Navigation Links
Molecular high-speed origami
Date:5/9/2014

Proteins are the workhorses of the cell and thus responsible for almost all biological functions including metabolism, signal transmission or the determination of the cell's shape. However, before they can fulfill their various tasks, the chain-like molecules must first adopt an intricate three-dimensional conformation. This process is called protein folding and is one of the most important processes in biology. In fact, in the event of improper folding, proteins are often no more able to carry out their duties, or even tend to clump together in aggregates. This in turn can lead to severe diseases like Alzheimer's or Parkinson's. In order to avoid this, specialized proteins, the so-called chaperones, help other proteins to adopt their proper shape.

The bacterial chaperones GroEL and GroES serve as an example for this principle: together, they build up a cage-like structure in which they encapsulate new, not yet folded proteins, thereby al-lowing them to fold properly. However, the exact way in which this is accomplished has so far been unclear and is a research topic of the MPIB team led by Manajit Hayer-Hartl and F. Ulrich Hartl, in collaboration with John Engen from Northeastern University in Boston.

Active acceleration of folding

Our results demonstrate that the chaperones not only prevent protein clumping, but also dramatically accelerate the folding process", explains Florian Georgescauld, scientist at the MPIB. Surprisingly, the chaperones achieve this by changing the mechanism of folding: Instead of folding in one large single block, the protein gets its final structure in a series of small, rapid steps like an elaborate high-speed Origami." The researchers think that splitting up the reaction might render it energetically more favorable, which in turn would lead to increased speed. Hence, the folding process is finished in a few seconds rather than in several minutes.

The study shows for the first time that c
'/>"/>

Contact: Anja Konschak
konschak@biochem.mpg.de
49-898-578-2824
Max Planck Institute of Biochemistry
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. International molecular screening program for metastatic breast cancer AURORA at IMPAKT
2. NIH scientist to receive Ross Prize in Molecular Medicine
3. Malfunction in molecular proofreader prevents repair of UV-induced DNA damage
4. Adjuvant chemotherapy increases markers of molecular aging in the blood of BC survivors
5. UNC researchers show cancer chemotherapy accelerates molecular aging
6. Big data tackles tiny molecular machines
7. Molecular aberration signals cancer
8. Study uncovers molecular keys to invasive bladder cancer
9. Short circuit in molecular switch intensifies pain
10. Molecular nano-spies to make light work of disease detection
11. Research shows molecular, protein targeting therapies may be best treatment for certain lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecular high-speed origami
(Date:8/27/2014)... Top 10 Best SEO Hosting, a well-known ... suppliers and announced iPage, Bluehost and GoDaddy are the most ... and Europe to buy useful hosting (including VPS and cloud ... iPage has been serving hosting small business websites ... grown into a leader in the hosting industry for its ...
(Date:8/27/2014)... Skirt Sports , the innovative women’s ... pioneer runner, Kathrine Switzer, most noted for her brave running ... a line of women’s running clothes that unites the history ... 261 Fearless Movement. , “It is such an ... DeBoom. “Kathrine is the original Skirt – she stood ...
(Date:8/27/2014)... 27, 2014 The Latinos In Action ... and 7th at the Florida State Fair Grounds from ... Latino art and cultures from around the world. Latinos ... sponsor Go Smart Mobile and Univision Mobile, a service ... expecting an estimate of 4,000 people from different backgrounds, ...
(Date:8/27/2014)... Calif. (PRWEB) August 27, 2014 Seventy-three ... of Pharmacy (SoP) celebrated the beginning of their careers ... on Saturday, August 23. Students entering a four-year PharmD ... and care ?to welcome them into the profession as ... the ceremony held at the Garrison Theater in Claremont, ...
(Date:8/27/2014)... Dennis Thompson HealthDay ... Someone who has been mugged in a dark alley will ... with a fear of being attacked. But neuroscientists working ... how memories are linked with positive and negative emotions. And ... emotions attached to a memory. In essence, they made ...
Breaking Medicine News(10 mins):Health News:Well-known SEO Hosts Review Site Top10BestSEOHosting.com Recommends iPage, Bluehost and GoDaddy To Webmasters 2Health News:Skirt Sports Launches Clothing Line with Legendary Runner Kathrine Switzer 2Health News:Marc Anthony to Perform at "Nieves Productions" Latinos in Action Festival 2Health News:Founding Class of the KGI School of Pharmacy Formally Welcomed into the Profession at a Traditional White Coat Ceremony 2Health News:Scientists 'Rewrite' Bad Memories in Mice 2Health News:Scientists 'Rewrite' Bad Memories in Mice 3
... , , NEW ... July 29, 2009 the Company will report second quarter 2009 financial results before ... with the release, the Company will hold a conference call on Wednesday, July ... Executive Officer, and John Henry, Senior Vice President and Chief Financial Officer, will ...
... second quarter financial results - , , LAVAL, QC, ... DDSS ) today announced that it will host a ... (ET) to discuss its second quarter 2009 financial results. Labopharm ... release at approximately 7:00 a.m. the same day. , To ...
... , LOS ANGELES, July 27 ... recently hired Sanford Devries for the position of ... the role of CFO/Controller for various companies. He has special ... With Wellspring,s goals for expansion and growth, Sanford is ...
... Midbrook ... well-suited for use in hospitals and other medical facilities that are working to prevent infections. ... (Vocus) July 27, 2009 ... well as case carts and storage cabinets has begun to use copper alloys as ...
... ... is now available through leading cold laser retailer Cold Laser-Therapy-US. The new programmable cold laser ... available to the medical field. , ... Cape Girardeau, MO (PRWEB) July 27, 2009 - Cold laser equipment also ...
... , , PITTSBURGH, July ... the following response to a news article published earlier today: ... about an issue related to a Standard Operating Procedure (SOP) ... anonymous sources. Simply put, our investigation of the issue demonstrates ...
Cached Medicine News:Health News:Labopharm to host conference call Friday, August 7, 2009 at 8:30 a.m. (ET) 2Health News:Wellspring Hires Sanford Devries as Controller 2Health News:Midbrook Utilizes Copper in Medical Environments 2Health News:Cold Laser Technology Made Even More Accessible with Powerful New Product Available from Laser-Therapy.US 2
(Date:8/27/2014)... Reportlinker.com announces that a new market ... Global Orthopedic Soft Tissue Repair Devices Market ... About Orthopedic Soft Tissue Repair Devices ... that connect, support, or surround bones. There are ... tendons, ligaments, cartilage, fascia, and other fibrous tissues. ...
(Date:8/27/2014)... According to the new ... Dental Chairs, Dental Lasers), Current Trends, Opportunities - Global ... Equipment Market is expected to reach $7,138.9 million ... at a CAGR of 5.7% between 2014 and ... and 61 figures spread through 167 pages and ...
(Date:8/27/2014)... Conn. , Aug. 27, 2014 Pulse ... Record (EHR) , Practice Management , and Revenue ... little known business practices performed by some RCM vendors, at ... Philadelphia, PA on September 19-20, 2014.  ... Systems will return in September with a new session encouraging ...
Breaking Medicine Technology:Global Orthopedic Soft Tissue Repair Devices Market 2014-2018 2Global Orthopedic Soft Tissue Repair Devices Market 2014-2018 3Global Orthopedic Soft Tissue Repair Devices Market 2014-2018 4Global Orthopedic Soft Tissue Repair Devices Market 2014-2018 5Dental Equipment Market Worth $7,138.9 Million by 2019 2Dental Equipment Market Worth $7,138.9 Million by 2019 3Pulse Systems Presents the Truth about Revenue Cycle Management Services at Practice Rx 2Pulse Systems Presents the Truth about Revenue Cycle Management Services at Practice Rx 3Pulse Systems Presents the Truth about Revenue Cycle Management Services at Practice Rx 4
... SPRING, Md., Oct. 7, 2011 The U.S. Food ... a fixed-dose combination (FDC) prescription medication that contains two ... adults who need both sitagliptin and simvastatin. ... people in the United States have type 2 diabetes, ...
... BEIJING and NEW YORK, Oct. 6, 2011 /PRNewswire-Asia-FirstCall/ -- ... the "Company"), one of the leading plasma-based biopharmaceutical companies ... changes in its board of directors. On ... positions as a director of China Biologic, a member ...
Cached Medicine Technology:FDA Approves Combination Therapy Juvisync 2FDA Approves Combination Therapy Juvisync 3China Biologic Announces Changes in Directors 2China Biologic Announces Changes in Directors 3China Biologic Announces Changes in Directors 4
Microplate incubator shaker used in a variety of immunoassay and research procedures requiring microplates....
... especially suited for cell analysis and ... allows to analyze scatter signals in ... channels. Data acquisition, analysis, and real-time ... PC employing Partec DPAC software, built-in ...
This unique system combines the analytical power of a research cytometer into a compact, truly walk away, clinical analyzer ergonomically designed to expedite sample throughput....
... The IMMULITE 1000 immunoassay system ... use, reliability, robust hardware and excellent ... onboard reagents and accommodates onboard dilutions, ... , , Worldwide, IMMULITE 1000 (and ...
Medicine Products: