Navigation Links
Molecular events involved in liver regeneration
Date:12/23/2008

The ability to regenerate after major tissue damage or surgical intervention is an important property of the liver. Since liver resection is an established therapeutic measure for severe liver diseases, it would be of importance to know which molecular events underly the regenerative process and if they depend on the extent of resection, as indicated in previous studies.

The group led by Prof. Schlaak from the Department of Gastroenterology and Hepatology of the University Hospital of Essen compared rats undergoing 70% and 90% liver resection. Serum parameters, activation of transcription factors, expression of cytokines known as imperative for the start of liver regeneration and apoptosis in the regenerating liver tissue were analyzed. A broad spectrum of methods came into use, including quantitative real time PCR on mRNA-isolates and TUNEL staining of histological samples. This will be published on December 14, 2008 in the World Journal of Gastroenterology.

They found that apart from increased liver damage and reduced liver function parameters found in serum samples, molecular events as cytokine expression, especially IL-6 and TNF-alpha were strongly reduced after extensive resection. In addition the activation of NF-kappa B was delayed by almost 24 h. Programmed cellular death, known as apoptosis, was partially increased at 24 h and at 7 d postoperatively in the livers of animals which underwent 90% resection in comparison to rats which only had 70% of their liver resected.

The findings show clearly that extended liver resection leads to a delay of regeneration. This is not only a reduction of the regenerative capacity due to a smaller amount of cells or tissue. The data presented by Prof. Schlaaks group suggest an impaired ability of the liver to regenerate on a molecular and cellular level. This seems to involve signalling of NF-kappa B and maybe highly conserved TLR systems. Upcoming projects of the research group already adress this possibility.

Further knowledge about the interrelation of liver regeneration and the molecular events involved may yield new approaches to improve patient outcome after extended hepatectomies or to make surgical intervention available for patients who could not undergo a liver resection due to severe previous liver damage.


'/>"/>

Contact: Lai-Fu Li
wjg@wjgnet.com
0086-105-908-0039
World Journal of Gastroenterology
Source:Eurekalert

Related medicine news :

1. A new molecular zip code, and a new drug target for Huntingtons disease
2. New knock-out gene model provides molecular clues to breast cancer
3. Molecular probe paints cancer cells in living animals, Stanford researchers find
4. Story ideas from molecular & cellular proteomics
5. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
6. SNM seeks novel approaches to molecular imaging to showcase at annual meeting
7. Molecular fingerprint of breast-cancer drug resistance can predict response to treatment
8. Molecular profiling can accurately predict survival in colon cancer patients
9. Xceed Molecular Names Fran Tuttle to Its Board of Trustees
10. Virginia G. Piper Charitable Trust and Flinn Foundation launch molecular diagnostics initiative
11. Xceed Molecular Launches Ziplex(R) Automated Gene-Expression System at the Association for Molecular Pathology, Booth 84/85
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... February 05, 2016 , ... Francisco Canales, MD and Heather ... Napa Valley office. The technique utilizes the body’s own healing abilities to quickly ... Furnas, are part of only a select few cosmetic surgeons bringing this procedure ...
(Date:2/5/2016)... , ... February 05, 2016 , ... ... devoted exclusively to funding innovative lymphoma research and serving the lymphoma community through ... poised to once again host, Swirl, A Wine Tasting Event at the La ...
(Date:2/5/2016)... York (PRWEB) , ... February 05, 2016 , ... Regular ... and find themselves having to wait longer to access the treadmills. It’s a predictable ... Year’s resolutions to lose weight and get in shape by joining gyms, starting new ...
(Date:2/5/2016)... New York, New York (PRWEB) , ... February 05, 2016 , ... ... (APDA) announced the election of Patrick McDermott as Chairman of the National Board of ... welcome Pat as Chairman of the Board,” stated Leslie A. Chambers , APDA ...
(Date:2/5/2016)... ... ... Colorize is a web theme package created exclusively for Final ... dynamic moving camera. Colorize is perfect for personal and web related videos and its ... to 5 focus points per scene, stage floor scene presets that are great for ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)... 2016 France , Germany ... UK, and Israel ). It includes a 10-year epidemiology ... GD, segmented by age and sex in these markets. GD epidemiology report ... is in-depth, high quality, transparent and market-driven, providing expert analysis of disease ... Germany , Italy , Spain ...
(Date:2/4/2016)... LONDON , Feb. 4, 2016 ... to achieve significant growth as next generation systems ... and use radiology for cancer surgery. New systems ... radiological overdosing that has been such a problem ... be delivered. Radiosurgery robots take cancer surgery far ...
(Date:2/4/2016)... , Feb. 4, 2016 Summary ... common cancer and the most common cancer in women ... the disease exceedingly prevalent. The number of women diagnosed ... decades, but the number of deaths has declined due ... cancer treatment has been revolutionized in the past four ...
Breaking Medicine Technology: