Navigation Links
Molecular high-speed origami

Proteins are the workhorses of the cell and thus responsible for almost all biological functions including metabolism, signal transmission or the determination of the cell's shape. However, before they can fulfill their various tasks, the chain-like molecules must first adopt an intricate three-dimensional conformation. This process is called protein folding and is one of the most important processes in biology. In fact, in the event of improper folding, proteins are often no more able to carry out their duties, or even tend to clump together in aggregates. This in turn can lead to severe diseases like Alzheimer's or Parkinson's. In order to avoid this, specialized proteins, the so-called chaperones, help other proteins to adopt their proper shape.

The bacterial chaperones GroEL and GroES serve as an example for this principle: together, they build up a cage-like structure in which they encapsulate new, not yet folded proteins, thereby al-lowing them to fold properly. However, the exact way in which this is accomplished has so far been unclear and is a research topic of the MPIB team led by Manajit Hayer-Hartl and F. Ulrich Hartl, in collaboration with John Engen from Northeastern University in Boston.

Active acceleration of folding

Our results demonstrate that the chaperones not only prevent protein clumping, but also dramatically accelerate the folding process", explains Florian Georgescauld, scientist at the MPIB. Surprisingly, the chaperones achieve this by changing the mechanism of folding: Instead of folding in one large single block, the protein gets its final structure in a series of small, rapid steps like an elaborate high-speed Origami." The researchers think that splitting up the reaction might render it energetically more favorable, which in turn would lead to increased speed. Hence, the folding process is finished in a few seconds rather than in several minutes.

The study shows for the first time that chaperones can act not only passively, by preventing aggregation, but as an active folding cage that catalyzes the folding process. This results in a high-speed folding mechanism which is of particular biological relevance, so the researchers say, since in this way proteins can be folded faster than they are produced. Thus, a backlog of proteins which are not yet or improperly folded and the disastrous consequences which might go along with this can be avoided. [HS]


Contact: Anja Konschak
Max Planck Institute of Biochemistry

Related medicine news :

1. International molecular screening program for metastatic breast cancer AURORA at IMPAKT
2. NIH scientist to receive Ross Prize in Molecular Medicine
3. Malfunction in molecular proofreader prevents repair of UV-induced DNA damage
4. Adjuvant chemotherapy increases markers of molecular aging in the blood of BC survivors
5. UNC researchers show cancer chemotherapy accelerates molecular aging
6. Big data tackles tiny molecular machines
7. Molecular aberration signals cancer
8. Study uncovers molecular keys to invasive bladder cancer
9. Short circuit in molecular switch intensifies pain
10. Molecular nano-spies to make light work of disease detection
11. Research shows molecular, protein targeting therapies may be best treatment for certain lung cancer
Post Your Comments:
Related Image:
Molecular high-speed origami
(Date:11/25/2015)... LOUIS, Missouri (PRWEB) , ... November 25, 2015 ... ... Project HEAL, will provide scholarships for people struggling with eating disorders as a ... Proceeds from the second annual event, held at Fox Run Golf Club in ...
(Date:11/25/2015)... Florida (PRWEB) , ... November 25, 2015 , ... ... LLC has announced that it has undertaken significant expansion of its current state ... The investment is part of PharmaTech’s strategy to increase its manufacturing capacity as ...
(Date:11/25/2015)... ... November 25, 2015 , ... Bcureful—a ... (TSC), as well as raising public awareness of the disorder while helping to ... third donation of $35,000 to bolster progress at the Tuberous Sclerosis Complex Center ...
(Date:11/25/2015)... ... November 25, 2015 , ... Bunion Bootie , the ... celebration of the early holiday shopping season. Starting Wednesday November 25th, Bunion Booties ... Black Friday promotional pricing is in addition to any automatic discounts applied when ...
(Date:11/24/2015)... ... November 24, 2015 , ... Dr. Todd S. Afferica, a ... services to many of his patients. Dr. Afferica now uses the BIOLASE WaterLase iPlus ... amount of time the doctor uses other traditional cutting tools, such as the scalpel ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... , Nov. 25, 2015 USP ... hazardous drug preparations (e.g. pharmacists, pharmacy technicians, nurses, ... veterinary technicians). The chapter also covers all entities ... (e.g., pharmacies, hospitals, other healthcare institutions, patient treatment ... --> --> What ...
(Date:11/25/2015)... 25, 2015  Mindray Medical International ... MR ), a leading developer, manufacturer ... today announced that it will hold ... shareholders at the Company,s Hong Kong office (FLAT/RM ... Edward West Road, Mongkok KL, Hong Kong) ...
(Date:11/25/2015)... 2015 Research and Markets ( ) ... - Global Forecast to 2020" report to their ... for 37.21% of the total market share in 2014. ... region is projected to growth at the highest CAGR ... primarily to the fast growing water, industrial gas treatment, ...
Breaking Medicine Technology: