Navigation Links
Molecular high-speed origami
Date:5/9/2014

Proteins are the workhorses of the cell and thus responsible for almost all biological functions including metabolism, signal transmission or the determination of the cell's shape. However, before they can fulfill their various tasks, the chain-like molecules must first adopt an intricate three-dimensional conformation. This process is called protein folding and is one of the most important processes in biology. In fact, in the event of improper folding, proteins are often no more able to carry out their duties, or even tend to clump together in aggregates. This in turn can lead to severe diseases like Alzheimer's or Parkinson's. In order to avoid this, specialized proteins, the so-called chaperones, help other proteins to adopt their proper shape.

The bacterial chaperones GroEL and GroES serve as an example for this principle: together, they build up a cage-like structure in which they encapsulate new, not yet folded proteins, thereby al-lowing them to fold properly. However, the exact way in which this is accomplished has so far been unclear and is a research topic of the MPIB team led by Manajit Hayer-Hartl and F. Ulrich Hartl, in collaboration with John Engen from Northeastern University in Boston.

Active acceleration of folding

Our results demonstrate that the chaperones not only prevent protein clumping, but also dramatically accelerate the folding process", explains Florian Georgescauld, scientist at the MPIB. Surprisingly, the chaperones achieve this by changing the mechanism of folding: Instead of folding in one large single block, the protein gets its final structure in a series of small, rapid steps like an elaborate high-speed Origami." The researchers think that splitting up the reaction might render it energetically more favorable, which in turn would lead to increased speed. Hence, the folding process is finished in a few seconds rather than in several minutes.

The study shows for the first time that c
'/>"/>

Contact: Anja Konschak
konschak@biochem.mpg.de
49-898-578-2824
Max Planck Institute of Biochemistry
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. International molecular screening program for metastatic breast cancer AURORA at IMPAKT
2. NIH scientist to receive Ross Prize in Molecular Medicine
3. Malfunction in molecular proofreader prevents repair of UV-induced DNA damage
4. Adjuvant chemotherapy increases markers of molecular aging in the blood of BC survivors
5. UNC researchers show cancer chemotherapy accelerates molecular aging
6. Big data tackles tiny molecular machines
7. Molecular aberration signals cancer
8. Study uncovers molecular keys to invasive bladder cancer
9. Short circuit in molecular switch intensifies pain
10. Molecular nano-spies to make light work of disease detection
11. Research shows molecular, protein targeting therapies may be best treatment for certain lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Molecular high-speed origami
(Date:12/22/2014)... (PRWEB) December 22, 2014 The ... than ever, having invested more than $5 million ... members, veterans and their families. , This includes ... a dozen nonprofits, helping with: veteran entrepreneurship; community ... and life-coaches for severely injured veterans. , “The ...
(Date:12/22/2014)... In recognition of Veteran’s Day, Discount ... Reward, a local organization that provides services to veterans ... Located on a couple hundred acres in the hills ... world class fishing, hunting, hiking, horseback riding, 4-wheeling, skeet ... years ago to support U.S. Service men and women, ...
(Date:12/22/2014)... 22, 2014 TheHardwareCity.com now stocks MagnoGrip ... many useful features. Customers of the large online tool ... new gloves delivered to their home or workplace with ... tools that incorporate heavy duty magnets, which make work ... workers to store metal parts on the back of ...
(Date:12/22/2014)... 2014 A substantial percentage of ... tomography (CT) to evaluate abnormal findings on outpatient ... according to a new study published online in ... findings show that radiologist recommendations for additional imaging ... patient care. , RAIs, which have grown 200 ...
(Date:12/21/2014)... December 22, 2014 Recently, BambooFlooringChina.com, a ... strand woven bamboo flooring collection , and launched a ... The promotion is valid until Jan. 30, 2015. , ... bamboo is the hardest bamboo flooring available today; it ... that of traditional teak hardwoods. Strand woven bamboo is ...
Breaking Medicine News(10 mins):Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 2Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 3Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 4Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 5Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 6Health News:Bob Woodruff Foundation Poised to Reach More Vets Thanks to Banner Year 7Health News:Discount Labels Donates Portion of November Sales to Hero Reward Program 2Health News:MagnoGrip Pro Utility Magnetic Gloves on Sale at TheHardwareCity.com 2Health News:RSNA: Radiologist Recommendations for Chest CT Have High Clinical Yield 2Health News:RSNA: Radiologist Recommendations for Chest CT Have High Clinical Yield 3Health News:BambooFlooringChina.com Announced Its Durable Strand Woven Bamboo Flooring Collection 2
... , Working Together to Share Records Safely, Improve ... of Veterans Affairs (VA) and Kaiser Permanente today announced an ... Nation,s heroes. VA and Kaiser Permanente are launching a pilot ... Nationwide Health Information Network (NHIN) created by the Department of ...
... ... of Feeding America,s SNAP Outreach Efforts , CHICAGO, Nov. 25 ... $1 million donation from the Bank of America Charitable Foundation to ... Nutrition Assistance Program (SNAP), formerly named the Food Stamp Program. ...
... to normal human development - the Wnt/Wingless (Wnt) and ... ways that can promote tumor cell invasion and metastasis, ... Cancer Center report in the Nov. 25 issue of ... involves three signaling components known to correlate with invasive ...
... Melvin R. Kaplan, MD, FACP, a former Board Chair ... became Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center ... Physicians for his lifetime devotion to the care of patients. ... American College of Physicians will present Dr. Kaplan with the ...
... 2009 Physicians at UT Southwestern Medical Center soon will ... patients with upper spinal-cord injuries or other diseases that keep ... St. Paul is only one of only two sites ... equipped to implant the device, called the NeuRx Diaphragm Pacing ...
... mitochondrial function plays in insulin production , WEDNESDAY, ... people with type 2 diabetes to lose insulin-producing ... treatments, U.S. researchers say. , Mitochondria provide energy ... when insulin-producing beta cells in the pancreas can,t ...
Cached Medicine News:Health News:VA and Kaiser Permanente Invite Veterans to Participate in Health Record Pilot Program 2Health News:Bank of America Charitable Foundation Presents $1 Million Contribution to Feeding America in an Effort to Help Connect Low-Income Americans With Federal Nutrition Programs 2Health News:Bank of America Charitable Foundation Presents $1 Million Contribution to Feeding America in an Effort to Help Connect Low-Income Americans With Federal Nutrition Programs 3Health News:Crosstalk between critical cell-signaling pathways holds clues to tumor invasion and metastasis 2Health News:Crosstalk between critical cell-signaling pathways holds clues to tumor invasion and metastasis 3Health News:1 of LA BioMed's founders to be honored 2Health News:New device implanted by surgeons help paralyzed patients breathe easier 2
(Date:12/22/2014)... a privately-held medical products and technologies company, today announced ... Officer of the company, effective December 22, 2014. ... Board of Directors of ConvaTec thanks Mr. Berger for ... years," said Magnus Lundberg , the Chairman of ... company is well positioned for the future."  The company ...
(Date:12/22/2014)... and STOCKHOLM , Dec. ... (Sobi) and partner Auxilium Pharmaceuticals, Inc. today announced that ... of the European Medicines Agency (EMA) has adopted a ... histolyticum) for the treatment of adult men with Peyronie,s ... at least 30 degrees at the start of therapy. ...
(Date:12/22/2014)... , Dec. 22, 2014  Mark Farrah Associates ... providing a summary of the 2015 marketplace exchange ... trends.  According to a recent ... and Evaluation, Department of Health and Human Services) ... in individual medical plans through the Marketplace as ...
Breaking Medicine Technology:ConvaTec Names Paul Moraviec Interim CEO Effective December 22, 2014 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 2Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 3Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 4Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 5Sobi's Xiapex receives positive opinion by CHMP for the treatment of Peyronie's disease 6Insights into the Marketplace and Individual Market Growth 2
... , CINCINNATI , Feb. 2 ... mail-order online pharmacy, and PrimaryCareOne, a clinic-based health care program in ... today they have partnered to offer patients a 30-day supply of ...   Combined with PrimaryCareOne,s preventive primary health care program for as ...
... , PRINCETON, N.J. ... Board: SNGX) (Soligenix or the Company), a late-stage biotechnology company, ... February 2010 edition of Vaccine, which describes ... stability. The article was authored by the Company,s collaborators at ...
Cached Medicine Technology:HealthWarehouse.com and PrimaryCareOne Form Partnership to Provide Low Cost Prescription Medications to Patients 2HealthWarehouse.com and PrimaryCareOne Form Partnership to Provide Low Cost Prescription Medications to Patients 3HealthWarehouse.com and PrimaryCareOne Form Partnership to Provide Low Cost Prescription Medications to Patients 4Soligenix Announces Publication of Positive Stability Results with RiVax(TM), its Vaccine Against Ricin Toxin 2Soligenix Announces Publication of Positive Stability Results with RiVax(TM), its Vaccine Against Ricin Toxin 3Soligenix Announces Publication of Positive Stability Results with RiVax(TM), its Vaccine Against Ricin Toxin 4Soligenix Announces Publication of Positive Stability Results with RiVax(TM), its Vaccine Against Ricin Toxin 5Soligenix Announces Publication of Positive Stability Results with RiVax(TM), its Vaccine Against Ricin Toxin 6Soligenix Announces Publication of Positive Stability Results with RiVax(TM), its Vaccine Against Ricin Toxin 7
Slick® Disposable Endotracheal Stylet, Nylon-coated wire, Malleable core, Sureloc Stop helps maintain desired length for patient safety. Handle forming capability for better grip. Sterile. Single...
... spine manipulation. Prevent dental and soft tissue ... alternative to X-ray. Light-guided intubation is based ... in the neck. This technique takes advantage ... relative to the esophagus. A well-defined, circumscribed ...
... of flexible lighting products. The first is ... different sizes 5", 10", and 15" (refers ... light). These lights are for use in ... ,The second group of flexible lights is ...
... of flexible lighting products. The first is ... different sizes 5", 10", and 15" (refers ... light). These lights are for use in ... ,The second group of flexible lights is ...
Medicine Products: