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Molecular discovery points to new therapies for brain tumors
Date:4/15/2010

. IDHI mutations were recently associated with lower grade gliomas.

The researchers note that a subset of grade IV glioblastoma patients tends to be younger and have a relatively favorable prognosis. These patients might be identified in advance by using biomarkers such as CpG island methylation and IDH1 gene mutations. By the same token, the markers could be used to identify patients with low- or intermediate grade gliomas who may have relatively unfavorable prospects for their tumor grade.

They also found that of the 1,520 genes with promoter hypermethylation, only 293 genes, or 19 percent, showed a decrease in expression. "Epigenetics controls expression potential (of genes), rather than expression state," the authors noted.

Hypermethylation might promote tumor development by silencing two tumor-suppressing genes, the team reported, or by silencing others to provide a favorable context for genetic damage to occur.

The 27 co-authors on the project are from eight academic institutions and one biotechnology company. "Complex problems, such as defining clinically relevant molecular changes in human cancer, require cooperation among many individuals with complementary expertise and therefore require a 'team science' approach," Aldape said.


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Contact: Scott Merville
smerville@mdanderson.org
713-792-0661
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert

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