional User Group (RUG) Conference in Baltimore, MD from ... Regional User Group provides an opportunity for clients to ... exhibitor gallery. , In addition to sponsoring the event, ... North Atlantic RUG Conference. Attendees can stop by the ...
(Date:5/4/2015)... (PRWEB) May 04, 2015 The American ... critical state policy reports which identify gaps in coverage ... “After ATA issued the State Telemedicine Gaps Reports last ... how their laws and regulations impact healthcare delivery in ... a result of state actions across the nation, ATA ...
(Date:5/4/2015)... Baptist Medical Center Jacksonville has received ... The Guidelines®-Stroke Gold Plus Quality Achievement Award along ... recognizes the hospital’s commitment and success in ensuring ... according to nationally recognized, research-based guidelines based on ... Gold Plus Quality Achievement Award, hospitals must achieve ...
(Date:5/4/2015)... METTLER TOLEDO has announced an ... Integrity in a GXP Regulated Laboratory ", featuring ... webinar will be presented on May 27, 2015 ... is a critical component of pharmaceutical product quality ... in recent years an increasing number of inspections ...
(Date:5/4/2015)... Now in its seventh year, the IPC ... made outstanding contributions to the company, to their facilities ... and post-acute care settings. The five award categories are: ... Year, Advanced Practice Clinician of the Year, Newcomer Provider ... Recipients are selected by IPC’s senior management team. , ...
Breaking Medicine News(10 mins):Health News:TROY Healthcare to Exhibit at the Cerner North Atlantic Regional User Group Conference 2Health News:TROY Healthcare to Exhibit at the Cerner North Atlantic Regional User Group Conference 3Health News:American Telemedicine Association Delivers New State Report Cards on Telemedicine 2Health News:American Telemedicine Association Delivers New State Report Cards on Telemedicine 3Health News:Baptist Medical Center Jacksonville Receives Top Honor for Stroke Care 2Health News:Baptist Medical Center Jacksonville Receives Top Honor for Stroke Care 3Health News:Baptist Medical Center Jacksonville Receives Top Honor for Stroke Care 4Health News:METTLER TOLEDO Announces Live Webinar on the Importance of Data Integrity in a GXP Regulated Laboratory 2Health News:IPC Healthcare Announces Clinicians of the Year 2Health News:IPC Healthcare Announces Clinicians of the Year 3
... Platform, Michigan Orthopedic ServicesDETROIT, Feb. 2 Huron Capital ... Services ("MOS") has acquired O&P Professional Care as part ... MI. The business will be managed under the ... disclosed. MOS operates a network of 11 patient ...
... a large, ongoing study to improve detection and prevention ... a specific heart rhythm abnormality idiopathic QT interval ... artery disease. , "More than 80 percent of ... who have significant coronary artery disease, but we currently ...
... Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL ) today ... with simultaneous webcast on Tuesday, February 3, 2009 at ... Rigel,s senior management team will provide an update on ... Webcast Information To access the live call, please dial ...
... 2 In celebration of American Heart Month, ... Forum showcasing a live- telecast of the ... disease on Tuesday, February 10, 2009. During ... Medical Director of Arizona Heart Institute and Arizona ...
... current rate of production for new mammography professionals, there will ... woman age 40 years and older over the next 15-20 ... Health and Workforce Studies at the Albany School of Public ... the year 2010 there will be approximately 20.6 radiologists per ...
... SANTA MONICA, Calif., Feb. 2 A national consumer ... lobbying positions on the electronic medical record provisions of ... an independent journalist that Google,s presence on the bill ... public policy team for an immediate answer. The letter ...
Cached Medicine News:Health News:Huron Capital Continues Acquisition Activity 2Health News:Rhythm abnormality of unknown origin strongly predicts sudden death risk in heart disease patients 2Health News:Rigel to Host Conference Call on February 3, 2009 2Health News:Arizona Heart Institute Announces FREE Public Forum Featuring Live Viewing of Surgical Procedures Via High-Definition (HD) Satellite 2Health News:Workforce shortages in mammography could threaten early detection rates for breast cancer 2Health News:Consumer Watchdog to Google: Publicly Disclose Your Lobbying Positions on Electronic Medical Record Provisions in Stimulus Bill 2
(Date:5/4/2015)... , May 4, 2015 Bayer HealthCare ... Isis Pharmaceuticals, Inc. (NASDAQ: ISIS ) on ISIS-FXI ... for the prevention of thrombosis. Under the agreement Bayer ... areas of high unmet medical need. As part of ... therapeutic profile of ISIS-FXI Rx in an appropriate ...
(Date:5/4/2015)... LOS ANGELES , May 4, 2015 /PRNewswire/ ... research and development company specializing in oncology, today ... phase 1b aldoxorubicin combination studies pairing aldoxorubicin with ... doses of gemcitabine or ifosfamide with escalating doses ... tolerated, and even at the lowest dose level ...
(Date:5/4/2015)... , May 4, 2015 Dyadic ... company whose patented and proprietary technologies are used ... proteins for the bioenergy, bio-based chemical, biopharmaceutical and ... report its financial results for quarter ending March ... 14, 2015 and will host a conference call ...
Breaking Medicine Technology:Bayer Licenses Investigational ISIS FXI(Rx) from Isis Pharmaceuticals to Develop and Commercialize for the Prevention of Thrombosis 2Bayer Licenses Investigational ISIS FXI(Rx) from Isis Pharmaceuticals to Develop and Commercialize for the Prevention of Thrombosis 3CytRx Reports Aldoxorubicin Demonstrates Both Tumor Shrinkage and Improved Quality of Life in Chemotherapy Resistant Cancers 2CytRx Reports Aldoxorubicin Demonstrates Both Tumor Shrinkage and Improved Quality of Life in Chemotherapy Resistant Cancers 3CytRx Reports Aldoxorubicin Demonstrates Both Tumor Shrinkage and Improved Quality of Life in Chemotherapy Resistant Cancers 4CytRx Reports Aldoxorubicin Demonstrates Both Tumor Shrinkage and Improved Quality of Life in Chemotherapy Resistant Cancers 5CytRx Reports Aldoxorubicin Demonstrates Both Tumor Shrinkage and Improved Quality of Life in Chemotherapy Resistant Cancers 6CytRx Reports Aldoxorubicin Demonstrates Both Tumor Shrinkage and Improved Quality of Life in Chemotherapy Resistant Cancers 7Dyadic International To Announce First Quarter 2015 Financial Results and Host Conference Call On Thursday, May 14, 2015 2Dyadic International To Announce First Quarter 2015 Financial Results and Host Conference Call On Thursday, May 14, 2015 3
... BIOD ) announced today the retirement of Dr. ... is a co-founder of Biodel and will remain a member ... chairman, president and chief executive officer from its founding in ... was named the company,s president and chief executive officer and ...
... 2010 Reportlinker.com announces that a new ... catalogue: Asia-Pacific Markets for ... 2011 http://www.reportlinker.com/p0339835/Asia-Pacific-Markets-for-Cardiac-Rhythm-Management-Electrophysiology--Ablation-Devices-2011.html ... Pacific markets for cardiac rhythm management (CRM), ...
Cached Medicine Technology:Biodel Announces Retirement of Dr. Solomon Steiner as Chief Scientific Officer 2Biodel Announces Retirement of Dr. Solomon Steiner as Chief Scientific Officer 3Biodel Announces Retirement of Dr. Solomon Steiner as Chief Scientific Officer 4Reportlinker Adds Asia-Pacific Markets for Cardiac Rhythm Management, Electrophysiology & Ablation Devices 2011 2Reportlinker Adds Asia-Pacific Markets for Cardiac Rhythm Management, Electrophysiology & Ablation Devices 2011 3Reportlinker Adds Asia-Pacific Markets for Cardiac Rhythm Management, Electrophysiology & Ablation Devices 2011 4Reportlinker Adds Asia-Pacific Markets for Cardiac Rhythm Management, Electrophysiology & Ablation Devices 2011 5Reportlinker Adds Asia-Pacific Markets for Cardiac Rhythm Management, Electrophysiology & Ablation Devices 2011 6Reportlinker Adds Asia-Pacific Markets for Cardiac Rhythm Management, Electrophysiology & Ablation Devices 2011 7Reportlinker Adds Asia-Pacific Markets for Cardiac Rhythm Management, Electrophysiology & Ablation Devices 2011 8Reportlinker Adds Asia-Pacific Markets for Cardiac Rhythm Management, Electrophysiology & Ablation Devices 2011 9Reportlinker Adds Asia-Pacific Markets for Cardiac Rhythm Management, Electrophysiology & Ablation Devices 2011 10Reportlinker Adds Asia-Pacific Markets for Cardiac Rhythm Management, Electrophysiology & Ablation Devices 2011 11Reportlinker Adds Asia-Pacific Markets for Cardiac Rhythm Management, Electrophysiology & Ablation Devices 2011 12Reportlinker Adds Asia-Pacific Markets for Cardiac Rhythm Management, Electrophysiology & Ablation Devices 2011 13Reportlinker Adds Asia-Pacific Markets for Cardiac Rhythm Management, Electrophysiology & Ablation Devices 2011 14Reportlinker Adds Asia-Pacific Markets for Cardiac Rhythm Management, Electrophysiology & Ablation Devices 2011 15Reportlinker Adds Asia-Pacific Markets for Cardiac Rhythm Management, Electrophysiology & Ablation Devices 2011 16Reportlinker Adds Asia-Pacific Markets for Cardiac Rhythm Management, Electrophysiology & Ablation Devices 2011 17Reportlinker Adds Asia-Pacific Markets for Cardiac Rhythm Management, Electrophysiology & Ablation Devices 2011 18Reportlinker Adds Asia-Pacific Markets for Cardiac Rhythm Management, Electrophysiology & Ablation Devices 2011 19Reportlinker Adds Asia-Pacific Markets for Cardiac Rhythm Management, Electrophysiology & Ablation Devices 2011 20Reportlinker Adds Asia-Pacific Markets for Cardiac Rhythm Management, Electrophysiology & Ablation Devices 2011 21
Space-saving storage cabinets for microscope slides....
High-quality, epoxy-coated, stackable steel cabinets for the storage of microscope slides, slide filing wallets, processing cassettes, tissue blocks, transparencies and A5 index cards....
All metal for storing 5 cm x 5 cm (2 inches x 2 inches) 35 mm color slides. Each is individually crafted of high grade steel and finished with a durable baked enamel finish....
A prepared Microscope Slide Cataloging and Storage System....
Medicine Products: