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Molecular glue with new effect
Date:1/31/2008

gulation of gene expression proceeds abnormally, developmental disorders are the result. The range of symptoms extends from subtle and hard-to-diagnose changes to massive, physical and cognitive impairments. One of the more well-known disorders of this kind is called Cornelia de Lange Syndrome. Affected persons suffer from numerous anomalies and malformations. A causative treatment is not available.

We cannot cure the disease, but we now know the molecular mechanisms that cause it. This helps us to better understand the disorder and its symptoms. Moreover, we expect that our findings will stimulate new exciting research, stated Jan-Michael Peters.

A valuable resource for this has already been created by the researchers in the course of their work: they have systematically searched the entire human genome for cohesin binding sites that is, the areas where cohesin is effective. Thus, the first genome-wide cohesin map in a mammalian species was developed. The database is open to the entire scientific community.


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Contact: Heidemarie Hurtl
hurtl@imp.ac.at
43-179-730-3625
Research Institute of Molecular Pathology
Source:Eurekalert

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