Navigation Links
Molecular events involved in liver regeneration
Date:12/23/2008

The ability to regenerate after major tissue damage or surgical intervention is an important property of the liver. Since liver resection is an established therapeutic measure for severe liver diseases, it would be of importance to know which molecular events underly the regenerative process and if they depend on the extent of resection, as indicated in previous studies.

The group led by Prof. Schlaak from the Department of Gastroenterology and Hepatology of the University Hospital of Essen compared rats undergoing 70% and 90% liver resection. Serum parameters, activation of transcription factors, expression of cytokines known as imperative for the start of liver regeneration and apoptosis in the regenerating liver tissue were analyzed. A broad spectrum of methods came into use, including quantitative real time PCR on mRNA-isolates and TUNEL staining of histological samples. This will be published on December 14, 2008 in the World Journal of Gastroenterology.

They found that apart from increased liver damage and reduced liver function parameters found in serum samples, molecular events as cytokine expression, especially IL-6 and TNF-alpha were strongly reduced after extensive resection. In addition the activation of NF-kappa B was delayed by almost 24 h. Programmed cellular death, known as apoptosis, was partially increased at 24 h and at 7 d postoperatively in the livers of animals which underwent 90% resection in comparison to rats which only had 70% of their liver resected.

The findings show clearly that extended liver resection leads to a delay of regeneration. This is not only a reduction of the regenerative capacity due to a smaller amount of cells or tissue. The data presented by Prof. Schlaaks group suggest an impaired ability of the liver to regenerate on a molecular and cellular level. This seems to involve signalling of NF-kappa B and maybe highly conserved TLR systems. Upcoming projects of the research group already adress this possibility.

Further knowledge about the interrelation of liver regeneration and the molecular events involved may yield new approaches to improve patient outcome after extended hepatectomies or to make surgical intervention available for patients who could not undergo a liver resection due to severe previous liver damage.


'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. A new molecular zip code, and a new drug target for Huntingtons disease
2. New knock-out gene model provides molecular clues to breast cancer
3. Molecular probe paints cancer cells in living animals, Stanford researchers find
4. Story ideas from molecular & cellular proteomics
5. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
6. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
7. Molecular fingerprint of breast-cancer drug resistance can predict response to treatment
8. Molecular profiling can accurately predict survival in colon cancer patients
9. Xceed Molecular Names Fran Tuttle to Its Board of Trustees
10. Virginia G. Piper Charitable Trust and Flinn Foundation launch molecular diagnostics initiative
11. Xceed Molecular Launches Ziplex(R) Automated Gene-Expression System at the Association for Molecular Pathology, Booth 84/85
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... February 05, 2016 , ... Pivot ... 2015 Best in KLAS: Software & Services for HIT Implementation Support & Staffing ... report independently ranks vendor performance by healthcare executives, managers and clinicians representing over ...
(Date:2/5/2016)... ... ... Dr. Justin Scott and Dr. Lydia Muccioli of Pure Dental Health ... in need. The event is scheduled to take place on February 27, 2016 from ... dental care to community members in need. Each patient will be given the opportunity ...
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... ... founder of CitiDent, announces that it is now welcoming orthodontist, Dr. Amanda ... CitiDent offers a complete range of oral health care, including general dentistry, cosmetic ...
(Date:2/5/2016)... , ... February 05, 2016 , ... In sleep, when ... as a dream. A hallmark feature of patients with eating disorders is significant self-criticism, ... eating disorder behaviors and obsessions are regarded as maladaptive means for coping with this ...
(Date:2/5/2016)... (PRWEB) , ... February 05, 2016 , ... ... manufactures practical mobile kitchens, recently announced the debut of their latest mobile kitchen ... Mobile Kitchens provides organizations with modern, high-volume commercial kitchens for use anywhere in ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... Feb. 4, 2016  The Senior Care Pharmacy ... Reform Committee Chairman Jason Chaffetz (R-UT) ... today,s hearing , "Developments in the Prescription ... and growing questions about abusive pharmacy benefit manager ... (R-UT) and Ranking Member Elijah Cummings (D-MD) are ...
(Date:2/4/2016)... , Feb. 4, 2016 Wegener ... Global Markets Direct,s, ,Wegener Polyangiitis - Pipeline ... Wegener Polyangiitis,s therapeutic pipeline. This report provides ... Polyangiitis, complete with comparative analysis at various stages, ... (MoA), route of administration (RoA) and molecule type, ...
(Date:2/4/2016)... Frontier Pharma: Chronic Obstructive Pulmonary Disease ... Chronic Obstructive Pulmonary Disease (COPD) is ... the airways and lungs. Persistent breathing difficulties and ... one of the leading causes of morbidity and ... COPD is linked to cumulative exposure to risk ...
Breaking Medicine Technology: