Navigation Links
Molecular link between diabetes and cancer described
Date:11/15/2011

Developing type 2 diabetes is a lengthy process. An early sign that it has begun is high levels of insulin in the blood. As long as the insulin-producing beta cells are able to compensate for the increased demand, for example when the individual is overweight, the blood sugar levels remain normal. It is not until the capacity for insulin secretion falls below the level needed that type 2 diabetes becomes a fact. The latter stage generally goes quickly, as the stressed beta cells work themselves to death.

"We have worked with the most well-known risk gene for type 2 diabetes, a variant of the TCF gene, and have studied its function in the beta cells", says Yuedan Zhou, a doctoral student at the Lund University Diabetes Centre and principal author of the published study.

The risk variant of TCF is common, 25 per cent of the population carry it and 31 per cent of diabetics, according to figures from the Malm Preventive Project population survey.

An equally well-established risk gene in cancer research is p53. The gene has been called the "protector of the genome" because it prevents the uncontrolled cell division that takes place in cancer. The p53 gene has been linked to protection against colon and liver cancer, among others.

"The function of the TCF gene in the beta cells is to protect the cells against high, stressful blood sugar levels. If that function fails, the beta cells die, which leads to diabetes", says Ola Hansson, researcher and principal author of the survey.

The two genes work in concert, TCF protects against cell death, while p53 prevents excessive cell division.

"It is here that the connection between diabetes and cancer arises. When the blood sugar levels are high, the TCF gene is activated and this impedes the activity of the p53 gene thereby protecting the beta cells from cell death" .

The research group began working with the TCF gene two years ago to understand its role in insulin production. The discovery of the link with p53 and cancer was mostly by chance.

"Or good intuition", they say.

The mapping of the TCF gene is continuing, this time in collaboration with the European Bioinformatics Institute in Cambridge.

Cancer researchers are working to try and influence p53 so that its tumour-preventing function is restored.

"In a similar way, strengthening the protective function of TCF against beta cell death in connection with high blood sugar would work as a drug for type 2 diabetes, or as a treatment before the disease has even developed fully", says Ola Hansson.


'/>"/>

Contact: Ola Hansson
Ola.Hansson@med.lu.se
46-739-549-923
Lund University
Source:Eurekalert

Related medicine news :

1. AACR-NCI-EORTC to hold molecular targets meeting in San Francisco
2. Nobel Laureate Bruce Beutler on molecular sensors as a trigger for autoimmune disease
3. Biodesign researchers to develop new reagent pipeline for molecular medicine
4. Molecular depth profiling modeled using buckyballs and low-energy argon
5. New equation predicts molecular forces in hydrophobic interactions
6. AACR hosts molecular targets and cancer therapeutics conference
7. Researchers identify potential molecular target to prevent growth of cancer cells
8. New clues to molecular understanding of autism
9. Molecular meet and greet
10. Hebrew U. scientists identify molecular basis for DNA breakage
11. Blocking molecular target could make more cancers treatable with PARP inhibitors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... October 12, 2017 , ... Information ... we intend to develop to enable prevention of a major side effect of ... loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed on-label ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... HMP ... the recipient of a 2017 Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare ... City on October 11, 2017. , The annual award competition recognizes editorial and design ...
(Date:10/12/2017)... FL (PRWEB) , ... October 12, 2017 , ... On ... holding a treadmill relay – Miles by Moonlight to raise money for the American ... $300 or more. , Teams will work together to keep their treadmills moving ...
(Date:10/12/2017)... ... October 12, 2017 , ... Health Literacy Innovations (HLI), ... software tool, and the Cancer Patient Education Network (CPEN), an independent professional organization ... a new strategic alliance. , As CPEN’s strategic partner, HLI will help ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... wound care advancements to physician colleagues, skilled nursing facility medical directors and other ... Treacherous Waters of Wound Care." , "At many of these conferences we get ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... 28, 2017 Hill-Rom Holdings, Inc. (NYSE: HRC), ... call and webcast on Friday, November 3, 2017, beginning ... ending at approximately 8:30 a.m. (CDT) / 9:30 a.m. ... 2017 financial performance and guidance for 2018, Hill-Rom executives ... enhance operational performance, and long-range financial outlook through 2020. ...
(Date:9/25/2017)... , Sept. 25, 2017   Montrium , ... File solutions, today—from the IQPC Trial Master Files ... , NL)—announced that EastHORN Clinical Services has selected ... programs and TMF management. EastHORN, a leading European ... platform to increase transparency to enable greater collaboration ...
(Date:9/22/2017)... Sept. 22, 2017 AVACEN Medical (AVACEN) announced ... now successfully helping those with the widespread pain associated ... diagnosed Amanda in Essex, England ... my hair, experiencing no sleep at all, tremendous pain, ... I cannot recommend [the AVACEN 100] enough, how this ...
Breaking Medicine Technology: