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Molecular fingerprint of breast-cancer drug resistance can predict response to treatment
Date:9/24/2007

as the ability to predict response to docetaxel in a patient who has undergone treatment with the drug. At the moment we have only tested this in cell lines, said Dr Brown, but we do believe these results may be translated into the clinical setting and benefit the patient. In essence, we have taken a clinical problem back to the laboratory, and now we intend to take this back to the bedside.

The scientists will start collecting tissue samples from patients within the next six months. If we find the same results in patient samples, we would expect that a simple test for docetaxel resistance could be developed and in clinical use within the next five years, said Dr. Brown. Such a test would mean that those who would not benefit from docetaxel chemotherapy could be spared its side effects, and also reduce costs for healthcare providers.

We think that the changes we have found may represent common drug resistance mechanisms in breast cancer cells, said Dr Brown. We are currently looking at these findings in other cancer types, especially those which are also treated with docetaxel, to see if the results may have a potential in other areas. This is the first time that the genetic pathways involved in the evolution of acquired resistance to docetaxel have been identified in a docetaxel resistant cell line model.


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Contact: Mary Rice
mary@mrcommunication.org
Federation of European Cancer Societies
Source:Eurekalert

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