Navigation Links
Molecular marker predicts patients most likely to benefit longest from 2 popular cancer drugs
Date:9/5/2013

Johns Hopkins scientists have identified a molecular marker called "Mig 6" that appears to accurately predict longer survival -- up to two years -- among patients prescribed two of the most widely used drugs in a class of anticancer agents called EGFR inhibitors.

The U.S. Food and Drug Administration-approved drugs, gefitinib (Iressa) and erlotinib (Tarceva), are prescribed for lung and pancreatic cancer patients but only a few who have mutations in the EGFR gene usually benefit with a prolonged reduction of tumor size. The two drugs block the gene's ramped-up protein production, but patients' response to the drug varies widely from no survival benefit to several years. The average is several months.

"Clinicians have had no reliable method for distinguishing patients who are not likely to respond to EGFR inhibitors and those who will respond very well," says David Sidransky, M.D., professor of otolaryngology, oncology, pathology, urology, and genetics at Johns Hopkins. Looking at the precise level of protein production from the EGFR gene alone in specific patients was not proven to be a good indicator of patients' response to EGFR-blocking drugs, but the presence or absence of Mig 6 might be, he adds.

In a preliminary study, described July 31 in the online journal, PLoS ONE, the Johns Hopkins scientists found the genetic marker in a series of experiments that began with laboratory-derived lung and head and neck cancer cell lines resistant to EGFR-inhibitor drugs. In the cell lines, the team found very high levels of protein production from the Mig 6 gene -- up to three times the level in sensitive cell lines. Mig 6 is one of the molecules that controls the activity of the EGFR protein.

"In the first set of experiments, we found that higher levels of Mig 6 occur often in cells that don't respond to EGFR inhibitors," says Sidransky. "Most tumors are known to have high Mig 6 levels and are not expected to respond to EG
'/>"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-614-2916
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Molecular Imaging, Inc. Announces New Webinar: Advancing Discovery and Development of Biologics Through Non-Invasive Biodistribution Imaging
2. Janina A. Longtine, MD of the Icahn School of Medicine at Mount Sinai Elected President of the Association for Molecular Pathology
3. Dartmouth researchers develop molecular switch that changes liquid crystal colors
4. Mount Sinai and Exosome Partner to Accelerate Translation of Body Fluid Molecular Diagnostics to Overcome Limitations of Tissue Biopsy in Areas of Unmet Medical Needs
5. Molecular Diagnostics Market - New Industry Research Report is Now Available for Pre-Order at Transparency Market Research
6. New study shows vitamin D-related molecular switches predict childhood bone mass
7. EurekaMag.com Publishes 64 Thousand New Animal Science References and Bibliography on Molecular Cloning
8. Molecular switch controls the destiny of self-eating cells
9. The Association for Molecular Pathology announces 2013 Leadership Award recipient
10. Abnormalities in new molecular pathway may increase breast cancer risk
11. Researchers gain new molecular-level understanding of the brains recovery after stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... Ticket Down is a reliable source for authentic tickets ... on Friday, July 3rd at LP Field in Nashville, TN. ... of international soccer. The number of chances to watch some of ... growing at a large clip. Over the past several years, many ... to play in front of the American people. The match between ...
(Date:5/21/2015)... (PRWEB) May 21, 2015 How do you ... dollar question for parents and school administrators, but a Miami ... company based in southern Florida, is devising new ways ... lice professionals will tell you, the first step is education ... and classrooms, head lice and how they spread are still ...
(Date:5/21/2015)... 2015 Jhon Tamayo, founder and ... is excited to announce the launch of the ... for use exclusively in Tamayo's NY studio. What ... it's mathematically designed with symmetrical lines and shapes ... strains, commonly experienced by both beginner and experienced ...
(Date:5/21/2015)... May 21, 2015 Amercanex today ... Exchange, the first fully electronic marketplace for industrial ... comprehensive electronic marketplace in which wholesale and retail ... their hemp-related inventories on a fully disclosed and ... this demand through a unique blend of cutting-edge ...
(Date:5/21/2015)... (PRWEB) May 21, 2015 PharmApprove ... consultancy to the pharmaceutical and biotechnology industries – will ... the 2015 BIO International Convention in Philadelphia, PA. PharmApprove’s ... Like a Payer,” will take place on June ... Smaldone , PharmApprove President and CSO, will moderate the ...
Breaking Medicine News(10 mins):Health News:USA vs. Guatemala Tickets: Ticket Down Slashes United States Men's Soccer Team (USMNT) vs. Guatemala Tickets at LP Field in Nashville on 7/3/15 2Health News:Local Lice Removal Company Partners with Schools to Combat Head Lice in the Classroom as Increase in Number of Cases Reported in May. 2Health News:NY's Atmananda Yoga Studio Launches Its Patented "Alignment" Yoga Mat for Public Sale 2Health News:Amercanex is Revolutionizing Order and Efficiency in the Hemp Industry 2Health News:PharmApprove Panel at BIO Addresses Success in Drug Development Beyond Regulatory Approval 2Health News:PharmApprove Panel at BIO Addresses Success in Drug Development Beyond Regulatory Approval 3
... child in Texas; CDC warns more deaths are likely ... child in Texas has become the first U.S. fatality ... said Wednesday morning. , Dr. Richard Besser, acting director ... confirmed the death. No other details on the case ...
... , - Bausch & ... , Bausch & Lomb unveils ... its continued effort to improve the habits of,contact lens-wearers ... THINK,EYEGIENE(TM) campaign, Bausch & Lomb is introducing ReNu MultiPlus(R) ...
... Make Healthy Choices on the Job-CHICAGO, April 29 ... of U.S. workers as one-in-ten report increased snacking during ... situation. Overall, 43 percent say they have gained weight ... survey. The survey was conducted from February 20 through ...
... Consent Recommendations Established by the Institutes of MedicineSAN BRUNO, ... (CBR), the global leader in the collection and preservation ... its support of legislation introduced by Congresswoman Jackie ... Awareness Act of 2009." If passed, this ground-breaking ...
... In his first book in almost a decade, and the first ... instructions for hunger-free weight loss with a fascinating, entertaining history of ... ... 29, 2009 -- On May 22nd, Dr. Siegal,s Cookie Diet Book ...
... to consider healthy hearing for spring 2009 , ... ... of spring marks an opportunity for Americans to refresh and revitalize ... a global initiative to inform and educate the public about the ...
Cached Medicine News:Health News:U.S. Reports First Swine Flu Death 2Health News:U.S. Reports First Swine Flu Death 3Health News:A Clear Solution for Healthy Eyes 2Health News:A Clear Solution for Healthy Eyes 3Health News:A Clear Solution for Healthy Eyes 4Health News:Four-in-Ten U.S. Employees Have Gained Weight at Their Current Jobs, CareerBuilder Study Finds 2Health News:Four-in-Ten U.S. Employees Have Gained Weight at Their Current Jobs, CareerBuilder Study Finds 3Health News:Cord Blood Registry Supports Introduction of the Cord Blood Education and Awareness Act of 2009 2Health News:Cord Blood Registry Supports Introduction of the Cord Blood Education and Awareness Act of 2009 3Health News:Dr. Siegal's Cookie Diet Book by Sanford Siegal, D.O., M.D., Available May 22nd 2Health News:Dr. Siegal's Cookie Diet Book by Sanford Siegal, D.O., M.D., Available May 22nd 3Health News:Dr. Siegal's Cookie Diet Book by Sanford Siegal, D.O., M.D., Available May 22nd 4Health News:This Spring, Hear the World 2Health News:This Spring, Hear the World 3
(Date:5/22/2015)... May 22, 2015 Today, Rhodes Pharmaceuticals ... system stimulant indicated for the treatment of Attention-Deficit/Hyperactivity ... Summer 2015. The announcement comes ... from the U.S. Food and Drug Administration (FDA). ... formulation of methylphenidate capsule with an onset of ...
(Date:5/22/2015)... , May 22, 2015 ... clinical research unit with a worldwide reputation for ... its frequent publications in peer reviewed medical journals. ... stakeholders and regulators in discussions about rules for ...      (Logo: http://photos.prnewswire.com/prnh/20150522/745125) , Clinical ...
(Date:5/22/2015)...  China Nepstar Chain Drugstore Ltd. (NYSE: NPD ) ... in China based on the ... of Mr. Fuxiang Zhang as the Company,s ... Rebecca Yingnan Zhang has been appointed as ... effective immediately. Meanwhile, Ms. Zhang resigned from the position ...
Breaking Medicine Technology:Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 2Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 3Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 4Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 5Rhodes Pharmaceuticals Announces Launch of New, Once-Daily Treatment for ADHD 6China Nepstar Chain Drugstore Ltd. Announces Management Change and New Director Appointment 2China Nepstar Chain Drugstore Ltd. Announces Management Change and New Director Appointment 3
... , , PALO ALTO, Calif., Dec. ... November 25, 2009, Varian, Inc. filed with the U.S. Securities and ... year ended October 2, 2009. This Annual Report may be ... "Investors" and "SEC Filings," and then on "10-K" in the table ...
... , ... that a new market research report is available in ... Market Trends , http://www.reportlinker.com/p0164230/Hemoglobin-A1c-Monitoring---Global-Market-Trends.html , The ... to manage diabetes has led to the emergence of ...
Cached Medicine Technology:Reportlinker Adds Hemoglobin A1c Monitoring - Global Market Trends 2Reportlinker Adds Hemoglobin A1c Monitoring - Global Market Trends 3Reportlinker Adds Hemoglobin A1c Monitoring - Global Market Trends 4Reportlinker Adds Hemoglobin A1c Monitoring - Global Market Trends 5Reportlinker Adds Hemoglobin A1c Monitoring - Global Market Trends 6Reportlinker Adds Hemoglobin A1c Monitoring - Global Market Trends 7
We offer small and large pre-gelled Surface Electrodes suitable for EGG or EMG recordings. Surface Electrodes, Skin Preparation and Conductive Cream complete the setup for a EGG study and are essenti...
Sandhill Scientific offers a comprehensive selection of solid state and water perfused catheters for both adult & pediatric applications.Contact Sandhill Scientific for full details...
... a family of single-use products to promote ... you. This single-use catheter reduces cross-contamination and ... of infection and, because cleaning is eliminated, ... ,We have water perfused manometric catheters ...
... motility testing simpler than ever ... up in seconds and protect ... sensor circumferential, Air-Charged Catheters improve ... For advanced performance made easy, ...
Medicine Products: