Navigation Links
Molecular high-speed origami
Date:5/9/2014

Proteins are the workhorses of the cell and thus responsible for almost all biological functions including metabolism, signal transmission or the determination of the cell's shape. However, before they can fulfill their various tasks, the chain-like molecules must first adopt an intricate three-dimensional conformation. This process is called protein folding and is one of the most important processes in biology. In fact, in the event of improper folding, proteins are often no more able to carry out their duties, or even tend to clump together in aggregates. This in turn can lead to severe diseases like Alzheimer's or Parkinson's. In order to avoid this, specialized proteins, the so-called chaperones, help other proteins to adopt their proper shape.

The bacterial chaperones GroEL and GroES serve as an example for this principle: together, they build up a cage-like structure in which they encapsulate new, not yet folded proteins, thereby al-lowing them to fold properly. However, the exact way in which this is accomplished has so far been unclear and is a research topic of the MPIB team led by Manajit Hayer-Hartl and F. Ulrich Hartl, in collaboration with John Engen from Northeastern University in Boston.

Active acceleration of folding

Our results demonstrate that the chaperones not only prevent protein clumping, but also dramatically accelerate the folding process", explains Florian Georgescauld, scientist at the MPIB. Surprisingly, the chaperones achieve this by changing the mechanism of folding: Instead of folding in one large single block, the protein gets its final structure in a series of small, rapid steps like an elaborate high-speed Origami." The researchers think that splitting up the reaction might render it energetically more favorable, which in turn would lead to increased speed. Hence, the folding process is finished in a few seconds rather than in several minutes.

The study shows for the first time that chaperones can act not only passively, by preventing aggregation, but as an active folding cage that catalyzes the folding process. This results in a high-speed folding mechanism which is of particular biological relevance, so the researchers say, since in this way proteins can be folded faster than they are produced. Thus, a backlog of proteins which are not yet or improperly folded and the disastrous consequences which might go along with this can be avoided. [HS]


'/>"/>

Contact: Anja Konschak
konschak@biochem.mpg.de
49-898-578-2824
Max Planck Institute of Biochemistry
Source:Eurekalert  

Related medicine news :

1. International molecular screening program for metastatic breast cancer AURORA at IMPAKT
2. NIH scientist to receive Ross Prize in Molecular Medicine
3. Malfunction in molecular proofreader prevents repair of UV-induced DNA damage
4. Adjuvant chemotherapy increases markers of molecular aging in the blood of BC survivors
5. UNC researchers show cancer chemotherapy accelerates molecular aging
6. Big data tackles tiny molecular machines
7. Molecular aberration signals cancer
8. Study uncovers molecular keys to invasive bladder cancer
9. Short circuit in molecular switch intensifies pain
10. Molecular nano-spies to make light work of disease detection
11. Research shows molecular, protein targeting therapies may be best treatment for certain lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecular high-speed origami
(Date:1/13/2017)... ... ... KOAMTAC ®, Inc., a leading manufacturer of Bluetooth barcode scanners and mobile ... collector at the National Retail Federation’s Big Show (NRF17) held January 15-17 in New ... need for more compact and rugged devices for collecting barcode data paired with a ...
(Date:1/13/2017)... ... ... Pahrump, Nev., used an unsavory medical experience to think of a way to improve the ... for a half year due to lazy bladder," he said. "Keeping these things on my ... to do this." , He then designed and created a prototype of the FOLEY CRADLE, ...
(Date:1/13/2017)... ... 2017 , ... People who have sensitive teeth are about as common as ... teeth. Sadly, most dental hygiene products in the market contain chemical ingredients that only ... continuing their daily oral care routine to keep their teeth white and healthy is ...
(Date:1/13/2017)... ... January 13, 2017 , ... Friday, January 13 at 5 ... game room, increasing the size of the location to 90,000 square feet. , Included ... golf course that takes customers on an educational tour of the historic route, with ...
(Date:1/13/2017)... Tennessee (PRWEB) , ... January 13, 2017 , ... MyGenetx, ... Director of Communications, and Sales Administration Specialist, Mary Taylor Smith, RD, LD, will serve ... President after serving one year as a board member and one year as Vice ...
Breaking Medicine News(10 mins):
(Date:1/13/2017)... Pharmaceuticals, Inc. ("InMed") (CSE: IN; OTCQB: IMLFF), today announced that ... Banking at Eli Lilly & Company, has been appointed to ... 28 years of senior financial and executive leadership to InMed,s ... ... significant leadership position in financial and business expertise with one ...
(Date:1/13/2017)... , January 13, 2017 Stock-Callers ... Wright Medical Group N.V. (NASDAQ: WMGI ), Varian ... Inc. (NASDAQ: MDXG ), and NuVasive Inc. (NASDAQ: ... sector which fell back to a negative finish on Thursday, ... Index falling about 0.1%, while shares of health care companies ...
(Date:1/13/2017)... January 13, 2017 According ... and Equipment Market by Method (Biochemical (Calcium Phosphate, ... Protein Production), End User - Global Forecast to ... global market from 2016 to 2021. This market ... 2021 from USD 715.4 Million in 2016, at ...
Breaking Medicine Technology: