Navigation Links
Molecular glue with new effect
Date:1/31/2008

This release is also available in German.

Ten years ago, researchers at the IMP - a basic research institute in Vienna - discovered a fundamental and amazingly plausible mechanism of cell division. They identified a protein complex, which, as a ring-shaped molecule, slides over the doubled chromosomes and holds precisely these together until the time they again separate. Because of its function as molecular glue, the protein complex was given the name cohesin.

In the working group of Jan-Michael Peters, Senior Scientist at the IMP, the molecule was continually monitored over the last ten years. Now Peters and his colleague, Kerstin Wendt, in cooperation with Katsuhiko Shirahige from the Tokyo Institute of Technology, were able to find evidence of another, also essential function of cohesin. As the researchers report in the online issue of the journal Nature, the molecule acts as a regulator of gene expression, and therefore plays an important role in the reading of genes. The molecule fulfills this function entirely independently of its thus far known activity.

Various inhibiting and promoting elements within the genome affect whether genes can be read in a particular situation and how intensively this process proceeds. Promoters initiate the reading process, whereas enhancers strengthen it, and silencers suppress it. The combination of these factors must be very finely tuned. The areas that are each influenced by the regulators are separated from each other by so-called insulators. It has now been ascertained at the IMP for the first time ever that cohesin is necessary for the function of such insulators.

This discovery not only enriches basic research by contributing to further fundamental knowledge. It should also be of medical interest: a number of rare but serious disorders can be traced back to mutations in cohesin. If the regulation of gene expression proceeds abnormally, developmental disorders are the result. The range of symptoms extends from subtle and hard-to-diagnose changes to massive, physical and cognitive impairments. One of the more well-known disorders of this kind is called Cornelia de Lange Syndrome. Affected persons suffer from numerous anomalies and malformations. A causative treatment is not available.

We cannot cure the disease, but we now know the molecular mechanisms that cause it. This helps us to better understand the disorder and its symptoms. Moreover, we expect that our findings will stimulate new exciting research, stated Jan-Michael Peters.

A valuable resource for this has already been created by the researchers in the course of their work: they have systematically searched the entire human genome for cohesin binding sites that is, the areas where cohesin is effective. Thus, the first genome-wide cohesin map in a mammalian species was developed. The database is open to the entire scientific community.


'/>"/>

Contact: Heidemarie Hurtl
hurtl@imp.ac.at
43-179-730-3625
Research Institute of Molecular Pathology
Source:Eurekalert

Related medicine news :

1. Story ideas from Molecular and Cellular Proteomics
2. Findings point to molecular Achilles heel for half of breast cancer tumors
3. The Journal of Biomolecular Screening garners Association TRENDS Bronze Award
4. Molecular pathway appears crucial in development of pulmonary fibrosis
5. New book presents comprehensive survey of research into the molecular basis of aging
6. Childrens Hospital researchers identify molecular switch that could save very young lives
7. In the Forefront of Research into Protein Folding and Macromolecular Complex Assembly
8. Cepheid and Broadlane Sign Group Purchasing Contract for GeneXpert(R) Systems and Xpert(TM) Molecular Diagnostic Tests, Including Xpert MRSA
9. A molecular map for aging in mice
10. Amsterdam Molecular Therapeutics Initiates Program for Late Stage Liver Cirrhosis and Reports Strong Progress in AMT-011 With Trial Fully Recruited and European and US Submission On Track for First Half of 2008
11. 3M, Gen-Probe to Discontinue Molecular Food Testing Collaboration
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... 2017 , ... PurhealthRX , a leading Health and Nutrition Company, is ... to full spectrum CBD oil will revolutionize the rapidly growing CBD market by reducing ... easily incorporated into liquid products, while reducing costs to end users. , The team ...
(Date:10/13/2017)... ... 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset Hills is ... vendors and unique items from across the nation, this holiday-themed event will raise funds ... by the VNA. The boutique will be open Saturday, November 4 (10:00 a.m. ...
(Date:10/13/2017)... , ... October 13, 2017 , ... ... and Agile Software Development, has been awarded a contract by the Center for ... Agreement (BPA) aims to accelerate the enterprise use of Agile methodologies in a ...
(Date:10/12/2017)... ... , ... Planet Fitness, one of the largest and fastest growing franchisors and ... flagship location in Covington, LA at 401 N. U.S. Highway 190, in January of ... Depot in the Holiday Square shopping center. Its location allows it to serve both ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... that we intend to develop to enable prevention of a major side effect ... hearing loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed ...
Breaking Medicine News(10 mins):
(Date:10/4/2017)...  South Korean-based healthcare product Development Company I.M. Lab ... Kickstarter. The device will educate the user about ,proper, ... efficiency compared to the dated and pricey CPR training ... of the compression for a more informed CPR training. ... raise $5,000. cprCUBE ...
(Date:10/4/2017)... 2017 OBP Medical , a ... devices, today announced regulatory approval from ... Agência Nacional de Vigilância Sanitária (ANVISA)) to market ... retractor with integrated LED light source and smoke ... exposure of a tissue pocket or cavity during ...
(Date:10/2/2017)... Oct. 2, 2017  Eli Lilly and Company (NYSE: ... for the third quarter of 2017 on Tuesday, October ... on that day with the investment community and media ... The conference call will begin at 9 a.m. Eastern ... a live webcast of the conference call through a ...
Breaking Medicine Technology: