Navigation Links
Molecular marker predicts patients most likely to benefit longest from 2 popular cancer drugs
Date:9/5/2013

Johns Hopkins scientists have identified a molecular marker called "Mig 6" that appears to accurately predict longer survival -- up to two years -- among patients prescribed two of the most widely used drugs in a class of anticancer agents called EGFR inhibitors.

The U.S. Food and Drug Administration-approved drugs, gefitinib (Iressa) and erlotinib (Tarceva), are prescribed for lung and pancreatic cancer patients but only a few who have mutations in the EGFR gene usually benefit with a prolonged reduction of tumor size. The two drugs block the gene's ramped-up protein production, but patients' response to the drug varies widely from no survival benefit to several years. The average is several months.

"Clinicians have had no reliable method for distinguishing patients who are not likely to respond to EGFR inhibitors and those who will respond very well," says David Sidransky, M.D., professor of otolaryngology, oncology, pathology, urology, and genetics at Johns Hopkins. Looking at the precise level of protein production from the EGFR gene alone in specific patients was not proven to be a good indicator of patients' response to EGFR-blocking drugs, but the presence or absence of Mig 6 might be, he adds.

In a preliminary study, described July 31 in the online journal, PLoS ONE, the Johns Hopkins scientists found the genetic marker in a series of experiments that began with laboratory-derived lung and head and neck cancer cell lines resistant to EGFR-inhibitor drugs. In the cell lines, the team found very high levels of protein production from the Mig 6 gene -- up to three times the level in sensitive cell lines. Mig 6 is one of the molecules that controls the activity of the EGFR protein.

"In the first set of experiments, we found that higher levels of Mig 6 occur often in cells that don't respond to EGFR inhibitors," says Sidransky. "Most tumors are known to have high Mig 6 levels and are not expected to respond to EG
'/>"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-614-2916
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Molecular Imaging, Inc. Announces New Webinar: Advancing Discovery and Development of Biologics Through Non-Invasive Biodistribution Imaging
2. Janina A. Longtine, MD of the Icahn School of Medicine at Mount Sinai Elected President of the Association for Molecular Pathology
3. Dartmouth researchers develop molecular switch that changes liquid crystal colors
4. Mount Sinai and Exosome Partner to Accelerate Translation of Body Fluid Molecular Diagnostics to Overcome Limitations of Tissue Biopsy in Areas of Unmet Medical Needs
5. Molecular Diagnostics Market - New Industry Research Report is Now Available for Pre-Order at Transparency Market Research
6. New study shows vitamin D-related molecular switches predict childhood bone mass
7. EurekaMag.com Publishes 64 Thousand New Animal Science References and Bibliography on Molecular Cloning
8. Molecular switch controls the destiny of self-eating cells
9. The Association for Molecular Pathology announces 2013 Leadership Award recipient
10. Abnormalities in new molecular pathway may increase breast cancer risk
11. Researchers gain new molecular-level understanding of the brains recovery after stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... testosterone falls below normal levels are more likely to ... heart disease and type 2 diabetes. A new simple ... testing and possible treatment is described in an article ... publication from Mary Ann Liebert, Inc., publishers. The article ... Health website at http://www.liebertpub.com/jmh . ...
(Date:4/23/2014)... accessible detection methods that can rapidly screen a ... single cell inside that population has been seriously ... , In the Royal Society of Chemistry journal ... he and his coworkers have developed a novel ... protein ( Chem. Sci. , 2014, DOI: 10.1039/C4SC00578C, ...
(Date:4/23/2014)... health benefits of probiotics, antioxidants and other nutritional compounds, ... chemical industry is getting in on the action. But ... so the industry is responding with clinical research to ... in Chemical & Engineering News (C&EN), the ... Melody M. Bomgardner, a senior editor at C&EN, writes ...
(Date:4/23/2014)... country as wealthy as the United States, it may come ... have access to adequate food due to lack of money ... Recent research at the University of Illinois using data from ... the seniors who are dealing with hunger are also facing ... percent of Americans over age 60 faced the threat of ...
(Date:4/23/2014)... A team of scientists led by a researcher from ... the National University of Singapore has identified the cancer ... opens up the possibility of developing new drugs for ... cancers. , The research group, led by Dr Chan ... for the first time that a cancer-specific variant of ...
Breaking Medicine News(10 mins):Health News:Following a protein's travel inside cells is key to improving patient monitoring, drug development 2Health News:More Americans in their golden years are going hungry 2Health News:Scientists identify cancer specific cell for potential treatment of gastric cancer 2Health News:Scientists identify cancer specific cell for potential treatment of gastric cancer 3
... are at a greater risk of catching bird flu, as the ... ,A study on cats in areas where outbreaks have ... than thought. It raises the chilling prospect that the disease could ... human pandemic. And it shows that should bird flu ever break ...
... have patented a device, which is capable of the ... by various bacteria, notable amongst which are Salmonella, Campylobacter ... due to food poisoning, as well as of other ... the aim of extending the uses of the device ...
... Dengue fever is a viral infection transmitted through the ... patients //never knowing they have been infected. However, in ... tendency triggering the often-fatal Dengue Shock Syndrome. Because some ... the virus from the tropics back to their home ...
... rise in pneumonia, bronchitis and other acute respiratory infections in ... the United Nations health agency is sending antibiotics for thousands ... many more from catching the illnesses. ,“Early ... save lives,” UN spokesman Adrian Edwards told a press briefing ...
... diuretic drugs should not be recommended as a way to ... caused during pregnancy. It is characterized by high blood pressure, ... urine. The high blood pressure can affect the brain, kidneys, ... in the 1960s to women in order to avoid dangerously ...
... of researchers has constructed a model that predicts how ... by airliners. ,The study, "Modeling the Worldwide ... appears in the January issue of the journal PLoS ... the world's largest-scale epidemic simulation of its kind. ...
Cached Medicine News:Health News:Cat Owners at Risk of Bird Flu 2Health News:A Patented Device for Rapid Diagnosis of Diseases 2Health News:Europeans Developing First-Ever Dengue Fever Vaccine 2Health News:UN Sends Medicine to Afghanistan 2Health News:Avoid Diuretic Pills During Pregnancy 2Health News:Scientists Assess Risk of Flu Pandemic Spread Via Global Airlines 2Health News:Scientists Assess Risk of Flu Pandemic Spread Via Global Airlines 3
(Date:1/15/2014)... 15, 2014  Echo Therapeutics, Inc. (Nasdaq: ECTE ... CGM System as a non-invasive, wireless continuous glucose monitoring ... Executive Chairman and Interim CEO of Echo Therapeutics, will ... Equity Conference. Mr. Doman will make ...
(Date:1/15/2014)... YORK , Jan. 15, 2014 ... report is available in its catalogue: ... India Drug Forecast and Market Analysis to ... PharmaPoint: Atopic Dermatitis - India Drug ...
(Date:1/15/2014)... 15, 2014  Zafgen, Inc., a leading biopharmaceutical company ... obese patients, today announced initial results from its ... of methionine aminopeptidase 2 (MetAP2), in patients with ... obesity.  These results showed improvements in body weight, ...
Breaking Medicine Technology:Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 2Echo Therapeutics to Present at the Noble Financial Capital Markets' Tenth Annual Equity Conference 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 2PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 3PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 4PharmaPoint: Atopic Dermatitis - India Drug Forecast and Market Analysis to 2022 5Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 2Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 3Zafgen Announces Initial Results from Phase 2a Study of Beloranib in Patients with Prader-Willi Syndrome 4
... ANAHEIM, Calif. , July 28 Siemens ... services and solutions for clinicians at the American Association for ... from July 27 through July 29, 2010 ... demonstrating how Siemens is focused on putting the power behind ...
... Commitment to Patient Safety; Approved Sites Eligible to Advertise through Search ... , , ... 28 The National Association of Boards of Pharmacy ® ... Drug as the first online pharmacy services to be approved through ...
Cached Medicine Technology:Siemens Showcases Broad Array of Innovative Diagnostic Solutions at 2010 AACC and ASCLS Annual Meetings and Clinical Lab Expo 2Siemens Showcases Broad Array of Innovative Diagnostic Solutions at 2010 AACC and ASCLS Annual Meetings and Clinical Lab Expo 3Siemens Showcases Broad Array of Innovative Diagnostic Solutions at 2010 AACC and ASCLS Annual Meetings and Clinical Lab Expo 4Siemens Showcases Broad Array of Innovative Diagnostic Solutions at 2010 AACC and ASCLS Annual Meetings and Clinical Lab Expo 5Siemens Showcases Broad Array of Innovative Diagnostic Solutions at 2010 AACC and ASCLS Annual Meetings and Clinical Lab Expo 6NABP Grants First 'Approved e-Advertiser' Status to Pharmahelper.com, QC Supply, and Kerr Drug 2NABP Grants First 'Approved e-Advertiser' Status to Pharmahelper.com, QC Supply, and Kerr Drug 3
... microplate incubator is an extremely compact ... single microplate up to 50C. ... requiring higher temperatures up to 65C. ... low cost and high performance for ...
... The Solo microplate incubator is an ... incubating a single microplate up to ... incubates applications requiring higher temperatures up ... solution offering low cost and high ...
... The iEMS Incubator/Shaker HT ... Thus, the iEMS Incubator/Shaker HT ... as DNA hybridization and primer ... is available as a one-cabinet ...
The iEMS Incubator/Shaker is a high performance microplate incubator and orbital shaker. Its superior temperature control and efficient orbital shaking reduce incubation times. -...
Medicine Products: