Navigation Links
Molecular imaging finds novel way to knock down breast cancer

St. Louis, Mo. (June 9, 2014) For years researchers have been developing molecular imaging techniques that visualize hormonally active breast cancer cellsspecifically those testing positive for human epidermal growth factor receptor 2 (HER2). A recent innovation in breast cancer biomarkers seeks the HER3 receptor instead, which could mean more comprehensive breast cancer imaging and potential treatments, say experts presenting data during the Society of Nuclear Medicine and Molecular Imaging's 2014 Annual Meeting.

Breast cancer is one of the most prevalent forms of cancer among women. Certain kinds of tumors have been found to be more aggressive and associated with less than favorable prognoses compared to others. HER2 positive tumors are a hallmark of high-risk breast cancer. Emerging molecular imaging agents join tumor-seeking antibodies and signaling radioisotopes in one radiopharmaceutical that is injected at the time of imaging in order to track and report active receptors.

One of these investigational agents, known in the lab as Cu-64 DOTA-HER3 F(ab')2, does just that by hunting down HER3, a messenger that has been shown to speak for HER2-positive cancers in multiple tissue models when used in conjunction with a scanner called a positron emission tomography (PET) imaging system. This could encourage better, more personalized care for breast cancer patients.

"HER3 is thought to be an important mediator of resistance to the HER2 inhibitors class of anti-cancer therapies, which are used to treat HER2-positive breast cancer representing approximately 20 percent of all breast cancers," said principal author Eric P. Wehrenberg-Klee, MD, from Massachusetts General Hospital in Boston, Mass. "Imaging of HER3 expression may allow for better understanding of how prevalent HER3 over-expression is among HER2 positive breast cancer patients, which in turn may allow for appropriate patient selection for the addition of HER3 inhibitors currently in clinical development."

The researchers expect that it may be another year or two before the agent will reach regulatory approval and enter general clinical practice.

An estimated 232,670 new cases of invasive breast cancer will be diagnosed in women this year, according to 2014 data from the American Cancer Society. Approximately 40,000 women will die from breast cancer this year.


Contact: Kimberly Brown
Society of Nuclear Medicine

Related medicine news :

1. Molecular breast imaging protocol unmasks more cancer
2. Scientists generate long-sought molecular map of critical genetic machinery
3. Scripps Florida scientists unravel the molecular secret of short, intense workouts
4. Molecular high-speed origami
5. International molecular screening program for metastatic breast cancer AURORA at IMPAKT
6. NIH scientist to receive Ross Prize in Molecular Medicine
7. Malfunction in molecular proofreader prevents repair of UV-induced DNA damage
8. Adjuvant chemotherapy increases markers of molecular aging in the blood of BC survivors
9. UNC researchers show cancer chemotherapy accelerates molecular aging
10. Big data tackles tiny molecular machines
11. Molecular aberration signals cancer
Post Your Comments:
(Date:6/24/2016)... ... June 24, 2016 , ... People across the U.S. are ... Code Talker Award, an essay contest in which patients and their families pay tribute ... presented at the 2016 National Society of Genetic Counselors (NSGC) Annual Education Conference (AEC) ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty ... Barry M. Weintraub as a prominent plastic surgeon and the network’s newest partner. ... and the most handsome men, look naturally attractive. Plastic surgery should be invisible.” ...
(Date:6/24/2016)... ... June 24, 2016 , ... Strategic Capital Partners, ... economy by obtaining investment capital for emerging technology companies. SCP has delivered ... already resulted in more than a million dollars of capital investment for five ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) ... held on June 20th at the Woodmont Country Club at 1201 Rockville Pike, ... organization dedicated to helping service members that have been wounded in battle and their ...
(Date:6/24/2016)... ... June 24, 2016 , ... Advanced Plastic Surgery Institute ( ... as its official Medspa Sponsor. Dr. Josh Olson, a board-certified plastic surgeon, owns ... Dr. Olson says the decision to support the pageant in an official capacity ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016 The Academy of Managed ... recommendations that would allow biopharmaceutical companies to more ... that make formulary and coverage decisions, a move that ... new medicines. The recommendations address restrictions in ... on the drug label, a prohibition that hinders decision ...
(Date:6/24/2016)... 2016 Research and Markets has announced ... Diagnostic Tests" report to their offering. ... The World Market for Companion Diagnostics covers ... Market analysis in the report includes the following: ... Diagnostic Kits) by Region (N. America, EU, ROW), 2015-2020 ...
(Date:6/24/2016)... , June 24, 2016 ... appointment of Dr. Edward Futcher to ... Director, effective June 23, 2016.Dr. Futcher was also ... and Governance Committees.  As a non-executive member of ... expertise and strategic counsel to VolitionRx in connection ...
Breaking Medicine Technology: