Navigation Links
Molecular coordination in evolution: A review in 'Nature Reviews Genetics'
Date:3/5/2013

0 YEARS OF RESEARCH PREDICTING MOLECULAR RELATIONSHIPS

In the revision, the authors describe those mathematical methods that, based on the evolution of pairs of proteins, are capable of predicting molecular interactions at different levels of complexity.

These methods include those approaches from the 1990s that predicted contact points between proteins; those that allow us to understand binding selectivity between very similar proteins -or ones that belong to the same family- and their ligands; or even, at a deeper level of complexity, those that predict interaction networks between the thousands of proteins that make up cells.

Over the last 20 years, Valencia's team has led several lines of research related to this field, many of which are still being studied by many other groups and in which his team continues to be a world leader.

"In 2012, we published a new set of predictions on the specificity of the binding of the Ras oncogene to other proteins. The tool was based on coevolution methods that we had developed a couple of years ago, and that are now being widely explored by other groups," explains Valencia. The Ras protein family is associated with a wide spectrum of cancers, so learning the language it uses with other proteins that are important for cells might open avenues for the development of novel drugs.

The authors of the study foresee a promising future for this field, in which bioinformatics programmers, physicists, biologists and mathematicians join forces in order to describe the complexity of protein dynamics.

"In the long term, we hope that unifying these methods will help us to manipulate or create new drugs that selectively target abnormal cells and therefore reduce side effects," says de Juan.


'/>"/>
Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Obesity, physical inactivity linked with risk for certain molecular subtype of colorectal cancer
2. UNC-led study documents head and neck cancer molecular tumor subtypes
3. Molecular master switch for pancreatic cancer identified, potential predictor of treatment outcome
4. New details on the molecular machinery of cancer
5. U of M researchers develop a molecular calcium sponge to tackle heart failure
6. Researchers use new molecular inhibitors to successfully hit difficult cancer target
7. PLEXERA® LLC Launches Contract Research Services Business for Biomolecular Interaction Studies
8. Research suggests molecular switch may play role in tumor suppression
9. Trying to halt hepatitis Cs molecular hijacking
10. Springer launches new journal with the Italian Association of Nuclear Medicine and Molecular Imaging
11. Metabolic biomarkers for preventive molecular medicine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/3/2015)... ... July 03, 2015 , ... Brendon ... 2nd creating a buzz of media attention. In an effort to spread the ... Tiffany Hendricks. , "These days many people are feeling overwhelmed by stress and ...
(Date:7/3/2015)... ... July 03, 2015 , ... B. E. ... been retained to lead a national president recruitment for Regional Care, ... healthcare industry, B. E. Smith has recently placed more than 1,000 healthcare executives ...
(Date:7/3/2015)... ... 2015 , ... Jennifer Renee Hanes, DO is the new Medical Director of ... of independent freestanding emergency rooms in the United States. , “We are excited to ... said Executive Medical Director of First Choice Emergency Room, Dr. James M. Muzzarelli. ...
(Date:7/3/2015)... ... 03, 2015 , ... The Celebrity Dresses is currently running a promotion through ... celebrities will have the opportunity to get 10% discount on orders that are over ... not have to use coupon codes or remember redemption codes. , There is ...
(Date:7/2/2015)... Alexandria, VA (PRWEB) , ... July 02, 2015 ... ... applauds Congresswoman Donna Edwards (D-Md.) for her introduction of the Stop Overdose Stat ... bill introduced by Senator Jack Reed (D-R.I.), this Act seeks to decrease drug ...
Breaking Medicine News(10 mins):Health News:High Performance Academy - Review Of Brendon Burchard's New High Performance Training Program Released 2Health News:High Performance Academy - Review Of Brendon Burchard's New High Performance Training Program Released 3Health News:Regional Care, Inc. Retains B. E. Smith to Recruit New President 2Health News:Regional Care, Inc. Retains B. E. Smith to Recruit New President 3Health News:Dr. Jennifer Renee Hanes Named by First Choice Emergency Room as Medical Director of Missouri City, TX Facility 2Health News:Dr. Jennifer Renee Hanes Named by First Choice Emergency Room as Medical Director of Missouri City, TX Facility 3Health News:Celebrity Fashion Summer Party Dresses on sale at TheCelebrityDresses.com 2Health News:AAPCC Supports the Stop Overdose Stat Act of 2015 2Health News:AAPCC Supports the Stop Overdose Stat Act of 2015 3
... status has been granted to twenty-seven Pennsylvania,hospitals for ... 30, 2008: Regional Resource Trauma Center (Level ... Johnstown -- Conemaugh Memorial Medical Center Philadelphia ... Hahnemann University Hospital Philadelphia -- Thomas Jefferson ...
... Study Calls for Measures to Recognize Value and ... Inadequate reimbursement,rates from private insurers threaten the future ... (CHCs) and their ability to continue serving all,patients, ... Health Care,Association of New York State (CHCANYS), and ...
... "Every school day, 54 million young people attend nearly 123,000 schools, ... to, provide healthy environments could be one of the most ... generation." Former ... President Bill Clinton, SAN DIEGO, Oct. ...
... order of appearance in the text) to have active are:,Anthony ... Change New Haven, Conn. ... important threat that calls for drastic action, and 40% say ... influence how they vote, according to a national survey conducted ...
... and schools to provide a bug busting approach to head ... and reduce healthcare costs, according to a review in the ... from the UK charity Community Hygiene Concern led a review ... since 1996. , The best results are obtained ...
... issue of the Journal of the American Dietetic Association contains ... is a summary of some of this months articles. For ... article, e-mail media@eatright.org . , A Dietary Quality ... Eating Index measures and compares factors in a persons diet ...
Cached Medicine News:Health News:Pennsylvania Trauma Systems Foundation Accreditation Status for Trauma Centers 2Health News:Commercial Insurers' Reimbursement Rate to New York's Community Health Centers Jeopardizes Care 2Health News:Commercial Insurers' Reimbursement Rate to New York's Community Health Centers Jeopardizes Care 3Health News:Commercial Insurers' Reimbursement Rate to New York's Community Health Centers Jeopardizes Care 4Health News:New Website Launches Healthy Vending in Schools Nationwide to Help Combat Childhood Obesity 2Health News:New Website Launches Healthy Vending in Schools Nationwide to Help Combat Childhood Obesity 3Health News:Americans consider global warming an urgent threat, according to poll 2Health News:Multicountry review shows that Bug Buster Kits reduce head lice and social stigma 2Health News:Multicountry review shows that Bug Buster Kits reduce head lice and social stigma 3Health News:Highlights from the October 2007 Journal of the American Dietetic Association 2Health News:Highlights from the October 2007 Journal of the American Dietetic Association 3
(Date:7/2/2015)... , June 25, 2015 Research and ... Diagnostics Market by Technology, Imaging and by Application - Forecast to ... diagnostics market is expected to reach $13.1 Billion in 2020 from ... 12.9%. The market is dominated by North ... Asia , and Rest of the World (RoW). The ...
(Date:7/2/2015)...  The Green Exchange, Inc., the developer,s of "Loud ... mobile app that connects cannabis growers directly to patients ... today that their service provides the fastest delivery on ... than half a dozen other delivery apps that have ... unique in that it connects growers directly with ...
(Date:7/2/2015)... Pharma Major Lupin Limited today announced ... Russia subject to certain closing conditions. ... which recorded RUB 765 billion in sales, placing it as ... in 2014 (IMS Health). For over a decade, Russian pharmaceutical ... this trend, projecting Russia to be ...
Breaking Medicine Technology:Global Cancer Diagnostics Market Report 2015 - Technology, Imaging and by Applications Forecasts to 2020 for the $13 Billion Industry 2New Cannabis Delivery App Gets Product to Patient in Under 7 Minutes 2Lupin Acquires Biocom in Russia 2Lupin Acquires Biocom in Russia 3
... Pharma, Inc.,(the Company) (Nasdaq: IDMI ) announced ... protocol finalized with the U.S. Food and Drug,Administration ... patients through a compassionate access study., "This ... number of,requests for compassionate access to L-MTP-PE," said ...
... emerging medical,device company in San Diego, CA, announced today ... of cerebral aneurysms was performed,by Dr. Sean Pakbaz at ... of a clinical protocol that had been approved by ... the patient,s aneurysm was a type and location,that is ...
Cached Medicine Technology:IDM Pharma Announces Availability of Mifamurtide (L-MTP-PE) Through Compassionate Access Study 2IDM Pharma Announces Availability of Mifamurtide (L-MTP-PE) Through Compassionate Access Study 3IDM Pharma Announces Availability of Mifamurtide (L-MTP-PE) Through Compassionate Access Study 4IDM Pharma Announces Availability of Mifamurtide (L-MTP-PE) Through Compassionate Access Study 5
... technology - Until now, if you wanted ... some of your patients while continuing to ... of patients, you had to keep a ... that has changed with Lifecard 12 - ...
This EIA microplate opens new perspectives in the direct detection of Chlamydia. The choice of microplate immunoenzymatic technology and the use of a monoclonal antibody result in a combination of c...
... Kit is a direct antigen detection system, that ... uses polyclonal and monoclonal antibodies to detect RSV ... the specificity and reproducibility of monoclonal antibodies with ... Qualitative results are availalbe within 90 minutes. The ...
... Every Bard BrachyStar® Needle is designed ... an efficient and clinically effective brachytherapy procedure. ... featuring ultra-sharp tips and polished surfaces for ... of needle configurations and sizes assures an ...
Medicine Products: