Navigation Links
Molecular events involved in liver regeneration
Date:12/23/2008

The ability to regenerate after major tissue damage or surgical intervention is an important property of the liver. Since liver resection is an established therapeutic measure for severe liver diseases, it would be of importance to know which molecular events underly the regenerative process and if they depend on the extent of resection, as indicated in previous studies.

The group led by Prof. Schlaak from the Department of Gastroenterology and Hepatology of the University Hospital of Essen compared rats undergoing 70% and 90% liver resection. Serum parameters, activation of transcription factors, expression of cytokines known as imperative for the start of liver regeneration and apoptosis in the regenerating liver tissue were analyzed. A broad spectrum of methods came into use, including quantitative real time PCR on mRNA-isolates and TUNEL staining of histological samples. This will be published on December 14, 2008 in the World Journal of Gastroenterology.

They found that apart from increased liver damage and reduced liver function parameters found in serum samples, molecular events as cytokine expression, especially IL-6 and TNF-alpha were strongly reduced after extensive resection. In addition the activation of NF-kappa B was delayed by almost 24 h. Programmed cellular death, known as apoptosis, was partially increased at 24 h and at 7 d postoperatively in the livers of animals which underwent 90% resection in comparison to rats which only had 70% of their liver resected.

The findings show clearly that extended liver resection leads to a delay of regeneration. This is not only a reduction of the regenerative capacity due to a smaller amount of cells or tissue. The data presented by Prof. Schlaaks group suggest an impaired ability of the liver to regenerate on a molecular and cellular level. This seems to involve signalling of NF-kappa B and maybe highly conserved TLR systems. Upcoming projects of the research group already
'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. A new molecular zip code, and a new drug target for Huntingtons disease
2. New knock-out gene model provides molecular clues to breast cancer
3. Molecular probe paints cancer cells in living animals, Stanford researchers find
4. Story ideas from molecular & cellular proteomics
5. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
6. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
7. Molecular fingerprint of breast-cancer drug resistance can predict response to treatment
8. Molecular profiling can accurately predict survival in colon cancer patients
9. Xceed Molecular Names Fran Tuttle to Its Board of Trustees
10. Virginia G. Piper Charitable Trust and Flinn Foundation launch molecular diagnostics initiative
11. Xceed Molecular Launches Ziplex(R) Automated Gene-Expression System at the Association for Molecular Pathology, Booth 84/85
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2015)... ... August 01, 2015 , ... ... are in “a trending profession” that comprises a growing percentage of U.S. physicians, ... most. , That was one part of the message delivered by John W. ...
(Date:8/1/2015)... ... ... Brig and Lita Hart, icons of the network marketing industry and founders of ... the HOPE Movement of EvolvHealth. In what has been a long-term relationship between the ... their missions of purpose together to change the course of the network marketing industry. ...
(Date:8/1/2015)... ... , ... “ reTXT ” was featured on NewsWatch as part of its ... market for iOS, Android, and Windows. Joe Toohey, the host of AppWatch and technology ... and delete any message including ones already sent. , While text messaging has more ...
(Date:7/31/2015)... Ind. (PRWEB) , ... August 01, 2015 , ... The ... the Global Advisory Panel on the Future of Nursing (GAPFON) 20-21 July 2015 in ... invited to participate in this meeting. , Dr. Silvia Cassiani, Advisor, Nursing and Allied ...
(Date:7/31/2015)... Alexandria, VA (PRWEB) , ... July 31, 2015 ... ... Foundation) introduced its new store run by GoodThreads. The store can be accessed ... products and designs, many of which are customizable. The best part: whenever a ...
Breaking Medicine News(10 mins):Health News:COMP-Northwest Welcomes Class of 2019 2Health News:COMP-Northwest Welcomes Class of 2019 3Health News:COMP-Northwest Welcomes Class of 2019 4Health News:COMP-Northwest Welcomes Class of 2019 5Health News:Looking for HOPE? Healthy Home Has Evolv’d 2Health News:Looking for HOPE? Healthy Home Has Evolv’d 3Health News:Correct Auto-Correct and Clarify the Unclear with reTXT Messaging App 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 2Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 3Health News:Key Latin American Nurse Leaders Identify Regional Issues During Global Advisory Panel on the Future of Nursing Meeting 4Health News:Mesothelioma Organization Launches New Store 2Health News:Mesothelioma Organization Launches New Store 3
... Foundation Applauds Patient Education In New National Guidelines, ... children and adults with asthma are getting a back-to-school ... U.S. health,officials, which affirm the primary importance of patient ... live without limits and,to improve their quality of life., ...
... report that exercise and yoga can help maintain ... in women with early-stage breast cancer. The first ... physical fitness, self-esteem and body composition, and that ... study demonstrated that yoga was particularly beneficial for ...
... Healthcare Technology Executive Brings Over 20 Years Of Experience ... in Sales, Marketing And Operational Excellence, ... (Nasdaq: MEDW ) announced the appointment of Thomas ... joins Mediware,following more than 20 years with 3M,s healthcare ...
... The results of a clinical trial, published in ... when used as part of routine therapy, high-dose ibuprofen ... in children with cystic fibrosis (CF). , Headed by ... Montreal Childrens Hospital of the McGill University Health Centre, ...
... Inc. (Nasdaq and SWX: BMRN) announced today that Emil,Kakkis, ... a,company update at the Bear Stearns 20th Annual Healthcare ... at 3:00 p.m. ET. Interested parties may access ... section of the BioMarin website, http://www.BMRN.com . A,replay ...
... a new study indicate a strong link between the ... cognitive impairment (MCI), often a harbinger of Alzheimer,s disease. ... binds specific substances. Researchers found reduced levels of LR11, ... tissue of people diagnosed with MCI. In addition, the ...
Cached Medicine News:Health News:School is Cool for Asthma Patients of All Ages 2Health News:Exercise and yoga improves quality of life in women with early-stage breast cancer 2Health News:Exercise and yoga improves quality of life in women with early-stage breast cancer 3Health News:Mediware Names Thomas K. Mann Chief Executive Officer 2Health News:Low level of neuronal receptor linked to mild cognitive impairment and Alzheimer's disease 2
(Date:7/30/2015)... IRIDEX Corporation (NASDAQ: IRIX ) today ... financial results after the market closes on Thursday, ... the Company will host a conference call with the ... Thursday, August 6, 2015 to discuss ... Interested parties may access the live conference ...
(Date:7/30/2015)... 2015  EP Global Communications, Inc. (Public OTC: EPGL) announced ... the Company about discussing EPGL,s electronic contact lens ... August 3, 2015.  Novartis CEO Joe Jimenez ... coming electronic contact lens market could be worth ... several years.  Novartis partnered with Google in 2014 ...
(Date:7/30/2015)... BOTHELL, Wash. and VANCOUVER ... OGXI ) announced today that it will report ... 13, 2015. Company management will host a conference call ... provide an overview of financial results, clinical development programs ... access the webcast, log on to the Investor Relations ...
Breaking Medicine Technology:IRIDEX Announces Second Quarter 2015 Conference Call and Release Date 2
... a leading designer of integrated medical imaging display systems, ... Medical achieved significant growth in sales, an expansion of ... Carrot Medical, recognized as a market leader, is the ... medical images and other visual data onto a single, ...
... Pharmaceuticals International, Inc. (NYSE: VRX ) (TSX: ... ("Valeant"), its wholly owned indirect subsidiary, launched its offer ... unsecured notes (the "Notes"). The Notes will ... as amended (the "Securities Act"), or any state securities ...
Cached Medicine Technology:Carrot Medical Reports 2010 Growth in Sales and Financing, Optimism for 2011 2Valeant Launches Senior Notes Offering 2Valeant Launches Senior Notes Offering 3
For vacuum-driven processing of spin columns; Reduced sample handling and accelerated processing; Parallel sample processing using QIAGEN spin columns; Easy cleaning of internal components by simpl...
Inquire...
... allows processing of up to 24 spin columns in ... columns into and out of a centrifuge. The ... savings rapid vacuum-driven purification and cleanup of ... Convenience minimal hands-on-time ...
... Caliper provide an automated alternative to Kuderna-Danish, Rotary, Vacuum-Style and Nitrogen Blow-Down Evaporators. For over ten years ... ... ... ...
Medicine Products: