Navigation Links
Molecular marker predicts patients most likely to benefit longest from 2 popular cancer drugs
Date:9/5/2013

Johns Hopkins scientists have identified a molecular marker called "Mig 6" that appears to accurately predict longer survival -- up to two years -- among patients prescribed two of the most widely used drugs in a class of anticancer agents called EGFR inhibitors.

The U.S. Food and Drug Administration-approved drugs, gefitinib (Iressa) and erlotinib (Tarceva), are prescribed for lung and pancreatic cancer patients but only a few who have mutations in the EGFR gene usually benefit with a prolonged reduction of tumor size. The two drugs block the gene's ramped-up protein production, but patients' response to the drug varies widely from no survival benefit to several years. The average is several months.

"Clinicians have had no reliable method for distinguishing patients who are not likely to respond to EGFR inhibitors and those who will respond very well," says David Sidransky, M.D., professor of otolaryngology, oncology, pathology, urology, and genetics at Johns Hopkins. Looking at the precise level of protein production from the EGFR gene alone in specific patients was not proven to be a good indicator of patients' response to EGFR-blocking drugs, but the presence or absence of Mig 6 might be, he adds.

In a preliminary study, described July 31 in the online journal, PLoS ONE, the Johns Hopkins scientists found the genetic marker in a series of experiments that began with laboratory-derived lung and head and neck cancer cell lines resistant to EGFR-inhibitor drugs. In the cell lines, the team found very high levels of protein production from the Mig 6 gene -- up to three times the level in sensitive cell lines. Mig 6 is one of the molecules that controls the activity of the EGFR protein.

"In the first set of experiments, we found that higher levels of Mig 6 occur often in cells that don't respond to EGFR inhibitors," says Sidransky. "Most tumors are known to have high Mig 6 levels and are not expected to respond to EG
'/>"/>

Contact: Vanessa Wasta
wastava@jhmi.edu
410-614-2916
Johns Hopkins Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Molecular Imaging, Inc. Announces New Webinar: Advancing Discovery and Development of Biologics Through Non-Invasive Biodistribution Imaging
2. Janina A. Longtine, MD of the Icahn School of Medicine at Mount Sinai Elected President of the Association for Molecular Pathology
3. Dartmouth researchers develop molecular switch that changes liquid crystal colors
4. Mount Sinai and Exosome Partner to Accelerate Translation of Body Fluid Molecular Diagnostics to Overcome Limitations of Tissue Biopsy in Areas of Unmet Medical Needs
5. Molecular Diagnostics Market - New Industry Research Report is Now Available for Pre-Order at Transparency Market Research
6. New study shows vitamin D-related molecular switches predict childhood bone mass
7. EurekaMag.com Publishes 64 Thousand New Animal Science References and Bibliography on Molecular Cloning
8. Molecular switch controls the destiny of self-eating cells
9. The Association for Molecular Pathology announces 2013 Leadership Award recipient
10. Abnormalities in new molecular pathway may increase breast cancer risk
11. Researchers gain new molecular-level understanding of the brains recovery after stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/22/2014)... Malaysia today became a founding partner in the Global ... to promoting young talent in science, technology, engineering and ... New York Academy of Sciences (NYAS), Malaysian Prime Minister ... Monday Sept. 22. , With the goal of developing ... countries by 2020, the initiative will create a host ...
(Date:9/22/2014)... September 22, 2014 This Flash Report ... stakeholder management needs for the Prostate Cancer market. , ... on stakeholder strategies for any launching Prostate Cancer product:, ... differentiation within an increasingly crowded market , ... impact of identifying community-based thought leaders and stakeholders ...
(Date:9/22/2014)... (PRWEB) September 22, 2014 The R&D ... the recent years. The statistically important data received from ... of cancer vaccines. The primary challenge to the development ... about the exact mechanism of how a human’s immune ... various results in different individuals owing to known factors ...
(Date:9/22/2014)... Sept. 22, 2014 (HealthDay News) -- Two new prescription ... (FDA) may provide some relief for people with migraine ... a new study. One device -- the Cefaly ... device -- the Cerena -- is meant to be ... news release. "Patients have been looking for alternative ...
(Date:9/22/2014)... Nanuet, NY (PRWEB) September 22, 2014 ... Blindness, Rockland Chrysler Jeep Dodge Ram is launching an ... Blind Egg Challenge (#blindeggchallenge or #ffbBEC) aims to raise ... Egg Challenge involves throwing an egg in the air ... at least three others and if a nominee does ...
Breaking Medicine News(10 mins):Health News:Growing scientists: World's future jobs are rooted in STEM 2Health News:Growing scientists: World's future jobs are rooted in STEM 3Health News:Download HeartBeat Experts White Paper: Stakeholder Management for new Prostate Cancer Products 2Health News:World Cancer Vaccines Market Landscape Examined by Kuick Research in New Study Published at MarketPublishers.com 2Health News:World Cancer Vaccines Market Landscape Examined by Kuick Research in New Study Published at MarketPublishers.com 3Health News:World Cancer Vaccines Market Landscape Examined by Kuick Research in New Study Published at MarketPublishers.com 4Health News:Noninvasive Devices May Help Migraines, FDA Says 2Health News:Blind Egg Challenge Raises Awareness for Foundation Fighting Blindness 2
... ... in pursing careers in medical transcription and medical coding and billing. , ... Provo, Utah (PRWEB) June 5, ... Community College in Roxboro, N.C. to offer training to individuals interested in pursing careers ...
... announced today its decision to expand its use of ... sanitizer, to all its service centers nationwide after testing ... the first major healthcare laundry processor to implement the ... wash process will elevate the standard of cleanliness in ...
... Univision, People en Espanol, Ser Padres and impreMedia health expert Aliza ... Doctora Aliza (TM), announced the launch of her Spanish-language health hub ... http://www.newscom.com/cgi-bin/prnh/20090604/SF28145 ) , , " VidaySalud.com ... wellness tools in Spanish on the web. It includes ...
... Gift Cards, Inspiring Star Cards Make Giving Easy , ... Maggiano,s Little Italy(R) restaurants begin the sixth annual "Eat-A-Dish ... five Chicago-area Maggiano,s are taking part in the program ... the nonprofit organization that makes wishes come true for ...
... Up 191% - , , - Total Net Sales in Line ... be Held Today at 3:30 pm Central Time - ... UPI ), a medical device company that develops, manufactures and markets innovative ... fourth quarter and full year ended March 31, 2009. Net sales ...
... could mutate and become more dangerous as it travels from ... In what would seem to be some encouraging news in ... official said Thursday that samples of the virus from points ... in the United States. , "We have tested isolates from ...
Cached Medicine News:Health News:Career Step Partners with Piedmont Community College to Help Students Gain Careers in Growing Healthcare Industry 2Health News:Angelica Corporation Raises Bar Again for Increased Patient Safety 2Health News:Univision's Doctora Aliza Launches VidaySalud.com(TM) 2Health News:Maggiano's Little Italy(R) Celebrates Sixth Annual 'Eat-A-Dish for Make-A-Wish(R)' in Chicago 2Health News:Maggiano's Little Italy(R) Celebrates Sixth Annual 'Eat-A-Dish for Make-A-Wish(R)' in Chicago 3Health News:Maggiano's Little Italy(R) Celebrates Sixth Annual 'Eat-A-Dish for Make-A-Wish(R)' in Chicago 4Health News:Uroplasty Reports Fourth Quarter and Full Year Fiscal 2009 Results 2Health News:Uroplasty Reports Fourth Quarter and Full Year Fiscal 2009 Results 3Health News:Uroplasty Reports Fourth Quarter and Full Year Fiscal 2009 Results 4Health News:Uroplasty Reports Fourth Quarter and Full Year Fiscal 2009 Results 5Health News:Uroplasty Reports Fourth Quarter and Full Year Fiscal 2009 Results 6Health News:Uroplasty Reports Fourth Quarter and Full Year Fiscal 2009 Results 7Health News:Uroplasty Reports Fourth Quarter and Full Year Fiscal 2009 Results 8Health News:Uroplasty Reports Fourth Quarter and Full Year Fiscal 2009 Results 9Health News:Uroplasty Reports Fourth Quarter and Full Year Fiscal 2009 Results 10Health News:Uroplasty Reports Fourth Quarter and Full Year Fiscal 2009 Results 11Health News:Global Testing Shows No Variation in Swine Flu Virus 2Health News:Global Testing Shows No Variation in Swine Flu Virus 3Health News:Global Testing Shows No Variation in Swine Flu Virus 4Health News:Global Testing Shows No Variation in Swine Flu Virus 5Health News:Global Testing Shows No Variation in Swine Flu Virus 6Health News:Global Testing Shows No Variation in Swine Flu Virus 7Health News:Global Testing Shows No Variation in Swine Flu Virus 8Health News:Global Testing Shows No Variation in Swine Flu Virus 9Health News:Global Testing Shows No Variation in Swine Flu Virus 10Health News:Global Testing Shows No Variation in Swine Flu Virus 11
(Date:9/22/2014)... Sept. 22, 2014 Paragon 28, ... commercial launch of its foot plating system that supplants ... The GORILLA TM R3CON PLATING SYSTEM greatly enhances ... TM & Mini-Monster TM Screw Systems and ... of 10 interchangeable subsystems, the GORILLA TM R3CON ...
(Date:9/22/2014)... NEW YORK , Sept. 22, 2014 /PRNewswire/ ... is in mature stage. It is largely a ... endoscopy suite expansion. The mergers, acquisitions and partnerships ... Europe . This research service provides details ... competitive environment and pricing trends across the country. ...
(Date:9/22/2014)... 2014 ... the addition of the  "Global Freeze Drying ... Market - Forecast to 2019"  report to ... ,The global freeze drying market was valued ... expected to reach at $2,655.9 million by ...
Breaking Medicine Technology:Paragon 28, Inc. Launches the GORILLA(TM) R3CON PLATING SYSTEM 2Automated Endoscope Reprocessor Market Trends in Western Europe 2Automated Endoscope Reprocessor Market Trends in Western Europe 3Global Freeze Drying / Lyophilization Equipment (Lab, Pilot, & Industrial) Market - Forecast to 2019 2Global Freeze Drying / Lyophilization Equipment (Lab, Pilot, & Industrial) Market - Forecast to 2019 3
Designed to meet the requirements of reagent grade water for routine analysis....
... L/min of Type I ultrapure water, , ... Plus System is designed to provide the ... pretreated by reverse osmosis, distillation or deionization. ... quality which exceeds Type I ASTM/CAP/NCCLS specifications.,The ...
... Basic Laboratory Needs, Synergy systems produce ultrapure water ... 1 to 1.2 L/min to meet the basic ... incorporates a dual-wavelength UV lamp (185 nm and ... of organic contaminants (< 5 ppb TOC when ...
... Compact System Produces Type I Water Directly from ... designed for scientists who need 5 to 15 ... not have easy access to acceptable quality pretreated ... 0.6 L/min of ultrapure (Type I) water on ...
Medicine Products: